lapaʻau Localized Drug Delivery for Cancer

Lapaʻau ʻana o ka lawe ʻana i nā lāʻau lapaʻau kūloko no ke kanesa

Hāʻawi kēia ʻatikala i kahi ʻike piha o nā ʻōnaehana lawe lāʻau kūloko no ka mālama ʻana i ka maʻi kanesa, e ʻimi ana i nā ʻano hana like ʻole, nā pono, nā palena, a me nā kuhikuhi e hiki mai ana. Hoʻopili mākou i nā mīkini, nā noi lapaʻau, a me nā hana noiʻi e hoʻomau nei i kēia kahua e ulu wikiwiki nei. E aʻo e pili ana i nā holomua hou loa i nā lāʻau lapaʻau i manaʻo ʻia e hoʻonui i ka pono ʻoiai e hōʻemi ana i nā hopena ʻaoʻao.

Hoʻomaopopo i ka hoʻouna ʻana i nā lāʻau lapaʻau kūloko

He aha ka hoʻouna lāʻau kūloko kūloko?

Hāʻawi ʻia ka lāʻau lapaʻau kūloko no ka maʻi maʻi e pili ana i nā ala e hāʻawi pololei ai i nā mea lapaʻau i ka pūnaewele tumor, e hōʻemi ana i ka ʻike ʻana i nā ʻiʻo olakino. ʻO kēia ala i manaʻo ʻia e hoʻomaikaʻi i ka maikaʻi, hōʻemi i ka ʻona, a hoʻomaikaʻi i nā hopena maʻi i hoʻohālikelike ʻia i nā ʻōnaehana systemic kuʻuna. Hoʻohana ʻia kekahi mau ʻenehana, kēlā me kēia me kona pono ponoʻī a me nā palena.

Mechanisms of Localized Drug Delivery

He mau mīkini maʻalahi hāʻawi lāʻau kūloko, e like me: ka hoʻokomo ʻana i nā mea hana lāʻau-eluting (e.g., biodegradable polymers, microspheres), hoʻokomo pono i nā mea lapaʻau i loko o ka ʻōpū, a me ka hoʻohana ʻana i nā nanoparticles i hoʻopaʻa ʻia e hōʻiliʻili maikaʻi ʻia i loko o ka ʻiʻo tumo. Hoʻohana kēia mau ʻano hana i nā hiʻohiʻona kūʻokoʻa o ka microenvironment tumor e hoʻomaikaʻi i ka ʻike ʻana i ka lāʻau lapaʻau ma ke kahua i kuhikuhi ʻia.

Nā ʻano o nā ʻōnaehana lawe lāʻau kūloko

Nā mea hiki ke kanu ʻia

Hāʻawi ʻia nā mea kanu i hoʻopili ʻia, e like me nā polymers biodegradable a me nā microspheres, i ka hoʻokuʻu mau ʻana o nā mea hana chemotherapeutic i ka manawa. Hoʻemi kēia ala i ka pinepine o ka hoʻoponopono ʻana a hiki ke hoʻomaikaʻi i ka hoʻokō ʻana o ka maʻi. Eia nō naʻe, pono ka hoʻokuʻu ʻana a me ka lōʻihi e hoʻokō pono i ka hopena therapeutic i makemake ʻia. Aia ka Shandong Baofa Cancer Research Institute ma mua o ka noiʻi ma kēia mau wahi.

Hoʻopiʻi

ʻO ka hoʻokomo pololei ʻana i nā lāʻau lapaʻau i loko o ka puʻupuʻu puʻupuʻu kekahi ala maʻamau. Hāʻawi kēia ʻano hana i nā ʻano lāʻau lapaʻau kūloko kiʻekiʻe akā ʻaʻole kūpono paha no nā ʻano tumo a me nā wahi āpau. Hoʻohana pinepine ʻia kēia ʻenehana me nā ʻano hana kiʻi ʻē aʻe no ka huli ʻana pololei.

Hāʻawi i ka Nanoparticle

Nanoparticle-based hāʻawi lāʻau kūloko Hoʻohana nā ʻōnaehana i ka hopena hoʻonui i ka permeability a me ka hoʻopaʻa ʻana (EPR) o ka vasculature tumor. Lawe kēia mau nanoparticles i ka lāʻau lapaʻau i ke koko, e hōʻiliʻili koho ma muli o nā kīʻaha koko leaky. Eia nō naʻe, ʻo ka hoʻokō ʻana i ka huli ʻana i ka maʻi tumora maikaʻi a me ka mālama ʻana i ka hoʻokuʻu nanoparticle mau mau pilikia koʻikoʻi. ʻO ka hoʻomohala ʻana i nā nanoparticles hou me ka hoʻomaikaʻi ʻana i nā waiwai huli ʻana he wahi ikaika ia o ka noiʻi.

Nā noi lāʻau lapaʻau a me ka noiʻi mau ʻana

Nā noi lāʻau lapaʻau o kēia manawa

Hāʻawi ʻia ka lāʻau lapaʻau kūloko Hoʻohana ʻia nā ʻōnaehana i kēia manawa i nā lāʻau lapaʻau like ʻole, e like me: ka lolo lolo (hoʻohana ʻana i nā wafers implantable), prostate cancer (hoʻohana ʻana i ka brachytherapy), a me kekahi mau ʻano o ka maʻi maʻi umauma. ʻO ke ala kikoʻī i koho ʻia ma muli o ke ʻano a me ka pae o ka maʻi kanesa.

Papa 1: Hoʻohālikelike o nā ʻokoʻa hāʻawi lāʻau kūloko ʻano hana.

Kuhikuhi e hiki mai ana

Ka noiʻi e hiki mai ana ma hāʻawi lāʻau kūloko e kālele ana i ka hoʻomaikaʻi ʻana i ka kikoʻī kikoʻī, ka hoʻonui ʻana i nā kinetics hoʻokuʻu lāʻau, a me ka hoʻomohala ʻana i nā kaʻa lawe lāʻau hou. Hoʻohui hāʻawi lāʻau kūloko me nā ala lapaʻau ʻē aʻe, e like me ka immunotherapy, hiki ke hoʻonui i nā hopena lapaʻau. ʻO ka hiki ke hana pilikino hāʻawi lāʻau kūloko, i hoʻopili ʻia i nā ʻano maʻi o kēlā me kēia kanaka, he wahi hoihoi nō hoʻi.

No ka ʻike hou aku e pili ana i ka noiʻi maʻi kanesa a me nā koho lapaʻau, e kipa i ka Shandong Baofa Cancer Research Institute pūnaewele puni honua.