ukwelashwa komdlavuza wamaphaphu we-squamous non small cell

Ukwelashwa komdlavuza wamaphaphu we-squamous ongewona omncane izinketho ziyahlukahluka kuye ngesiteji, indawo, kanye nempilo yonke yesiguli. Izinhlelo zokwelapha zingase zihlanganise ukuhlinzwa, ukwelapha ngemisebe, ukwelashwa ngamakhemikhali, ukwelashwa okuhlosiwe, i-immunotherapy, noma inhlanganisela yalezi zindlela. Ukuqonda lezi zinketho nokuxoxa ngazo kahle nethimba lakho lezempilo kubalulekile ukuze wenze izinqumo ezinolwazi mayelana nokunakekelwa kwakho. Lo mhlahlandlela unikeza umbono ojulile wezindlela zokwelapha ezihlukahlukene ezitholakalayo ze-NSCLC ene-squamous, okuhloswe ngayo ukukunika amandla olwazi lokuhamba ohambweni lwakho lokwelashwa.Ukuqonda I-Squamous Non-Small Cell Lung Cancer (NSCLC)Umdlavuza wamaphaphu we-squamous ongewona omncane (NSCLC) wuhlobo lomdlavuza wamaphaphu olusuka kumaseli e-squamous axhume imigudu yomoya. Iwuhlobo oluncane lwe-NSCLC, okuwuhlobo oluvame kakhulu lomdlavuza wamaphaphu. Ukwehlukanisa phakathi kwe-NSCLC ene-squamous kanye ne-non-squamous kubalulekile ngoba indlela yokwelapha ingahluka.Izinto Eziyingozi Ze-Squamous NSCLCSIzici eziningana zingandisa ingozi yokuthuthukisa umdlavuza wamaphaphu we-squamous ongewona omncane:Ukubhema: Isici esiyingozi kakhulu esiyingozi.Ukuchayeka entuthuni kagwayi.Ukuchayeka ku-asbestos, i-radon, nezinye izinto ezidala umdlavuza.Umlando womndeni womdlavuza wamaphaphu.Ukwelashwa ngemisebe kwangaphambilini esifubeni.Izinketho Zokwelapha ze-Squamous NSCLCThe treatment options for ukwelashwa komdlavuza wamaphaphu we-squamous ongewona omncane kunqunywa isigaba somdlavuza, impilo yesiguli iyonke, nezinye izici zomuntu ngamunye. Lokhu kungase kuhlanganise:UkuhlinzwaUkuhlinzwa kuvame ukuba umugqa wokuqala wokwelapha esigabeni sokuqala umdlavuza wamaphaphu we-squamous ongewona omncane. Umgomo uwukukhipha isimila nanoma yimaphi ama-lymph nodes athintekile. Izinhlobo zokuhlinza zihlanganisa:Ukukhishwa kwe-Wedge: Ukususwa kwesiqephu sethishu yamaphaphu esincane esimise okumise okwe-wedge.I-Lobectomy: Ukususwa kwengxenye yonke yephaphu.I-Pneumonectomy: Ukukhishwa kwephaphu lonke (okungavamile kakhulu).Ukuhlinzwa kusebenza kahle kakhulu lapho umdlavuza usendaweni futhi ungasabaleleli ezingxenyeni ezikude zomzimba.I-Radiation Radiation Therapy isebenzisa i-Radiation Cancer Therapy. Ingasetshenziswa njengokwelashwa okuyinhloko, noma ihlanganiswe nokuhlinzwa noma i-chemotherapy. Izinhlobo zokwelapha ngemisebe zihlanganisa:Ukwelashwa ngemisebe yangaphandle (EBRT): Ukwelashwa ngemisebe ekhishwe emshinini ongaphandle komzimba.I-Stereotactic body radiation therapy (SBRT): Iletha imithamo ephezulu yemisebe esimila esiqondiswe ngqo ekwelapheni okumbalwa.Ukwelashwa ngemisebe kungasetshenziswa futhi ukukhulula izimpawu zomdlavuza oseqophelweni eliphezulu, njengobuhlungu noma ukuphelelwa umoya. Ukwelashwa komdlavuza wamaphaphu we-squamous ongewona omncane ngokuvamile kuhlanganisa nemisebe.I-ChemotherapyI-Chemotherapy isebenzisa imithi ukuze ibulale amangqamuzana omdlavuza emzimbeni wonke. Ivame ukusetshenziselwa izigaba ezithuthuke kakhulu ze umdlavuza wamaphaphu we-squamous ongewona omncane noma lapho umdlavuza ususabalele kwezinye izindawo. Inganikezwa ngaphambi