uburyo bwo kuvura kanseri ya prostate

Kanseri ya prostate metastatike ni kanseri ya prostate yakwirakwiriye hejuru ya glande ya prostate no mu bindi bice byumubiri. Uburyo bwo kuvura buratandukanye bitewe nubunini bwakwirakwijwe, ubuvuzi bwabanje, nubuzima bwumurwayi muri rusange. Ubuvuzi busanzwe burimo kuvura imisemburo, chimiotherapie, immunotherapy, hamwe no kuvura imirasire. Ubuvuzi bushya nka radiofarmaceuticals na PARP inhibitor nabwo burakoreshwa cyane. Ikigo cy’ubushakashatsi cya Kanseri ya Shandong Baofa cyihaye intego yo gutanga ubushakashatsi n’ubuvuzi bwo mu rwego rwo hejuru kugira ngo abarwayi barusheho kunozwa. kanseri ya prostate iyo ikwirakwiriye muri glande ya prostate ikagera mu tundi turere, cyane cyane amagufwa, imisemburo ya lymph, umwijima, n'ibihaha. Ni ngombwa gusobanukirwa icyiciro n'urwego rwa kanseri kugirango umenye inzira nziza y'ibikorwa. Kwipimisha mubisanzwe bikubiyemo kwipimisha amashusho nko gusikana amagufwa, CT scan, na MRIs, hamwe na biopsies. Niki Gitera Kanseri ya Prostate Metastatike? Uturemangingo twa kanseri dukura ubushobozi bwo gutandukana nikibyimba kibanza muri prostate, tunyura mumaraso cyangwa sisitemu ya lymphatique, kandi tugashyiraho ibibyimba bishya mubice bya kure. Imihindagurikire ya genetike hamwe nibintu bifitanye isano na microen ibidukikije yibibyimba birashobora kugira uruhare muriki gikorwa. Amanota ya Gleason no kuba hari biomarkers yihariye nabyo bigira uruhare runini muguhishurira ibyago byo kwandura metastasis. kanseri ya prostate. Ibi bikunze gukoreshwa muburyo bukurikiranye cyangwa bikurikiranye kugirango bigerweho neza.Ubuvuzi bwa Hormone (Androgen Deprivation Therapy - ADT) Ubuvuzi bwa Hormone, buzwi kandi ku izina rya androgene devuvu therapy (ADT), bugamije kugabanya urugero rwa hormone zabagabo (androgène) mu mubiri, zitera gukura kwa selile ya kanseri ya prostate. Ibi birashobora kugerwaho hifashishijwe kubaga (orchiectomy) cyangwa kuvura kwa muganga ukoresheje LHRH agoniste cyangwa antagonist. Ingaruka zisanzwe zirimo flash zishyushye, gutakaza libido, kudakora neza, n'umunaniro. ADT akenshi niwo murongo wambere wo kuvura kanseri ya prostate.ChemotherapyChemotherapie ikubiyemo gukoresha imiti yica kanseri. Bikunze gukoreshwa mugihe imiti ya hormone itagikora neza (kanseri ya prostate irwanya kanseri - CRPC). Imiti isanzwe ya chimiotherapie ikoreshwa muri kanseri ya prostate harimo docetaxel na cabazitaxel. Ingaruka zishobora kubamo isesemi, kuruka, guta umusatsi, umunaniro, hamwe no kwandura indwara. Ikigo cy’ubushakashatsi cya kanseri ya Shandong Baofa gishimangira gucunga ingaruka ziterwa no kuzamura imibereho. Ubuvuzi bwa Radiyoyasi ikoresha imirasire y’ingufu nyinshi cyangwa ibice byica kanseri. Irashobora gukoreshwa mu kuvura glande ya prostate ubwayo (imiti ivura imirasire yo hanze cyangwa brachytherapy) cyangwa ikareba ahantu metastatike iri mu magufa (imiti ivura imirasire yo hanze). Imiti ivura imirasire irashobora gufasha kugabanya ububabare no kuzamura imibereho. Ingaruka mbi ziterwa n'ahantu havurirwa ariko hashobora kuba harimo umunaniro, kurwara uruhu, nibibazo byo munda. Kubaga Kubaga, nka prostatectomie radical, ntibikoreshwa cyane kuri kanseri ya prostate. Ariko, birashobora gutekerezwa mubihe byihariye, nko gukuraho ikibyimba cyibanze kugirango ugabanye ibimenyetso cyangwa ufatanije nubundi buvuzi. Gukuraho kubaga ibikomere metastatike ntibikunze gukorwa.Ubuvuzi bushya kandi bwihuse Ubushakashatsi bushya uburyo bwo kuvura kanseri ya prostate ihora itera imbere, itanga ibyiringiro kubisubizo byiza hamwe nubuzima bwiza. Dore bumwe mu buryo bushya: RadiopharmaceuticalsRadiopharmaceuticals ni imiti itanga imirasire mu ngirabuzimafatizo za kanseri. Radium-223 dichloride (Xofigo) ni radiofarmaceutical ikoreshwa mu kuvura metastase yamagufwa kubarwayi barwaye CRPC. Lutetium-177 PSMA-617 nubundi buryo bwa radiofarmaceutical yibasira antigen yihariye ya prostate (PSMA), poroteyine iboneka hejuru ya selile kanseri