unyango lwe-brca gene prostate umhlaza

Ubukho be-a Uhlobo lwe-BRCA Uguqulo, olunxulunyaniswa nomhlaza webele kunye nesiyilelo-maqanda, nako kunokudlala indima ebalulekileyo kuphuhliso nakunyango lwe umhlaza wedlala lesinyi. Ukuqonda iziphumo zolu tshintsho kubalulekile kwizicwangciso zonyango lomntu ngamnye kunye neziphumo eziphuculweyo zesigulana. Eli nqaku liphonononga ikhonkco phakathi Ufuzo lwe-BRCA kwaye umhlaza wedlala lesinyi, ukuphonononga uxilongo, iindlela zonyango, kunye nophando oluqhubekayo.Ukuqonda i-BRCA yemfuza kunye nendima yaboYintoni i-BRCA1 kunye ne-BRCA2 Genes?I-BRCA1 kwaye I-BRCA2 zimfuza zomntu ezivelisa iiproteni ezinoxanduva lokulungisa iDNA eyonakeleyo. Ezi proteni zidlala indima ebalulekileyo ekugcineni ukuzinza kolwazi lwethu lwemfuza kunye nokuthintela ukukhula kweeseli okungalawulwayo. Xa ezi zakhi zofuzo ziguqulwa, azikwazi ukulungisa ngokufanelekileyo umonakalo we-DNA, ukwandisa umngcipheko wokuphuhlisa i-cancer ethile. I-BRCA1 kwaye I-BRCA2 zidla ngokunxulunyaniswa nomngcipheko owonyukayo womhlaza webele kunye nomhlaza wesibeleko kwabasetyhini. Nangona kunjalo, olu tshintsho luphakamisa umngcipheko wezinye ii-cancer, kubandakanywa umhlaza wedlala lesinyi, umhlaza we-pancreatic, kunye ne-melanoma. Amadoda ane a Uhlobo lwe-BRCA ukuguquka kwemfuza kunethuba eliphezulu lokukhula ngokundlongondlongo umhlaza wedlala lesinyi usemncinci.Ukuguqulwa kwe-BRCA kunye noMhlaza weProstateUkonyuka koMngcipheko kunye noBundlobongelaUphononongo lubonise ukuba amadoda ane I-BRCA1 okanye I-BRCA2 iinguqulelo zenguquko zinomngcipheko ophezulu kakhulu wokuphuhla umhlaza wedlala lesinyi xa kuthelekiswa namadoda ngaphandle kolu tshintsho. Ngaphezu koko, umhlaza wedlala lesinyi emadodeni ane I-BRCA Utshintsho lwenguqu luthanda ukuba ndlongondlongo, ludla ngokunikezela emva kwexesha kunye namanqaku aphezulu eGleason. Iziko lomhlaza leSizwe inikeza ulwazi oluthe vetshe malunga I-BRCA imfuza kunye nobungozi bomhlaza.UkuHlolwa kunye noVavanyo lwemfuzoKunikwe umngcipheko owandayo, uvavanyo lwemfuzo lwe I-BRCA1 kwaye I-BRCA2 ukuguqulwa kweenguqu kuyacetyiswa kumadoda anembali yosapho umhlaza wedlala lesinyi, ngakumbi ukuba umhlaza ufunyenwe usemncinci okanye ukuba kukho imbali yebele, i-ovarian, okanye i-pancreatic umhlaza kwintsapho. Ukufunyaniswa kwangoko ngovavanyo, olufana novavanyo lwe-PSA (i-prostate-specific antigen) kunye novavanyo lwedijithali lwe-rectal, lubalulekile kumadoda asemngciphekweni omkhulu. Uvavanyo lwemfuzo lukwafumaneka nakumaziko afana IZiko loPhando ngoMhlaza laseShandong Baofa, apho uvavanyo lwengozi yomhlaza wobuqu lunikezelwa.Ukhetho loNyango lweProstate Cancer kuMadoda aneBRCA MutationsTargeted Therapies: PARP InhibitorsPARP (poly ADP-ribose polymerase) inhibitors ludidi lwamachiza abonise iziphumo ezithembisayo ekunyangeni. umhlaza wedlala lesinyi emadodeni ane I-BRCA iinguqulelo zemfuza. I-PARP inhibitors isebenza ngokuthintela i-enzyme ye-PARP, ebandakanyekayo ekulungiseni i-DNA. Iiseli zomhlaza nge I-BRCA iinguqu zisengozini ngakumbi kwi-PARP inhibition kuba sele zinendlela yokulungisa i-DNA ephazamisekileyo. Ezinye i-PARP inhibitors eziqhelekileyo ziquka i-olaparib (i-Lynparza) kunye ne-rucaparib (i-Rubraca). Indlela i-PARP Inhibitors eSebenza ngayo I-BRCA izakhi zofuzo ziguqulwa, iiseli zomhlaza zixhomekeke kwezinye iindlela zokulungisa i-DNA, kuquka indlela ye-PARP. Ngokuvala i-enzyme ye-PARP, i-PARP inhibitors ikhusela iiseli zomhlaza ekulungiseni umonakalo we-DNA, okukhokelela ekufeni kweeseli. Le ndlela ekujoliswe kuyo isebenza ngokukodwa kwi umhlaza wedlala lesinyi iiseli nge I-BRCA iinguqu, njengoko zingakwazi ukulungisa ngokufanelekileyo umonakalo we-DNA ngokusebenzisa ezinye iindlela.Idatha yokuHlola yeClinical kunye ne-EfficacyIzilingo zekliniki zibonise ukuphumelela