lapaʻau ʻekolu ʻino ka maʻi maʻi umauma

Lapaʻau ʻana no Triple Negative Breast Cancer: He Alakaʻi Loaʻa ka ʻike ʻana i ka Triple Negative Breast Cancer and Available TreatmentsTriple-negative breast cancer (TNBC) he subtype o ka maʻi maʻi umauma ʻaʻole e hōʻike i nā mea loaʻa no ka estrogen, progesterone, a i ʻole HER2. ʻO kēia nele o nā mea hoʻokipa hormone e ʻoi aku ka paʻakikī a paʻakikī i ka mālama ʻana i hoʻohālikelike ʻia me nā ʻano subtypes maʻi maʻi umauma. Hāʻawi kēia alakaʻi i kahi ʻike piha o lapaʻau ʻekolu ʻino ka maʻi maʻi umauma nā koho, e nānā ana i nā holomua a me nā ala hou loa. Pono lapaʻau ʻekolu ʻino ka maʻi maʻi umauma koi i kahi hoʻolālā pilikino i kūpono i nā ʻano o kēlā me kēia maʻi a me ka pae o ko lākou maʻi kanesa.

ʻO ka ʻike a me ka hoʻopaʻa ʻana i ka maʻi maʻi maʻi ʻaʻohe ʻekolu

He mea koʻikoʻi ka ʻike pololei a me ka hoʻonohonoho ʻana no ka hoʻoholo ʻana i ke ala maikaʻi loa lapaʻau ʻekolu ʻino ka maʻi maʻi umauma. Hoʻopili kēia i nā hoʻokolohua kiʻi (mammograms, ultrasounds, MRIs), biopsies e hōʻoia i ka hōʻoia ʻana a nānā i nā ʻano o ka ʻōpū, a me nā hoʻokolohua hou aʻe e hoʻoholo ai i ka nui o ka laha ʻana o ke kanesa (staging). Hoʻololi nui ka pae o ka maʻi kanesa i nā hoʻoholo lapaʻau.

Ka hoʻomaopopo ʻana i nā pae TNBC

ʻO ka ʻōnaehana staging, maʻamau e hoʻohana ana i ka ʻōnaehana TNM (Tumor, Node, Metastasis), hoʻokaʻawale i ka nui o ka maʻi kanesa. ʻO ka TNBC mua loa e pili ana i ka mālama kūloko, ʻoiai ʻo TNBC kiʻekiʻe a i ʻole metastatic e koi i nā ʻōnaehana systemic. Hiki ke loaʻa ka ʻike kikoʻī e pili ana i ka hoʻokō ʻana mai kāu oncologist a i ʻole nā ​​hui maʻi kanesa kaulana.

Nā Koho Lapaʻau no Triple Negative Breast Cancer

Hoʻomaʻamaʻa i ka maʻi maʻi umauma triple negative ʻO ka mea maʻamau e pili ana i ka hui ʻana o nā hoʻokokoke, e pili ana i ke kahua a me nā ʻano o ka maʻi kanesa. Hiki i kēia mau mea ke komo:

ʻO ka ʻoki ʻana

He hana mua maʻamau ka ʻoki ʻana lapaʻau ʻekolu ʻino ka maʻi maʻi umauma, e manao ana e wehe i ka ma'i ma'i 'a'ai. ʻO nā koho he lumpectomy (ka wehe ʻana i ke koko a me kekahi ʻiʻo a puni) a i ʻole mastectomy (wehe i ka umauma holoʻokoʻa). Ke hoʻomau mau nei nā ʻenehana ʻokiʻoki e hoʻomaikaʻi i nā hopena a hōʻemi i nā hopena ʻaoʻao.

Lapaʻau Radiation

Hoʻohana ka lāʻau lapaʻau i ka pāhawewe ikaika nui e pepehi i nā maʻi maʻi maʻi. Hiki ke hoʻohana ʻia ma mua a ma hope paha o ka ʻoki ʻana, a i ʻole e mālama i ka maʻi metastatic. ʻO nā ʻenehana radiation hou e hiki ai ke ʻoi aku ka pololei, e hōʻemi ana i ka pōʻino i nā ʻiʻo olakino a puni.

Kemoterapi

Hoʻohana ka Chemotherapy i nā lāʻau lapaʻau e pepehi i nā maʻi maʻi maʻi a puni ke kino. Hoʻohana pinepine ʻia i loko lapaʻau ʻekolu ʻino ka maʻi maʻi umauma, ma mua o ka oki (neoadjuvant chemotherapy) e emi ai ke koko, ma hope o ke oki (adjuvant chemotherapy) e hoemi i ka pilikia o ka ho'i hou, a i 'ole e mālama i ka ma'i metastatic. Loaʻa nā ʻano hana chemotherapy like ʻole, a ʻo ke koho e pili ana i nā kumu pilikino.