ya prostate. Ingaruka zishobora kubamo guhagarika amagufwa hamwe numunaniro.ImmunotherapyImmunotherapy ikoresha imbaraga za sisitemu yumubiri yo kurwanya kanseri. Sipuleucel-T (Ihorere) nubuvuzi bwikingira bwemejwe na CRPC idafite ibimenyetso cyangwa ibimenyetso simusiga. Harimo gukusanya ingirabuzimafatizo z'umurwayi, kuzihindura kugirango tumenye kanseri ya prostate, hanyuma uyisubize mu murwayi. Pembrolizumab, inzitizi yo kugenzura, irashobora kuba amahitamo kubarwayi bafite ihindagurika ry’imiterere yihariye cyangwa ihungabana rikomeye rya microsatellite (MSI-H) .Ibikoresho bya PARP InhibitorPARP ni imiti ibuza imisemburo ya PARP, igira uruhare mu gusana ADN. Iyi miti irashobora kugira akamaro kubarwayi bafite ihindagurika ryimiterere, nka BRCA1 / 2 ihinduka. Olaparib na rucaparib ni PARP inhibitor zemewe kuvura CRPC. Ingaruka zisanzwe zirimo kubura amaraso, umunaniro, no kugira isesemi. Ikigo cy’ubushakashatsi cya kanseri ya Shandong Baofa kigira uruhare runini mu bushakashatsi bwiga ku ikoreshwa rya inhibitori ya PARP ifatanije n’ubundi buvuzi. Urashobora kwiga byinshi kubyerekeranye na PARP inhibitor kuri Urubuga rwigihugu rwa kanseri.Ubuvuzi bugamije Ubuvuzi bugamije gukoresha imiti yibasira molekile zimwe na zimwe zigira uruhare mu mikurire ya kanseri no kubaho. Ingero zirimo ibiyobyabwenge bibuza inzira zerekana inzira nka PI3K / AKT / mTOR inzira. Ubu buryo bwo kuvura bukoreshwa mubigeragezo byamavuriro kandi biracyakurikiranwa kugirango bigire akamaro mu kuvura kanseri ya prostate.Ingamba zo kuvura zishingiye ku cyiciro cy’indwara n’ingaruka ziterwa n’impanuka Guhitamo imiti biterwa nimpamvu nyinshi zirimo urugero rw’indwara, ubuzima bw’umurwayi muri rusange, ndetse n’ubuvuzi bwabanje. Imbonerahamwe ikurikira iragaragaza muri make uburyo rusange bwo kuvura: Icyiciro / Ibyago bisanzwe byo kuvura Amahitamo ya kanseri ya prostate ya Hormone-yanduza ADT + androgene reseptor inhibitor (urugero: abiraterone, enzalutamide), chimiotherapie, cyangwa kwipimisha kwa muganga. Kanseri ya prostate irwanya kanseri (CRPC) Chimiotherapie, andorogi ya reseptor inhibitor, radiofarmaceuticals, immunotherapy, inhibitori ya PARP (niba bishoboka), cyangwa kwipimisha kwa muganga. Amagufa ya Metastase Imiti ivura imirasire, radiofarmaceuticals, bisphosifone cyangwa denosumab (ibikoresho bikomeza amagufwa). Ibigeragezo bya Clinical hamwe nicyerekezo kizaza Ibigeragezo byubuvuzi nibyingenzi mugutezimbere uburyo bushya kandi bunoze bwo kuvura kanseri ya prostate. Abarwayi barashobora gutekereza kwitabira ibizamini byubuvuzi kugirango babone imiti igezweho kandi batange umusanzu mubushakashatsi bwubuvuzi. Ubushakashatsi burimo kwibanda ku guteza imbere uburyo bunoze bwo kuvura, gukingira indwara, hamwe no kuvura. Ikigo cy’ubushakashatsi cya kanseri ya Shandong Baofa gifite uruhare runini mu gukora ibizamini by’amavuriro no guteza imbere urwego rwo kuvura kanseri ya prostate. Urashobora kuvugana Shandong Baofa Ikigo Cyubushakashatsi Kanseri kumakuru kubigeragezo byamavuriro nuburyo bwo kuvura.Kubaho na Kanseri ya Prostate ya Prostate Kubaho hamwe kanseri ya prostate irashobora kwerekana ingorane zikomeye. Gucunga ibimenyetso, guhangana n'ingaruka, no gukomeza ubuzima bwiza nibintu byingenzi byitaweho. Amatsinda atera inkunga, ubujyanama, hamwe na serivisi zita ku barwayi barashobora gutanga ubufasha bw'ingirakamaro. Gushyikirana kumugaragaro nabashinzwe ubuvuzi nibyingenzi kugirango bafate ibyemezo byuzuye kandi bahabwe ubuvuzi bwiza bushoboka.Umwanzuro Mugihe kanseri ya prostate ni ibintu bikomeye, uburyo bwinshi bwo kuvura burahari kugirango bufashe kurwanya indwara, kuzamura imibereho, no kongera ubuzima. Gukomeza kumenyeshwa ibyagezweho mu buvuzi no gukorana bya hafi nitsinda ryinshi ryinzobere mu buvuzi ni ngombwa mu gufata ibyemezo neza no kwitabwaho neza. Ikigo cy’ubushakashatsi cya kanseri ya Shandong Baofa cyiyemeje gutanga ubuvuzi bwuzuye no guteza imbere urwego rw’ubushakashatsi bwa kanseri ya prostate.