Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza: Ushwankathelo olubanzi 

Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza ijolise ekunikezeleni iiarhente zonyango ngokukodwa kwiiseli zomhlaza, ukunciphisa ukwenzakala kwizicubu ezisempilweni. Le ndlela isebenzisa iindlela ezahlukeneyo, kubandakanya nee-nanopargarcles, ii-antibodies, kunye neseli-ingene kwi-peptides esebenzisa iziyobisi, ukuphucula ukusebenza kweziyobisi kunye nokucutha unyango oluchanekileyo nolwabuqu kunye nolwalamano oluchanekileyo nolwenziwa luhlobo lomhlaza.

Ukuqonda Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza

Unyango lomhlaza luye lwavela kakhulu, kunye Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza ivela njengesicwangciso esithembisayo. Le ndlela ijolise ekukhetheni iziyobisi ngokukhethekileyo iziyobisi kwiiseli zomhlaza, zandisa iziphumo zonyango ngelixa kuncitshiswa umonakalo kwizicubu ezisempilweni. Ngokungafaniyo nonyango oluqhelekileyo chemotherapy, olusasaza iziyobisi kulo lonke umzimba, ukuhanjiswa ekujoliswe kubo kusebenzisa iindlela ezahlukeneyo ukuze zijolise kwiiseli zomhlaza.

Ngoba Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Imicimbi

I-chemotherapy yesiqhelo ihlala ikhokelela kwiziphumo ebezingalindelekanga ezibalulekileyo kuba ichaphazela iiseli zomhlaza kunye nempilo. Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza inikezela ngesisombululo ngokuhambisa iziyobisi ngokuthe ngqo kwi-tumoor. Oku kunciphisa ityhefu ye-stcino, kuphucula ukusebenza kweziyobisi, kwaye oku kunokubangela ukuba ubomi bobuguli bobomi.

Izicwangciso ze Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza

Izicwangciso eziliqela ezinobuchule zisetyenziswa Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza, nganye inezibonelelo zayo kunye nokusikelwa umda.

I-nanoparclecles

I-nanopalicles ngamasuntswana amancinci (i-1-100 NM) eyenzelwe ukuhambisa i-ecayitha kwaye ihambise iziyobisi kwiiseli zomhlaza. Banokubekwa injineli ukujolisa ii-receptors ezithile kwiiseli zomhlaza, ezinjenge-ENFR okanye i-HE2. I-LIOSOMES, iPolymeric Nanopalicals, kunye ne-nanopalic napticcurgacticles zisetyenziswa rhoqo. Iziphumo eziphuculweyo kunye nokugcinwa (i-EPRT) ivumela i-nanopalicals ukuba iqokelele ngokupheleleyo kwizicubu ze-tumor ngenxa ye-vasculature evuyiweyo.

Umzekelo: I-Doxil, i-piposomal doxormicinaubin, yindawo ekhoyo yezorhwebo i-Nanoparcicle-esekwe kwiziyobisi esetyenziselwa ukuphatha umhlaza we-ovari kunye ne-myloma ezininzi.

I-Antictur-Iyobisi leziyobisi (ADCs)

I-ADCS iquka i-antidnAl antiddom edityaniswe kwichiza le-cytotoovity. I-antiddy ibopha ngokuthe ngqo kwi-Antigen yeAntigen yeeseli zomhlaza, ekhokelela ekusebenzeni kwangaphakathi kwe-ADC kunye nokukhutshwa kwechiza ngaphakathi kwiseli.

Umzekelo: I-Adcetris (i-Brentimanab Vedotin) Ithagethi ye-CD30, iprotein efumaneka kwiiseli ezithile ze-lymphoma, ehambisa iarhente ephazamisayo ye-microrubule.

I-Pepeting Preptides (CPPS)

I-CPPs ilandelelana emfutshane ye-amino acid ngokulandelelana okuqokelele ukungena kwamachiza okanye i-nanopalicalles kwiiseli. Banokuthuthuzelwa kwiiarhente zonyango okanye kwii-nanopalicals zokuphucula ukuphakama kwabo.

I-ReadPric-i-Endocytosis yesifo

Esi sicwangciso siquka ukujolisa ii-Rectors ezihamba nge-ofisi yeeseli zomhlaza. I-ligands okanye ii-antibodies ezibophelele kolu zihlomelo zisetyenziselwa ukuhambisa iziyobisi okanye i-nanopalicles nge-endocytosis.

