daaweynta kansarka sambabada metastatic

Daaweynta kansarka sambabada Metastatic waxay diiradda saartaa fidinta nolosha iyo hagaajinta tayada nolosha marka kansarku uu ku faafo meel ka baxsan sambabada. Ikhtiyaarada daawaynta way kala duwan yihiin iyadoo ku xidhan nooca kansarka, heerka, isbedelada, iyo caafimaadka guud. Hababka caadiga ah waxaa ka mid ah kiimoterabi, daawaynta la beegsaday, immunotherapy, daaweynta shucaaca, iyo qalliin. Hagahan ayaa si faahfaahsan u sahaminaya fursadahan, isaga oo siinaya fikrado ku saabsan hababkooda, faa'iidooyinkooda, iyo waxyeeladooda.Kansarka sambabada Metastatic, oo sidoo kale loo yaqaan heerka IV kansarka sanbabada, waxay dhacdaa marka unugyada kansarka ee buro sambabada asalka ah ay ku faafaan qaybaha fog ee jirka. Goobaha caadiga ah ee metastasis-ka waxaa ka mid ah maskaxda, lafaha, beerka, iyo qanjidhada adrenal. Noocyada Kansarka SambabadaLabada nooc ee ugu waaweyn ee kansarka sanbabada waa: Kansarka Sambabada Unug Yaryar (NSCLC): Nooca ugu caansan, oo ay ku jiraan adenocarcinoma, kansarka unugyada squamous, iyo kansarka unugyada waaweyn. Kansarka Sambabada Unug Yar (SCLC): Nooca kansarka sanbabada si degdeg ah u koraya oo si xooggan ula xidhiidha sigaarka Daawaynta waxay caawisaa in la go'aamiyo inta uu le'eg yahay kansarka waxayna hagtaa go'aamada daawaynta. daaweynta kansarka sambabada metastatic waa in la xakameeyo korriinka kansarka, la maareeyo calaamadaha, lana hagaajiyo tayada nolosha. Qorshayaasha daawaynta ayaa inta badan la shakhsiyeeyaa iyadoo lagu salaynayo xaalada gaarka ah ee qofka. Dawaynta Kiimiko waxay isticmaashaa daawooyin si ay u disho unugyada kansarka ee jidhka oo dhan. Inta badan waxa loo isticmaalaa daawaynta safka kowaad kansarka sambabada metastatic. Daawooyinka kemotherabi ee caadiga ah waxaa ka mid ah: Daawooyinka ku salaysan Platinum (cisplatin, carboplatin) Taxanes (paclitaxel, docetaxel) Pemetrexed GemcitabineChemotherapy waxay yeelan kartaa waxyeelooyin kale sida lallabbo, daal, timo lumis, iyo khatarta sii kordheysa ee caabuqa. Baaritaanka molecular waa lama huraan si loo ogaado haddii bukaanku u qalmo daawaynta la beegsaday. Qaar ka mid ah bartilmaameedyada caadiga ah iyo daawooyinka u dhigma waxaa ka mid ah: EGFR (Qaybiyaha Cunsurka Kobaca Epidermal): Gefitinib, erlotinib, afatinib, osimertinib. Daawooyinkani waxay si gaar ah waxtar ugu leeyihiin bukaanka NSCLC ee leh isbeddellada EGFR. ALK (anaplastic Lymphoma Kinase): Crizotinib, alectinib, ceritinib, brigatinib, lorlatinib. Loo isticmaalo bukaanada NSCLC ee leh dib u habeynta ALK. BRAF: Dabrafenib, trametinib. Loo isticmaalo bukaannada NSCLC ee leh isbeddellada BRAF V600E. ROS1: Crizotinib, entrectinib. Loo isticmaalo bukaanada NSCLC ee leh fiyuusyada ROS1. NTRK: Larotrectinib, entrectinib. Loo isticmaalo bukaanada NSCLC ee leh fiyuuska NTRK. MET: Capmatinib, tepotinib. Waxaa loo adeegsaday bukaannada NSCLC ee leh MET exon 14 oo ka booday isbeddellada. RET: Selpercatinib, pralsetinib. Waxaa loo isticmaalaa bukaanada NSCLC ee leh isku-dhafka RET. Dawooyinka la bartilmaameedsado badanaa waxay leeyihiin waxyeelooyin ka yar kiimoterabiga, laakiin waxay waxtar leeyihiin kaliya haddii kansarku leeyahay bartilmaameed gaar ah.Immunotherapy Kahortagga isbaarada difaaca ayaa ah nooca caadiga ah ee daaweynta difaaca jirka ee loo isticmaalo daaweynta kansarka sambabada metastatic. Tusaalooyinka waxaa ka mid ah: Pembrolizumab (Keytruda) Nivolumab (Opdivo) Atezolizumab (Tecentriq) Durvalumab (Imfinzi) Ipilimumab (Yervoy) Daawooyinkaan waxay xannibaan borotiinnada ka hortagaya habka difaaca si uu u weeraro unugyada kansarka, taas oo u oggolaanaysa habka difaaca inuu kor u qaado jawaab