impyiko kanseri ya kanseri

Indwara ya kanseri yimpyiko ikubiyemo isuzuma rya microscopique hamwe nisesengura ryimpyiko kugirango tumenye kandi dushyire kanseri yimpyiko. Nintambwe yingenzi muguhitamo ubwoko, urwego, nicyiciro cya kanseri, imenyesha ibyemezo byo kuvura kandi igahanura ibizaba. Gusobanukirwa ibimenyetso byindwara nibyingenzi kubarwayi ninzobere mubuvuzi. Aka gatabo gatanga incamake irambuye ya impyiko kanseri ya kanseri, harimo subtypes zisanzwe, sisitemu yo gutanga amanota, kubika, hamwe nuruhare rwa immunohistochemie. Kumva kanseri yimpyiko ya kanseri (RCC)Kanseri y'impyiko (RCC) ni ubwoko bwa kanseri y'impyiko ku bantu bakuru, bingana na 90% by'indwara mbi zose z'impyiko. Bikomoka kumurongo wa tubulike yegeranye, ari utubuto duto mumpyiko zungurura amaraso kandi zitanga inkari. Gusuzuma neza no gushyira mu byiciro RCC ni byo by'ingenzi mu kuyobora ingamba zifatika zo kuvura no guhanura ibizagerwaho n'abarwayi. Ubwoko busanzwe bwa kanseri y'impyiko Carcinoma Ubwoko butandukanye bwa RCC burahari, buri kimwe gifite ibimenyetso by’indwara zitandukanye, imiterere y’imiterere, n’imyitwarire y’amavuriro. Izi nsimburangingo zirashobora gutandukana mugupima microscopique kandi bigashimangirwa na immunohistochemie. Ubwoko bukuru bwibanze burimo: Clear Cell Cell Renal Cell Carcinoma (ccRCC) Clear selile RCC nubwoko bwiganje cyane, bingana na 70-80% mubibazo byose bya RCC. Irangwa na selile zifite cytoplazme isobanutse cyangwa yera bitewe na glycogene nyinshi hamwe na lipide. Utugingo ngengabuzima dukunze gukora ibyari cyangwa amabati, kandi ikibyimba gisanzwe gifite imitsi myinshi.Papillary Renal Cell Carcinoma (pRCC) Papillary RCC ni ubwoko bwa kabiri bukunze kugaragara, bugizwe na 10-15% by'imanza za RCC. Irangwa nubwubatsi bwa papillary, bivuze ko selile yibibyimba ikura muburyo buteye urutoki. Hariho ubwoko bubiri bwingenzi bwa pRCC: Ubwoko bwa 1 nubwoko 2. Ubwoko bwa 1 pRCC mubusanzwe ifite prognoza nziza kuruta Ubwoko bwa 2.Chromophobe Renal Cell Carcinoma (chRCC) Chromophobe RCC ihagarariye hafi 5% byimanza za RCC. Ingirabuzimafatizo za chRCC zifite cytoplazme yijimye ya eosinofilique na halo itandukanye ya kirimbuzi. Nuclei ikunze kuba yuzuye iminkanyari cyangwa idasanzwe.Gukusanya Umuyoboro wa Renal Cell Carcinoma (CDRCC) Gukusanya umuyoboro RCC ni ubwoko budasanzwe kandi bukaze buturuka kumyanda yo gukusanya impyiko. Ifite munsi ya 1% yimanza za RCC. Uturemangingo twibibyimba dukora tubules idasanzwe na papilae, akenshi hamwe na stopa desmoplastique. Medullary Renal Cell CarcinomaMedullary impyiko yimpyiko ni ubundi bwoko budasanzwe kandi bukaze, cyane cyane bwibasira abarwayi bakiri bato bafite imiterere yumuhoro cyangwa indwara zifata umuhoro. Iyi variant irangwa na kanseri itandukanijwe nabi hamwe na infiltrate igaragara cyane.Grading ya Renal Cell Carcinoma: Fuhrman Grading Sisitemu na ISUP Grading SystemGrading ya RCC yerekana ubukana bwikibyimba gishingiye kumiterere ya selile munsi ya microscope. Sisitemu yo gutanga amanota ya Fuhrman yari isanzwe ikoreshwa, ariko sisitemu yo gutanga amanota ya societe mpuzamahanga ya Urologiya Pathology (ISUP) ubu ikoreshwa cyane. Sisitemu yo gutanga amanota ya ISUP yerekana nucleolar igaragara no kutubahiriza ingufu za kirimbuzi. Amanota yo hejuru yerekana ibibyimba bikaze