Isiteji sesi-3 sokwelashwa komdlavuza wamaphaphu ongewona amangqamuzana amancane

I-China Stage 3 Ukwelashwa Komdlavuza Wengqamuzana Ongewona Owomncane: Umhlahlandlela OpheleleLe ndatshana inikeza umbono obanzi wezinketho zokwelapha umdlavuza wamaphaphu ongewona omncane wamangqamuzana (NSCLC) wesigaba 3 (NSCLC) eShayina, ohlanganisa ukuxilongwa, izindlela zokwelashwa, nokunakekelwa okusekelayo. Ihlose ukuhlomisa abafundi ngolwazi olubalulekile lokuzulazula kulolu hambo oluyinkimbinkimbi.

I-China Stage 3 Ukwelashwa Komdlavuza Wengqamuzana Ongewona Omncane: Umhlahlandlela Ophelele

Isiteji sesi-3 Isiteji sesi-3 sokwelashwa komdlavuza wamaphaphu ongewona amangqamuzana amancane inikeza izinselelo ezinkulu, kodwa ukuthuthuka kwe-oncology kuholele emiphumeleni ethuthukisiwe. Lo mhlahlandlela uhlola amasu okwelapha ahlukahlukene, ugcizelela ukubaluleka kwezindlela zomuntu siqu ezisekelwe ezintweni zesiguli ngasinye. Ukuqonda ama-nuances wenketho ngayinye yokwelashwa kubalulekile ekwenzeni izinqumo ezinolwazi nokuzuza imiphumela engcono kakhulu.

Ukuxilongwa kanye Nezigaba

Ukuxilongwa okunembile kanye nesiteji yikona okuyisisekelo sokuphumelela Isiteji sesi-3 sokwelashwa komdlavuza wamaphaphu ongewona amangqamuzana amancane. Lokhu ngokuvamile kuhilela inhlanganisela yamasu okucabanga (CT scans, PET scans), biopsies, nezinye izinqubo zokuxilonga ukuze kutholwe izinga lokusabalala komdlavuza. Uhlelo lwesiteji lwe-TNM lusetshenziselwa ukuhlukanisa i-NSCLC, ngesigaba 3 esimele isifo esithuthuke endaweni.

Ukuqonda Isigaba 3 NSCLC

Isigaba sesi-3 se-NSCLC siphinde sahlukaniswa ngezigaba IIIA kanye ne-IIIB, ebonisa amazinga ahlukahlukene osayizi wesimila, ukubandakanyeka kwama-lymph node, kanye nokumetastase okukude. Isigaba esithile sithonya izincomo zokwelashwa kanye nokubikezela.

Izindlela Zokwelapha ZeSigaba 3 NSCLC eShayina

Ukwelashwa kwesigaba sesi-3 se-NSCLC e-China kuvame ukubandakanya indlela yemikhakha eminingi, ehlanganisa izindlela ezimbalwa ukuze kukhuliswe ukusebenza kahle. Amasu ajwayelekile afaka:

I-Chemotherapy

I-Chemotherapy yindlela yokwelapha ehlelekile esebenzisa izidakamizwa ukubulala amangqamuzana omdlavuza emzimbeni wonke. Imithi eminingana yokwelapha ngamakhemikhali isetshenziselwa isigaba sesi-3 se-NSCLC, ngokuvamile elungiselelwe izici zesiguli ngasinye kanye nohlobo lwesimila. Izidakamizwa ezisetshenziswa kakhulu zingabandakanya i-cisplatin, i-carboplatin, i-paclitaxel, nezinye.

Ukwelapha Ngemisebe

Ukwelapha ngemisebe kusebenzisa imisebe enamandla amakhulu ukukhomba nokubhubhisa amangqamuzana omdlavuza. Ingalawulwa ngaphandle (i-external beam radiation therapy) noma ngaphakathi (i-brachytherapy). Ukwelashwa ngemisebe kuvame ukuhlanganiswa ne-chemotherapy ukuze kuthuthukiswe ukusebenza kahle kokwelashwa.

Ukwelapha Okuhlosiwe

Izindlela zokwelapha ezihlosiwe ziyizidakamizwa eziklanyelwe ukuhlasela ama-molecule athile ahilelekile ekukhuleni komdlavuza. Lezi zindlela zokwelapha zibaluleke kakhulu uma isimila siphethe izinguquko ezithile zofuzo (isb., EGFR, ALK, ROS1). Ukutholakala nokufaneleka kwezindlela zokwelapha ezihlosiwe kuzoncika emiphumeleni yokuhlolwa kofuzo.

Ukuhlinzwa

Ukuhlinzwa kungase kube inketho yeziguli ezithile ze-NSCLC zesigaba sesi-3, ikakhulukazi lezo ezinamathumba amancane kanye nokubandakanyeka okulinganiselwe kwama-lymph node. Ukususwa ngokuhlinzwa kwesimila kungathuthukisa kakhulu amazinga okusinda. Uhlobo lokuhlinzwa luzoncika endaweni kanye nobukhulu besimila.

I-Immunotherapy

I-Immunotherapy ihlanganisa amasosha omzimba ukuze alwe nomdlavuza. Ama-Checkpoint inhibitors, njenge-pembrolizumab ne-nivolumab, aya ngokuya esetshenziswa esigabeni sesi-3 se-NSCLC, kwesinye isikhathi ahlanganiswe nokwelashwa ngamakhemikhali noma ngemisebe. Le mithi ingaholela ekuphenduleni okuhlala isikhathi eside kwezinye iziguli.

Ukunakekela Okusekelayo

Ukunakekelwa okusekelayo kudlala indima ebalulekile ekwenzeni ngcono izinga lempilo yeziguli ezibhekene nazo Isiteji sesi-3 sokwelashwa komdlavuza wamaphaphu ongewona amangqamuzana amancane. Lokhu kuhlanganisa ukuphatha imiphumela engemihle yokwelashwa, ukuhlinzeka ngosizo lokudla okunempilo, nokubhekana nempilo engokwengqondo nengokomzwelo.

Ukukhetha Uhlelo Lokwelapha Olulungile

Ukukhetha uhlelo lokwelapha olulungile lwesigaba sesi-3 se-NSCLC kudinga ukucatshangelwa ngokucophelela kwezici eziningi, okuhlanganisa impilo yesiguli iyonke, izici zesimila, kanye nezintandokazi zomuntu siqu. Ithimba lemikhakha eminingi yodokotela bezifo zomdlavuza, odokotela abahlinzayo, ongoti be-radiation oncologists, kanye nabanye ochwepheshe bezempilo basebenza ndawonye ukuze bakhe isu lokwelapha elihambisanayo.

Ukuze uthole ulwazi olwengeziwe kanye nokuxoxa ngezidingo zakho ngazinye, sicela uthintane nodokotela we-oncologist oqeqeshiwe. Ungaphinda uhlole izinsiza kanye namaqembu okusekela atholakala ngezinhlangano ezihlonishwayo ezigxile kumdlavuza wamaphaphu. Cabangela ukuxhumana I-Shandong Baofa Cancer Research Institute ukuze uthole ulwazi olwengeziwe.