ʻO ka lawe ʻana i ka lāʻau lapaʻau i manaʻo ʻia no ka maʻi maʻi maʻi: He Manaʻo Nui 

Hāʻawi ʻia ka lāʻau lapaʻau no ka maʻi kanesa e kālele ana i ka hāʻawi ʻana i nā lāʻau lapaʻau kūikawā i nā cell cancer, e hōʻemi ana i ka pōʻino i nā ʻiʻo olakino. Ke hoʻohana nei kēia ala i nā hoʻolālā like ʻole, me nā nanoparticles, antibodies, a me nā peptides cell-penetrating, e hoʻomaikaʻi i ka pono o ka lāʻau lapaʻau a hōʻemi i nā hopena ʻaoʻao, e hāʻawi ana i kahi lāʻau lapaʻau maʻi maʻi maʻi.

ka hoomaopopo ana Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi

Ua ulu nui ka mālama ʻana i ka maʻi maʻi, me ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa e puka mai ana ma ke ʻano he hoʻolālā hoʻohiki. Ke manaʻo nei kēia ala e hāʻawi i nā lāʻau lapaʻau i nā cell cancer, e hoʻonui i nā hopena therapeutic aʻo ka hōʻemi ʻana i ka pōʻino i nā ʻiʻo olakino. ʻAʻole like me ka chemotherapy maʻamau, ka mea e puʻunaue ana i nā lāʻau lapaʻau a puni ke kino, hoʻohana ʻia ka lawe ʻana i nā ʻano hana like ʻole e hoʻopaʻa pono ai i nā cell cancer.

No ke aha Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi Nā mea pili

ʻO ka chemotherapy maʻamau ka hopena i nā hopena koʻikoʻi no ka mea e pili ana i nā maʻi maʻi a me nā cell olakino. Hāʻawi ʻia ka lāʻau lapaʻau no ka maʻi kanesa hāʻawi i kahi hoʻonā ma ka hāʻawi ʻana i nā lāʻau lapaʻau i ka pūnaewele tumor. Hoʻemi kēia i ka ʻona ʻōnaehana, hoʻomaikaʻi i ka pono o ka lāʻau, a hiki ke hoʻonui i ka maikaʻi o ke ola o ka maʻi.

Nā papahana no Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi

Hoʻohana ʻia kekahi mau hoʻolālā hou i ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa, kēlā me kēia me kona pono pono'ī a me nā palena.

Nanoparticles

ʻO nā nanoparticles nā ʻāpana liʻiliʻi (1-100 nm) i hoʻolālā ʻia e hoʻopili a hāʻawi i nā lāʻau lapaʻau i nā maʻi kanesa. Hiki iā lākou ke hana ʻia e hoʻopaʻa i nā mea loaʻa kikoʻī ma nā pūnaewele maʻi kanesa, e like me EGFR a i ʻole HER2. Hoʻohana mau ʻia nā liposomes, nā nanoparticles polymeric, a me nā nanoparticles inorganic. ʻO ka hopena i hoʻonui ʻia i ka permeability a me ka hoʻopaʻa ʻana (EPR) hiki i nā nanoparticles ke hōʻiliʻili i nā ʻiʻo tumora ma muli o ka leaky vasculature.

Laʻana: ʻO Doxil, kahi liposomal doxorubicin, he lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana i ka maʻi ovarian a me ka myeloma lehulehu.

ʻO nā mea hoʻohui lāʻau antibody (ADC)

Aia nā ADC i kahi antibody monoclonal i hoʻopili ʻia i kahi lāʻau cytotoxic. Hoʻopaʻa paʻa ka antibody i kahi antigen i hoʻopaʻa ʻia ma nā maʻi kanesa, e alakaʻi ana i ka internalization o ka ADC a me ka hoʻokuʻu ʻana o ka lāʻau i loko o ke kelepona.

Laʻana: Hoʻokumu ʻo Adcetris (brentuximab vedotin) i ka CD30, he pūmua i loaʻa ma kekahi mau pūnaewele lymphoma, e hāʻawi ana i kahi microtubule-disrupting agent.

Nā Peptides Kuʻi Paʻi Paʻa (CPP)

ʻO nā CPP nā ʻāpana amino acid pōkole e hoʻomaʻamaʻa i ke komo ʻana o nā lāʻau lapaʻau a i ʻole nā nanoparticles i loko o nā cell. Hiki iā lākou ke hoʻohui ʻia i nā mea therapeutic a i ʻole nanoparticles e hoʻomaikaʻi i kā lākou cellular uptake.

Endocytosis i hoʻopili ʻia e ka Receptor

Hoʻopili kēia hoʻolālā i ka huli ʻana i nā mea loaʻa i hoʻohālikelike ʻia i nā maʻi kanesa. Hoʻohana ʻia nā ligands a i ʻole nā ​​antibodies e hoʻopaʻa i kēia mau mea loaʻa e hoʻopuka i nā lāʻau lapaʻau a i ʻole nanoparticles ma o ka endocytosis.