kokuhlinzwa (i-neoadjuvant), ngemva kokuhlinzwa (i-adjuvant), noma njengokwelashwa okuyinhloko kwesifo esithuthukisiwe.Izidakamizwa zokwelapha ezihlosiwe eziqondiswe kuma-molecule athile noma izindlela ezihilelekile ekukhuleni kwamangqamuzana omdlavuza kanye nokuphila. Ngokungafani ne-chemotherapy, ehlasela wonke amangqamuzana ahlukana ngokushesha, izindlela zokwelapha ezihlosiwe zenzelwe ukuhlasela amangqamuzana omdlavuza kuphela, okungenzeka kunciphise imiphumela engemihle. Kodwa-ke, izindlela zokwelapha ezihlosiwe zisebenza kuphela uma amaseli wesimila enethagethi ethile ehlaselwa umuthi. Ukuhlolwa kwamangqamuzana kwenziwa kumasampula esimila ukuze kuhlonzwe lezi zinhloso. Nakuba ingavamile kumdlavuza wamaphaphu we-squamous cell kunezinye izinhlobo zomdlavuza wamaphaphu, ucwaningo lusaqhubeka.I-ImmunotherapyImmunotherapy isiza amasosha omzimba ukulwa nomdlavuza. Le mithi isebenza ngokuvimbela amaprotheni athile avimbela amasosha omzimba ekuhlaseleni amangqamuzana omdlavuza. I-Immunotherapy ibonise isithembiso ekwelapheni umdlavuza wamaphaphu we-squamous ongewona omncane, ikakhulukazi ezigabeni ezithuthukile. Izidakamizwa ezijwayelekile ze-immunotherapy ezisetshenziswa ku-NSCLC zihlanganisa i-pembrolizumab, i-nivolumab, ne-atezolizumab.Ithimba ku- I-Shandong Baofa Cancer Research Institute ubambe iqhaza ngokukhuthele ekucwaningeni nasekusebenziseni ama-immunotherapies amasha omdlavuza wamaphaphu.Isivivinyo SemitholampiloIzivivinyo zezokwelapha izifundo zocwaningo ezihlola izindlela zokwelapha ezintsha noma izinhlanganisela zokwelapha. Iziguli nge umdlavuza wamaphaphu we-squamous ongewona omncane ingase icabangele ukubamba iqhaza ezivivinyweni zokwelashwa ukuze ifinyelele ekwelashweni okuphambili okungakatholakali kabanzi.Ukwelashwa Ngesiteji Se-Squamous NSCLCIsigaba umdlavuza wamaphaphu we-squamous ongewona omncane kuyisici esibalulekile ekunqumeni indlela yokwelapha engcono kakhulu. Isiteji sisiza ukunquma izinga lomdlavuza nokuthi ingabe ususabalele kwezinye izingxenye zomzimba. Izinketho zokwelashwa ziyehluka kakhulu kuye ngesiteji.Isigaba I kanye nesigaba se-IIE sasekuqaleni (I kanye no-II) ukwelashwa komdlavuza wamaphaphu we-squamous ongewona omncane ngokuvamile kuhilela ukuhlinzwa ukuze kukhishwe isimila, okulandelwa yi-adjuvant chemotherapy uma kudingeka. Ukwelapha ngemisebe kungase futhi kusetshenziswe, ikakhulukazi uma ukuhlinzwa kungeyona inketho.Isigaba IIIIsigaba III umdlavuza wamaphaphu we-squamous ongewona omncane iyinkimbinkimbi futhi ngokuvamile idinga inhlanganisela yokwelashwa, njengokuhlinzwa, ukwelapha ngemisebe, nokwelashwa ngamakhemikhali. I-Immunotherapy ingase icatshangelwe ngemva kwe-chemoradiation. Indlela eqondile incike ezingeni lomdlavuza kanye nempilo yonke yesiguli.Isigaba IVIsigaba IV ukwelashwa komdlavuza wamaphaphu we-squamous ongewona omncane igxile ekulawuleni umdlavuza, ekudambiseni izimpawu, nasekuthuthukiseni izinga lempilo. Izinketho zokwelapha zingabandakanya ukwelashwa ngamakhemikhali, ukwelashwa okuhlosiwe (uma kusebenza), i-immunotherapy, nokwelashwa ngemisebe. Ukunakekelwa kwe-Palliative nakho kuyingxenye ebalulekile yokwelashwa ukuze ulawule izinhlungu nezinye izimpawu.Side Effects of TreatmentInketho ngayinye yokwelashwa