unyango lomhlaza wemiphunga adenocarcinoma

I-Adenocarcinoma lolona hlobo luqhelekileyo lomhlaza wemiphunga. Ukhetho lonyango luxhomekeke kwizinto ezininzi, kubandakanywa inqanaba lomhlaza, impilo yesigulana ngokubanzi, kunye nokukhethwa komntu. Esi sikhokelo sinika amagqabantshintshi aneenkcukacha ezahlukeneyo unyango lomhlaza wemiphunga adenocarcinoma iinketho ezikhoyo, ezinikezela ngengqiqo malunga nokusebenza kwazo kunye neziphumo ebezingalindelekanga ezinokubakho.Ukuqonda i-Adenocarcinoma Umhlaza WemiphungaYintoni i-Adenocarcinoma?Adenocarcinoma luhlobo lomhlaza wemiphunga weseli engeyiyo encinci (NSCLC) eqala kwiiseli zamadlala ezivelisa imiphunga emiphungeni. Idla ngokuvela kwimimandla engaphandle yemiphunga. Ukuxilongwa kwangoko kubalulekile ukuze kusebenze unyango lomhlaza wemiphunga adenocarcinoma. I IZiko loPhando ngoMhlaza laseShandong Baofa uzibophelele ekuqhubeleni phambili ukuqonda kunye nokunyangwa kwesi sifo esinzima.Imiba yoMngcipheko we-AdenocarcinomaNgelixa ukutshaya kungumngcipheko omkhulu weentlobo ezininzi zomhlaza wemiphunga, i-adenocarcinoma ibonwa kakhulu kubantu abangatshayiyo kunezinye iintlobo. Eminye imiba esemngciphekweni ibandakanya: Ukuvezwa kwirhasi ye-radon Ukutyhileka kwi-asbestos Imbali yosapho lomhlaza wemiphunga Ungcoliseko lomoya Uxilongo kunye neSigaba se-Adenocarcinoma Iimvavanyo ezininzi zokuxilonga. i-adenocarcinoma, kuquka: X-reyi yesifuba: Ibonelela ngomfanekiso wokuqala wemiphunga. CT Scan: Yenza imifanekiso eneenkcukacha zemiphunga kunye nezicubu ezijikelezileyo. I-PET Scan: Inceda ukuchonga iindawo zokwanda komsebenzi we-metabolic, ebonisa umhlaza onokubakho. Ibronchoscopy: Ivumela oogqirha ukuba bajonge iindlela zomoya kwaye baqokelele iisampulu zethishu. I-Biopsy: Isampulu yethishu ivavanywa phantsi kwe-microscope ukuqinisekisa ukuxilongwa.I-Staging AdenocarcinomaStaging inceda ukumisela ubungakanani bomhlaza kunye nesikhokelo. unyango lomhlaza wemiphunga adenocarcinoma. Iqonga lisekelwe kwi: T (Ithumba): Ubungakanani kunye nendawo ye-tumor yokuqala. N (iiNodi): Nokuba umhlaza usasazeke kwii-lymph nodes ezikufutshane. M (iMetastasis): Ingaba umhlaza usasazeke kumalungu akude.Amanqanaba asusela kwiNqanaba 0 (umhlaza kwindawo) ukuya kwiSigaba IV (umhlaza wemetastatic).IAdenocarcinoma Iinketho zoNyango loMhlaza weLungEzona zilungileyo unyango lomhlaza wemiphunga adenocarcinoma Isicwangciso sixhomekeke kwinqanaba, impilo yonke yesigulana, kunye nezinto abazikhethayo. Iinketho zonyango eziqhelekileyo zibandakanya: UtyandoUtyando lujolise ekususeni ithumba lomhlaza kunye nezicubu ezijikelezileyo. Ukhetho lotyando lubandakanya: Ukususwa kweWedge: Ukususwa komphunga omncinci, omise okwe wedge. Lobectomy: Ukususwa kwelobe yonke yomphunga. Inyumoniya: Ukususwa komphunga uphela. Utyando ludla ngokucetyiswa kwangethuba unyango lomhlaza wemiphunga adenocarcinoma xa ithumba lihlala kwindawo kwaye isigulane sisempilweni ngokwaneleyo ukuba singene kwinkqubo.Unyango lweRadiation TherapyRadiation therapy isebenzisa imitha ephezulu yamandla ukubulala iiseli zomhlaza. Ingasetyenziswa: Njengonyango lokuqala: Kwizigulane ezingakwaziyo ukwenza utyando. Emva kotyando: Ukubulala naziphi na iiseli zomhlaza eziseleyo. Ukuthomalalisa iimpawu: Ezinje ngeentlungu okanye ukuphelelwa ngumphefumlo.Iintlobo zonyango lwemitha ziquka: Unyango lweBeam Radiation yangaphandle (EBRT): Imitha ihanjiswa kumatshini ongaphandle komzimba. Unyango lweRadiation Body Stereotactic (SBRT): Ihambisa iidosi eziphezulu zemitha yemitha kwindawo encinci.I-ChemotherapyI-Chemotherapy isebenzisa amayeza ukubulala iiseli zomhlaza kuwo wonke umzimba. Isetyenziswa rhoqo: Ngaphambi kotyando: Ukunciphisa i-tumor (i-neoadjuvant chemotherapy). Emva kotyando: Ukubulala naziphi na iiseli zomhlaza eziseleyo (i-adjuvant chemotherapy). Njengonyango lokuqala: Kwinqanaba eliphezulu i-adenocarcinoma.Iziyobisi eziqhelekileyo zechemotherapy ezisetyenziselwa ukunyanga i-adenocarcinoma zibandakanya i-cisplatin, i-carboplatin, i-pemetrexed, kunye ne-docetaxel.I-Targeted TherapyTargeted therapy iziyobisi ezijoliswe kwiimolekyuli ezithile (umzekelo, iiprotheni, iijini) ezibandakanyekayo ekukhuleni kweeseli zomhlaza kunye nokuphila. Olu nyango luhlala lusetyenziselwa i-adenocarcinoma ngokuguqulwa kwemfuzo ethile.Imizekelo yonyango ekujoliswe kuyo ibandakanya: I-EGFR inhibitors: I-Erlotinib, i-gefitinib, i-afatinib, i-osimertinib (yeenguqu ze-EGFR) I-ALK inhibitors: I-Crizotinib, i-alectinib, i-ceritinib, i-brigatinib, i-lorlatinib (ukulungiselela ukulungiswa kwakhona kwe-ALK) I-ROS1 inhibitors: I-Crizotinib, i-entrectinib (ye-ROS1 ukulungiswa kwakhona) I-BRAF inhibitors: I-Dabrafenib, i-trametinib (yeenguqu ze-BRAF) Uvavanyo lwemfuzo lubalulekile ukufumanisa ukuba isigulana sikufanele na kunyango ekujoliswe kulo. I IZiko loPhando ngoMhlaza laseShandong Baofa igxininisa ukubaluleka kweyeza lomntu kwi unyango lomhlaza wemiphunga adenocarcinoma.ImmunotherapyImmunotherapy amayeza anceda amajoni omzimba ukulwa umhlaza. Basebenza ngokuthintela iiproteni ezithintela amajoni omzimba ekuhlaseleni iiseli zomhlaza.Imizekelo yamachiza e-immunotherapy ibandakanya: PD-1 inhibitors: Pembrolizumab, nivolumab PD-L1 inhibitors: I-Atezolizumab, i-durvalumabImmunotherapy isoloko isetyenziselwa inqanaba eliphezulu i-adenocarcinoma, ngakumbi xa iiseli zomhlaza zivakalisa i-PD-L1.Iimpembelelo ezisecaleni zoNyangoZonke unyango lomhlaza wemiphunga adenocarcinoma iinketho zinokubangela iziphumo ebezingalindelekanga. Iziphumo ezithile ebezingalindelekanga zixhomekeke kuhlobo lonyango, ithamo, kunye nempendulo yomntu ngamnye yesigulane. Iziphumo ebezingalindelekanga eziqhelekileyo ziquka: Ukudinwa Isicaphucaphu nokugabha Ukuphuma kweenwele Ukuphulukana neenwele Izilonda emlonyeni Ukuphulukana nomdla wokutya Ubuthathaka bokusebenza kwamajoni