ʻO Shandong Baofa Cancer Research Institute's Role

Ke komo ikaika nei ka Shandong Baofa Cancer Research Institute i ka noiʻi ʻana a me ka hoʻomohala ʻana i ka moʻolelo ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa ʻōnaehana. Ke nānā nei kā lākou noiʻi ʻana i nā ala pilikino e noʻonoʻo ana i nā ʻano genetic a me nā molecular profiles o kēlā me kēia maʻi, e manaʻo ana e hoʻomaikaʻi i nā hopena lapaʻau a hōʻemi i nā hopena ʻaoʻao.

Hana pū ʻo Shandong Baofa Cancer Research Institute me nā halemai e like me ka Shandong Baofa Cancer Hospital (https://baofahospital.com) e hana i nā hoʻokolohua lapaʻau a unuhi i nā ʻike noiʻi i loko o nā noi kūpono.

Pono o Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi

Hāʻawi ʻia ka lāʻau lapaʻau no ka maʻi kanesa Hāʻawi ia i kekahi mau mea pono nui ma mua o ka chemotherapy maʻamau:

• Hoʻemi ʻia ka ʻawaʻawa: Ma ka huli pono ʻana i nā cell cancer, hoʻemi ʻia ka ʻike ʻana o nā ʻiʻo olakino i nā lāʻau ʻawaʻawa, e alakaʻi ana i ka liʻiliʻi o nā hopena ʻaoʻao.
• Hoʻomaikaʻi maikaʻi ʻia: Hiki ke hāʻawi pololei ʻia ka ʻoi aku o ka nui o nā lāʻau lapaʻau i ka pae maʻi maʻi, hiki ke hoʻonui i ka hopena therapeutic.
• Lapaʻau pilikino: Hāʻawi ʻia ka lāʻau lapaʻau no ka maʻi kanesa hiki ke hoʻohālikelike ʻia i nā ʻano kikoʻī o ka maʻi maʻi maʻi, e alakaʻi ana i nā hoʻolālā lapaʻau ʻoi aku ka maikaʻi a pilikino.
• Ke lanakila 'ana i ka lā'au kū'ē: ʻO kekahi ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa hiki i nā ʻōnaehana ke lanakila i nā mīkini kūʻē i ka lāʻau lapaʻau, e ʻoi aku ka maʻalahi o nā cell cancer i ka mālama ʻana.

Nā pilikia ma Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi

ʻOiai kāna ʻōlelo hoʻohiki, ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa ke alo nei i kekahi mau pilikia:

• Kūlana kikoʻī: He mea koʻikoʻi ka hōʻoia ʻana e hoʻopaʻa ʻia ka mea hoʻopaʻa ʻia i nā maʻi kanesa a ʻaʻole i nā ʻiʻo olakino.
• ʻO ke komo ʻana o ka tumora: He mea paʻakikī ka hāʻawi ʻana i nā lāʻau lapaʻau i nā wahi āpau o ka ʻōpū, ʻoi aku ka paʻakikī me ka stroma paʻa.
• Hoʻokuʻu lāʻau lapaʻau: ʻO ka hoʻomalu ʻana i ka hoʻokuʻu ʻana o ka lāʻau lapaʻau ma ka pūnaewele tumor ka mea nui e hoʻonui i kona hopena therapeutic.
• Immunogenicity: ʻO kekahi ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa ʻO nā ʻōnaehana, e like me nā mea i hoʻokumu ʻia i nā antibodies a i ʻole nā ​​viruses, hiki ke kiʻi i kahi pane kūlohelohe, e kaupalena ana i ko lākou pono.
• Uku: ʻO ka hoʻomohala ʻana a me ka hana ʻana o ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa hiki ke pipiʻi nā ʻōnaehana.

Nā laʻana o Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi i ka hoʻohana lāʻau lapaʻau

He mau ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa ʻae ʻia nā ʻōnaehana i kēia manawa no ka hoʻohana lāʻau lapaʻau:

Nā kuhikuhi e hiki mai ana ma Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi

Ke kahua o ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa ke ulu wikiwiki nei. E nānā ka noiʻi e hiki mai ana ma:

• Ke hoʻomohala ʻana i nā mea kikoʻī kikoʻī a maikaʻi hoʻi.
• Hoʻomaikaʻi i ke komo ʻana o ka tumora a me ka hoʻokuʻu lāʻau.
• Hoʻohui ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa me nā lāʻau lapaʻau ʻē aʻe, e like me ka immunotherapy a me ka radiation therapy.
• Ke hoʻomohala ʻana i ka pilikino ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa nā hoʻolālā e pili ana i nā hiʻohiʻona kūʻokoʻa o nā maʻi maʻi o kēlā me kēia maʻi.
• Ke hoʻohana ʻana i ka naʻauao artificial e hoʻolālā a hoʻopono ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa ʻōnaehana.

Hāʻawi ʻia ka lāʻau lapaʻau no ka maʻi kanesa paʻa i ka ʻōlelo hoʻohiki nui no ka hoʻomaikaʻi ʻana i ka mālama ʻana i ka maʻi kanesa a me nā hopena maʻi. Ke hoʻomau nei ka noiʻi, hiki iā mākou ke manaʻo e ʻike ʻoi aku ka maikaʻi a pilikino ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa puka mai nā hoʻolālā, i ka hopena e alakaʻi i ka mālama maʻi maʻi ʻoi aku ka maikaʻi.