Impumelelo entsha yokwelashwa komdlavuza wamaphaphu ngo-2020

Ngo-2020, kwenziwa intuthuko enkulu ekwelashweni komdlavuza wamaphaphu, okuhlanganisa nokugunyazwa kwezindlela zokwelapha ezintsha ezihlosiwe kanye ne-immunotherapies, enikeza imiphumela ethuthukisiwe nezindlela eziqondene nomuntu ezigulini. Lokhu kuphumelela kunikeze izinketho ezintsha kulabo abalwa nomdlavuza wamaphaphu, ukubhekana nokuguquka kwezakhi zofuzo ezithile kanye nokuthuthukisa ukusabela komzimba komzimba ukulwa nesifo.Unyaka Wenqubekelaphambili: Ukhiye Ukuphumelela Okusha Kokwelashwa Komdlavuza Wamaphaphu 2020Unyaka ka-2020 umake unyaka obalulekile ekulweni nomdlavuza wamaphaphu. Ngenkathi unyaka ububuswa ubhubhane lomhlaba wonke, abacwaningi kanye nodokotela baqhubekile nokuphusha imingcele yezinketho zokwelapha. Kwavela intuthuko eminingana ethembisayo, enikeza ithemba ezigulini futhi kwalolongwa kabusha isimo sokunakekelwa komdlavuza wamaphaphu. I-Shandong Baofa Cancer Research Institute ibilokhu ilandela lezi ntuthuko eduze.Izindlela Zokwelapha Ezihlosiwe: Precision Medicine AdvancesIzindlela zokwelapha ezihlosiwe, eziklanyelwe ukuhlasela ubuthakathaka obuthile kumangqamuzana omdlavuza, zabona inqubekela phambili ebalulekile ngo-2020. Lezi zindlela zokwelapha ngokuvamile ziholela emiphumeleni engemihle embalwa kunokwelapha ngamakhemikhali endabuko ngoba aqondise amangqamuzana omdlavuza ngokunembile. umdlavuza wamaphaphu weseli (NSCLC). Ngo-2020, ama-EGFR inhibitors amasha nathuthukisiwe agunyazwa, anikeza ukusinda okungcono kakhulu kokungaqhubeki ezigulini ezinalezi zinguquko. Lawa ma-inhibitors esizukulwane esisha ngokuvamile anqoba izindlela zokungazweli ezikhawulela ukusebenza kwemithi yangaphambilini. Ngokukhethekile, ama-ejenti aqondise ukuguqulwa kokufakwa kwe-EGFR exon 20 abonise umsebenzi othembisayo.Isibonelo, umenzeli oyedwa onjalo yi-amivantamab. Ithebula elilandelayo libonisa imiphumela yokuhlolwa komtholampilo kwe-amivantamab: Isilinganiso Sokusabela Sesigaba Sokuhlola (ORR) Ubude Besikhathi Sempendulo (DoR) Isigaba I 40% 11.1 izinyanga Umthombo: I-FDAI-ALK Inhibitors: Ukwandisa Izinketho ZokwelashwaUkuhlelwa kabusha kwe-lymphoma kinase (ALK) kungokunye ukuguqulwa komshayeli ku-NSCLC. Ama-ALK inhibitor amaningana asevele etholakala, futhi ngo-2020, ucwaningo lwagxila ekunqobeni ukumelana nale mithi kanye nokuthuthukisa ama-inhibitor anamandla. Izindlela zokwelapha ezihlanganisiwe ezintsha nazo zahlolwa ukuze kuthuthukiswe imiphumela kumdlavuza wamaphaphu we-ALK-positive.Immunotherapy: Ukusebenzisa Amandla E-Immune SystemImmunotherapy, ethuthukisa amasosha omzimba ukuze alwe nomdlavuza, iqhubekile yaba yindawo enkulu yenqubekelaphambili ekwelashweni komdlavuza wamaphaphu