chithandizo aimpso cell carcinoma pathology akufotokoza zipatala

Kumvetsetsa Renal Cell Carcinoma: Pathology Outlines & Hospital Treatment OptionsKuchiza kwa renal cell carcinoma (RCC) kumafuna njira zosiyanasiyana, kuphatikiza luso la matenda, radiology, ndi oncology. Bukuli limafotokoza za matenda a RCC, kufotokoza zofunikira zowunikira, magawo, ndi njira zamankhwala zomwe zikupezeka kuzipatala zotsogola.

Renal Cell Carcinoma: A Pathological Overview

Renal cell carcinoma (chithandizo aimpso cell carcinoma pathology akufotokoza zipatala) ndi mtundu wofala kwambiri wa khansa ya impso, yochokera ku maselo a epithelial a renal tubules. Kuzindikira kolondola kwa pathological ndikofunikira pakuwongolera zosankha zamankhwala ndikulosera zam'tsogolo. Kufufuza kwa histological kumawonetsa mitundu yosiyana ya maselo, zomwe zimakhudza nkhanza komanso kuyankha kwamankhwala. Ma subtypes oyambira amaphatikiza cell RCC (ccRCC), papillary RCC, chromophobe RCC, ndi ena. Mtundu uliwonse wa subtype umakhala ndi mawonekedwe apadera ang'onoang'ono, omwe amakhudza momwe amachiritsira komanso njira zamankhwala.

Clear Cell Renal Cell Carcinoma (ccRCC)

ccRCC imawerengera milandu yambiri ya RCC. Pathologically, imadziwika ndi cytoplasm yowoneka bwino m'maselo otupa chifukwa cha kuchuluka kwa glycogen ndi lipid. Maselowa nthawi zambiri amawonetsa kakulidwe kosiyana, kupanga zisa kapena ma tubules. Kukhalapo kwa kusintha kwa majini, monga kusintha kwa jini ya VHL, kumawonedwa kawirikawiri.

Papillary Renal Cell Carcinoma

Papillary RCC imasiyanitsidwa ndi mawonekedwe ake akukula kwa papillary, okhala ndi ma cell omwe amapanga masamba osakhwima kapena ma papillae. Mosiyana ndi ccRCC, cytoplasm ndiyosamveka bwino. Ma subtypes awiri alipo: mtundu 1 ndi mtundu wa 2, ndi mtundu wa 2 womwe umalumikizidwa ndi matenda oyipa.

Chromophobe Renal Cell Carcinoma

Chromophobe RCC siidziwika bwino ndipo imadziwika ndi ma cell omwe ali ndi cytoplasm yotuwa, eosinophilic cytoplasm komanso zida za nyukiliya zopanda tanthauzo. Nthawi zambiri imakhala ndi kakulidwe kosiyana, kupanga zisa kapena mapepala.

Ma Subtypes Ena

Ma subtypes angapo osowa alipo, kuphatikiza kutolera duct carcinoma, medullary RCC, ndi RCC yosadziwika. Ma subtypes awa nthawi zambiri amafunikira ukatswiri wapadera pakuzindikira komanso kukonza chithandizo.

Zomwe Zimachitika ndi Zomwe Zimachitika mu RCC

Pathological staging, yotengera dongosolo la TNM (kukula kwa chotupa, kukhudzidwa kwa nodal, ndi metastasis yakutali), ndikofunikira kudziwa kukula kwa matendawa. Chidziwitso ichi, pambali pa mtundu wa RCC ndi zinthu zina zam'tsogolo monga kalasi (momwe ma cell a khansa amawonekera pa microscope), zimakhudza njira zothandizira. Pokwera siteji, m'pamenenso mankhwala amakula kwambiri.

Njira Zochizira Renal Cell Carcinoma

Zosankha zachipatala zimadalira zinthu zosiyanasiyana, kuphatikizapo siteji, kalasi, ndi thanzi la wodwalayo. Zosankha zimachokera ku opaleshoni (pang'ono nephrectomy kapena radical nephrectomy), chithandizo chomwe mukufuna, immunotherapy, ndi chithandizo cha radiation.

Kuchotsa Opaleshoni

Kuchotsa opareshoni kwa chotupa nthawi zambiri kumakhala chithandizo choyambirira cha RCC yokhazikika. nephrectomy yapang'onopang'ono imateteza minofu yathanzi ya impso, pomwe nephrectomy yayikulu imaphatikizapo kuchotsa impso zonse ndi ma lymph nodes ozungulira. Kusankha kumadalira zinthu zingapo, kuphatikizapo kukula ndi malo a chotupacho, ndi ntchito ya impso zonse za wodwalayo.

Chithandizo Chachindunji

Njira zochiritsira, monga tyrosine kinase inhibitors (TKIs), zimayang'ana makamaka mapuloteni omwe amayendetsa kukula kwa RCC. Mankhwalawa asintha chithandizo chapamwamba cha RCC, kupititsa patsogolo kupulumuka. Zitsanzo zikuphatikizapo sunitinib, sorafenib, ndi pazopanib.

Immunotherapy

Immunotherapy imagwiritsa ntchito chitetezo cha mthupi kulimbana ndi maselo a khansa. Checkpoint inhibitors, monga nivolumab ndi ipilimumab, ndi mankhwala othandiza pa RCC yapamwamba. Mankhwalawa amagwira ntchito potulutsa mabuleki pa chitetezo chamthupi, kulola kuti izindikire ndikuukira maselo a khansa.

Chithandizo cha radiation

Thandizo la radiation lingagwiritsidwe ntchito nthawi zina, monga chithandizo chamankhwala chapamtima pa matenda apamwamba kapena kuphatikiza ndi mankhwala ena.

Kusankha Chipatala Choyenera cha RCC Chithandizo

Kusankha chipatala choyenera chithandizo aimpso cell carcinoma pathology akufotokoza zipatala ndizofunikira. Yang'anani mabungwe omwe ali ndi magulu odziwa ntchito zosiyanasiyana kuphatikizapo akatswiri a urologist, oncologists, pathologists, ndi radiologists odziwa za khansa ya genitourinary. The Shandong Baofa Cancer Research Institute (https://www.baofahospital.com/) ndi chitsanzo cha chipatala choperekedwa kuti chipereke chisamaliro chokwanira cha khansa, chomwe chili ndi akatswiri odziwa za matenda ndi chithandizo cha renal cell carcinoma. Ganizirani zinthu monga luso laukadaulo, kukhudzidwa ndi kafukufuku, ndi chithandizo cha odwala popanga chisankho.

Mapeto

Zapambana chithandizo aimpso cell carcinoma pathology akufotokoza zipatala imafunika kuzindikiridwa bwino, kukhazikika bwino, ndi dongosolo lamankhwala logwirizana. Pomvetsetsa mawonekedwe a RCC, ma subtypes ake osiyanasiyana, ndi njira zochiritsira zomwe zilipo, odwala amatha kupanga zisankho zodziwitsidwa mogwirizana ndi gulu lawo lazaumoyo. Chisankho choyenera chachipatala ndi chofunikira kuti pakhale zotsatira zabwino kwambiri.