Nnyefe ọgwụ mpaghara maka ọrịa kansa

Mbufe ọgwụ na mpaghara maka ọrịa kansa bụ usoro ezubere iche nke na-etinye ọgwụ ozugbo na saịtị etuto ahụ, na-abawanye uru ya ma na-ebelata mmetụta nke sistemu. Usoro a na-eme ka ọgwụgwọ ọgwụgwọ dịkwuo mma site n'ịkwalite bioavailability ọgwụ n'ime ụbụrụ ahụ na ibelata ikpughe n'anụ ahụ dị mma, na-enye ụzọ dị mma maka ọgwụgwọ ọrịa cancer. Ịghọta Ọgwụgwọ Ọgwụ Na-ahụ Maka Mpaghara Na-ahụ Maka Ọrịa Cancer dị ka chemotherapy na-agụnyekarị nchịkwa ọgwụ usoro, ebe ọgwụ na-ekesa n'ime ahụ dum. Ọ bụ ezie na ọ dị irè n'igbu mkpụrụ ndụ cancer, ụzọ a nwekwara ike imerụ anụ ahụ dị mma, na-ebute mmetụta dị egwu. Mbufe ọgwụ na mpaghara maka ọrịa kansa Ebumnuche imeri mmachi a site na ibuga ọgwụ ọgwụgwọ ozugbo na microenvironment tumor.Uru nke nnyefe ọgwụ mpaghara. Enwetara arụmọrụ: Ọnụnọ ọgwụ dị elu na ebe akpụ akpụ na-eduga n'ịgbu mkpụrụ ndụ cancer ka mma. Mbelata nsị: Ibelata mkpughe usoro na-ebelata mmetụta ndị na-adịghị mma ma na-eme ka ndụ onye ọrịa dịkwuo mma. Omume ezubere iche: Na-enye ohere ịnye ọgwụ ndị nwere ike ịdị oke nsí maka nchịkwa sistemu. Nnweta bioavailability emelitere: Na-emeri ihe mgbochi na nnyefe ọgwụ n'ime microenvironment tumor.Uzo esi enweta ọgwụ na mpaghara mpaghara ọtụtụ usoro a na-eji eme ihe. nnyefe ọgwụ mpaghara maka ọrịa kansa. Enwere ike ekewa usoro ndị a n'ụzọ sara mbara dị ka: Injection Direct Injection Direct gụnyere nchịkwa anụ ahụ nke ọgwụ n'ime etuto ahụ ma ọ bụ anụ ahụ gbara ya gburugburu. Usoro a dị mfe ma dị ọnụ ala, na-eme ka ọ dabara maka ụdị ọrịa cancer ụfọdụ, karịsịa ndị dị mfe ịnweta. Maka ọganihu ọhụrụ na nlekọta ọmịiko na ọgwụgwọ ọrịa cancer, gaa na Shandong Baofa Cancer Research Institute.Ngwaọrụ enweghị ike ịkụnye, dị ka wafers, microchips, na hydrogels, nwere ike ịwa ahụ n'ime ma ọ bụ n'akụkụ tumor. Ngwaọrụ ndị a na-ahapụ ọgwụ n'ime oge na-adịgide adịgide, na-enye ọgwụgwọ na-aga n'ihu na nke mpaghara. Enwere ike iji Catheter Based DeliveryCatheter na-ebuga ọgwụ ozugbo na saịtị tumo site na arịa ọbara ma ọ bụ ụzọ ndị ọzọ. Usoro a bara uru karịsịa maka ịgwọ ọrịa kansa na akụkụ ahụ dị ka imeju ma ọ bụ ụbụrụ. Nnyefe Nanoparticle dabere na obere irighiri ihe (1-100 nm) nke enwere ike ibunye ọgwụ ma lekwasị anya na mkpụrụ ndụ kansa. Enwere ike ịhazi ụmụ irighiri ihe ndị a ka ha na-akpakọba na etuto ahụ n'ihi na ha nwere ihe pụrụ iche na vasculature nke anụ ahụ kansa na-agbapụta. Ha nwere ike nwekwuo nkwalite nnyefe ọgwụ mpaghara maka ọrịa kansa ọgwụgwọ. Gụkwuo maka nanoparticles.Ụdị Ọrịa Cancer Na-agwọ Ya na Nnyefe Ọgwụ Na-ahụ Maka MpagharaMbufe ọgwụ na mpaghara maka ọrịa kansa a na-enyocha maka ụdị ọrịa kansa dị iche iche, gụnyere: Brain Cancer, wafers ndị nwere ọgwụ chemotherapy egosila nkwa n'ịgwọ glioblastoma, ụdị ụbụrụ ụbụrụ. Dịka ọmụmaatụ, a na-akụnye Gliadel wafers nke nwere carmustine ozugbo n'ime oghere ụbụrụ mgbe a gbasasịrị etuto ahụ. A na-ejikarị usoro a agwọ ọrịa carcinoma hepatocellular (HCC).Prostate CancerBrachytherapy gụnyere ịkụnye mkpụrụ osisi redioaktivu n'ime gland prostate iji nye ọgwụgwọ radieshon mpaghara. Usoro a dị irè n'ịgwọ ọrịa cancer prostate n'oge. Ndị na-eme nchọpụta na-emepe usoro nnyefe nke nanoparticle iji lekwasị mkpụrụ ndụ ọrịa ara ara ma na-ebuga ọgwụ chemotherapy ozugbo na saịtị tumor, na-ebelata toxicity nke sistemu. nnyefe ọgwụ mpaghara maka ọrịa kansa. Nke a bụ ọmụmaatụ ole na ole ama ama: Gliadel Wafers maka Glioblastoma Nnwale ụlọ ọgwụ egosila na Gliadel wafers nwere ike imeziwanye ọnụego nlanarị na ndị ọrịa nwere glioblastoma a chọpụtara ọhụrụ ma ọ bụ na-emegharịghachi. Nnyocha e bipụtara na * Journal of Clinical Oncology * gosipụtara uru nlanarị nke etiti nke ọtụtụ ọnwa ma e jiri ya tụnyere placebo. E gosipụtara TACE maka Hepatocellular CarcinomaTACE iji meziwanye ọnụọgụ ndụ na ndụ ndụ na ndị ọrịa nwere HCC na-enweghị ike imezi. Nnyocha meta nke ọtụtụ ọmụmụ chọpụtara na TACE belatara ihe egwu ọnwụ ma e jiri ya tụnyere naanị nlekọta nkwado. Nke nnyefe ọgwụ mpaghara maka ọrịa kansa Nanoparticles na Clinical Trials Ọtụtụ nnwale ụlọ ọgwụ na-enyocha iji sistemụ nnyefe ọgwụ nanoparticle maka ụdị ọrịa kansa dị iche iche. Dịka ọmụmaatụ, ule ụlọ ọgwụ na-enyocha iji liposomal doxorubicin (Doxil) maka ọgwụgwọ ọrịa cancer ovarian. Ntuziaka na nyocha nke ubi nke nnyefe ọgwụ mpaghara maka ọrịa kansa na-eto ngwa ngwa. A na-elekwasị anya nyocha na-aga n'ihu n'ịmepụta ụzọ nnyefe ọhụrụ na nke ka mma, gụnyere:Smart Drug Delivery Systems Ezubere usoro nnyefe ọgwụ na-emepụta iji hapụ ọgwụ na nzaghachi maka mkpali pụrụ iche, dị ka pH, okpomọkụ, ma ọ bụ ọrụ enzyme. Usoro ndị a nwere ike ịnye ọbụna nnyefe ọgwụ ezubere iche na nke a na-achịkwa achịkwa. Ngwakọta ọgwụ mgbochi ijikọ nnyefe ọgwụ mpaghara na immunotherapy bụ mpaghara na-akpali akpali nke nyocha. Site n'inyefe ihe na-akpali akpali ngwa ngwa na microenvironment tumor, ndị nchọpụta na-atụ anya ịkwalite ịdị irè nke immunotherapy. Ụzọ a ahaziri onwe ya nwere ike iduga n'ịgwọ ọrịa kansa na-egbu egbu karịa nke ọma. Shandong Baofa Cancer Research Institute na-emesi atụmatụ ọgwụgwọ ahaziri onwe ya dabere na nyocha dị oke ọnụ. Mụtakwuo banyere ntinye aka anyị na nyocha ọrịa cancer.Tụnyere usoro nnyefe ọgwụ na mpaghara mpaghara Uru ọghọm Ọmụmaatụ Direct Injection Dị Mfe, ọnụ ala na-enwetaghị etuto ahụ, obere oge ịgbanye ọgwụgwọ chemotherapy n'ime ọnya anụ ahụ Akụnye n'ime ngwa ntọhapụ, omume mpaghara chọrọ ịwa ahụ, ihe ize ndụ nke ibute ọrịa Gliadel wafers maka glioter. rute anụ ahụ miri emi na-emerụ ahụ, ihe ize ndụ nke nsogbu TACE maka ọrịa kansa imeju Nanoparticle-Dabere Nnyefe Ezubere, Mgbagwoju bioavailability ka mma, ihe nwere ike ime Liposomal doxorubicin (Doxil) maka ọrịa cancer ovarian mmechi.Mbufe ọgwụ na mpaghara maka ọrịa kansa na-enye ụzọ dị mma iji melite nsonaazụ ọgwụgwọ ọrịa cancer. Site n'itinye ọgwụ na saịtị tumor na ibelata ikpughe sistemu, usoro a nwere ike ịkwalite nrụpụta ọrụ, belata nsị, yana melite ogo ndụ onye ọrịa. Ka nyocha na-aga n'ihu na-aga n'ihu, anyị nwere ike ịtụ anya ịhụ ọbụna usoro nnyefe ọgwụ na mpaghara dị irè karị na-apụta, n'ikpeazụ na-ebute nsonaazụ ka mma maka ndị ọrịa cancer.Nkwuputa: Edemede a bụ maka ebumnuche ozi naanị na e kwesịghị ịtụle ndụmọdụ ahụike. Kpọtụrụ onye ọkachamara ahụike ruru eru maka nsogbu ahụike ọ bụla ma ọ bụ tupu ịme mkpebi ọ bụla metụtara atụmatụ ọgwụgwọ gị.Ntụaka:National Cancer InstituteỌrịa Cancer Research UKAkwụkwọ akụkọ Oncology Clinical*