kurapwa renal cell carcinoma pathology inotsanangura Zvipatara

Kunzwisisa Renal Cell Carcinoma: Pathology Outlines & Hospital Treatment OptionsKurapwa kwerenal cell carcinoma (RCC) kunoda nzira yakasiyana-siyana, kubatanidza pathology, radiology, uye oncology unyanzvi. Iri gwara rakazara rinoongorora pathology rondedzero yeRCC, inotsanangura akakosha ekuongorora maficha, danho, uye nzira dzekurapa dziripo kuzvipatara zvinotungamira.

Renal Cell Carcinoma: A Pathological Overview

Renal cell carcinoma (kurapwa renal cell carcinoma pathology inotsanangura Zvipatara) ndiyo inowanzozivikanwa yekenza yeitsvo, inobva mumasero epithelial erenal tubules. Yakarurama pathological kuongororwa kwakakosha pakutungamira sarudzo dzekurapa uye kufanotaura fungidziro. Histological ongororo inoratidza akasiyana maseru marudzi, achikanganisa hukasha uye mhinduro yekurapa. Iwo ekutanga subtypes anosanganisira akajeka cell RCC (ccRCC), papillary RCC, chromophobe RCC, nevamwe. Imwe neimwe subtype inoratidza yakasarudzika microscopic maficha, inokanganisa kufungidzira uye nzira dzekurapa.

Clear Cell Renal Cell Carcinoma (ccRCC)

ccRCC inoverengera mazhinji eRCC kesi. Pathologically, inoratidzirwa nekujeka cytoplasm mumaseru bundu nekuda kwekuwanda kweglycogen uye lipid yemukati. Aya masero anowanzoratidza maitiro akasiyana ekukura, kugadzira matendere kana tubules. Kuvapo kwekuchinja kwemajini chaiwo, akadai seVHL ​​gene mutations, kunowanzoonekwa.

Papillary Renal Cell Carcinoma

Papillary RCC inosiyaniswa nemaitiro ayo ekukura kwepapillary, ane maseru anoumba mashizha akatetepa kana papillae. Kusiyana neCCRCC, iyo cytoplasm haina kujeka. Maviri madiki ariko: mhando 1 uye mhando 2, ine mhando 2 ichibatanidzwa nehuipi hwakaipisisa.

Chromophobe Renal Cell Carcinoma

Chromophobe RCC haina kunyanya kuwanda uye inoratidzwa nemasero ane ganda rakachenuruka, eosinophilic cytoplasm uye zvinyoro zvinyoro zvenyukireya. Kazhinji ine chimiro chakasiyana chekukura, kugadzira matendere kana mashizha.

Zvimwe Subtypes

Mamwe akati wandei asingawanzo subtypes aripo, anosanganisira kuunganidza duct carcinoma, medullary RCC, uye unclassified RCC. Aya ma subtypes anowanzoda hunyanzvi hwekuongororwa uye kuronga kurapwa.

Staging uye Prognostic Zvinhu muRCC

Pathological staging, yakavakirwa paTNM system (tumor size, nodal kubatanidzwa, uye kure metastasis), yakakosha pakuona kukura kwechirwere. Ruzivo urwu, padivi peiyo chaiyo subtype yeRCC uye zvimwe zvinhu zvekufungidzira segiredhi (kuti masero egomarara anoonekwa sei pasi pemaikorosikopu), anokanganisa nzira dzekurapa. Iyo yakakwirira nhanho, kurapa kunowanzova kwakakura.

Kurapa Sarudzo dzeRenal Cell Carcinoma

Sarudzo dzekurapa dzinoenderana nezvinhu zvakasiyana, kusanganisira danho, giredhi, uye hutano hwemurwere hwese. Sarudzo dzinobva pakuvhiyiwa (partial nephrectomy kana radical nephrectomy), kurapa kwakanangwa, immunotherapy, uye radiation therapy.

Kuvhiya Resection

Kubviswa kwekuvhiya kwebundu kazhinji ndiko kurapwa kwekutanga kweRCC yemuno. Partial nephrectomy inochengetedza hutano hweitsvo, nepo radical nephrectomy inosanganisira kubvisa itsvo yese nemalymph nodes akatenderedza. Sarudzo inotsamira pane zvakati wandei, zvinosanganisira saizi nenzvimbo yebundu, uye kushanda kweitsvo kwemurwere.

Targeted Therapy

Mishonga inotarirwa, yakadai setyrosine kinase inhibitors (TKIs), inonangana nemapuroteni asina kujairika anotyaira RCC kukura. Mishonga iyi yakashandura kurapwa kweRCC yepamusoro, kuvandudza mararamiro ehupenyu. Mienzaniso inosanganisira sunitinib, sorafenib, uye pazopanib.

Immunotherapy

Immunotherapy inoshandisa immune system yemuviri kurwisa cancer maseru. Checkpoint inhibitors, senge nivolumab uye ipilimumab, mishonga inoshanda yeRCC yepamusoro. Mishonga iyi inoshanda nekuburitsa mabhureki pa immune system, ichiibvumira kuziva zvirinani nekurwisa maseru egomarara.

Radiation Therapy

Radiation therapy inogona kushandiswa mune mamwe mamiriro ezvinhu, senge palliative kutarisirwa kwechirwere chepamusoro kana musanganiswa nemamwe marapirwo.

Kusarudza Chipatara Chakakodzera cheRCC Kurapwa

Kusarudza chipatara chakakodzera kurapwa renal cell carcinoma pathology inotsanangura Zvipatara kwakakosha. Tarisa masangano ane ruzivo rwakasiyana-siyana zvikwata zvinosanganisira urologists, oncologists, pathologists, uye radiologists nyanzvi mugenitourinary cancers. Iyo Shandong Baofa Cancer Research Institute (https://www.baofahospital.com/) muenzaniso wechipatara chakazvipira kupa hutano hwakakwana hwegomarara, nenyanzvi dzine ruzivo mukuongororwa nekurapwa renal cell carcinoma. Funga zvinhu zvakaita sehunyanzvi hwetekinoroji, kubatanidzwa mukutsvagisa, uye masevhisi ekutsigira murwere paunenge uchiita sarudzo yako.

Mhedziso

Kubudirira kurapwa renal cell carcinoma pathology inotsanangura Zvipatara inoda kuongororwa chaiko, kurongeka kwakaringana, uye chirongwa chekurapa chakaenderana. Nekunzwisisa maitiro ehurwere eRCC, akasiyana subtypes, uye nzira dzekurapa dziripo, varwere vanogona kuita sarudzo dzine ruzivo mukubatana neboka ravo rehutano. Chisarudzo chakakodzera chechipatara chakakosha pamhedzisiro yakanakisa.