izimbangela zomdlavuza wesibindi

Izimbangela zomdlavuza wesibindi ziyinkimbinkimbi futhi ngokuvamile zihlanganisa inhlanganisela yezinto. Ukutheleleka okungamahlalakhona nge-hepatitis B noma C, ukuphuza kakhulu utshwala, nesifo sesibindi esinamafutha angenalo utshwala (NAFLD) kuphakathi kwezinto ezibaluleke kakhulu. Ukutholwa kusenesikhathi kanye nokubhekana nalezi zimo ezibalulekile kubalulekile ukuze kuvinjwe futhi kube nemiphumela engcono.Ukuqonda Umdlavuza Wesibindi Umdlavuza wesibindi, owaziwa nangokuthi umdlavuza wesibindi, kwenzeka lapho amangqamuzana esibindi engavamile futhi engalawuleki. Kunezinhlobo eziningana zomdlavuza wesibindi, kanti i-hepatocellular carcinoma (HCC) iyona evame kakhulu. Ezinye izinhlobo zihlanganisa i-cholangiocarcinoma (umdlavuza we-bile duct) kanye ne-hepatoblastoma (umdlavuza wezingane ongavamile). Izimbangela Zomdlavuza Wesibindi kanye Nezici Eziyingozi Nakuba ingaziwa njalo imbangela yomdlavuza wesibindi, izici eziningana eziyingozi zandisa kakhulu amathuba okuba nesifo. Lokhu kufaka phakathi:Izifo zeHepatitis Ezingamahlalakhona Ukutheleleka okungapheli ngegciwane le-hepatitis B (HBV) noma igciwane le-hepatitis C (HCV) lihamba phambili. imbangela yomdlavuza wesibindi emhlabeni wonke. Lawa magciwane angabangela ukuvuvukala kwesikhathi eside kanye nokulimala esibindini, ekugcineni kuholele ku-cirrhosis kanye nengozi eyengeziwe yomdlavuza. Ngokusho kweWorld Health Organisation (WHO), i-HBV ne-HCV zifinyelela ku-80% wabantu abanomdlavuza wesibindi emhlabeni jikelele. [1]I-CirrhosisIsifo sokuqina kwesibindi, isimo esibonakala ngokuba nezibazi zesibindi, esinye isici esiyingozi esiyingozi. Kungabangelwa izici ezihlukahlukene, okuhlanganisa i-hepatitis engapheli, ukuphuza utshwala ngokweqile, isifo sesibindi esinamafutha angenalo utshwala (NAFLD), kanye nezimo ezithile zofuzo. Ngokuhamba kwesikhathi, i-cirrhosis ingaphazamisa ukusebenza kwesibindi futhi yandise kakhulu ingozi yokuthuthukiswa umdlavuza wesibindi.Ukuphuza UtshwalaUkuphuza utshwala kakhulu kuyisici esisungulwe kahle esiyingozi sesifo sesibindi, okuhlanganisa ukusha kwesibindi kanye nesifo sokuqina kwesibindi. umdlavuza wesibindi. Ukuphuza ngokweqile kungalimaza amangqamuzana esibindi, okuholela ekuvuvukeni kanye nezibazi. I-National Institute on Alcohol Abuse and Alcoholism (NIAAA) ichaza ukuphuza ngokweqile njengokusebenzisa iziphuzo ezingaphezu kwezine nganoma yiluphi usuku noma iziphuzo ezingaphezu kuka-14 ngesonto kwabesilisa, neziphuzo ezingaphezu kwezintathu nganoma yiluphi usuku noma iziphuzo ezingaphezu kweziyisikhombisa ngesonto kwabesifazane. [2]I-Non-Alcoholic Fatty Liver Disease (NAFLD) kanye ne-NASHNon-alcoholic fatty liver disease (NAFLD) yisimo lapho amafutha enqwabelana khona esibindini sabantu abaphuza utshwala obuncane noma