ka lapaʻau ʻana i ka maʻi maʻi ʻaʻai nui

ʻO ka maʻi maʻi ʻaʻai ʻana o ka pūpū nui (LCLC) he ʻano ʻano koʻikoʻi o ka maʻi maʻi ʻaʻai maʻi ʻaʻai liʻiliʻi liʻiliʻi (NSCLC). He ʻokoʻa nā koho lapaʻau a hilinaʻi i ka pae maʻi maʻi, ke olakino holoʻokoʻa, a me nā makemake o nā mea maʻi. ʻO nā ala maʻamau e pili ana i ka ʻokiʻoki, radiation therapy, chemotherapy, targeted therapy, a me ka immunotherapy. ʻO ka hui pū ʻana i nā lāʻau lapaʻau e hāʻawi pinepine i nā hopena maikaʻi loa.ʻO ka maʻi maʻi ʻaʻai ʻana o ka pūpū nui (LCLC) ʻike ʻia e nā cell nui, ʻano like ʻole ke nānā ʻia ma lalo o kahi microscope. Aia ma kahi o 5-10% o nā maʻi kanesa āpau. Ma muli o kona ʻano koʻikoʻi, koʻikoʻi ka ʻike mua ʻana a me ka mālama ʻana. He ʻano liʻiliʻi ia o ka NSCLC, ʻo ia hoʻi, ʻokoʻa kona ʻano a mālama ʻia ʻo ia ma mua o ka liʻiliʻi cell lung cancer (SCLC). LCLC, hiki ke hana hou i ka subtyping e alakaʻi maikaʻi i nā hoʻolālā lapaʻau. Aia kēia mau mea: ʻO ka maʻi maʻi neuroendocrine cell nui (LCNEC): Hāʻawi kēia subtype i nā ʻano me nā mea ʻelua ka maʻi maʻi ʻaʻai nui o ka maʻi a me ka ma'i ma'i ma'i ma'i li'ili'i. Basaloid carcinoma: ʻO kahi subtype kakaʻikahi a hoʻopaʻapaʻa. Lymphoepithelioma-like carcinoma: ʻOi aku ka maʻamau i nā poʻe o ka lāhui ʻAsia a pili pinepine me ka maʻi maʻi Epstein-Barr. Hoʻomaʻemaʻe i ka maʻi maʻi maʻi kino: Hōʻike ʻia e nā cell me kahi hiʻohiʻona a i ʻole ka hakahaka ma lalo o kahi microscope.Diagnosis of Large Cell Lung CancerDiagnosing ka maʻi maʻi ʻaʻai nui o ka maʻi ʻO ka mea maʻamau e pili ana i kahi hui o nā hoʻokolohua kiʻi a me nā biopsies. Nā hoʻāʻo kiʻi: X-ray o ka umauma: Hoʻohana pinepine ʻia ka hoʻāʻo kiʻi mua e ʻike i nā mea ʻino i loko o ka māmā. CT Scan Hāʻawi i nā kiʻi kikoʻī hou aʻe o nā māmā a me nā hale a puni, e kōkua ana e hoʻoholo i ka nui a me kahi o ka ʻōpū. PET Scan (Positron Emission Tomography): ʻIke i nā cell metabolically active, kōkua i ka ʻike ʻana i nā ʻiʻo maʻi kanesa a hoʻoholo inā ua laha ka maʻi kanesa. MRI Hiki ke hoʻohana ʻia e loiloi i ka laha ʻana o ka maʻi kanesa i ka lolo a i ʻole ke kuamoʻo. Biopsy: Lawe ʻia kahi laʻana o ka ʻiʻo no ka nānā ʻana ma lalo o kahi microscope. Aia nā ʻano hana biopsy: Bronchoscopy: Hoʻokomo ʻia kahi paipu lahilahi a maʻalahi me ka pahupaʻikiʻi ma ka ihu a i ʻole ka waha i loko o ka māmā e ʻike a hōʻiliʻili i nā laʻana kiko. ʻO ka biopsy o ka nilala: Hoʻokomo ʻia kahi nila