Unyango lwe UMPIC

Unyango lwe UMPIC

Unyango lweDepo yokuKhupha kancinci

Ubuncinci be-Ultra Minimum Incision Personalized Intra-Tumoral Chemo-Immuno Therapy

Iyeza elichasayo lomhlaza elenziwe ngokudityaniswa kokwenziwa kokukhutshwa okuzinzileyo, ichiza lechemotherapy (iziyobisi ezimbini), kunye ne-immune adjuvant ifakwe ngqo kwithumba kwaye ifakwe kwithumba phantsi kolwalathiso lwe-CT, i-ultrasound, okanye i-endoscopy. Ichiza elichasayo lomhlaza likhutshwa ngokuthe ngcembe kwiintsuku ezingama-7-20, ukubulala iiseli zomhlaza, ukuphepha iziphumo ezinobungozi zeziyobisi kuwo wonke umzimba kunye nokufezekisa injongo yokuphelisa ithumba; I-self tumor antigens ekhutshwe ziiseli zomhlaza ezibulewe ngamachiza ahlanganisiweyo ngaxeshanye, ngoncedo lwe-immune adjuvants, yenza kusebenze inkqubo yokusabela komzimba kwi-immune, ngaloo ndlela idlala indima ekucoceni iiseli zomhlaza ophindaphindiweyo okanye we-metastatic. Ngokuthe ngqo ngokwasemzimbeni okujoliswe kuko ekubulaweni okujoliswe kuko kunye nonyango lokunqunyulwa kwentloko lunokwenziwa kumathumba anobungozi kunye nezilonda zemetastatic kwiindawo ezahlukeneyo zomzimba, zilungele kwangethuba, eliphakathi, kunye nenqanaba lasemva kwamathumba aqinileyo kuwo onke amalungu omzimba. Olu nyango lufumene itekhnoloji enelungelo elilodwa lomenzi wechiza eTshayina, eMelika, naseOstreliya. Ukusukela kwisicelo sayo ngo-1998, iye yanyanga ngaphezulu kwe-80000 yezigulane ezinomhlaza kwaye yafumana iziphumo ezilungileyo zonyango!

Igalelo lethu elikhulu kukuba unyango olusisigxina ludibanisa izibonelelo ze-chemotherapy kunye ne-immunotherapy, kwaye ngokokuqala ngqa, ezi zimbini zidibene kwaye zisetyenziselwa unyango lwe-intratumoral ngokungenelela. Idibanisa unyango lwasekhaya kunye nehlabathi jikelele, kwaye inyusa ugxininiso kunye nexesha lesenzo sechiza ngokukhutshwa okuqhubekayo kwamachiza ngaphakathi kwethumba, elingadlali kuphela impembelelo ye-anticancer yendawo yamachiza e-chemotherapy, kodwa ithathela ingqalelo indima ye-systemic immunotherapy, ngaloo ndlela yenza ukusilela kolunye unyango, ibonelela ngeembono ezintsha kunye neendlela zonyango lomhlaza, ngakumbi kumathumba aphakathi kunye naphambili, ngakumbi ekunciphiseni ukuphindaphinda kwe-tumor ebaluleke kakhulu; Unyango lwe-UMPIC lunenzuzo yokusebenzisa ithumba njengomthombo we-antigen kunye nogonyo lwe-autologous, olukwahambelana nendlela yophuhliso lwe-Personalized Medicine. Kwaye ifakwe kwiklinikhi, i-hapten idityaniswe namachiza e-chemotherapy ukwenzela unyango oluqhubekayo lokukhululwa komhlaza we-pancreatic ugxininiso oluphambili, ngelixa lubangela umphumo we-distal, undoqo wayo kukubangela impendulo yomzimba, i-CD4 ehlobene ne-T-cell, i-CD8, i-DC, i-T kunye ne-NK iiseli, kunye ne-B-cell-related tumor autoantibodies: Antibodies ukuya kwi-P53, i-P16, i-Cmytac, i-Survic, i-HCC, i-HCC kunye nezinye i-oncogenes, eli lixesha lokuqala lokufumanisa ukuba i-T kunye ne-B zibandakanyeka kwi-immune response, kunye nemisebenzi yeklinikhi yempembelelo ye-distal kwaye olu nyango lukhethwe "Izikhokelo zeClinical Operation Guidelines for Interventional Treatment of Advanced Pancreatic Cancer" (Trial) (i-7th edition) edibeneyo eyenziwe yi-Chinese Anti-Cancer Association, i-National Clinical Medical Research Centre kunye ne-National Clinical Research Centre epapashwe kwi-National Clinical Research kunye neZiko loPhando lwezoNyango.

Ijenali ye-Clinical Radiology, umthamo we-43, inombolo ye-19, i-2024, i-1636-1648.

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UGqr.Baofa Yu kunye neqela lakhe eyona nto anomdla kuyo uphando lubandakanywe ngolu hlobo lulandelayo:

I-1.I-tumor ezincinci ezikude zingalawulwa, kunye nobungqina kunye namanqaku;

I-2.I-subclinical focus inokulawulwa, ngoko ixesha lokusinda kwezigulane lide;

3.Ikwanciphisa iiseli zethumba elijikelezayo (CTC) ngama-80%, inqaku eliza kupapashwa;

I-4.Inokukhuthaza i-hypothalamus yengqondo ukuba ithathe inxaxheba kwi-immune response, kwaye ngexesha elifanayo, inokugcina umdla wobuchopho kunye nomculo ukulungelelanisa i-anti-cancer. Eli nqaku ligqityiwe, kwaye unjingalwazi we-UCSD ucebisa ukuba ulingenise kwindalo okanye iyeza lendalo.

I-UMIPIC-Therapy: Ukuqulunqwa kwekhompawundi yeziyobisi

I-Adjuvant: ukwandisa ukusabela kwe-immunological kunye nokuthe ngqo
I-arhente egcinayo: ukubamba konke kugxininiso oluphezulu ixesha elide
Ii-Antitumor agents: Iinkqubo ezivunyiweyo ze-FDA ziye zabangela ukufa kwethumba ukukhulula ii-antigens ekujikeni.

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Iingenelo ezintandathu eziphambili zoNyango lweDepo yokuKhululwa kancinci: ukujolisa okuncinci, ukunqunyulwa kwethumba, ukungenelela komzimba, ugonyo oluninzi, oluhlala ixesha elide, lukhuselekile kwaye luyasebenza.

I-Advantages kumagqabi amaninzi e- interception  tumor
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(2) Ukugcinwa kwechiza le-anticancer: i-oxidant induced coagulation kwi-tumor ukubamba iyeza ixesha elide kwaye iphumelele ukusebenza kakuhle.
(3) Immunological interception: de-bulking main tumor okwangoku ibangela ukusabela kwe-immunological ukulawula isilonda esincinci sethumba kwindawo yesibini yethumba.
(4) Autologous multiple antigens ithumba : antigens ithumba ezinxulumene ngumthombo haptenation kunye nogonyo: lokwenyani antigen autologous, iantigens lokwenene ezininzi kunye antigens ngokwenene lobuqu.
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(6) Ikhuselekile kwaye iyasebenza.

Ekhaya
Amatyala aqhelekileyo
Malunga Nathi
Qhagamshelana nathi

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