ka maʻi ʻaʻai umauma ʻekolu maikaʻi ʻole

Triple Negative Breast Cancer: A Comprehensive Guide Understanding Triple-Negative Breast Cancer: A Patient's Guide ʻO kēia nele o nā mea hoʻokipa e ʻoi aku ka paʻakikī a ʻoi aku ka paʻakikī o ka mālama ʻana i hoʻohālikelike ʻia me nā subtypes maʻi maʻi umauma ʻē aʻe. Hāʻawi kēia alakaʻi i kahi ʻike piha o ka maʻi ʻaʻai umauma ʻekolu maikaʻi ʻole, e uhi ana i kona mau hiʻohiʻona, ka maʻi maʻi, nā koho lapaʻau, a me nā kumuwaiwai kākoʻo. Manaʻo mākou e hāʻawi iā ʻoe i ka ʻike a me ka ʻike e hoʻokele i kēia huakaʻi paʻakikī.

Ka hoʻomaopopo ʻana i nā ʻano o TNBC

He aha ka mea e ʻokoʻa ai ka TNBC?

ʻAʻole like me nā ʻano maʻi maʻi umauma ʻē aʻe, ka maʻi ʻaʻai umauma ʻekolu maikaʻi ʻole nele i ka estrogen receptor (ER), progesterone receptor (PR), a me ke kanaka epidermal growth factor receptor 2 (HER2). Hoʻopili pinepine ʻia kēia mau mea loaʻa i nā lāʻau lapaʻau no nā maʻi maʻi umauma ʻē aʻe, akā ʻo ko lākou haʻalele ʻana i ka TNBC e kaupalena i nā koho lapaʻau. ʻO kēia ka mea e alakaʻi pinepine ai i kahi papa maʻi koʻikoʻi a ʻoi aku ka nui o ka hoʻi hou ʻana.

Ka Laha a me ka Poino

ʻAʻai maʻi umauma ʻekolu maikaʻi ʻole Aia ma kahi o 10-20% o nā maʻi maʻi umauma āpau. ʻO nā mea pilikia e pili ana i ka TNBC e pili ana i ka ʻōpio i ka maʻi maʻi, BRCA1 gene mutations, African American mothnicity, a me kahi moʻolelo ʻohana o ka maʻi maʻi umauma. Eia nō naʻe, nui nā wahine i loaʻa i ka TNBC ʻaʻohe kumu pilikia e ʻike ʻia.

ʻO ka hōʻailona a me ke kau ʻana o TNBC

Nā Kaʻina Hana Hoʻomaʻamaʻa

Ka hoʻopaʻa ʻana ka maʻi ʻaʻai umauma ʻekolu maikaʻi ʻole ʻO ka mea maʻamau e pili ana i kahi biopsy e nānā i nā ʻōpū ma lalo o kahi microscope. ʻO nā ho'āʻo immunohistochemical staining (IHC) e hoʻoholo i ka hiki ʻole a i ʻole ka loaʻa ʻana o ER, PR, a me HER2. Hiki ke hoʻohana ʻia nā hoʻokolohua ʻē aʻe, e like me ke kiʻi kiʻi (mammography, ultrasound, MRI), e nānā i ka nui o ke kanesa.

ʻO ke kūlana a me ka wānana

Hoʻoholo ka staging i ka nui a me ka nui o ke kanesa, e pili ana i nā hoʻoholo lapaʻau a me ka wānana. Hoʻohana mau ʻia ka ʻōnaehana staging TNM, no ka loiloi ʻana i ka nui o ka tumo (T), ke komo ʻana o ka lymph node (N), a me ka metastasis mamao (M). Hoʻololi ka wānana no TNBC ma muli o ke kahua a me nā kumu ʻē aʻe; He mea koʻikoʻi ka ʻike mua a me ka mālama ʻana i ka manawa no ka hoʻomaikaʻi ʻana i nā hopena.