Indima yoMhlaza weShandong Bae

IZiko loPhando lwe-Shandong Baena lithatha inxaxheba ngenkuthalo kuphando kunye nokuphuhlisa inoveli Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza iinkqubo. Uphando lwabo lujolise kwiindlela ezenziwe ngobuntu eziqwalasele iiprofayili ezizodwa zemfuza kunye neemolekyuli zezigulana nganye, ezijolise ekuphuculeni iziphumo zonyango kwaye zinciphise iziphumo ebezingalindelekanga.

IZiko loPhando lweShandong Baefhttps //baofital.com) Ukuqhuba iimvavanyo zeklinikhi kwaye uguqulele iziphumo zophando kwizicelo ezisebenzayo.

Izibonelelo ze Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza

Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza inika izibonelelo ezininzi eziphambili zokunyanga okuqhelekileyo chemotherapy:

• Incitshiswe ityhefu yobuso: Ngokujongisisa iiseli zohlaza ngokuthe ngqo, ukubonakaliswa kwezicubu ezinempilo ukuya kumachiza anetyhefu kuyancitshiswa, kukhokelela kwiziphumo ebezingalindelekanga ezimbalwa.
• Ukuphuculwa kokusebenza kakuhle: Ukugxininiswa okuphezulu kwamachiza kunokusiwa ngokuthe ngqo kwi-tumor indawo, enokwandisa ukusebenza kakuhle konyango.
• Unyango olwenziweyo: Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza inokulungelelaniswa kwiimpawu ezithile zomhlaza wesigulana, ezikhokelela kwizicwangciso zonyango ezisebenzayo nezinemisebenzi.
• Ukuphelisa ukumelana namachiza: Ezinye Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Iinkqubo zinokoyisa iindlela zokunyangwa ngamachiza, zenza iiseli zomhlaza zingaphezulu kunyango.

Imiceli mngeni kwi Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza

Ngaphandle kwedinga laso, Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Ubujongele imiceli mngeni eliqela:

• Ithagethi: Ukuqinisekisa ukuba iarhente ekujoliswe kuyo ibopha kuphela kwiiseli zomhlaza kwaye hayi kwizicubu ezisempilweni kubalulekile.
• I-Tumor Penation: Ukuhambisa amachiza ngokufanelekileyo kuzo zonke iindawo zethumba, ngakumbi kumathumba aqinileyo nge-troma eqinileyo, kunokuba ngumceli mngeni.
• Ukukhutshwa ngamachiza: Ukulawula ukukhululwa kwechiza kwindawo ye-tumor kubalulekile ukukhulisa isiphumo sayo sonyango.
• I-MUROGENICIZUTIT: Ezinye Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Iinkqubo, ezinjengezo zisekwe kwii-antibodies okanye iintsholongwane, zinokufikelela kwimpendulo yomzimba, ukunciphisa ukusebenza kwabo ukusebenza.
• Ixabiso: Uphuhliso kunye nemveliso ye Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Iinkqubo zinokubiza kakhulu.

Imizekelo ye Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza ekusebenziseni kweklinikhi

Iqela Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Iinkqubo ezivunyiweyo ngoku zisetyenziselwa iKlinikhi:

Izikhombisi zexesha elizayo Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza

Intsimi ye Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza ivele ngokukhawuleza. Uphando lwexesha elizayo luya kugxila:

• Ukuphuhlisa iiarhente ezijolise kuzo kunye neziyimfuneko.
• Ukuphucula ukungena kwesisu kunye nokukhululwa kweziyobisi.
• Ukudibanisa Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Ngomnye unyango lomhlaza, njengokuhlwa kunye nonyango lwe-radiation.
• Ukuphuhlisa umntu Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Izicwangciso zobuchule ezisekwe kwiimpawu ezizodwa zomhlaza ozifundileyo zabaguli.
• Ukusebenzisa ubukrelekrele bokwenyani kuyilo kunye nokwandisa Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza iinkqubo.

Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Ibambe isithembiso esikhulu sokuphucula unyango lomhlaza kunye nezigulana. Njengoko uphando luyaqhubeka, sinokulindela ukubona ukusebenza ngakumbi kwaye sibe senzelwe wena Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Izicwangciso eziphumayo, ekugqibeleni zikhokelela kwinkathalo yomhlaza ongcono.