chithandizo cha khansa ya m'mapapo yosasuta

Khansara ya m'mapapo mwa anthu omwe sanasutepo fodya imakhala ndi zovuta komanso njira zothandizira. Ngakhale kuti kusuta kuli pachiwopsezo chodziwika bwino, mbali yaikulu ya khansa ya m'mapapo imapezeka mwa anthu omwe alibe mbiri ya kusuta fodya. Nkhaniyi ikufotokoza mbali zosiyanasiyana za chithandizo cha khansa ya m'mapapo yosasuta, kuphatikizapo matenda, njira zochiritsira, ndi kufufuza kosalekeza.Kuzindikira ndi Mitundu ya Khansa ya M'mapapo kwa Osasuta Ndudu Kuzindikira khansa ya m'mapapo mwa osuta omwe samasuta nthawi zambiri kumawoneka mosiyana ndi osuta. Ndikofunikira kumvetsetsa zamitundu yosiyanasiyana ya khansa ya m'mapapo yomwe yafala pakati pa anthuwa.Zovuta Zodziwira MwamsangaLimodzi mwazovuta zazikulu ndi kusakayikira. Chifukwa khansa ya m'mapapo nthawi zambiri imagwirizanitsidwa ndi kusuta, sikungaganizidwe kuti ndi kosavuta kwa omwe sasuta, zomwe zimachititsa kuti achedwe kuzindikira. Zizindikiro zimatha kukhala zosamveka bwino kapena chifukwa cha zovuta zina. Njira zodziwira msanga ngati kuyezetsa khansa ya m'mapapo pogwiritsa ntchito CT scans ya mlingo wocheperako nthawi zambiri sikuvomerezeka kwa anthu omwe sasuta, zomwe zimapangitsa kuti azindikire msanga. Adenocarcinoma nthawi zambiri imapezeka kumadera akunja a mapapu, zomwe zimapangitsa kuti adziwike asanafalikire. Zina, mitundu yosowa kwambiri imathanso kuchitika.The Shandong Baofa Cancer Research Institute (https://baofahospital.com) yadzipereka kuti tipititse patsogolo kumvetsetsa kwathu mitundu yosiyanasiyana ya khansa ya m'mapapo ndi kukonza njira zodziwira matenda. Njira Zochizira Anthu Osasuta Khansa ya M'mapapo Njira zochizira khansa ya m'mapapo mwa anthu omwe sasuta nthawi zambiri zimagwirizana ndi mtundu ndi gawo la khansayo, komanso thanzi la munthu. Njira zochepetsera pang'ono monga opaleshoni ya thoracoscopic (VATS) yothandizidwa ndi kanema (VATS) ikugwiritsidwa ntchito mochulukira kuchepetsa nthawi yochira ndikuwongolera zotsatira.Radiation TherapyRadiation therapy imagwiritsa ntchito kuwala kwamphamvu kwambiri kupha maselo a khansa. Itha kugwiritsidwa ntchito ngati chithandizo choyambirira kwa odwala omwe sali oyenera kuchitidwa opaleshoni, kapena ngati chithandizo chothandizira pambuyo pa opaleshoni kuti athetse ma cell a khansa omwe atsala. Njira monga stereotactic body radiation therapy (SBRT) imapereka ma radiation olunjika kwambiri ku chotupacho kwinaku akuchepetsa kuwonongeka kwa minofu yozungulira yathanzi.ChemotherapyChemotherapy imaphatikizapo kugwiritsa ntchito mankhwala kupha maselo a khansa mthupi lonse. Nthawi zambiri amagwiritsidwa ntchito pa magawo apamwamba kwambiri a khansa ya m'mapapo kapena kuphatikiza ndi opaleshoni kapena chithandizo cha radiation. Mankhwala apadera a chemotherapy amasiyana malinga ndi mtundu wa khansa ya m'mapapo komanso thanzi la wodwalayo. Ambiri samasuta ndi adenocarcinoma amakhala ndi masinthidwe amtundu, monga EGFR, ALK, ROS1, kapena BRAF. Kuzindikira masinthidwewa kumathandiza madokotala kuti apereke mankhwala omwe amawatsogolera omwe amalepheretsa makamaka ntchito ya mapuloteni osinthikawa, zomwe zimapangitsa kuti pakhale zotsatira zabwino.ImmunotherapyImmunotherapy imalimbitsa chitetezo cha mthupi kuti chiteteze khansa. Checkpoint inhibitors, monga PD-1 ndi PD-L1 inhibitors, ndi mtundu wa immunotherapy umene wasonyeza lonjezo pochiza mitundu ina ya khansa ya m'mapapo, kuphatikizapo omwe amapezeka mwa osasuta. Kuchita bwino kwa chitetezo chamthupi kumadalira zinthu zosiyanasiyana, kuphatikiza kukhalapo kwa zolembera zenizeni.Kufunika Koyesa Ma Genetic mu Khansa Yamapapo Osasuta Mayesero amtundu ndi wofunikira pakuwongolera khansa ya m'mapapo yosasuta. Kuzindikiritsa masinthidwe