Nā Koho Lapaʻau no TNBC

ʻO ka ʻoki ʻana

ʻO ka ʻoki pinepine ka lālani mua o ka lāʻau lapaʻau no ka maʻi ʻaʻai umauma ʻekolu maikaʻi ʻole, e manao ana e wehe i ka ma'i ma'i 'a'ai. Hiki i kēia ke komo i ka lumpectomy (wehe i ke koko) a i ʻole mastectomy (wehe i ka umauma). Hiki ke hana ʻia ka biopsy Sentinel lymph node a i ʻole axillary lymph node dissection no ka nānā ʻana i ke komo ʻana o ka lymph node.

Kemoterapi

He pōhaku kihi o ka lāʻau lapaʻau TNBC, hoʻohana pinepine ʻia ma mua o ka ʻoki ʻana (neoadjuvant chemotherapy) e hōʻemi i ka ʻōpū a i ʻole ma hope o ke ʻoki ʻana (adjuvant chemotherapy) e hōʻemi i ka pilikia o ka hoʻi hou ʻana. Loaʻa nā regimens chemotherapy like ʻole, koho ʻia ma muli o nā kumu pilikino. Ka noiʻi Ke hoʻomau nei ka ʻimi ʻana i nā hui chemotherapy hou e hoʻomaikaʻi i ka pono.

Lapaʻau Radiation

Hoʻohana ka lāʻau lapaʻau i ka pāhawewe ikaika nui e pepehi i nā maʻi maʻi maʻi. Hoʻohana pinepine ia ma hope o ke kaʻa ʻana no ka luku ʻana i nā keʻena maʻi ʻaʻai i koe i loko o ka umauma a i ʻole nā ​​​​lui lymph kokoke. Hiki ke hoʻohana ʻia e mālama i ka maʻi metastatic.

ʻO nā lāʻau lapaʻau i hoʻopaʻa ʻia a me ka Immunotherapy

ʻOiai ʻaʻole pane ʻo TNBC i ka hormone therapy a i ʻole HER2-target therapies, ke hoʻomau nei ka noiʻi ʻana i nā lāʻau lapaʻau a me nā immunotherapies. Ke nānā aku nei kekahi mau lāʻau lapaʻau i nā ala kikoʻī e pili ana i ka ulu ʻana o TNBC, aʻo nā immunotherapies e hoʻoikaika i ka ʻōnaehana pale o ke kino e hakakā i ka maʻi kanesa. Hōʻike kēia mau lāʻau lapaʻau i ka ʻōlelo hoʻohiki akā ke hoʻokolokolo ʻia nei.

Noho pū me TNBC

Malama hahai

He mea nui ka hoʻopaʻa ʻana ma hope o ka mālama ʻana e nānā no ka hoʻi hou ʻana. Hoʻopili maʻamau kēia mau koho i nā hoʻokolohua kino, nā kiʻi kiʻi, a me nā hoʻāʻo koko. He mea koʻikoʻi ka ʻike mua ʻana o ka hoʻi hou ʻana no ka hoʻokele pono.

Kākoʻo a me nā kumuwaiwai

ʻO ka hoʻopaʻa ʻana me kahi hōʻailona o ka maʻi ʻaʻai umauma ʻekolu maikaʻi ʻole hiki ke paʻakikī. He mea waiwai nui ke kākoʻo mai ka ʻohana, nā hoaaloha, a me nā hui kākoʻo. Nui nā hui e hāʻawi i nā kumuwaiwai a me ke kākoʻo no nā poʻe i hoʻopilikia ʻia e TNBC. E noʻonoʻo e hoʻopili i ka Shandong Baofa Cancer Research Institute no ka ʻike hou aku a me nā kumuwaiwai. Hāʻawi lākou i ka mālama maʻi maʻi āpau, me ka ʻike i ka mālama ʻana i nā ʻano subtypes maʻi kanesa āpau.

Noi hou a me na hoao

E noiʻi i ka ka maʻi ʻaʻai umauma ʻekolu maikaʻi ʻole ke ulu mau nei, me nā hoʻokolohua lapaʻau e ʻimi ana i nā hoʻolālā lapaʻau hou a me ka hoʻomaikaʻi ʻana i nā hopena. Hiki i kāu kauka lāʻau lapaʻau ke kūkākūkā i ke komo ʻana i nā hoʻokolohua lapaʻau i kūpono i kāu kūlana kikoʻī. He mea koʻikoʻi ka noho ʻana e pili ana i nā holomua hou i ka noiʻi TNBC.