ọgwụgwọ ọrịa gbasara akụrụ cell carcinoma pathology

Ọgwụgwọ Carcinoma Renal Cell: Ihe Nchọpụta Ọdịnaya Ịghọta Pathology of Renal Cell Carcinoma: Nduzi Ntuzi zuru okeRenal cell carcinoma (RCC), ụdị ọrịa kansa akụrụ na-adịkarị, na-enye atụmatụ dị iche iche nke pathological na-emetụta usoro ọgwụgwọ. Ntuziaka a na-akọwapụta akụkụ ndị bụ isi nke ọgwụgwọ ọrịa gbasara akụrụ cell carcinoma pathology, na-enyere aka ịghọta nchoputa na njikwa. Ozi a bụ maka ebumnuche mmụta na ọ bụghị ndụmọdụ ahụike. Gakwuru onye ọkachamara ahụike mgbe niile maka nsogbu ahụike ọ bụla.

Nkewa Renal Cell Carcinoma

Ụdị nke akụkọ ihe mere eme

RCC na-egosiputa subtypes histological dị iche iche, nke ọ bụla nwere njirimara pụrụ iche na-emetụta prognosis na ọgwụgwọ. Nke kachasị ewu ewu bụ cell RCC (ccRCC), nke ejiri cytoplasm doro anya mara n'ihi glycogen na nchịkọta lipid. Ụdị subụdị ndị ọzọ dị ịrịba ama gụnyere papillary RCC (pRCC), chromophobe RCC (chRCC), na ịnakọta duct RCC (cdRCC). Ụdị ndị a dị iche na mgbanwe mkpụrụ ndụ ihe nketa ha, usoro uto ha na nzaghachi ọgwụgwọ. Nkewa ziri ezi dị oke mkpa maka nduzi ọgwụgwọ ọrịa gbasara akụrụ cell carcinoma pathology. Maka ozi ndị ọzọ gbasara ụdị subtypes ndị a, lelee akụrụngwa ndị nwere aha ọma.

Nhazi na nhazi ọkwa

Sistemụ grading Fuhrman na-enyocha ọkwa nuklia nke RCC, na-egosipụta ike ike nke etuto ahụ. Ọkwa dị elu na-emekọrịta ihe na amụma adịghị mma. Nhazi, iji usoro TNM (Tumor, Node, Metastasis), na-akọwa oke mgbasa nke etuto ahụ, dị oke mkpa maka ikpebi ụzọ ọgwụgwọ. Nghọta nke ọma nke ma grading na nhazi dị mkpa maka nhazi ọgwụgwọ dị irè. Ọkwa kwesịrị ekwesị na ọkwa ga-emetụta gị nke ukwuu ọgwụgwọ ọrịa gbasara akụrụ cell carcinoma pathology.

Ọrịa Molecular na usoro ọgwụgwọ ezubere iche

Mgbanwe mkpụrụ ndụ ihe nketa

Mmụba mkpụrụ ndụ ihe nketa na mgbanwe na-akwalite mmepe na ọganihu RCC. VHL (von Hippel-Lindau) gene inactivation ka a na-ahụkarị na ccRCC, na-eduga n'ịrụ ọrụ nke ụzọ hypoxia-inducible factor (HIF). Ịghọta ndị ọkwọ ụgbọ ala mkpụrụ ndụ ihe nketa na-eme ka nhọrọ nke usoro ọgwụgwọ ezubere iche. Ịmara ọdịiche mkpụrụ ndụ ihe nketa ndị a nwere ike inye aka mepụta kpọmkwem ọgwụgwọ ọrịa gbasara akụrụ cell carcinoma pathology.

Usoro ọgwụgwọ ezubere iche

Usoro ọgwụgwọ ezubere iche na-erigbu adịghị ike mkpụrụ ndụ ihe nketa ndị a, na-ahọrọ nke ọma na-egbochi ụzọ molekụla a kapịrị ọnụ na-etinye aka na uto tumor. Ihe atụ gụnyere tyrosine kinase inhibitors (TKIs), dị ka sunitinib na pazopanib, bụ ndị na-elekwasị anya na vaskụla endothelial growth factor (VEGF). Usoro ọgwụgwọ ndị a na-abụkarị akụkụ nke atụmatụ ọgwụgwọ dabere na kpọmkwem ọgwụgwọ ọrịa gbasara akụrụ cell carcinoma pathology mara.

Immunohistochemistry (IHC) na RCC

IHC na-arụ ọrụ dị oke egwu n'ịchọpụta na ịdepụta RCC. Ihe nrịbama dị ka CD10 na vimentin nwere ike inye aka ịmata ọdịiche nke subtypes RCC. A na-ejikwa IHC nyochaa ihe ndị na-emepụta ihe na-emepụta ihe nke nwere ike ibu amụma nzaghachi na ọgwụgwọ ezubere iche.

Onyonyo na Nchọpụta na Nlebaanya Ọgwụgwọ

Usoro ihe onyonyo dị ka nyocha CT na nyocha MRI na-enye ozi bara uru gbasara nha etuto, ọnọdụ, na metastasis. Ihe ndị a bụ akụkụ dị mkpa n'ịmepụta nkọwa ọgwụgwọ ọrịa gbasara akụrụ cell carcinoma pathology. A na-eji onyonyo mgbe niile iji nyochaa nzaghachi ọgwụgwọ ma chọpụta nlọghachi azụ.

Usoro ọgwụgwọ

Nhọrọ ọgwụgwọ dabere n'ọtụtụ ihe, gụnyere ọkwa etuto, ọkwa ọkwa na njirimara onye ọrịa. Nhọrọ gụnyere ịwa ahụ, ọgwụgwọ ezubere iche, immunotherapy, na ọgwụgwọ radieshon. A na-ekpebi ụzọ kachasị mma site n'iji nlezianya tụlee kpọmkwem ọgwụgwọ ọrịa gbasara akụrụ cell carcinoma pathology.

Ọrụ Shandong Baofa Cancer Research Institute

Maka nlekọta ọrịa kansa zuru oke, gụnyere ikike nchọpụta dị elu yana usoro ọgwụgwọ ahaziri maka carcinoma renal cell, tụlee nka nke Shandong Baofa Cancer Research Institute. Mụtakwuo maka nyocha ha dị elu na ntinye aka na nlekọta onye ọrịa site na ịga na webụsaịtị ha: https://www.baofahospital.com/. Ihe ha lekwasịrị anya na nyocha dị mkpụmkpụ na-emetụta mmepe nke emelitere ọgwụgwọ ọrịa gbasara akụrụ cell carcinoma pathology.

Okpokoro nchịkọta: Ụdị nke RCC

Subụdị	Njirimara	Amụma
Kpochapụ cell RCC	Cytoplasm doro anya, arụghị ọrụ mkpụrụ ndụ VHL	Na-agbanwe agbanwe, na-ejikọta ya na metastasis
Papillary RCC	Papillary architecture, MET mgbanwe	N'ozuzu mma
Chromophobe RCC	Cytoplasm na-acha uhie uhie, ọdịdị ọdịdị mara mma	N'ozuzu mma

Disclaimer: Ozi a bụ naanị maka ebumnuche nkuzi na ekwesighi ịtụle ndụmọdụ ahụike. Kpọtụrụ onye ọkachamara ahụike tozuru etozu maka nyocha na ọgwụgwọ ọnọdụ ahụike ọ bụla.