umdlavuza wamaphaphu we-squamous ongewona omncane ingaba nemiphumela engemihle. Kubalulekile ukuxoxa ngale miphumela engemihle engaba khona nethimba lakho lezokunakekelwa kwempilo futhi wenze uhlelo lokuyilawula ngempumelelo. Imiphumela emibi evamile ihlanganisa ukukhathala, isicanucanu, ukulahlekelwa izinwele (ngokwelashwa ngamakhemikhali), ukucasuka kwesikhumba (ngemisebe), kanye nemiphumela engemihle ehlobene nokuzivikela komzimba (nge-immunotherapy).I-Palliative CarePalliative ukunakekelwa kwezokwelapha okukhethekile okugxile ekunikezeni ukukhululeka ezimpawu nokucindezeleka kokugula okungathi sína. Kuyafaneleka kunoma iyiphi iminyaka futhi kunoma yisiphi isigaba umdlavuza wamaphaphu we-squamous ongewona omncane. Ukunakekelwa kwe-Palliative kungathuthukisa izinga lempilo yesiguli kanye nomndeni waso.Ukunakekelwa KokulandelelaNgemva kokuqeda ukwelashwa umdlavuza wamaphaphu we-squamous ongewona omncane, ama-aphoyintimenti okulandelela avamile abalulekile ukuze kuqashwe ukuvela futhi nokulawula noma yimiphi imiphumela emibi yesikhathi eside. Lawa ma-aphoyintimenti angabandakanya izivivinyo zomzimba, ukuhlolwa kwezithombe, nokuhlolwa kwegazi.Iziqondiso Ezintsha ku-Squamous NSCLC TreatmentResearch into ukwelashwa komdlavuza wamaphaphu we-squamous ongewona omncane iyaqhubeka, kuthuthukiswa izindlela zokwelapha ezintsha ngaso sonke isikhathi. Izivivinyo zemitholampilo zihlola izindlela zokwelapha ezihlosiwe ezintsha, ama-immunotherapies, nezinhlanganisela zokwelapha. Lokhu kuthuthuka kunikeza ithemba ngemiphumela ethuthukisiwe yeziguli ezine-NSCLC ene-squamous.Ukwenza Izinqumo EzinolwaziUkubhekana Nokuxilongwa umdlavuza wamaphaphu we-squamous ongewona omncane kungaba nzima. Kubalulekile ukuqoqa ulwazi oluningi ngangokunokwenzeka futhi uxoxe ngezinketho zakho zokwelapha kahle nethimba lakho lezempilo. Ungangabazi ukubuza imibuzo futhi ufune ukucaciseleka nganoma yini ongayiqondi. Ukwenza izinqumo ezinolwazi kubalulekile ukuze uzulazule ohambweni lwakho lokwelashwa.Isifinyezo Sezinketho Zokwelashwa Ukwelashwa Incazelo Ukuhlinzwa Kwemiphumela Emihle Evamile Ukususwa kwesimila kanye nezicubu ezizungezile. Ubuhlungu, ukutheleleka, ukopha, ukuphefumula. I-Radiation Therapy Isebenzisa imisebe enamandla amakhulu ukubulala amangqamuzana omdlavuza. Ukukhathala, ukucasuka kwesikhumba, isicanucanu, ubunzima bokugwinya. I-Chemotherapy Isebenzisa izidakamizwa ukubulala amangqamuzana omdlavuza emzimbeni wonke. Isicanucanu, ukuhlanza, ukuqothuka kwezinwele, ukukhathala, izilonda emlonyeni. Ukwelashwa Okuhlosiwe Kuqondiswe kuma-molecule athile abandakanyeka ekukhuleni kwamangqamuzana omdlavuza. Iyahlukahluka kuye ngokuthi umuthi; kungase kuhlanganise ukuqubuka kwesikhumba, isifo sohudo, ukukhathala. I-Immunotherapy Isiza amasosha omzimba ukulwa nomdlavuza. Ukukhathala, ukuqubuka kwesikhumba, isifo sohudo, ukuvuvukala kwezitho. Umshwana wokuzihlangula: Lolu lwazi ngelezinjongo zokwaziswa kuphela futhi akufanele luthathwe njengeseluleko sezokwelapha. Hlala uthintana nochwepheshe bezempilo abaqeqeshiwe nganoma yikuphi ukukhathazeka ngezempilo noma ngaphambi kokwenza noma yiziphi izinqumo ezihlobene nempilo noma ukwelashwa kwakho.Amapharamitha edatha kuthebula atholakala kuwo I-American Cancer Society.