ngo-2020.Checkpoint Inhibitors in Earlier StagesCheckpoint,zumab inhibiluma kanye ne-peppermint. yenza izinguquko ekwelapheni umdlavuza wamaphaphu osethuthukile. Ngo-2020, ucwaningo lwahlola ukusetshenziswa kwale mithi ezigabeni zangaphambili zesifo, okuhlanganisa ngemva kokuhlinzwa noma ngokuhlanganiswa ne-chemotherapy. Lezi zifundo zibonise ukuthi ukwelapha ngokuzivikela komzimba kungathuthukisa amazinga okusinda futhi kunciphise ingozi yokuphindeka kwezinye iziguli.Imithi Yokuhlanganisa I-Immunotherapy Abacwaningi baphinde baphenya ukuhlanganisa imithi ye-immunotherapy ehlukene ukuze kuthuthukiswe ukusebenza kahle kwayo. Ukuvinjwa kwezindawo zokuhlola okukabili, kusetshenziswa izinhlobo ezimbili ezihlukene zama-immune checkpoint inhibitors, kubonise isithembiso kwezinye iziguli ezingazange zisabele ku-immunotherapy ye-ejenti eyodwa. Izivivinyo zemitholampilo ziqhubekile nokuthuthukisa lezi zindlela zokuhlanganisa ukuze kuhlonzwe iziguli okungenzeka zizuze kakhulu.Iqhaza Lokuhlola I-BiomarkerUkuthuthukiswa kwezindlela zokwelapha ezihlosiwe kanye ne-immunotherapies kugcizelele ukubaluleka kokuhlolwa okuphelele kwe-biomarker kumdlavuza wamaphaphu. Ngo-2020, kwaba nokugcizelelwa okwengeziwe kokuhlolwa kwezinhlobonhlobo zokuguqulwa kofuzo kanye nenkulumo ye-PD-L1 ukuqondisa izinqumo zokwelashwa. Le ndlela yomuntu siqu iqinisekisa ukuthi iziguli zithola ukwelashwa okufanele kakhulu futhi okuphumelelayo komdlavuza wazo othile.I-Shandong Baofa Cancer Research Institute igcizelela ukubaluleka kokuhlolwa okuphelele ukuze kuzuzwe imiphumela engcono kakhulu. Ukuphumelela okusha kokwelashwa komdlavuza wamaphaphu ngo-2020 kwavula indlela yentuthuko eyengeziwe eminyakeni ezayo. Ucwaningo oluqhubekayo lugxile ekuthuthukiseni izindlela zokwelapha ezintsha ezihlosiwe, ukuthuthukisa amasu e-immunotherapy, kanye nokuhlonza ama-biomarker anoveli. Umgomo omkhulu uwukuthuthukisa izindlela zokwelapha ezisebenza ngempumelelo neziqondene nomuntu siqu ezithuthukisa amazinga okusinda kanye nezinga lempilo yazo zonke iziguli ezinomdlavuza wamaphaphu. Isiphetho2020 bekuwunyaka wentuthuko enkulu ekwelashweni komdlavuza wamaphaphu. Ukugunyazwa kwezindlela zokwelapha ezintsha ezihlosiwe kanye ne-immunotherapies, kanye nokugcizelelwa okwengeziwe kokuhlolwa kwe-biomarker, kuguqule isimo sokunakekelwa komdlavuza wamaphaphu. Lokhu kuphumelela kunikeza ithemba ezigulini nasemindenini yazo futhi kugqamisa ukubaluleka kokuqhubeka kocwaningo kanye nokusungula izinto ezintsha ekulweni nalesi sifo esibhubhisayo. Cabangela ukuvakasha I-Shandong Baofa Cancer Research Institute's iwebhusayithi ukuze uthole ulwazi olwengeziwe ngezivivinyo zomtholampilo kanye nokwelashwa komdlavuza okuthuthukile.