Renal cell carcinoma pathology

Renal cell carcinoma pathology inosanganisa kuongororwa kwemicroscopic uye kuongororwa kwetishu yeitsvo kuti uongorore uye kuronga gomarara reitsvo. Idanho rakakosha pakuona mhando, giredhi, uye nhanho yegomarara, iro rinozivisa sarudzo dzekurapa uye kufanotaura kufungidzira. Kunzwisisa maitiro epathological kwakakosha kune vese varwere uye nyanzvi dzekurapa. Gwaro iri rinopa mucherechedzo wakadzama we Renal cell carcinoma pathology, kusanganisira zvakajairika subtypes, grading masisitimu, staging, uye basa re immunohistochemistry.Kunzwisisa Renal Cell Carcinoma (RCC)Renal cell carcinoma (RCC) ndiyo inowanzozivikanwa yekenza yeitsvo muvanhu vakuru, inoverengera ingangoita 90% yezvirwere zvese zveitsvo. Inosimuka kubva mumucheka we proximal convoluted tubule, ari machubhu madiki muitsvo anosefa ropa uye anoburitsa weti. Kuongororwa kwakarurama uye kuiswa kweRCC kunokosha pakutungamirira nzira dzekurapa dzinoshanda uye kufanotaura migumisiro yevarwere.Common Subtypes yeRenal Cell CarcinomaSeveral subtypes yeRCC iripo, imwe neimwe ine maitiro akasiyana-siyana ehutano, maitiro ezvinyorwa, uye maitiro ekliniki. Aya ma subtypes anogona kusiyaniswa pasi pekuongororwa kwemicroscopic uye anosimbiswa zvakare ne immunohistochemistry. Iwo makuru madiki anosanganisira: Clear Cell Renal Cell Carcinoma (ccRCC)Clear cell RCC ndiyo yakanyanya kupararira subtype, inoverengera ingangoita 70-80% yezvose RCC kesi. Iyo inoratidzirwa nemasero ane cytoplasm yakajeka kana yakajeka nekuda kwepamusoro glycogen uye lipid content. Masero aya anowanzoita matendere kana masheets, uye bundu racho rinowanzoita vascularized.Papillary Renal Cell Carcinoma (pRCC)Papillary RCC ndiyo yechipiri inonyanya kuzivikanwa subtype, inoita 10-15% yeRCC kesi. Iyo inoratidzirwa ne papillary architecture, zvichireva kuti bundu masero anokura mumunwe-senge fungidziro. Kune mhando mbiri huru dzepRCC: Rudzi 1 uye Rudzi rwechipiri. Rudzi rwe 1 pRCC kazhinji rine fungidziro iri nani pane Type 2.Chromophobe Renal Cell Carcinoma (chRCC)Chromophobe RCC inomiririra inenge 5% yeRCC kesi. Masero eChRCC ane yakachenuruka eosinophilic cytoplasm uye yakasarudzika perinuclear halo. Iyo nuclei kazhinji yakaunyana kana kusarongeka.Collecting Duct Renal Cell Carcinoma (CDRCC)Collecting duct RCC is a rare and aggressive subtype inobuda kubva kunhonga dzeitsvo. Inoverengera isingasviki 1% yemakesi eRCC. Masero ebundu anogadzira tubules uye papillae, kazhinji ane desmoplastic stroma.Medullary Renal Cell CarcinomaMedullary renal cell carcinoma imwe isingawanzoitiki uye ine hukasha subtype, inonyanya kubata varwere vechidiki vane siko sero hunhu kana chirwere chegomarara. Musiyano uyu unoratidzwa necarcinoma isina kunyatsosiyaniswa ine kuzvimba kwakakura kunopinda.Kudhirowa kweRenal Cell Carcinoma: The Fuhrman Grading System uye ISUP Grading SystemKudhirowa kweRCC kunoratidza hukasha hwebundu hunoenderana nekuonekwa kwemasero pasi pemaikorosikopu. Iyo Fuhrman grading system yaiwanzo shandiswa, asi iyo International Society of Urological Pathology (ISUP) grading system ikozvino yave kunyanya kugamuchirwa. Iyo ISUP grading system inotarisa nucleolar mukurumbira uye nyukireya kusagadzikana. Magiredhi epamusoro anoratidza mamota ane hutsinye uye anosanganisirwa nehurombo husina kunaka. ISUP Grade Characteristics Giredhi 1 Diki, yunifomu nuclei ine inconspicuous