brca gene prostate kuvura

Kubaho a BRCA ihindagurika, ubusanzwe rifitanye isano na kanseri y'ibere na ovarian, irashobora kandi kugira uruhare runini mu iterambere no kuvura kanseri ya prostate. Gusobanukirwa ningaruka zibi byahinduwe ningirakamaro muburyo bwo kuvura bwihariye no kuvura neza abarwayi. Iyi ngingo irasobanura isano iri hagati Imirasire ya BRCA na kanseri ya prostate.BRCA1 na BRCA2 ni genes zabantu zitanga proteyine zishinzwe gusana ADN yangiritse. Izi poroteyine zigira uruhare runini mu kubungabunga ituze ry’amakuru yacu no gukumira imikurire idakurikiranwa. Iyo izo genes zahinduwe, ntizishobora kongera gusana ibyangiritse kuri ADN, byongera ibyago byo kwandura kanseri zimwe. Nigute ihinduka rya BRCA rigira ingaruka kuri kanseri. BRCA1 na BRCA2 bikunze kuba bifitanye isano no kwiyongera kwa kanseri yamabere na ovarian kubagore. Ariko, ihinduka ryimiterere kandi ryongera ibyago byizindi kanseri, harimo kanseri ya prostate, kanseri y'urwagashya, na melanoma. Abagabo bafite a BRCA mutation ifite amahirwe menshi yo gutera imbere cyane kanseri ya prostate akiri muto.Imihindagurikire ya BRCA na Kanseri ya ProstateKongera ibyago no gukomeretsaAbanyeshuri berekanye ko abagabo bafite BRCA1 cyangwa BRCA2 ihindagurika rifite ibyago byinshi byo gutera imbere kanseri ya prostate ugereranije nabagabo badafite iyi mutation. Byongeye kandi, kanseri ya prostate mu bagabo hamwe BRCA ihindagurika ikunda kuba ubukana, akenshi ikerekana mugihe cyakurikiyeho hamwe n amanota menshi ya Gleason. Ikigo cy'igihugu gishinzwe kanseri itanga andi makuru kuri BRCA ingirabuzimafatizo hamwe na kanseri. Kwipimisha no Kwipimisha Gutanga ibyago byiyongera, kwipimisha genetike kuri BRCA1 na BRCA2 ihinduka risabwa kubagabo bafite amateka yumuryango wa kanseri ya prostate, cyane cyane niba kanseri yarasuzumwe akiri muto cyangwa niba hari amateka ya kanseri y'ibere, intanga ngore, cyangwa kanseri y'urwagashya mu muryango. Kumenya hakiri kare hifashishijwe ibizamini, nka PSA (prostate yihariye ya antigen) no gupima ibizamini bya rectal, nabyo ni ingenzi kubagabo bafite ibyago byinshi. Kwipimisha genetike biraboneka no mubigo nka Shandong Baofa Ikigo Cyubushakashatsi Kanseri. kanseri ya prostate mu bagabo hamwe BRCA ihinduka. Inzitizi ya PARP ikora ihagarika enzyme ya PARP, igira uruhare mu gusana ADN. Ingirabuzimafatizo za kanseri hamwe BRCA ihinduka ryibasiwe cyane cyane no kubuza PARP kuberako basanzwe bafite uburyo bwo gusana ADN bwangiritse. Bimwe mubisanzwe PARP inhibitor zirimo olaparib (Lynparza) na rucaparib (Rubraca). Uburyo PARP Inhibitor ikora BRCA ingirabuzimafatizo zahinduwe, selile za kanseri zishingikiriza ku zindi nzira zo gusana ADN, harimo n'inzira ya PARP. Muguhagarika enzyme ya PARP, PARP inhibitor irinda selile kanseri gusana ibyangiritse bya ADN, biganisha ku rupfu. Ubu buryo bugamije ni bwiza cyane muri kanseri ya prostate selile hamwe BRCA ihinduka ry’imiterere, kubera ko ridashoboye gusana neza ibyangiritse kuri ADN hakoreshejwe ubundi buryo. Ikigereranyo cy’ibigereranyo cya Clinical na EfficacyIgeragezwa ry’amavuriro ryerekanye imikorere ya PARP inhibitor mu kuvura iterambere kanseri ya prostate mu bagabo hamwe BRCA ihinduka. Kurugero, igeragezwa rya PROfound ryerekanye ko