ma ka paia o ka umauma e hōʻiliʻili i kahi laʻana kiko mai ka ʻōpū. Hiki ke alakaʻi ʻia kēia ma CT no ka pololei. ʻO ka biopsy ʻokiʻoki: I kekahi mau hihia, pono paha ka ʻoki ʻana no ka loaʻa ʻana o kahi laʻana kikoʻī lawa. ʻO nā koho Large Cell Lung Cancer Treatment Options ʻO ka maikaʻi loa ka lapaʻau ʻana i ka maʻi maʻi ʻaʻai nui pili i kekahi mau kumu, e like me ka pae o ka maʻi kanesa, ke olakino holoʻokoʻa o ka mea maʻi, a me kā lākou makemake. Hiki ke hoʻohana wale ʻia nā koho lapaʻau ka maʻi maʻi ʻaʻai nui o ka maʻi i ka wā e ʻike ʻia ai ka ʻōpū a hiki ke wehe loa ʻia. Loaʻa nā koho ʻokiʻoki: Wedge Resection: Ka wehe ʻana i kahi ʻāpana liʻiliʻi o ke akemāmā i loko o ka ʻōpū. Hoʻokaʻawale ʻia: ʻO ka wehe ʻana i kahi ʻāpana nui o ka māmā ma mua o kahi ʻoki ʻoki. Lobectomy: Ka wehe ʻana i kahi lobe holoʻokoʻa o ka māmā. Pneumonectomy: Ka wehe ʻana i kahi māmā holoʻokoʻa. ʻO kā mākou hoa pili, Shandong Baofa Cancer Research Institute, ma baofahospital.com, loea i nā ʻenehana hana hou no ka maʻi maʻi ʻaʻai. Hiki ke hoʻohana ʻia e like me ka lāʻau lapaʻau mua no ka maʻi maʻi ʻaʻai nui o ka maʻi inā ʻaʻole he koho ke ʻoki ʻana, a i ʻole hiki ke hoʻohana ʻia ma hope o ke kaʻa ʻana e pepehi i nā maʻi kanesa i koe. ʻO nā ʻano o ka radiation therapy nā: ʻO ka hoʻomaʻamaʻa ʻana i ka lāʻau lapaʻau waho (EBRT): Hāʻawi ʻia ka radiation mai kahi mīkini ma waho o ke kino. ʻO ka hoʻomaʻamaʻa ʻana o ke kino stereootactic (SBRT): Hāʻawi i nā kiʻekiʻe kiʻekiʻe o ka radiation i kahi wahi liʻiliʻi i kuhikuhi pono ʻia. ʻO Brachytherapy (Hoʻomaʻamaʻa Radiation Loko): Hoʻokomo pololei ʻia nā hua radioactive a i ʻole nā uea i loko a kokoke paha i ka maʻi maʻi. Hoʻohana pinepine ʻia no ka maʻi maʻi ʻaʻai nui o ka maʻi ka mea i laha ma waho o ka akemāmā a i ʻole hiki ke ʻoki ʻia. Hoʻohana pinepine ʻia nā lāʻau lapaʻau Chemotherapy me ka intravenously (ma o ka vein) a i ʻole ka waha. ʻOi aku ka maikaʻi o kēia mau lāʻau i ka wā e loaʻa ai nā ʻano hoʻololi genetic kikoʻī o ka maʻi kanesa. Loaʻa nā pahuhopu maʻamau: EGFR (Epidermal Growth Factor Receptor): ʻOi aku ka maʻamau o ka hoʻololi ʻana i ka EGFR i kekahi mau heluna kanaka. ALK (Anaplastic Lymphoma Kinase): Hiki ke hana maikaʻi loa nā mea hoʻopaneʻe ALK i nā poʻe maʻi me ka ALK-maikaʻi ka maʻi maʻi ʻaʻai nui o ka maʻi. ROS1: Hoʻohana ʻia nā mea hoʻopaneʻe ROS1 no nā maʻi maʻi ROS1-maikaʻi. ka lapaʻau ʻana i ka maʻi maʻi