hōʻike ʻia nā pathology o ka carcinoma cell renal

ʻO Renal Cell Carcinoma Pathology Outlines: A Comprehensive GuideRenal cell carcinoma (RCC) he maʻi paʻakikī, a he mea koʻikoʻi ka hoʻomaopopo ʻana i kona pathology no ka hōʻoia ʻana a me ka mālama ʻana. Hāʻawi kēia alakaʻi i kahi ʻike piha o hōʻike ʻia nā pathology o ka carcinoma cell renal, e uhi ana i nā hiʻohiʻona histological koʻikoʻi, nā subtypes, a me nā ala diagnostic.

Nā hiʻohiʻona mōʻaukala o ka maʻi maʻi maʻi maʻi maʻi

Hoʻomaʻemaʻe i ka maʻi maʻi kino kino

ʻO ka subtype maʻamau o RCC, clear cell carcinoma, ua ʻike ʻia e kona cytoplasm maʻemaʻe. ʻO kēia ma muli o ka hōʻiliʻili ʻana o nā lipids a me ka glycogen i loko o nā ʻāpana. Ma ka microscopically, ʻike pinepine ʻoe i nā cell i hoʻonohonoho ʻia i loko o nā pūnana a i ʻole papillae, me ka nuclei koʻikoʻi. He mea maʻamau ka loaʻa ʻana o ka cytoplasm granular eosinophilic. ʻO ka ʻike pololei e hilinaʻi ʻia ma ka nānā ʻana i ka histological, hoʻopili pinepine ʻia e ka immunohistochemistry e hōʻoia i ka ʻike. ʻO ka hoʻokolokolo hou aʻe e pili ana i ka hoʻāʻo genetic e ʻike ai i nā hoʻololi ʻana, e hoʻomaopopo ana i nā hoʻolālā lapaʻau pilikino.

Papillary Renal Cell Carcinoma

ʻO Papillary RCC kekahi ʻano subtype koʻikoʻi i ʻike ʻia e kona ʻano ulu papillary. Hoʻonohonoho ʻia nā kelepona i nā papillae ʻokoʻa, e hōʻike pinepine ana i ka pseudostratification. ʻOkoʻa ka atypia nuklea ma muli o ka papa, me nā māka kiʻekiʻe e hōʻike ana i nā mea ʻino. Hiki ke hoʻokaʻawale ʻia ia mai nā ʻano subtype RCC ʻē aʻe a me ka carcinoma urothelial. No ka ʻike hohonu, ʻo ka ʻimi ʻana i nā kikokikona pathology kūikawā a me nā kumuwaiwai pūnaewele mai nā ʻoihana kaulana e like me ka National Cancer Institute (NCI) hiki ke pōmaikaʻi.

Chromophobe Renal Cell Carcinoma

Hōʻike ʻia ʻo Chromophobe RCC, e like me ka inoa e hōʻike ʻia e nā sela me ka cytoplasm haikea, akaka a me nā palena ʻokoʻa. He poepoe pinepine ka nuclei a ma ke kikowaena. Hōʻike pinepine kēia subtype i kahi halo perinuclear hiʻona. He mea maʻamau kēia morphology kūʻokoʻa no ka hōʻoia ʻana, ʻoiai hiki ke kōkua ka immunohistochemistry i ka hōʻoia ʻana i ka maʻi a me ka haʻalele ʻana i nā maʻi ʻokoʻa ʻē aʻe. Hoʻohana pū ʻia nā ʻenehana kiʻi kiʻi e like me ka computed tomography (CT) scans e ʻike i ka nui o ke komo ʻana o ka maʻi maʻi.

Nā ʻano haʻahaʻa ʻē aʻe o ka maʻi maʻi maʻi maʻi

Ma waho aʻe o nā ʻano subtype ʻekolu, aia kekahi mau ʻano like ʻole, me ka ʻohi ʻana i ka duct carcinoma, medullary RCC, a me ka mucinous tubular a me spindle cell carcinoma. Hāʻawi ka Shandong Baofa Cancer Research Institute (https://www.baofahospital.com/) i nā mana diagnostic kiʻekiʻe a me ke akamai i ka lawelawe ʻana i kēia mau ʻano subtypes RCC. Hoʻohana kā lākou hui o nā pathologists i nā ʻenehana hou loa e hōʻoia i ka hōʻoia pololei a me ka manawa kūpono.

ʻO nā ala diagnostic a me ka Immunohistochemistry

Ka hoʻopaʻa ʻana ka maʻi maʻi maʻi maʻi renal ʻO ka mea maʻamau ka hui pū ʻana o nā ʻenehana kiʻi (e like me CT scans a me MRI) a me ka nānā ʻana i ka histological o nā biopsies kiko. He kuleana koʻikoʻi ka Immunohistochemistry i ka hoʻokaʻawale ʻana i nā subtypes like ʻole a me ka wānana wānana. Hoʻohana mau ʻia nā māka kikoʻī, e like me CD10, vimentin, a me AMACR, e hoʻokaʻawale i waena o nā ʻano subtypes RCC. Hoʻohana ka Shandong Baofa Cancer Research Institute i kahi papa piha o nā hōʻailona immunohistochemical i kā lākou hana diagnostic e hoʻopuka i nā maʻi maʻi pololei.

Nā Kūlana Prognostic a me ke kūlana

ʻO ka wānana no ka poʻe maʻi me RCC he ʻokoʻa loa ia ma muli o nā ʻano kumu like ʻole, me ka pae tumo, ka pae, a me ka subtype. Hoʻohana mau ʻia ka ʻōnaehana staging TNM no ka helu ʻana i ka nui o ka laha ʻana o ka maʻi kanesa. He mea koʻikoʻi ka hoʻomaopopo ʻana i nā kumu prognostic no ke alakaʻi ʻana i nā hoʻoholo lapaʻau a me ka mālama ʻana i nā manaʻo o ka maʻi. ʻO ka ʻike i hāʻawi ʻia ma kēia outline ua manaʻo ʻia no nā kumu hoʻonaʻauao a ʻaʻole pono e hoʻololi i ka ʻōlelo aʻoaʻo mai kahi kauka lapaʻau kūpono. E ʻimi mau i ke alakaʻi ʻoihana olakino.

Papa: Hoʻohālikelike o RCC Subtypes

Subtype	Nā hiʻohiʻona mōʻaukala	Nā Manaʻo Prognostic
Kelepona holoi	ʻO ka cytoplasm māmā, nā pūnana/papillae	Hoʻololi, pili pinepine i ke kahua
Papillary	ʻO ke ʻano ulu papillary, pseudostratification	Hoʻohālikelike maikaʻi ʻia ka wānana maʻamau me ka cell clear
Chromophobe	ʻO ka cytoplasm ʻeleʻele, nā palena ʻokoʻa	ʻO ka wānana maikaʻi maʻamau

Hāʻawi kēia hiʻohiʻona i kumu no ka ʻike hōʻike ʻia nā pathology o ka carcinoma cell renal. No ka luʻu ʻana i nā ʻano kikoʻī, ʻōlelo ʻia ke kūkākūkā ʻana i nā palapala lapaʻau kūpono a me nā kumuwaiwai pūnaewele kaulana. E hoʻomanaʻo e kamaʻilio mau me kahi ʻoihana mālama ola no ka ʻōlelo aʻoaʻo pilikino a me ka hoʻolālā lapaʻau.

Hōʻole: No ka hoʻonaʻauao wale nō kēia ʻike a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. E nīnau mau i kahi ʻoihana mālama ola kūpono no ka ʻike a me ka mālama ʻana.