ʻO ka Lapaʻau Kūlohelohe

ʻAʻole like me nā lāʻau lapaʻau hormone e kuhikuhi ana i nā mea hoʻokipa hormone, ʻo nā mea lapaʻau i hoʻopaʻa ʻia e kālele ana i nā molekole kikoʻī e pili ana i ka ulu ʻana o ka maʻi kanesa. ʻOiai ʻaʻole pane ʻo TNBC i nā lāʻau lapaʻau hormone, hōʻike kekahi mau lāʻau lapaʻau i hoʻohiki ʻia. He laʻana ka PARP inhibitors, kūpono i kekahi mau maʻi TNBC me nā hoʻololi genetic kikoʻī. Ke hoʻomau nei ka noiʻi ma kēia wahi, e alakaʻi ana i ka hoʻomohala ʻana i nā lāʻau lapaʻau hou a ʻoi aku ka maikaʻi.

Immunotherapy

Hoʻohana ka Immunotherapy i ka mana o ka ʻōnaehana pale o ka mea maʻi e hakakā i ka maʻi kanesa. Ke hōʻike nei nā mea hoʻopaʻapaʻa Checkpoint, kahi ʻano immunotherapy, i kekahi mau maʻi TNBC. Ke hana nei kēia mau lāʻau lapaʻau ma ke kāohi ʻana i nā protein e pale ai i ka ʻōnaehana pale mai ka hoʻouka ʻana i nā maʻi maʻi maʻi. Ke nānā nei ka noiʻi hou aku i ka pono o nā immunotherapies like ʻole i ka mālama ʻana i ka TNBC.

ʻO ka maʻi maʻi maʻi umauma kiʻekiʻe a me ka Metastatic Triple Negative Breast Cancer

No nā poʻe maʻi me ka holomua a i ʻole ka metastatic lapaʻau ʻekolu ʻino ka maʻi maʻi umauma, ka lāʻau lapaʻau e hoʻomalu i ka holomua o ka maʻi, hoʻomaikaʻi i ka maikaʻi o ke ola, a hoʻolōʻihi i ke ola. Hoʻopili pinepine kēia i ka hui pū ʻana o ka chemotherapy, ka maʻi i hoʻopaʻa ʻia, a me ka immunotherapy. Hāʻawi nā hoʻokolohua lapaʻau i ke komo ʻana i nā lāʻau lapaʻau ʻokiʻoki a kōkua i ka hoʻonui ʻana i ko mākou ʻike no TNBC. Hiki i kāu kauka oncologist ke kūkākūkā i ka loaʻa a me ke kūpono o nā hoʻokolohua lapaʻau no kou kūlana kikoʻī.

Kākoʻo mālama a me nā kumuwaiwai

Ka mālama ʻana i nā hopena ʻaoʻao o lapaʻau ʻekolu ʻino ka maʻi maʻi umauma he mea koʻikoʻi no ka mālama ʻana i ka maikaʻi o ke ola. ʻO ka mālama kākoʻo e pili ana i ka mālama ʻana i ka ʻeha, luhi, nausea, a me nā hopena ʻaoʻao ʻē aʻe ma o ka lāʻau lapaʻau, ka hoʻololi ʻana i ka nohona, a me ke kākoʻo noʻonoʻo. Hiki i ka hui ʻana me nā hui kākoʻo, e like me nā mea i hāʻawi ʻia e ka American Cancer Society a i ʻole nā ​​​​hui ʻē aʻe, hiki ke hāʻawi pū i ke kākoʻo noʻonoʻo a me ka pono. No nā kumuwaiwai hou aʻe a me ka ʻike e pili ana i ka hoʻokele ʻana i kēia huakaʻi paʻakikī, ʻike paha ʻoe he mea kōkua ke ʻimi i ka pūnaewele o ka Shandong Baofa Cancer Research Institute a i ʻole nā kikowaena maʻi kanesa kaulana like.

ʻAno Lapaʻau	wehewehe	Nā pono	Nā pōʻino
ʻO ka ʻoki ʻana	ʻO ka wehe ʻana i ke koko.	Hiki ke ho'ōla i ka wā mua.	Loaʻa paha nā hopena ʻaoʻao e like me ka scarring a i ʻole lymphedema.
Kemoterapi	ʻO nā lāʻau e pepehi ai i nā maʻi kanesa.	Pono i ka emi ʻana o nā maʻi koko a pale i ka hoʻi hou ʻana.	Hiki ke hana i nā hopena ʻaoʻao e like me ka nausea, ka luhi, a me ka poho lauoho.
ʻO ka Lapaʻau Kūlohelohe	ʻO nā lāʻau lapaʻau e kālele ana i nā molekala.	Hiki ke hana i kekahi mau maʻi TNBC.	ʻAʻole kūpono no nā maʻi TNBC āpau.

Hōʻole: No ka hoʻonaʻauao wale nō kēia ʻike a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. E kūkākūkā mau me kāu mea mālama ola no ka ʻike a me ka mālama ʻana i kekahi maʻi olakino. ʻO ka ʻike i hōʻike ʻia ma ʻaneʻi e pili ana i ka ʻike olakino i loaʻa i kēia manawa a hiki ke loli.