kho tshiab uas tsis yog me me ntawm lub ntsws cancer kho

Kev kho mob rau mob qog noj ntshav tsis yog me me

Cov lus qhia dav dav no tshawb txog qhov kev nce qib tshiab kawg hauv kev kho mob tshiab uas tsis yog-me me ntawm lub ntsws cancer kho. Peb yuav hais txog ntau yam kev kho mob, suav nrog cov kev kho mob, kev tiv thaiv kab mob, thiab tshuaj khomob, muab kev nkag siab txog lawv cov txiaj ntsig, kev mob tshwm sim, thiab tsim nyog rau cov neeg mob sib txawv. Kawm txog kev hloov pauv ntawm thaj chaw ntawm NSCLC kev kho mob thiab yuav ua li cas cov kws tshawb fawb tau ua haujlwm txuas ntxiv mus rau kev xaiv zoo dua thiab tsis muaj tshuaj lom.

Nkag siab Tsis yog-Small Cell Lung Cancer (NSCLC)

NSCLC yog dab tsi?

Cov qog nqaij hlav qog hlwb tsis me (NSCLC) suav txog li 85% ntawm tag nrho cov qog nqaij hlav ntsws. Nws yog ib pawg ntawm cov qog nqaij hlav uas loj hlob hauv lub ntsws thiab muaj cov tsos mob sib txawv ntawm cov cellular tshwm sim hauv lub tshuab tsom. Kev kuaj mob ntxov yog qhov tseem ceeb rau kev kho kom zoo dua qub. Cov theem ntawm mob qog noj ntshav ntawm kev kuaj mob cuam tshuam rau kev txiav txim siab kho mob thiab kev kwv yees. Lub koom haum Shandong Baofa Cancer Research Institute (https://www.baofahospital.com/) yog tus thawj coj hauv kev ua haujlwm, muab kev saib xyuas thiab kev tshawb fawb hauv NSCLC.

Staging thiab Diagnosis ntawm NSCLC

Qhov tseeb staging yog qhov tseem ceeb hauv kev txiav txim siab qhov kev kawm zoo tshaj plaws kev kho mob tshiab uas tsis yog-me me ntawm lub ntsws cancer kho. Qhov no suav nrog ntau yam kev sim, suav nrog kev kuaj pom (CT, PET), biopsies, thiab kuaj ntshav. TNM staging system feem ntau yog siv los faib NSCLC raws li qog loj (T), lymph node kev koom tes (N), thiab metastasis (M). Kev kuaj pom thaum ntxov, feem ntau los ntawm kev tshuaj ntsuam xyuas tsis tu ncua rau cov tib neeg muaj kev pheej hmoo siab, txhim kho txoj hauv kev ntawm kev kho kom zoo.

Kev Xaiv Kev Kho Mob rau NSCLC

Hom Kev Kho Mob

Cov phiaj xwm kho mob tsom mus rau cov molecules tshwj xeeb koom nrog hauv kev loj hlob qog noj ntshav. Cov tshuaj no tuaj yeem ua tau zoo dua thiab muaj kev phiv tsawg dua li cov tshuaj khomob hauv qee cov neeg mob. Piv txwv xws li EGFR inhibitors (xws li gefitinib thiab erlotinib) thiab ALK inhibitors (xws li crizotinib). Kev xaiv txoj kev kho mob yog nyob ntawm qhov tshwj xeeb kev hloov pauv caj ces tam sim no hauv cov qog nqaij hlav cancer.

Immunotherapy

Immunotherapy siv lub zog ntawm lub cev tiv thaiv kab mob los tiv thaiv qog noj ntshav. Checkpoint inhibitors, xws li pembrolizumab thiab nivolumab, thaiv cov proteins uas tiv thaiv lub cev tiv thaiv kab mob los ntawm kev tawm tsam cov qog nqaij hlav cancer. Cov tshuaj no tau pom tias muaj kev vam meej hauv kev kho NSCLC, tshwj xeeb tshaj yog rau cov neeg mob uas muaj qee yam biomarkers. Immunotherapy tuaj yeem muaj kev phiv ntau dua li kev siv tshuaj khomob, yuav tsum tau saib xyuas zoo los ntawm cov kws kho mob.