kana absent nucleoli. Grade 2 Makuriro akati kurei ane nucleoli inooneka. Grade 3 Huru, irregular nuclei ine prominent nucleoli. Giredhi 4 Yakanyanya kusarongeka, pleomorphic nuclei ine zvimiro zvinoshamisa kana sarcomatoid musiyano. Staging of Renal Cell Carcinoma: Iyo TNM SystemStaging yeRCC inotsanangura kukura kwegomarara, kusanganisira saizi yebundu rekutanga (T), kubatanidzwa kweregional lymph nodes (N), uye kuvapo kwemametastasis ari kure (M). Iyo TNM staging system ndiyo inonyanya kushandiswa hurongwa hwekuita RCC. Kurongeka kwakasimba kwakakosha pakuona fungidziro uye nzira dzekurapa.Matanho chaiwo emapoka eT, N, uye M akaomesesa uye akadzama, anosanganisira kukura kwebundu, kupinda kwezvimiro zvakatenderedza, uye kuvapo kwemetastasis kumalymph nodes kana nhengo dziri kure. Vanamazvikokota vanoshandisa microscopic zvakawanikwa uye mhedzisiro yekufungidzira kupa nhanho yakakodzera yeTNM.Immunohistochemistry muRenal Cell Carcinoma PathologyImmunohistochemistry (IHC) chishandiso chakakosha mu Renal cell carcinoma pathology. Zvinosanganisira kushandisa masoja ekudzivirira chirwere kuona mapuroteni chaiwo mumasampuli ematishu. Iyi tekinoroji inobatsira mukusiyanisa pakati peRCC subtypes, kusimbisa kuongororwa, uye kuona zvinogona kurapa zvinangwa. Makara eIHC akajairika anoshandiswa muRCC anosanganisira: PAX8: Mucherechedzo unowanzo kuratidzwa murenal cell carcinomas, kunyanya clear cell uye papillary subtypes. CAIX: Inowanzo ratidzwa mune yakajeka cell renal cell carcinomas. CK7: Inobatsira mukusiyanisa pakati peRCC subtypes dzakasiyana, kazhinji yakanaka mupapillary uye chromophobe RCC. Vimentin: Kazhinji yakanaka mune sarcomatoid RCC. CD117 (c-KIT): Inogona kubatsira pakuongorora chromophobe RCC.Pathology Report: Key ElementsChirevo chechirwere chechirwere igwaro rakakosha rinopfupikisa zvakawanikwa pakuongororwa kwezvirwere. Inosanganisira zvinotevera zvakakosha zvinhu: Ruzivo rwemurwere uye ruzivo rwemuenzaniso. Ross tsananguro yebundu. Microscopic tsananguro ye tumor masero uye zvivakwa. RCC subtype kuongororwa. ISUP giredhi. TNM stage. Immunohistochemical staining results. Margins mamiriro (kana maseru egomarara aripo kumicheto yetishu yakabviswa). Zvinotaurwa nePathologist uye muchidimbu.Basa reShandong Baofa Cancer Research Institute muCancer ResearchMasangano akaita se Shandong Baofa Cancer Research Institute kuita basa rakakosha mukusimudzira kunzwisisa kwedu uye kurapwa kwegomarara, kusanganisira renal cell carcinoma. Nokuita tsvakurudzo uye miedzo yekiriniki, masangano aya anobatsira mukugadzirwa kwezvitsva zvekuongorora maturusi nemishonga, pakupedzisira kugadzirisa migumisiro yevarwere.Renal cell carcinoma pathology ibasa rakaoma rinosanganisira kunyatsoongorora uye kuongororwa kwenyama yeitsvo. Kunzwisisa akasiyana ma subtypes, magiredhi masisitimu, staging, uye basa re immunohistochemistry kwakakosha pakuongororwa, kufungidzira, uye kuronga kurapwa. Kudyidzana pakati pevanorapa zvirwere, oncologists, uye vamwe vashandi vehutano kwakakosha pakupa tarisiro yakanakisa yevarwere vane RCC.Disclaimer: Ruzivo urwu nderweruzivo rwakakwana uye zvinangwa zveruzivo chete, uye haruunze zano rekurapa. Zvakakosha kubvunzana nenyanzvi yezvehutano ine ruzivo rwezvehutano kana usati waita chero sarudzo dzine chekuita nehutano hwako kana kurapwa.References: American Cancer Society National Kidney Foundation