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Slow Release Depot Therapy
Ultra Minimum Incision Yakasarudzika Intra-Tumoral Chemo-Immuno Therapy
Mushonga unopesana negomarara wakagadzirwa nemusanganiswa wekuramba-kuburitswa kugadzirwa, chemotherapy drug (dual drug), uye immune adjuvant inobaiwa zvakananga mubundu uye yakanyudzwa mubundu ichitungamirwa neCT, ultrasound, kana endoscopy. Mushonga unopesana nekenza unobudiswa zvishoma nezvishoma mukati memazuva 7-20, uchiuraya masero emukenza, kudzivisa migumisiro ine chepfu yemishonga pamuviri wose uye kuzadzisa chinangwa chekubvisa bundu; Iyo self tumor antigens inoburitswa nemaseru egomarara akaurayiwa nemishonga yakakoniwa panguva imwe chete, nerubatsiro rwema immune adjuvants, inomisa systemic immune immune yemuviri, nekudaro ichiita basa mukubvisa masero ekenza anodzokororwa kana metastatic. Yakananga yemuviri yakanangwa yakanangwa kuuraya uye decapitation kurapa inogona kuitirwa mamota akashata uye metastatic maronda munzvimbo dzakasiyana dzemuviri, akakodzera ekutanga, epakati, uye ekupedzisira nhanho akasimba mapundu munzvimbo dzese dzemuviri. Mushonga uyu wakawana matekinoroji ane patented kuChina, United States, neAustralia. Kubva payakashandiswa muna 1998, yakarapa vanopfuura 80000 varwere vegomarara uye yakawana mhedzisiro yakanaka yekurapa!
Mupiro wedu mukuru ndewekuti kurapa-kusunungurwa kwakasimba kunobatanidza zvakanakira chemotherapy uye immunotherapy, uye kekutanga, maviri acho akabatanidzwa uye anoshandiswa kune intratumoral therapy kuburikidza nekupindira. Inobatanidza kurapa kwemuno neyepasirese, uye inowedzera kusungirirwa uye nguva yekushandiswa kwezvinodhaka kuburikidza nekuburitswa kwakasimba kwezvinodhaka mukati mebundu, iro risingangoite yemuno anticancer mhedzisiro yechemotherapy mishonga, asi zvakare inofunga nezve basa resystemic immunotherapy, nekudaro kugadzira kukanganisa kwemamwe marapirwo, ichipa mazano matsva uye nzira dzekurapwa kwegomarara, kunyanya kumamota epakati uye epamusoro, kunyanya kudzikisa bundu rakakosha kudzoka. UMPIC kurapa ine mukana wekushandisa bundu seantigen sosi uye autologous vaccine, iyo inofambirana nemaitiro ekusimudzira eMushonga Wemunhu. Uye inoshandiswa kukiriniki, hapten yakasanganiswa nemishonga yechemotherapy yekuenderera mberi kusunungurwa kurapwa kwepancreatic cancer primary focus, uku ichikonzera distal effect, musimboti wayo ndeyekuunza immune system, T-cell-inoenderana CD4, CD8, DC, T uye NK masero, uye B-cell-inoenderana nebundu autoantibodies: Antibodies kuP53, P16, Cmy2c, 6MP, HCC, Ivivic, HCC uye mamwe oncogenes, ino inguva yekutanga kuwana kuti T uye B vanobatanidzwa mukupindura kwekudzivirira, uye mabasa ekiriniki eiyo distal effect uye kurapa uku kwakasarudzwa ku "Clinical Operation Guidelines for Interventional Treatment of Advanced Pancreatic Cancer" (Trial) (7th edition) yakaitwa pamwe chete neChinese Anti-Cancer Association, National Clinical Medical Research uye National Clinical Research Center yakadhindwa muNational Clinical Medical Research uye Interrapy Alliance yakabudiswa.
Journal of Clinical Radiology, bhuku 43, nhamba 19, 2024, 1636-1648.
Dr.Baofa Yu nechikwata chake chikuru chezvido tsvakurudzo zvinosanganisira zvinotevera:
1.Remote tumarara maduku anogona kudzorwa, ane uchapupu uye zvinyorwa;
2.The subclinical focus inogona kudzorwa, saka nguva yekurarama yevarwere yakareba;
3.Iyo zvakare inoderedza kutenderera bundu masero (CTC) ne80%, chinyorwa chinofanira kuburitswa;
4.Inogona kukurudzira hypothalamus yehuropi kuti iite chikamu mumhinduro yekudzivirira, uye panguva imwechete, inogonawo kuchengetedza kufara kwehuropi nemimhanzi kuronga kurwisa kenza. Chinyorwa ichi chapedzwa, uye purofesa weUCSD anokurudzira kuendesa kune zvisikwa kana mushonga wechisikigo.
UMIPIC-Therapy: Mushonga wemushonga wekuumbwa
Adjuvant: kuwedzera immunological reaction uye yakananga
Sustaining agent: kubata zvese zvakakwirira kwenguva yakareba
Antitumor agents: FDA dzakatenderwa hurumende dzakakonzera kufa kwebundu kuburitsa maantigen kubva mukugwamba.
Mabhenefiti matanhatu makuru eSlow Release Depot Therapy: kushomeka kunongedza kunanga, bundu decapitation, kudzivirira immune, majekiseni akawanda, anogara kwenguva refu, akachengeteka uye anoshanda.
Zvakanakira pane akawanda mashizha e interception bundu
(1) Tumoricidal Interception at primary site of bundu: under CT or ultrasound guiding, zvichienderana nekukura kwebundu, unogona kubaya dosi rakakodzera remushonga wekomboni.
(2) Kutsigira anticancer drug: oxidant induced coagulation mubundu kubata mushonga kwenguva yakareba uye kuita zvirinani kushanda.
(3) Immunological interception: de-bulking main bulking uku ichikonzera immunological reaction kudzora diki diki rebundu panzvimbo yechipiri yebundu.
(4) Autologous multiple bundu antigens : bundu rinosanganisirwa maantigens ndiwo bviro ye haptenation uye vaccination: iyo chaiyo autologous antigen, iwo chaiwo maantigen akawanda uye chaiwo maantigen akasarudzika.
(5) Yakareruka kushandisa: Inogona kurapa yekutanga bundu zvakare inogona kurapa yechipiri bundu zvakare uye inogona kukurudzira yakasarudzika immunotherapy.
(6) Yakachengeteka uye inoshanda.
