Kudzora Kuburitswa Kununurwa kwezvinodhaka: Nhungamiro Yakakwana 

Kudzora Kuburitswa Kutumirwa kwezvinodhaka Systems inopa zvakakosha zvakanakira nzira dzemagungano nekuchengetedza zvinodhaka mukati mehwindo rekurapa kwenguva yakareba. Izvi zvinoderedza kurovera kuwanda, kuderedza mhedzisiro, uye kunovandudza kutevedzera kwemurwere. Ichi chinyorwa chinopera mumitemo, mashini, zvikumbiro, uye nezvenguva yemberi maitiro e Kudzora Kuburitswa Kutumirwa kwezvinodhaka.

Nhanganyaya yekudzora kusunungurwa

Nzira dzechinyakare dzinodhaka dzinowanzoita kuti dziwanzo kuitika mukusvitsa zvinodhaka mumuviri mumuviri, zvichitungamira kusvika pakusangana kwepamusoro Kudzora Kuburitswa Kutumirwa kwezvinodhaka Systems inovavarira kukunda izvi zvisingakwanisi nekuburitsa zvinodhaka pachiyero chakagadzirirwa, chichiita kuti chigadzikiso chinoenderana uye chinodzivirira mukati memuviri.

Zvakanakira Kusunungurwa Kudzoserwa

• Yakaderedzwa doosing frequency: Mashoma madhawa anodikanwa, kuvandudza kutevedzera kwemurwere.
• Mhedzisiro Yakaderedzwa: Nzvimbo dzakasimba dzemishonga dzinoderedza njodzi yemhedzisiro ine chekuita nedunhu.
• Kuvandudzwa kwekuratidzira kugona: Kuchengeta zviyero zvinodhaka mukati meiyo kurapa kwepahwindo kunokosha kwazvo zvinodhaka.
• Yakavandudzwa murwere nyore: Kushoma kakawanda dosing inoita kuti kurapwa kwakanyanya kune varwere.

Michina yekudzorwa kusunungurwa

Manyawi akati wandei anoshandiswa kuzadzisa kudzorwa kusunungurwa, imwe neimwe nezvigadzirwa zvayo uye zvakashata. Aya maitiro anogona kuve akakombama zvakazara muzvikamu zvakadzama, erosion-inodzorwa, uye osmotically akadzora masisitimu.

Kusarudzika-kwakadzorwa masisitimu

Mune kusarudzika-kwakadzorwa masisitimu, mushonga unoburitswa kuburikidza ne polymer matrix. Muyero wekuburitswa kwezvinodhaka unogadzwa neakasiyana ceaction of the mushonga mukati mePolymer uye geometry yemushini. Kune marudzi maviri makuru:

• Reservoir zvishandiso: Chinhu chemishonga chakakomberedzwa neyeyero-kudzora membrane. Iyo inodhaka inosetsa kuburikidza nemembrane pane yakatarwa chiyero.
• Matrix zvishandiso: Mushonga unopararira muPolymer Matrix. Iyo inodhaka inosiyana kubva kune iyo matrix se polymer inozvimba uye / kana kushatisa.

Erosion-inodzorwa masisitimu

Erosion-inodzorwa masisitimu inosunungura mushonga sePolymer matrix eroots kana degrades. Muyero wekuparadza unogona kudzorwa nePolymer's kuumbwa uye mamiriro ezvinhu epamhepo (i.e., Ph, enzymes).

• Kumusoro Kwemukati: Iyo polymer inodonha kubva kumusoro, kusunungura mushonga mu zero-order fashoni.
• Kurovera kugura: Iyo polymer inosvibisa mukati mehuwandu hwayo hwese, inotungamira kune yakaomarara kuburitsa chimiro.

Osmotically inodzora masisitimu

Osmotically inodzora masisitimu anoshandisa Oldmotic kumanikidza kuti atyaire kusunungurwa kwezvinodhaka. Memi-inobvumirwa membrane inokomberedza mushonga mushonga une osmotic mumiriri. Mvura inokweverwa muiyo core, kugadzira kumanikidzwa kunosundira iyo mushonga kunze kuburikidza nediki orifice. Aya masystem anowanzopa chaizvo kudzorwa kusunungurwa profiles.

Zvikumbiro zvekudzorwa zvinodzorwa zvinodhaka

Kudzora Kuburitswa Kutumirwa kwezvinodhaka ine huwandu hwakawanda hwekushandisa munzvimbo dzakasiyana siyana dzekurapa. Nheyo dzinogona kutofanira kushandiswa pakutsvagisa kenza, sekutsvagisa kwakaitwa Shandong baofa cancer researching Institute iyo inovandudza nzira dzekurapa dzekurapa. Heano mimwe mienzaniso:

Muromo unodzorwa kusunungurwa

Pamuromo kudzorwa kusunungurwa mafomu akagadzirirwa kusunungura mushonga zvishoma nezvishoma mumakomba egastrointestinal. Izvi zvinogona kuderedza dosing freastency uye nekuvandudza kuridza kwezvinodhaka. Mienzaniso inosanganisira:

• Mahwendefa ekusimudzira-akadzika uye makapu: Aya mafambiro anoshandisa maitiro akasiyana-siyana (i.e., matrix disfusic, osmotic kumanikidza) kudzora kusunungurwa kweanodhaka kwemaawa akawanda.
• Enter's Mahwendefa Mahwendefa aya akavezwa ne polymer iyo inonyungudika munzvimbo yeAlkaline yemukati madiki, ichidzivirira zvinodhaka kubva mudumbu acid uye ichisunungura nenzira yakatarwa.