enieni a majini kumalola madokotala kuti azitha kusintha mapulani awo amankhwala ndikusankha njira zochiritsira zomwe zimagwira ntchito bwino kwambiri kapena ma immunotherapies.Masinthidwe amtundu wambaPafupifupi ma genetic masinthidwe amapezeka mu khansa ya m'mapapo mwa omwe samasuta, kuphatikiza:EGFR (Epidermal Growth Factor Receptor) mutationsALK (Anaplastic Lymphoma KiAFnase) kugwiritsa ntchito njira zochiritsira zomwe zimalepheretsa makamaka ntchito ya mapuloteni osinthika, zomwe zimapangitsa kuti pakhale zotsatira zabwino komanso kukhala ndi moyo wautali.Ubwino wa Chithandizo ChamunthuKuchiza kwamunthu payekhapayekha kutengera kuyesedwa kwa majini kumapangitsa kuti pakhale njira yolondola komanso yothandiza pakusamalira khansa. Poyang'ana madalaivala enieni a khansa, madokotala amatha kuchepetsa zotsatirapo ndikusintha moyo wonse wa odwala. The Shandong Baofa Cancer Research Institute imagogomezera mankhwala amunthu payekha pakuchiza khansa.Mayesero a Zachipatala ndi Kafukufuku Wopitilira Mayesero achipatala amagwira ntchito yofunikira pakupititsa patsogolo chithandizo chamankhwala. khansa ya m'mapapo yosasuta. Maphunzirowa amawunika njira zatsopano zochiritsira, kuphatikiza mankhwala, ndi njira zodziwira matenda.Kupeza Mayesero a ZachipatalaOdwala omwe ali ndi chidwi chotenga nawo mbali m'mayesero achipatala angathe kufufuza mayesero kudzera m'magwero odalirika, monga: National Cancer Institute (NCI): https://www.cancer.gov/about-cancer/treatment/clinical-trialsClinicalTrials.gov: https://clinicaltrials.gov/Madera a KafukufukuZoyeserera zaposachedwa za kafukufuku zikuyang'ana pa:Kupanga njira zochiritsira zatsopano zosinthira ma geneticKupititsa patsogolo mphamvu ya immunotherapyKuzindikira zozindikiritsa zatsopano zodziwikiratu komanso kuyankhidwa kwamankhwalaKumvetsetsa kwapadera kwachilengedwe cha khansa ya m'mapapo mwa omwe sasuta chithandizo cha khansa ya m'mapapo yosasuta zimasiyanasiyana malinga ndi siteji ya khansa pa matenda, mtundu weniweni wa khansa, ndi thanzi lonse la munthu. Nthawi zambiri, osasuta omwe ali ndi khansa ya m'mapapo amakhala ndi chidziwitso chabwinoko kuposa osuta, makamaka ngati ali ndi zotupa zomwe zimatha kusintha ma chibadwa. Zinthu Zomwe Zingakhudze Zomwe Zingathe Kuyambitsa Matendawa ndi: Gawo la khansa pakuzindikiridwa Mtundu wa khansa ya m'mapapoKupezeka kwa kusintha kwa majini komwe kungathekePali thanzi labwino komanso kulimba Mayankho ku chithandizo chamankhwala Ravival Kupulumuka kwa khansa amasiyana m'maphunziro osiyanasiyana, kafukufuku wa 2020 wofalitsidwa mu *Journal of Thoracic Oncology* adapeza kuti osasuta omwe ali ndi kusintha kwa adenocarcinoma ndi EGFR anali ndi moyo wapakatikati wa miyezi 38.6 ndi chithandizo chomwe amayang'anira, poyerekeza ndi miyezi 26.7 ya osuta omwe ali ndi masinthidwe omwewo omwe amathandizidwa ndi chemotherapy. Gulu 1 la Chithandizo cha Kupulumuka Kwapakatikati (Miyezi) Osasuta ndi EGFR+ Advanced Adenocarcinoma Targeted Therapy 38.6 Osuta ndi EGFR+ Advanced Adenocarcinoma Chemotherapy 26.7 Gwero: 1. Journal of Thoracic Oncology, 2020MapetoChithandizo cha khansa ya m'mapapo yosasuta ndi gawo lomwe likukula lomwe lili ndi mwayi wochulukirachulukira wa machiritso amunthu payekha komanso ogwira mtima. Kumvetsetsa mawonekedwe enieni a khansa ya m'mapapo mwa omwe samasuta, kuphatikiza mitundu ya khansa ndi masinthidwe amtundu wamba, ndikofunikira pakuwongolera zotsatira zamankhwala. Kafukufuku wopitilira komanso mayesero azachipatala ndikofunikira kuti apititse patsogolo chisamaliro cha anthu omwe ali ndi khansa ya m'mapapo omwe sanasutepo. Kufunafuna upangiri wa akatswiri azachipatala ndikufufuza njira zachipatala zomwe zilipo ndi njira zofunika kwambiri pothana ndi vutoli.