Kupambana kwatsopano kwa khansa ya m'mapapo 2020

Mu 2020, kupita patsogolo kwakukulu kunachitika pazamankhwala a khansa ya m'mapapo, kuphatikiza kuvomereza kwamankhwala atsopano omwe akuwunikiridwa ndi ma immunotherapies, omwe amapereka zotsatira zabwino komanso njira zosinthira odwala. Kupambana kumeneku kunapereka njira zatsopano kwa iwo omwe akulimbana ndi khansa ya m'mapapo, kuthana ndi kusintha kwa majini komanso kulimbikitsa chitetezo chamthupi polimbana ndi matendawa. Chaka Chopita Patsogolo: Chinsinsi Kupambana Kwatsopano Kwa Chithandizo Cha Khansa Yam'mapapo 20202020 idakhala chaka chofunikira kwambiri polimbana ndi khansa ya m'mapapo. Ngakhale kuti chaka chinali cholamulidwa ndi mliri wapadziko lonse lapansi, ofufuza ndi azachipatala adapitilizabe kukankhira malire a njira zamankhwala. Zosangalatsa zingapo zidawonekera, zopatsa chiyembekezo kwa odwala ndikukonzanso mawonekedwe a chisamaliro cha khansa ya m'mapapo. Shandong Baofa Cancer Research Institute yakhala ikutsatira mosamalitsa kupititsa patsogolo kumeneku.Zochiza Zolinga: Precision Medicine AdvancesTargeted Therapies, yopangidwa kuti iwononge zofooka zenizeni m'maselo a khansa, idawona kupita patsogolo kwakukulu mu 2020. Mankhwalawa nthawi zambiri amabweretsa zotsatirapo zochepa kusiyana ndi mankhwala achikhalidwe a chemotherapy chifukwa amaloza maselo a khansa molondola.Zovomerezeka Zatsopano za EGFR Mutations mutations zodziwika bwino (EGFR Mutations) khansa ya m'mapapo (NSCLC). Mu 2020, zoletsa zatsopano komanso zowongolera za EGFR zidavomerezedwa, zomwe zimapereka kupulumuka kwapang'onopang'ono kwa odwala omwe ali ndi masinthidwe awa. Zoletsa za m'badwo watsopanozi nthawi zambiri zimagonjetsa njira zomwe zimachepetsa mphamvu ya mankhwala akale. Makamaka, othandizira omwe amayang'ana kusintha kwa EGFR exon 20 amawonetsa ntchito yabwino.Mwachitsanzo, wothandizira wotere ndi amivantamab. Gome lotsatirali likuwonetsa zotsatira za mayeso azachipatala a amivantamab: Trial Phase Overall Response Rate (ORR) Kutalika kwa Response (DoR) Phase I 40% Miyezi 11.1 Source: FDAALK Inhibitors: Kukulitsa Zosankha ZochiziraAnaplastic lymphoma kinase (ALK) kukonzanso ndikusintha kwina koyendetsa mu NSCLC. Ma ALK inhibitors angapo alipo kale, ndipo mu 2020, kafukufuku adayang'ana kwambiri kuthana ndi kukana mankhwalawa ndikupanga zoletsa zamphamvu kwambiri. Mankhwala ophatikiza atsopano adafufuzidwanso kuti apititse patsogolo zotsatira za khansa ya m'mapapo ya ALK-positive.Immunotherapy: Harnessing the Power of the Immune SystemImmunotherapy, yomwe imalimbikitsa chitetezo cha mthupi kuti kulimbana ndi khansa, idapitilirabe kukhala gawo lalikulu lachizachipatala cha khansa ya m'mapapo mu 2020. inasintha kwambiri chithandizo cha khansa yapamwamba ya m'mapapo. Mu 2020, kafukufuku adafufuza kugwiritsa ntchito mankhwalawa m'magawo oyamba a matendawa, kuphatikiza atachitidwa opaleshoni kapena kuphatikiza ndi chemotherapy. Kafukufukuyu adawonetsa kuti immunotherapy imatha kuwongolera kuchuluka kwa kupulumuka ndikuchepetsa chiopsezo cha kubwereza kwa odwala ena.Kuphatikiza kwa Immunotherapy RegimensOfufuza adafufuzanso kuphatikiza mankhwala osiyanasiyana a immunotherapy kuti apititse patsogolo mphamvu zawo. Kutsekereza kwapawiri, pogwiritsa ntchito mitundu iwiri yosiyana ya ma immune checkpoint inhibitors, kunawonetsa lonjezano mwa odwala ena omwe sanayankhe ku single-agent immunotherapy. Mayesero azachipatala adapitilizabe kukonzanso njira zophatikizirazi kuti azindikire odwala omwe angapindule kwambiri.Udindo wa Kuyesa kwa BiomarkerKupita patsogolo kwamankhwala omwe akuwunikiridwa ndi ma immunotherapies awonetsa kufunikira kwa kuyezetsa kwathunthu kwa biomarker mu khansa ya m'mapapo. Mu 2020, panali kutsindika kowonjezereka pakuyesa kusintha kwamitundu yosiyanasiyana ya ma genetic ndi PD-L1 kufotokozera zisankho za chithandizo. Njira yaumwiniyi imatsimikizira kuti odwala amalandira chithandizo choyenera komanso chothandiza kwambiri cha khansa yawo yeniyeni.Shandong Baofa Cancer Research Institute ikugogomezera kufunikira kwa kuyezetsa mwatsatanetsatane kuti tipeze zotsatira zabwino kwambiri.Kuyang'ana Patsogolo: Malangizo Amtsogolo Kupambana kwatsopano kwa khansa ya m'mapapo 2020 inatsegula njira ya kupita patsogolo kowonjezereka m’zaka zikudzazo. Kafukufuku wopitilira amayang'ana kwambiri pakupanga njira zochiritsira zatsopano, kukonza njira zachitetezo cha immunotherapy, komanso kuzindikira ma biomarker atsopano. Cholinga chachikulu ndikupanga chithandizo chamankhwala chogwira mtima komanso chamunthu chomwe chimapangitsa kupulumuka komanso moyo wabwino kwa odwala onse omwe ali ndi khansa ya m'mapapo. Kuvomerezedwa kwamankhwala atsopano omwe akuwunikiridwa ndi ma immunotherapies, komanso kutsindika kwakukulu pakuyesa kwa biomarker, kwasintha mawonekedwe a chisamaliro cha khansa ya m'mapapo. Kupambana kumeneku kumapereka chiyembekezo kwa odwala ndi mabanja awo ndikugogomezera kufunika kopitiliza kufufuza ndi zatsopano polimbana ndi matendawa. Ganizirani zochezera Bungwe la Shandong Baofa Cancer Research Institute Webusaitiyi kuti mudziwe zambiri zamayesero azachipatala komanso chithandizo chamankhwala chapamwamba cha khansa.