omzimbaKubalulekile ukuxoxa ngeziphumo ebezingalindelekanga ezinokubakho nogqirha wakho kwaye wenze isicwangciso sokuzilawula. I IZiko loPhando loMhlaza laseShandong Baofa unyango lujolise ekunciphiseni iziphumo ebezingalindelekanga ngelixa kwandisa ukusebenza kakuhle. unyango lomhlaza wemiphunga adenocarcinoma iindlela. Izigulana zinokuthatha inxaxheba kulingo lwezonyango ukuze zifikelele kunyango olutsha olungekafumaneki ngokubanzi. Funda ngakumbi malunga nophando olutsha lomhlaza kwiziko loPhando loMhlaza laseShandong Baofa.Uqikelelo kunye namazinga okusindaUqikelelo lwe i-adenocarcinoma kuxhomekeke kwizinto eziliqela, kuquka inqanaba lomhlaza, impilo yomguli ngokubanzi, kunye nendlela asabela ngayo kunyango. Ukufunyaniswa kwangethuba kunye nonyango kunokuphucula ngokubonakalayo amazinga okusinda.Amazinga okusinda kumhlaza wemiphunga ewonke ahlala eboniswa njengamazinga okusinda kweminyaka emi-5, okuthetha ukuba ipesenti yabantu abasaphila kwiminyaka emihlanu emva kokuxilongwa. Ngokutsho kwe-American Cancer Society, izinga lokusinda leminyaka emi-5 kuzo zonke izigaba zomhlaza wemiphunga limalunga nama-25%. Nangona kunjalo, eli nani liyahluka ngokubanzi ngokuxhomekeke kwinqanaba lokuxilongwa. Umzekelo, izinga leminyaka emi-5 lokusinda kumhlaza wemiphunga wendawo (umhlaza ongakhange usasazeke ngaphandle kwemiphunga) uphezulu kakhulu kunomhlaza wemiphunga we-metastatic (umhlaza oye wasasazeka kwizitho ezikude). [Umthombo: American Cancer Society]Nantsi itheyibhile eyenziwe lula ebonisa uqikelelo lweminyaka emi-5 yamazinga okuphila ngokwenqanaba: Inqanaba eliqikelelweyo leminyaka emi-5 yokuSinda kwiNdawo yasekuhlaleni (Umhlaza awunwenwanga ngaphandle kwemiphunga) 59% yoMmandla (Umhlaza unwenwele kwii-lymph nodes ezikufutshane) 33% Ukude (Umhlaza unwenwele kumalungu akude) 6% Onke Amanqanaba Adityanisiwe, kwaye isiphumo esibalulekileyo sinokuthi sikhumbule ukuba umntu ngamnye uqikelelwa ngama-25% ziyahluka kakhulu.Ukuphila AdenocarcinomaUkuphila nge i-adenocarcinoma kunokuba lucelomngeni, kodwa kukho izibonelelo ezikhoyo zokunceda izigulane kunye neentsapho zazo zihlangabezane nazo. Ezi zixhobo zibandakanya: Amaqela enkxaso Ukucebisa Ukhathalelo lwePalliative Unyango oludibeneyoUkugcina impilo esempilweni, kubandakanywa ukutya okunesondlo kunye nokuzilolonga rhoqo, nako kunokuphucula umgangatho wobomi.IsipheloUnyango lomhlaza wemiphunga we-Adenocarcinoma iqhubele phambili kakhulu kwiminyaka yakutshanje, inika izigulana iinketho ezisebenzayo kunye nezobuqu. Ukusiqonda esi sifo, unyango olukhoyo, kunye nemiphumo enokubakho kubalulekile ukuze wenze izigqibo ezizizo. Soloko ubonisana nengcali yezonyango eqeqeshiweyo ukuze uphuhlise okona kulungileyo unyango lomhlaza wemiphunga adenocarcinoma cwangcisa imeko yakho. I IZiko loPhando ngoMhlaza laseShandong Baofa luzinikele ekunikeni ukhathalelo olubanzi novelwano kwizigulane ezine i-adenocarcinoma.