ʻO China renal cell carcinoma pathology outlines

China Renal Cell Carcinoma Pathology Outlines Understanding the Pathology of Renal Cell Carcinoma in China Hāʻawi kēia ʻatikala i kahi ʻike piha o nā hiʻohiʻona pathological o ka maʻi maʻi maʻi maʻi renal (RCC) ma Kina, e kālele ana i nā subtypes maʻamau, nā ala diagnostic, a me nā hopena prognostic. E ʻimi mākou i ka noiʻi hou loa a me nā alakaʻi lapaʻau e hāʻawi i kahi ʻike maopopo o kēia maʻi maʻi maʻi. Kuhi ʻia kēia kumuwaiwai no nā ʻoihana mālama olakino a me nā mea noiʻi makemake i ka RCC pathology.

Epidemiology a me Risk Factors o RCC ma Kina

Hōʻike ka maʻi maʻi maʻi Renal cell i kahi pilikia olakino olakino ma Kina. ʻOiai ʻokoʻa ka nui o ka helu ʻana ma nā wahi āpau, hōʻike nā haʻawina i ka piʻi ʻana o ke ʻano, e hōʻike ana i nā ʻano honua. Hoʻokomo ʻia kekahi mau mea pilikia i ka hoʻomohala ʻana i ka RCC, me ka puhi paka, ka momona, ka hypertension, a me ka mōʻaukala ʻohana. Eia kekahi, ʻo ka ʻike ʻana i kekahi mau toxins kaiapuni hiki ke pāʻani. He mea koʻikoʻi ka hoʻomaopopo ʻana i kēia mau mea pilikia no ka hoʻokō ʻana i nā hoʻolālā pale pono.

Hoʻokaʻawale Pathological o RCC

ʻO ka subtype histological nui o ʻO ka maʻi maʻi kino o Kina ʻO ia ka cell RCC (ccRCC), ka helu no ka hapa nui o nā hihia. Eia nō naʻe, loaʻa pū kekahi mau ʻano subtypes, e like me ka papillary RCC, chromophobe RCC, a me ka duct duct RCC. ʻO ka hoʻokaʻawale pathological pololei ka mea nui no ke alakaʻi ʻana i nā hoʻoholo lapaʻau a me ka wānana ʻana i ka prognosis. Hoʻohana nui ʻia nā ʻenehana pathological hou, me ka immunohistochemistry a me ka molecular profiling, e hoʻomaʻemaʻe i ka pololei diagnostic.

Hoʻomaʻemaʻe i ka maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi maʻi (ccRCC)

Hōʻike ʻia ka ccRCC e ka cytoplasm maʻemaʻe i loko o nā cell tumor ma muli o ka nui o ka glycogen a me ka lipid content. Hōʻike pinepine ia i ke ʻano o nā pūnana paʻa a me nā tubules. Hoʻopili pinepine ʻia nā hoʻololi molekala kikoʻī, e like me ka VHL gene mutations, me ccRCC. He mea koʻikoʻi ka hoʻomaopopo ʻana i kēia mau ʻano molekala no ka hoʻomohala ʻana i ka lāʻau lapaʻau.

Nā ʻano subtype ʻē aʻe o RCC

Hōʻike ʻia ʻo Papillary RCC e nā hale papillae-like, e hōʻike pinepine ana i kahi prognosis ʻoi aku ka maikaʻi ma mua o ka ccRCC. ʻAʻole maʻamau ka Chromophobe RCC a hōʻike i ke ʻano cytoplasm eosinophilic. ʻO ka hōʻiliʻili ʻana i ka duct RCC he subtype kakaʻikahi a paʻakikī. Pono ka hoʻokaʻawale pololei ʻana ma waena o kēia mau ʻano subtypes no nā hoʻolālā lapaʻau kūpono.

ʻO nā ala diagnostic no RCC ma Kina

ʻIkepili o ʻO ka maʻi maʻi kino o Kina ʻO ka mea maʻamau e pili ana i ka hui pū ʻana o nā haʻawina kiʻi (CT, MRI) a me ka nānā ʻana i ka histopathological o ka biopsy a i ʻole nā ​​mea hoʻokalakupua. ʻO nā holomua i nā ʻenehana kiʻi, me ka multiphasic CT, e hoʻonui i ka ʻike a me ke ʻano o ka nui o ka renal. Hiki ke hāʻawi i ka biopsy aspiration fine-needle i ka ʻike cytological preliminary, ʻoiai ʻo ka ʻoki ʻoki ʻana e ʻae i ka maʻi pathological definitive.

Nā Kūlana Prognostic a me nā hopena lapaʻau

Nui nā mea e hoʻopili i ka wānana o RCC, me ka pae tumo (TNM staging), histological grade, a me ka hele ʻana o ka metastasis. Hāʻawi ka ʻōnaehana staging TNM i kahi ala kūpono i ka stratification pilikia. Eia kekahi, loiloi ka ʻōnaehana helu Fuhrman i nā hiʻohiʻona nuklea o nā pūnaewele RCC e wānana i ka hana ʻino. Ke alakaʻi nei kēia mau mea i nā hoʻoholo lapaʻau, mai ka ʻoki ʻoki ʻana i nā lāʻau lapaʻau a me ka immunotherapy.

Noiʻi a me nā kuhikuhi e hiki mai ana

Ke hoʻomau nei ka noiʻi ʻana ma Kina i ka hoʻomaikaʻi ʻana i ka ʻike mua, ka hoʻomaʻemaʻe ʻana i nā ʻenehana diagnostic, a me ka hoʻomohala ʻana i nā lāʻau lapaʻau noʻonoʻo. ʻO ka maʻi maʻi kino o Kina. Hoʻopili kēia i nā noiʻi i nā biomarkers no ka ʻike mua ʻana, ka ʻimi ʻana i nā pahuhopu therapeutic novel, a me nā hoʻokolohua lapaʻau e loiloi ana i nā ala lapaʻau hou. ʻO ka hui pū ʻana ma waena o nā mea noiʻi, nā kauka, a me nā mea hana kulekele he mea nui e holomua i ka ʻike a me ka hoʻokele ʻana o RCC ma Kina.

Papa: Hoʻohālikelike o RCC Subtypes

Hōʻole: No ka hoʻonaʻauao wale nō kēia ʻike a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. E kūkākūkā mau me kekahi kauka mālama ola no nā pilikia olakino a i ʻole ma mua o ka hoʻoholo ʻana e pili ana i kou olakino a lapaʻau paha.

No ka ʻike hou aku e pili ana i ka noiʻi maʻi kanesa a me nā koho lapaʻau, e kipa Shandong Baofa Cancer Research Institute.