celin xooggan. Dhibaatooyinka soo raaca waxaa ka mid noqon kara daal, finan, shuban, iyo bararka xubnaha kala duwan. Daaweynta shucaaca waxay isticmaashaa fallaadhaha tamarta sare si ay u dilaan unugyada kansarka. Waxaa loo isticmaali karaa in lagu yareeyo burooyinka, xanuunka laga yareeyo, ama lagu daaweeyo metastases meelo gaar ah sida maskaxda ama lafaha. Noocyada daawaynta shucaaca waxaa ka mid ah: Daaweynta shucaaca dibadda ee Istaraatiijiyada Stereotactic body radiation therapy (SBRT) Qalliinka shucaaca ee Stereotactic (SRS) Dhibaatooyinka soo raaca waxay ku xiran yihiin goobta iyo qiyaasta shucaaca. Qalliinka guud ahaan maaha daawaynta aasaasiga ah kansarka sambabada metastatic, laakiin waxaa laga yaabaa in la tixgeliyo xaaladaha qaarkood, sida in meesha laga saaro metastasis keligiis ah ama in la yareeyo calaamadaha. Tusaale ahaan, the Shandong Baofa Machadka Cilmi-baarista Kansarka marmar waxay isticmaashaa farsamooyinka qalliinka ee ugu yar si wax looga qabto goobo gaar ah oo metastatic ah. Tijaabooyinka kiliinikada waa daraasado cilmi baaris oo qiimeeya daawaynta cusub ama isku darka daaweynta. Bukaanka qaba kansarka sambabada metastatic Waxaa laga yaabaa inay tixgeliso ka qaybqaadashada tijaabooyinka bukaan-socodka si ay u helaan daawaynta gees-goynta.Maaraynta Calaamadaha iyo Saamaynta Dhinacyada Maareynta calaamadaha iyo waxyeellooyinka waa qayb muhiim ah daaweynta kansarka sambabada metastatic. Tan waxaa ka mid noqon kara: Maareynta xanuunka Taageerada nafaqada Maareynta lallabada iyo matagga Taageerada neefsiga Saadaasha iyo Heerarka BadbaadaSaadaasha kansarka sambabada metastatic way kala duwan tahay iyadoo ku xidhan dhawr arrimood, oo ay ku jiraan nooca kansarka sanbabada, baaxadda fiditaanka, caafimaadka guud ee bukaanka, iyo jawaabta daawaynta. Horumarkii ugu dambeeyay ee daawaynta la beegsaday iyo immunotherapy ayaa wanaajiyay heerarka badbaadada bukaannada qaarkood. Sida laga soo xigtay Ururka Kansarka Mareykanka, heerka badbaadada 5-sano ee kansarka sambabada metastatic waa qiyaastii 7% (dhammaan marxaladaha kansarka sanbabada oo la isku daray, heerka waa 25%). [1] Tani waxay muujinaysaa muhiimada cilmi-baarista socda iyo horumarinta daawaynta cusub. Halkan waxaa ah isbarbardhigga fudud ee fursadaha daaweynta, ujeedadooda, iyo saameynaha suurtagalka ah: Daaweynta Ujeeddada Saamaynta Dhinacyada Ka-hortagga ah ee Chemotherapy Dila unugyada kansarka ee jirka oo dhan Lalabbo, daal, timo lumis, caabuqa Daaweynta la beegsanayo Block molecules gaar ah oo ku lug leh koritaanka kansarka Waxay ku xiran tahay daawada; Waxaa ku jiri kara finan maqaarka ah, shuban, dhibaatooyinka beerka Immunotherapy Caawi habka difaaca jirka inuu weeraro unugyada kansarka Daal, finan, shuban, bararka xubnaha daweynta shucaaca Dila unugyada kansarka meel gaar ah Daal, maqaarka oo isbedelaya, dhaawaca xubnaha jirka ee agagaarka goobta qaliinka ka saar metastases ama nafiso calaamadaha Xanuunka, caabuqa, dhiigbaxa GabagaboDaaweynta kansarka sambabada Metastatic waa goob adag oo horumaraysa. Horumarrada laga gaaray daawaynta la beegsaday iyo daawaynta difaaca jirka ayaa si weyn u wanaajiyay natiijooyinka bukaannada qaarkood. Aad bay muhiim ugu tahay bukaanada inay si dhow ula shaqeeyaan kooxdooda daryeelka caafimaadka si ay u horumariyaan qorshe daawayn gaar ah oo ka hadlaya baahiyahooda iyo yoolalkooda gaarka ah. Had iyo jeer la tasho xirfadle caafimaad oo u qalma ogaanshaha iyo daaweynta xaalad kasta oo caafimaad. Tixraacyada[1] Ururka Kansarka Mareykanka. (n.d) Heerarka Badbaadinta Kansarka Sambabada. Laga soo celiyay https://www.cancer.org/cancer/lung-cancer/detection-diagnosis-staging/survival-rates.html