abangabuphuzi nhlobo. I-Nonalcoholic steatohepatitis (NASH) iwuhlobo olubi kakhulu lwe-NAFLD olubonakala ngokuvuvukala nokulimala kwamangqamuzana esibindi. I-NAFLD ne-NASH ziya ngokuya ziqashelwa njengezici ezibalulekile zengozi ye-cirrhosis kanye umdlavuza wesibindi, ikakhulukazi emazweni asethuthukile.I-AflatoxinsI-flatoxins ubuthi obukhiqizwa isikhunta esithile esingangcolisa izitshalo zokudla ezifana namakinati, ummbila, nelayisi. Ukuchayeka kuma-aflatoxin kuxhunyaniswe nengozi eyandayo umdlavuza wesibindi, ikakhulukazi ezifundeni lapho lokhu kudla kuyizitshalo eziyisisekelo nezimo zokulondoloza zingezinhle. I-International Agency for Research on Cancer (IARC) ihlukanisa i-aflatoxin njenge-carcinogens yeQembu 1. [3]Ezinye Izinto Eziyingozi Isifo sikashukela: Abantu abanesifo sikashukela basengozini enkulu yokuthola i-NAFLD nomdlavuza wesibindi. Ukukhuluphala ngokweqile: Ukukhuluphala kuyingozi engozini ye-NAFLD ne-NASH, engandisa ingozi yomdlavuza wesibindi. Izimo ezithile zofuzo: Ezinye izimo ezizuzwe njengefa, njenge-hemochromatosis (i-iron overload), zingandisa ingozi yesifo sesibindi nomdlavuza. Ukubhema: Ukubhema kuye kwaxhunyaniswa nengozi eyengeziwe yokuba nomdlavuza ohlukahlukene, kuhlanganise nomdlavuza wesibindi. Ukusetshenziswa kwe-Anabolic Steroid: Ukusetshenziswa isikhathi eside kwama-anabolic steroids kungalimaza isibindi futhi kwandise ingozi yomdlavuza wesibindi. I-Vinyl Chloride Exposure: Ukuchayeka isikhathi eside ku-vinyl chloride, ikhemikhali esetshenziswa ekukhiqizeni amapulasitiki, kungandisa ingozi yohlobo olungavamile lomdlavuza wesibindi olubizwa ngokuthi i-angiosarcoma. Umdlavuza WesibindiNakuba kungezona zonke izimo zomdlavuza wesibindi ezingagwemeka, kunezinyathelo ezimbalwa ongazithatha ukuze unciphise ingozi yakho: Ukugonyelwa I-Hepatitis BUkugomela i-hepatitis B kusebenza kahle kakhulu ekuvimbeleni ukutheleleka kwe-HBV futhi, ngenxa yalokho, kunciphisa ingozi yomdlavuza wesibindi. I-WHO incoma ukugonywa kwe-hepatitis B kubo bonke abantwana. [1]Ukuvimbela Nokwelashwa Kwesifo Sesibindi C Awukho umgomo wesifo sokusha kwesibindi kohlobo C, kodwa izindlela zokwelapha ezisebenzayo ziyatholakala ukwelapha isifo. Ukuhlolelwa i-HCV kanye nokuhlinzeka ngokwelashwa kubantu abanaleli gciwane kungasiza ekuvimbeleni ukukhula kwe-cirrhosis nomdlavuza wesibindi. [4]Nciphisa Ukuphuza Utshwala Ukunciphisa noma ukuqeda ukuphuza kunganciphisa kakhulu ingozi yesifo sesibindi nomdlavuza. Uma ukhetha ukuphuza utshwala, kwenze ngokulinganisela.Londoloza Isisindo Esinempilo NokudlaUkugcina isisindo esinempilo nokudla ukudla okulinganiselayo kungasiza ekuvimbeleni i-NAFLD ne-NASH. Lokhu kuhlanganisa ukunciphisa ukudla kwakho iziphuzo ezinoshukela, ukudla okugayiwe, namafutha agcwele.Gwema I-Aflatoxin Exposure Ukugcina kahle