Tshuaj kho mob

Tshuaj kho mob siv tshuaj tua kab mob qog noj ntshav. Nws tuaj yeem siv ib leeg lossis ua ke nrog lwm yam kev kho mob. Muaj ntau hom kev kho mob sib txawv, ua raws li cov kev xav tau tshwj xeeb ntawm tus neeg mob thiab theem ntawm lawv cov qog nqaij hlav. Cov tshuaj siv feem ntau suav nrog cisplatin, carboplatin, thiab paclitaxel. Kev siv tshuaj khomob tuaj yeem muaj kev phiv loj heev, thiab tswj cov kev mob tshwm sim no yog ib feem tseem ceeb ntawm kev kho mob.

Kev kho hluav taws xob

Kev kho hluav taws xob siv hluav taws xob hluav taws xob ntau los tua cov qog nqaij hlav cancer. Nws tuaj yeem siv los txo cov qog, txo cov tsos mob, lossis tiv thaiv kev mob qog noj ntshav. Ntau hom kev kho hluav taws xob muaj nyob, suav nrog kev siv hluav taws xob sab nraud thiab brachytherapy. Kev kho hluav taws xob kuj tuaj yeem muaj kev phiv, nyob ntawm thaj chaw uas tau kho thiab qhov ntau npaum li cas.

Kev Kho Mob Tshiab thiab Kev Tshawb Fawb

Kev sim tshuaj

Kev koom tes hauv kev sim tshuaj tuaj yeem muab kev nkag mus rau qhov tshiab kev kho mob tshiab uas tsis yog-me me ntawm lub ntsws cancer kho ua ntej lawv tau dav dav. Cov kev sim no tau ua tib zoo saib xyuas thiab muab sijhawm rau cov neeg mob los pab txhawb kev kho mob kom zoo thaum tau txais kev saib xyuas zoo. Cov kws tshawb fawb ntawm Shandong Baofa Cancer Research Institute tau koom tes nrog ntau qhov kev sim tshuaj ntsuam xyuas cov kev kho tshiab rau NSCLC.

Ua kua Biopsies

Ua kua biopsies yog ib txoj hauv kev tsis tshua muaj kev cuam tshuam los kuaj thiab saib xyuas mob qog noj ntshav. Lawv koom nrog kev tshuaj xyuas cov ntshav kuaj rau cov qog DNA (ctDNA), uas tuaj yeem muab kev nkag siab zoo rau cov caj ces ntawm cov qog nqaij hlav thiab qhia kev txiav txim siab kho mob. Qhov kev siv thev naus laus zis tshiab no tso cai rau kev siv tshuaj kho tus kheej, txhim kho cov phiaj xwm kho mob raws li tus neeg mob xav tau.

Xaiv txoj kev kho mob

Qhov zoo tshaj plaws kev kho mob tshiab uas tsis yog-me me ntawm lub ntsws cancer kho txoj kev sib txawv nyob ntawm ntau yam, nrog rau theem ntawm tus mob qog noj ntshav, tus neeg mob txoj kev noj qab haus huv tag nrho, thiab muaj kev hloov pauv caj ces tshwj xeeb. Ib pab neeg ua haujlwm ntau yam ntawm cov kws kho mob oncologist, kws phais mob, thiab lwm tus kws kho mob feem ntau koom nrog hauv kev tsim cov phiaj xwm kho tus kheej. Qhib kev sib txuas lus nrog koj tus kws kho mob yog qhov tseem ceeb los xyuas kom meej tias koj nkag siab koj cov kev xaiv thiab txiav txim siab paub.

Disclaimer: Cov ntaub ntawv no yog tsim los rau kev kawm nkaus xwb thiab yuav tsum tsis txhob suav hais tias yog cov lus qhia kho mob. Nco ntsoov sab laj nrog ib tus kws kho mob uas tsim nyog rau kev kuaj mob thiab kho txhua yam mob.