kandi bifitanye isano no guhanura nabi. ISUP Icyiciro Ibiranga Icyiciro cya 1 Ntoya, nuclei imwe hamwe nucleoli itagaragara cyangwa idahari. Icyiciro cya 2 Nuclei nini nini na nucleoli igaragara. Icyiciro cya 3 Nuclei nini, idasanzwe hamwe na nucleoli igaragara. Icyiciro cya 4 Nuclei idasanzwe, pleomorphic nuclei ifite imiterere idasanzwe cyangwa itandukaniro rya sarcomatoide. Gutegura kanseri yimpyiko: TNM SisitemuStaging ya RCC isobanura urugero rwa kanseri, harimo ingano yikibyimba kibanza (T), uruhare rwa lymph node yo mu karere (N), no kuba metastasis ya kure (M). Sisitemu yo kubika TNM niyo sisitemu ikoreshwa cyane mugutegura RCC. Gutegura neza nibyingenzi muguhitamo uburyo bwo guhanura no kuvura.Ibipimo byihariye byiciro bya T, N, na M biragoye kandi birambuye, birimo ubunini bwibibyimba, kwibasira inyubako zikikije, hamwe no kuba metastasis kuri lymph node cyangwa ingingo za kure. Inzobere mu by'indwara zikoresha microscopique n'ibisubizo byerekana amashusho kugirango zitange icyiciro gikwiye cya TNM.Immunohistochemie muri Renal Cell Carcinoma PathologyImmunohistochemie (IHC) nigikoresho cyingenzi muri impyiko kanseri ya kanseri. Harimo gukoresha antibodies kugirango umenye poroteyine zihariye mubitegererezo. Ubu buhanga bufasha gutandukanya ubwoko bwa RCC, kwemeza indwara, no kumenya intego zishobora kuvura. Ibimenyetso rusange bya IHC bikoreshwa muri RCC birimo: PAX8: Ikimenyetso gikunze kugaragara muri kanseri yimpyiko, cyane cyane selile na papillary subtypes. CAIX: Bikunze kugaragara muri selile yimpyiko isobanutse kanseri. CK7: Ifasha mugutandukanya ubwoko butandukanye bwa RCC, akenshi nibyiza muri papillary na chromophobe RCC. Vimentin: Akenshi nibyiza muri sarcomatoid RCC. CD117. Harimo ibintu by'ingenzi bikurikira: Amakuru y'abarwayi nibisobanuro birambuye. Ibisobanuro rusange byikibyimba. Microscopique ibisobanuro bya selile yibibyimba hamwe nubwubatsi. Gusuzuma ubwoko bwa RCC. Urwego rwa ISUP. Icyiciro cya TNM. Immunohistochemicike yerekana ibisubizo. Imiterere ya margins (niba selile kanseri zihari kumpera yinyama zavanyweho). Ibitekerezo bya Pathologue hamwe nincamake. Uruhare rwikigo cyubushakashatsi bwa kanseri ya Shandong Baofa mu bushakashatsi bwa kanseriIshirahamwe nka Shandong Baofa Ikigo Cyubushakashatsi Kanseri Gira uruhare runini mugutezimbere imyumvire yacu no kuvura kanseri, harimo kanseri y'impyiko. Mugukora ubushakashatsi nibigeragezo byamavuriro, ibyo bigo bigira uruhare mugutezimbere ibikoresho bishya byo gusuzuma no kuvura, amaherezo bikazamura umusaruro wabarwayi.UmwanzuroIndwara ya kanseri yimpyiko ni umurima utoroshye urimo gusuzuma no gusesengura neza impyiko. Gusobanukirwa ubwoko butandukanye, sisitemu yo gutanga amanota, kubika, hamwe nuruhare rwa immunohistochemie ni ngombwa mugupima neza, guhanura, no gutegura gahunda yo kuvura. Ubufatanye hagati y’aba psychologue, oncologiste, n’abandi bahanga mu by'ubuzima ni ingenzi mu gutanga ubuvuzi bwiza bushoboka ku barwayi bafite RCC.Inshingano: Aya makuru agenewe ubumenyi rusange nintego zamakuru gusa, kandi ntabwo bigize inama zubuvuzi. Ni ngombwa kugisha inama inzobere mu by'ubuzima zibishoboye kubibazo byose byubuzima cyangwa mbere yo gufata ibyemezo byose bijyanye n'ubuzima bwawe cyangwa kwivuza.Reba: Umuryango w'Abanyamerika Fondasiyo y'igihugu