izitshalo zokudla kungasiza ukuvimbela ukungcoliswa kwe-aflatoxin. Hlola ukudla ukuze uthole isikhunta ngaphambi kokudliwa, futhi ugweme ukudla ukudla okubonakala kukhuntile.Ukuhlola Okuvamile Kwabantu Abasengozini EphakemeAbantu abanesifo sokusha kwesibindi sokuqina kwesibindi esingamahlalakhona, i-cirrhosis, noma ezinye izici ezisengozini yomdlavuza wesibindi kufanele bahlolwe njalo ngokuhlolwa kwegazi kwe-ultrasound ne-alpha-fetoprotein (AFP). Ukutholwa kusenesikhathi kungathuthukisa imiphumela yokwelashwa.Abacwaningi abazinikele ku I-Shandong Baofa Cancer Research Institute sizibophezele ekuthuthukiseni ukuqonda kwethu umdlavuza wesibindi kanye nokwenza ngcono izindlela zokwelapha. Uma unokukhathazeka ngengozi yakho yomdlavuza wesibindi, khuluma nodokotela wakho mayelana namasu afanele okuhlola kanye nokuvimbela. Isikhungo sethu sigxile ocwaningweni nokwelapha umdlavuza, silwela ukuba nomthelela omkhulu ekunakekelweni kweziguli. Ukuze ufunde kabanzi mayelana I-Shandong Baofa Cancer Research Institute kanye nomsebenzi wethu, sicela uvakashele iwebhusayithi yethu. Ukuqhathaniswa Kwezici Eziyinhloko Zengozi Yomdlavuza Wesibindi Isici Sengozi Incazelo Amasu Okuvimbela I-Hepatitis B & C Ukutheleleka ngegciwane okungapheli okubangela ukuvuvukala kwesibindi nokulimala. Ukugoma (HBV), ukwelashwa ngezidambisigciwane (HCV & HBV), izindlela zokujova eziphephile. I-Cirrhosis Ukulimala kwesibindi ngenxa yezizathu ezihlukahlukene (utshwala, i-hepatitis, i-NAFLD). Lawula izimbangela eziwumsuka (ukuphela kotshwala, ukwelashwa ngezidambisigciwane, ukulawula isisindo). Ukusetshenziswa Utshwala Ukuphuza kakhulu utshwala okuholela ekulimaleni kwesibindi. Nciphisa noma ugweme ukuphuza utshwala. I-NAFLD/NASH Ukuqoqwa kwamafutha nokuvuvukala esibindini (okuvame ukuhlotshaniswa nokukhuluphala nesifo sikashukela). Ukulawulwa kwesisindo, ukudla okunempilo, ukulawula isifo sikashukela kanye ne-cholesterol. I-Aflatoxins Ubuthi obukhiqizwa isikhunta ekudleni okungcolile. Ukugcina ukudla ngendlela efanele, gwema ukudla okukhuntile. Amareferensi Inhlangano Yezempilo Yomhlaba. (2023, Julayi 19). I-Hepatitis B. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b I-National Institute on Alcohol Abuse and Alcoholism. (n.d.). Siyini Isiphuzo Esijwayelekile?. https://www.niaaa.nih.gov/alcohol-health/overview-alcohol-consumption/what-standard-drink I-International Agency for Research on Cancer. (2012). I-IARC Monographs Volume 100B: Ukuhlolwa Kwezinhlanu Ze-Polycyclic Aromatic Hydrocarbons kanye Nezinye Nitroarenes. https://www.iarc.fr/fr/news-events/iarc-monographs-volume-100b-evaluation-of-five-polycyclic-aromatic-hydrocarbons-and-some-nitroarenes/ Centers for Disease Control and Prevention. (2024, Januwari 29). I-Hepatitis C. https://www.cdc.gov/hepatitis/hcv/index.htm