ʻO ka hoʻouna ʻana i nā lāʻau lapaʻau kūloko no ka maʻi maʻi: He alakaʻi holoʻokoʻa ke hoʻololi nei nā ʻōnaehana hoʻopuka lāʻau kūloko i ka mālama ʻana i ka maʻi maʻi ma o ka hoʻopaʻa ʻana i nā mea lapaʻau ma ka pūnaewele tumor. 

ʻO ka lawe ʻana i ka lāʻau lapaʻau kūloko no ka maʻi maʻi: He alakaʻi piha ʻo nā ʻōnaehana hoʻopuka lāʻau i hoʻololi ʻia i ka mālama ʻana i ka maʻi maʻi ma o ka hoʻopaʻa ʻana i nā mea lapaʻau ma ke kahua maʻi tumora, e hōʻemi ana i ka ʻona a me ka hoʻonui ʻana i ka pono. Ke ʻimi nei kēia ʻatikala i nā ala like ʻole, nā pōmaikaʻi, nā pilikia, a me nā kuhikuhi o ka wā e hiki mai ana ka lawe ʻana i ka lāʻau lapaʻau kūloko no ka maʻi kanesa.

Nā ʻano o nā ʻōnaehana lawe lāʻau kūloko

1. Nā mea hiki ke kanu ʻia

ʻO nā mea i hoʻokomo ʻia, e like me nā pamu a me nā waihona, hāʻawi i ka hoʻokuʻu ʻia ʻana o nā mea hana chemotherapeutic pololei i loko o ka microenvironment tumor. Hāʻawi kēia mau mea hana i ka hāʻawi ʻana i ka lāʻau lapaʻau hoʻomau, e hōʻemi ana i ka pinepine o ka hoʻokele ʻana a me ka hoʻomaikaʻi ʻana i ka mālama ʻana i ka maʻi. ʻO nā laʻana me nā wafers Gliadel no ka lolo lolo a me nā polymers biodegradable no ka lawe ʻana i nā lāʻau anticancer. Ke ʻimi nei ka Shandong Baofa Cancer Research Institute i nā holomua hou loa i nā ʻenehana implantable no ka lawe ʻana i ka lāʻau lapaʻau kūloko no ka maʻi kanesa.

2. Nanoparticles

ʻO nā nanoparticles nā ʻāpana microscopic e hiki ke hoʻopili a hāʻawi i nā lāʻau lapaʻau i ka pūnaewele tumor. ʻO ko lākou liʻiliʻi e hiki ai ke hoʻonui i ke komo ʻana i loko o ka ʻiʻo tumo, a hiki ke hoʻololi ʻia ko lākou ʻili e hoʻopaʻa i nā pūnaeho maʻi maʻi. Hoʻohana mau ʻia nā liposomes, nā nanoparticles polymeric, a me nā nanoparticles inorganic ka lawe ʻana i ka lāʻau lapaʻau kūloko no ka maʻi kanesa. Ke hoʻomau nei ka noiʻi no ka hoʻomaikaʻi ʻana i ka pono o ka huli ʻana a me ka hiki ke hoʻouka lāʻau o kēia mau nanoparticles. No ka ʻike hou aku e pili ana i nā holomua hou, e kipa i ka pūnaewele ʻo Shandong Baofa Cancer Research Institute. https://www.baofa-hospital.com/

3. ʻO nā lāʻau lapaʻau i koho ʻia

Hoʻohana nā lāʻau lapaʻau i hoʻopaʻa ʻia i nā antibodies a i ʻole nā ​​molekole ʻē aʻe e hoʻopaʻa pono i nā pūnaeau maʻi maʻi, e hāʻawi pololei ana i nā lāʻau lapaʻau i ka ʻōpū aʻo ka mālama ʻana i ke kino olakino. Hoʻemi kēia ala i nā hopena ʻaoʻao a hoʻomaikaʻi i ka maikaʻi o ka mālama ʻana. ʻO nā antibodies monoclonal i hui pū ʻia me nā lāʻau cytotoxic (Antibody-drug conjugates a i ʻole ADCs) he kumu hoʻohālike o ka mea i manaʻo ʻia. ka lawe ʻana i ka lāʻau lapaʻau kūloko no ka maʻi kanesa.

4. Nā Paʻi Microneedle

Hāʻawi nā ʻāpana Microneedle i kahi ala ʻeha a me ka liʻiliʻi loa no ka lawe ʻana i ka lāʻau. Aia i loko o kēia mau ʻāpana nā microneedles e komo i loko o ka ʻili, e hāʻawi pololei ana i nā lāʻau lapaʻau i ka ʻōpū a i ʻole nā ​​​​limp nodes kokoke. ʻO kēia ʻenehana he mea hoʻohiki maikaʻi loa no ka mālama ʻana i nā maʻi maʻi ʻili a me nā maʻi ʻokoʻa ʻē aʻe.

Nā Pōmaikaʻi a me nā Paʻakikī o ka Hāʻawi ʻana i ka Laʻau Kūloko

Nā kuhikuhi no ka wā e hiki mai ana i ka lawe ʻana i nā lāʻau lapaʻau kūloko no ke kanesa

Ke hoʻomau nei ka noiʻi e hoʻomaikaʻi i ka pono a me ka palekana o ka lawe ʻana i ka lāʻau lapaʻau kūloko no ka maʻi kanesa. Hoʻopili kēia i ka hoʻomohala ʻana i nā ʻōnaehana lawe lāʻau hou, hoʻomaikaʻi i nā hoʻolālā hoʻolālā, a me nā ala lapaʻau pilikino. ʻO ka hui ʻana o hāʻawi lāʻau kūloko me nā lāʻau lapaʻau maʻi maʻi ʻē aʻe, e like me ka immunotherapy, he wahi hoʻohiki no ka noiʻi. Ua kūpaʻa ka Shandong Baofa Cancer Research Institute i ka holomua ʻana i ke kahua o ka lawe ʻana i ka lāʻau lapaʻau kūloko no ka maʻi kanesa ma o ka noiʻi hou a me nā hoʻokolohua lapaʻau.

Ka hopena

Hāʻawi ʻia ka lāʻau lapaʻau kūloko no ka maʻi kanesa hāʻawi i nā pōmaikaʻi koʻikoʻi ma mua o nā ʻōnaehana systemic kuʻuna. ʻOiai e mau ana nā paʻakikī, ke hoʻomau nei ka noiʻi a me ka hoʻomohala ʻana i ke ala no ka hoʻomaʻamaʻa ʻana i ka maʻi maʻi ʻoi aku ka maikaʻi a me ka liʻiliʻi. ʻO ka wā e hiki mai ana o ka mālama ʻana i ka maʻi maʻi e pili ana i ka hui pū ʻana o nā lāʻau lapaʻau i manaʻo ʻia a me nā ʻōnaehana lawe lāʻau holomua.