kwe-PARP inhibitors ekuphatheni okuphezulu. umhlaza wedlala lesinyi emadodeni ane I-BRCA iinguqulelo zemfuza. Umzekelo, uvavanyo olunzulu lubonise ukuba i-olaparib iphucule kakhulu ukusinda okupheleleyo kunye ne-radiographic progression-free-free kumadoda ane-metastatic castration-resistant. umhlaza wedlala lesinyi (mCRPC) kunye I-BRCA1 okanye I-BRCA2 iinguqulelo zemfuza. Iziphumo zolingo olunzulu zinokufumaneka kwi New England Journal of Medicine.Ezinye Iindlela zoNyangoNgelixa i-PARP inhibitors iyindlela yonyango ekujoliswe kuyo, omnye umgangatho umhlaza wedlala lesinyi Unyango lunokusetyenziswa nakumadoda ane I-BRCA iinguqulelo zemfuza. Ezi ziquka: Utyando: I-Radical prostatectomy (ukususwa kwedlala lengqula) inokuba lukhetho lwendawo umhlaza wedlala lesinyi. Unyango ngemitha: Unyango lwemitha yangaphandle okanye ibrachytherapy (imitha yangaphakathi) ingasetyenziselwa ukujolisa nokutshabalalisa iiseli zomhlaza. Unyango lweHormone: I-Androgen deprivation therapy (ADT) ijolise ekuthobeni amanqanaba e-testosterone, anokucothisa ukukhula kwe umhlaza wedlala lesinyi iiseli. Unyango ngamachiza: Amachiza onyango lwekhemotherapy anokusetyenziswa ukunyanga inqanaba eliphezulu umhlaza wedlala lesinyi ethe yanwenwela kwamanye amalungu omzimba.Ikamva loNyango lwe-BRCA-Related Prostate Cancer TreatmentUPhando oluqhubekayo kunye ne-Clinical TrialsUphando luyaqhubeka ukuqonda ngakumbi indima I-BRCA utshintsho kwi umhlaza wedlala lesinyi kunye nokuphuhlisa iindlela ezintsha zonyango ezisebenzayo. Ulingo lwezonyango luphonononga ukusetyenziswa kwe-PARP inhibitors kudityaniswe nolunye unyango, kunye nokuphanda ekujoliswe kuko kwamachiza kunye neendlela zonyango zomntu. I-BRCA utshintsho kwi umhlaza wedlala lesinyi izigulane zigxininisa ukubaluleka kweyeza lomntu kunye ne-oncology echanekileyo. Ngokuqonda iimpawu zofuzo zomhlaza womntu ngamnye, oogqirha banokulungisa iindlela zonyango zokwandisa ukusebenza kakuhle kunye nokunciphisa iziphumo ebezingalindelekanga. Uvavanyo lwemfuzo ye I-BRCA kunye nezinye izakhi zofuzo ezinxulumene-nomhlaza ziya zixhaphaka ngakumbi kwi umhlaza wedlala lesinyi ulawulo.Itheyibhile: Isishwankathelo soKhetho loNyango lwe-BRCA-mutated Prostate Cancer Treatment Option Inkcazo Ukufaneleka kwe-BRCA-mutated Prostate Cancer PARP Inhibitors Iziyobisi ezivimba i-enzyme ye-PARP, ukuthintela ukulungiswa kwe-DNA kwiiseli zomhlaza. Isebenza kakhulu, ngakumbi kumanqanaba aphezulu. Utyando Ukususwa kwedlala lengqula. Ilungele umhlaza wendawo; ukusebenza akunxulumananga ngokuthe ngqo nemo ye-BRCA. Unyango lweRadiation Ukusetyenziswa kwemitha ephezulu yamandla ukubulala iiseli zomhlaza. Iyasebenza, kodwa imeko ye-BRCA inokuchaphazela impendulo. Unyango lweHormone Yehlisa amanqanaba e testosterone ukucothisa ukukhula komhlaza. Unyango olusemgangathweni, ukusebenza akudityaniswanga ngokuthe ngqo kwisimo se-BRCA. I-Chemotherapy Ukusetyenziswa kwamachiza okubulala iiseli zomhlaza. Isetyenziswe kwizigaba eziphambili, isimo se-BRCA sinokuchaphazela impendulo. IsipheloUkuqonda ikhonkco phakathi Ufuzo lwe-BRCA kwaye umhlaza wedlala lesinyi kubalulekile ekuphuculeni ukuxilongwa, unyango, kunye neziphumo kubantu abachaphazelekayo. Uvavanyo lwemfuza, unyango olujoliswe kuyo njenge-PARP inhibitors, kunye nophando oluqhubekayo luvula indlela yobuqu kunye neendlela ezisebenzayo zokulawula. umhlaza wedlala lesinyi emadodeni ane I-BRCA iinguqulelo zemfuza. Amadoda anembali yosapho lwe umhlaza wedlala lesinyi okanye ezinye ii-cancer ezinxulumeneyo kufuneka zithathele ingqalelo uvavanyo lwemfuzo kwaye zixoxe ngeendlela zovavanyo ezifanelekileyo kunye nababoneleli bezempilo. Iingcali ezizinikeleyo kumaziko afana I-Shandong Baofa Cancer Research Institute, eyaziwa ngonyango lomhlaza, banegalelo elibonakalayo kwinkqubela phambili kulo mmandla.