ʻaʻai nui.ImmunotherapyHe kōkua ka Immunotherapy i ke kino o ke kino e hakakā i ka ma'i 'a'ai. Ke hana nei kēia mau lāʻau lapaʻau ma ke kāohi ʻana i nā protein e pale ai i ka ʻōnaehana pale mai ka hoʻouka ʻana i nā maʻi maʻi maʻi. Hoʻohana pinepine ʻia nā lāʻau immunotherapy no ka holomua ka maʻi maʻi ʻaʻai nui o ka maʻi.Lapaʻau ʻana ma ke kahuaThe stage of ka maʻi maʻi ʻaʻai nui o ka maʻi hoʻoikaika nui i ke ʻano lapaʻau. Hoʻokokoke ʻia ka Lapaʻau maʻamau i ka pae I & II (Papa Mua) ʻO ka ʻoki ʻana (lobectomy a i ʻole ka wedge resection) a ukali ʻia e ka chemotherapy inā pono. Hiki ke noʻonoʻo ʻia ka lāʻau lapaʻau inā ʻaʻole he koho. Ka Papa III (Locally Advanced) Hui o ka chemotherapy a me ka radiation therapy. Hiki ke noʻonoʻo ʻia ke ʻoki ʻana i nā hihia koho. Hiki ke hoʻohana ʻia ka immunotherapy ma hope o ka chemoradiation. Ka Papa IV (Metastatic) Kemotherapy, ka lāʻau lapaʻau i manaʻo ʻia (inā loaʻa nā hoʻololi kūpono), a me ka immunotherapy. Hiki ke hoʻohana ʻia ka lāʻau lapaʻau e hoʻopau i nā hōʻailona. ʻO nā hoʻokolohua lapaʻau ʻo nā hoʻokolohua hoʻokolohua he noiʻi noiʻi e loiloi i nā mea hou ka lapaʻau ʻana i ka maʻi maʻi ʻaʻai nui nā koho. ʻO ke komo ʻana i kahi hoʻokolohua lapaʻau hiki ke hāʻawi i ke komo ʻana i nā lāʻau lapaʻau ʻokiʻoki a kōkua i nā holomua i ka mālama ʻana i ka maʻi kanesa. ka maʻi maʻi ʻaʻai nui o ka maʻi 'oko'a ma muli o ka pae o ka ma'i 'a'ai ma ka hō'ike 'ana a me ka lā'au i loa'a. ʻO ka ʻike mua ʻana a me ka mālama koʻikoʻi hiki ke hoʻomaikaʻi i nā hopena. He mea nui nā koho hoʻopaʻa maʻamau no ka nānā ʻana no ka hoʻi hou ʻana. Ka noho ʻana me ka maʻi maʻi maʻi maʻi maʻi maʻi nui ka maʻi maʻi ʻaʻai nui o ka maʻi hiki ke paʻakikī ka ʻike. Hiki i nā hui kākoʻo, ka ʻōlelo aʻo, a me nā hoʻololi ʻana i ke ʻano o ka nohona (e like me ka haʻalele ʻana i ka puhi paka a me ka mālama ʻana i ka meaʻai olakino) hiki ke kōkua i nā poʻe maʻi e hoʻokō i nā pilikia kino a me ka naʻau o ka maʻi.Hōʻole: ʻO kēia ʻike no ka ʻike ākea a me ka ʻike ʻike wale nō, ʻaʻole ia he ʻōlelo aʻoaʻo olakino. He mea nui e kūkākūkā me kekahi kauka lapaʻau koʻikoʻi no nā pilikia olakino a i ʻole ma mua o ka hoʻoholo ʻana e pili ana i kou olakino a lapaʻau paha. Pono e hoʻoholo ʻia nā koho lapaʻau e ke kauka mālama ola ma muli o nā mea maʻi pilikino.Kuhikuhi: American Cancer Society: https://www.cancer.org/ National Cancer Institute: https://www.cancer.gov/