Transdermal patches

Transdermal patches inoendesa zvinodhaka kuburikidza neganda pachiyero chakadzorwa. Aya matanda akakodzera uye anogona kupa systemic zvinodhaka pasina kudiwa kwejekiseni. Mienzaniso inosanganisira:

• Nicotine Patches: Inoshandiswa pakuputa fodya, aya matanda anoendesa nicotine pamutengo unodzorwa kuti uderedze zvishuwo.
• Fentanyl Patches: Inoshandiswa pakurwadziwa manejimendi, aya matanda anunura Fentanyl, opioid ine simba, pamatanho anodzorwa.

Jekiseni inodzorwa kusunungurwa

Jekiseni kudzorwa kusunungurwa mafomu akagadzirirwa kusunungura zvinodhaka anopfuura mavhiki kana mwedzi. Aya mafambiro anobatsira kuti zvinodhaka zvinoda kurapwa kwenguva refu uye kune varwere vanonetsa kuomerera kumishonga yemiromo. Mienzaniso inosanganisira:

• Microspheerfers: Mishonga inodhaka inodhonzwa inoiswa mumuviri, uko zvishoma nezvishoma kusunungura mushonga sezvo polymer degrades.
• Maimplants: Solid IMPLANTS inoiswa pasi peganda, kwavanosunungura mushonga pamusoro wenguva yakareba.

Zvinhu zvinokanganisa kudzorwa kusunungurwa

Zvinhu zvinoverengeka zvinogona kukurudzira chiyero uye nguva yekuburitswa kwezvinodhaka kubva kudzorwa kusunungurwa masisitimu. Izvi zvinhu zvinosanganisira:

• Zvivakwa zvinodhaka: Solubility, Molecular uremu, uye kugadzikana kwemushonga.
• Polymer Properties: Suremu, hydrophosity, uye chiyero chinosvibisa chemapolymer.
• Mudziyo Geometry: Saizi, chimiro, uye nzvimbo yemukati yemushini.
• Zvakatipoteredza Zvinhu: Ph, tembiricha, uye enzymes munzvimbo dzakapoteredza.

Runako Runyorwa Mukudzorwa Kusunungurwa

Munda we Kudzora Kuburitswa Kutumirwa kwezvinodhaka inogara ichishanduka, ine tekinoroji matsva uye zvikumbiro zvinobuda. Dzimwe dzeBhaibheri dzinokosha dzinosanganisira:

Inotarisirwa Kutumirwa kwezvinodhaka

Target Izvi zvinogona kuwanikwa nekushandisa:

• Ligand-yakadururwa chinangwa: Kukwezva ligands kune iyo inotakura zvinodhaka inosunga kune yakatarwa rekodhi pamasero emahara.
• Stimulu-anoteerera masisitimu: Kugadzira vatakuri vezvinodhaka vanosunungura mushonga mukupindura kwakananga kukurudzira, senge ph, tembiricha, kana ma enzymes.

Kudhinda 3D mukudzorwa kusunungurwa

3D kudhinda tekinoroji iri kushandiswa kugadzira yakagadziriswa kudzorwa kusunungurwa zvishandiso zvine midziyo yakaoma uye zvinodhaka zvinodhaka profiles. Izvi zvinobvumira mishonga yakasarudzika uye kukura kweiyo nyonganiso yekuzvitakura system.

Nanotechnology In Contround Kusunungurwa

NAANOPTCICCLICCLICles, polosomerigs, polymeric naneparticles, uye madhiri madhiri, ari kushandiswa kuvandudza kutumirwa kwezvinodhaka kuti zvinyore tishu. Nuoparticles inogona kusimudzira maitiro ezvinodhaka, chengetedza zvinodhaka kubva mukushatirisa, uye uvandudze zvinokonzeresa zvinodhaka nemasokisi.

Semuenzaniso data: Kuenzanisa kwezvinodhaka zvinodhaka profiles

* Data ndeyekuenzanisira zvinangwa chete uye zvinogona kusiyana zvichienderana nezvakananga kuumbwa.

Mhedziso

Kudzora Kuburitswa Kutumirwa kwezvinodhaka Inopa zvakakwanisika zvakanakira nzira dzekutengesa zvinodhaka, kusanganisira dzakaderedzwa doosence frequency, yakaderedzwa mhedzisiro, uye yakavandudzwa kushanda kwekuita. Nekufambira mberi kufambira mberi muzvinyorwa zvesainzi, Nanotechnology, uye 3D kudhinda, ramangwana re kudzorwa kusunungurwa inopenya, ichivimbisa kunyange kurapwa kwakanyanyisa uye kwakarongeka kuti urwere hwakawanda hwezvirwere.