olaparib yazamuye cyane kubaho muri rusange no kubaho kwiterambere rya radiografiya kubagabo bafite metastatike idashobora kwihanganira kanseri ya prostate (mCRPC) na BRCA1 cyangwa BRCA2 ihinduka. Ibisubizo bivuye mu rubanza PROfound murashobora kubisanga kuri Ikinyamakuru gishya cy’ubuvuzi.Ubundi buryo bwo kuvura Mugihe PARP inhibitor ari uburyo bwo kuvura bugenewe, ubundi buryo busanzwe kanseri ya prostate kuvura birashobora kandi gukoreshwa kubagabo bafite BRCA ihinduka. Muri byo harimo: Kubaga: Prostatectomie radical (gukuraho glande ya prostate) irashobora kuba amahitamo yaho kanseri ya prostate. Ubuvuzi bw'imirasire: Imiti ivura imishwarara yo hanze cyangwa brachytherapy (imirasire y'imbere) irashobora gukoreshwa muguhitamo no gusenya selile. Ubuvuzi bwa Hormone: Ubuvuzi bwa Androgene bwo kuvura (ADT) bugamije kugabanya urugero rwa testosterone, ishobora kudindiza imikurire ya kanseri ya prostate selile. Chimoterapi: Imiti ya chimiotherapie irashobora gukoreshwa mukuvura iterambere kanseri ya prostate ibyo byakwirakwiriye mu bindi bice byumubiri. Ejo hazaza h’ubuvuzi bwa Kanseri ya Prostate ifitanye isano na BRCAUbushakashatsi bukomeje n’ibigeragezo bya ClinicalUbushakashatsi burakomeje kugira ngo urusheho gusobanukirwa uruhare rwa BRCA ihinduka kanseri ya prostate no gutegura ingamba nshya kandi nziza zo kuvura. Igeragezwa rya Clinical ririmo gushakisha ikoreshwa rya inhibitori ya PARP ifatanije nubundi buvuzi, ndetse no gukora iperereza ku ntego z’ibiyobyabwenge ndetse n’uburyo bwo kuvura bwihariye. BRCA ihinduka kanseri ya prostate abarwayi bagaragaza akamaro k'ubuvuzi bwihariye hamwe na oncology isobanutse. Mugusobanukirwa imiterere yimiterere ya kanseri yumuntu, abaganga barashobora guhuza ingamba zo kuvura kugirango barusheho gukora neza no kugabanya ingaruka mbi. Ikizamini cya genetike ya BRCA nizindi genes zijyanye na kanseri ziragenda zimenyekana muri kanseri ya prostate imicungire. Byiza cyane, cyane cyane mubyiciro byateye imbere. Kubaga Gukuraho glande ya prostate. Bikwiranye na kanseri yaho; imikorere idahuye neza na status ya BRCA. Ubuvuzi bwimirasire Gukoresha imirasire yingufu nyinshi kugirango wice kanseri. Bikora neza, ariko imiterere ya BRCA irashobora guhindura igisubizo. Ubuvuzi bwa Hormone Kugabanya urugero rwa testosterone kugirango umuvuduko wa kanseri ukure. Ubuvuzi busanzwe, imikorere idahuye neza na status ya BRCA. Chimoterapi Gukoresha imiti yica kanseri. Byakoreshejwe mubyiciro byambere, imiterere ya BRCA irashobora guhindura igisubizo. UmwanzuroKumva isano iri hagati Imirasire ya BRCA na kanseri ya prostate ni ngombwa mu kunoza isuzumabumenyi, kuvura, n'ibisubizo ku bantu bagizweho ingaruka. Kwipimisha genetike, kuvura bigamije nka PARP inhibitor, hamwe nubushakashatsi burimo gukorwa burimo gutanga inzira yuburyo bwihariye kandi bunoze bwo kuyobora kanseri ya prostate mu bagabo hamwe BRCA ihinduka. Abagabo bafite amateka yumuryango wa kanseri ya prostate cyangwa izindi kanseri zifitanye isano zigomba gusuzuma ibizamini bya geneti no kuganira ku ngamba zikwiye zo gusuzuma hamwe n'abashinzwe ubuzima. Abanyamwuga bitanze mubigo nka Shandong Baofa Kanseri Yubushakashatsi, izwiho kuvura kanseri, batanga umusanzu mubikorwa byiterambere muriki gice.