China umhlaza webele negative kathathu

Ukuqonda kunye nokulawula uMhlaza wamabele kaThathu-Negative eTshayina

Esi sikhokelo sibanzi siphonononga ubunzima be China umhlaza webele kathathu-negative, enikezela ngengqiqo malunga nokuxhaphaka kwayo, ukuxilongwa, ukhetho lonyango olukhoyo e-China, kunye neenzame zophando eziqhubekayo. Singena kwinkqubela phambili yamva nje kwaye sixoxe ngokubaluleka kokufunyanwa kwangoko kunye nokhathalelo lomntu. Funda malunga nezibonelelo zenkxaso kunye nokuvela komhlaba we umhlaza webele one-triple-negative unyango ngaphakathi kwenkqubo yezempilo yaseTshayina.

Ukuxhaphaka kunye neMingcipheko ye-Triple-Negative Breast Cancer e-China

Ukuqonda uMhlaza wamabele kaThathu-Negative

Umhlaza webele one-triple-negative (TNBC) i-subtype yomhlaza wesifuba ongenayo inkcazo ye-receptors ezintathu: i-estrogen receptor (ER), i-progesterone receptor (PR), kunye ne-epidermal growth factor receptor 2 (HER2). Oku kungabikho kwenza ukuba kube ndlongondlongo kwaye kube nzima ukunyanga xa kuthelekiswa nezinye iintlobo zomhlaza wamabele. Ukunqongophala kwezi zamkeli kuthetha ukuba iindlela zonyango ekujoliswe kuzo azisebenzi, nto leyo efuna ukuthembela kwichemotherapy, utyando, kunye nemitha.

Ukuxhaphaka eTshayina

Ngelixa amanani achanekileyo esahluka, uphando lucebisa ukuba ukuxhaphaka kwe I-TNBC e-China iyathelekiseka okanye iphezulu kancinane kuneyabemi baseNtshona. Oku kugxininisa imfuneko yokwandisa ulwazi kunye nokufikelela okuphuculweyo kuxilongo kunye nonyango ngaphakathi kwenkqubo yezempilo yaseTshayina. Uphando olongezelelweyo lubalulekile ukuqonda imiba ethile yemfuza kunye nemeko yomngcipheko wokusingqongileyo enegalelo ekuxhaphakeni kwayo e-China.

Imiba yoMngcipheko

Ziliqela izinto ezandisa umngcipheko wokukhula I-TNBC, kubandakanywa nobudala obuncinane ekuxilongeni, i-BRCA1 / 2 yokuguqulwa kofuzo (uvavanyo lofuzo lunokunceda ukuchonga olu tshintsho), inzala yaseAfrika (nangona ifanelekile kwihlabathi jikelele, impembelelo yayo kwi-subpopulations ethile yaseTshayina ifuna uphando olongezelelweyo), kunye nembali yentsapho yomhlaza webele. Imiba yendlela yokuphila efana nokutyeba kakhulu kunye nokungabikho kokwenza umthambo nako kunokudlala indima. Kubalulekile ukubonisana nengcali yokhathalelo lwempilo ukwenza uvavanyo olulolwakho lomngcipheko.

Ukuxilongwa kunye noKhetho loNyango

Ukufunyaniswa Kwangethuba ngundoqo

Ukufunyaniswa kwangoko kuphucula kakhulu i-prognosis ye I-TNBC. Ukuzivavanya amabele rhoqo, i-mammograms (ingakumbi kubasetyhini abangaphezu kweminyaka engama-40), kunye nonyango olukhawulezileyo lwalo naluphi na utshintsho lwamabele lubalulekile. Iziko loPhando ngoMhlaza laseShandong Baofa (https://www.baofahospital.com/) ibonelela ngeenkonzo zokuxilonga ezikumgangatho ophezulu zomhlaza webele.

IiNdlela zoNyango

Unyango lwe I-TNBC ngokuqhelekileyo ibandakanya indibaniselwano yeendlela:

• Utyando: I-Lumpectomy okanye i-mastectomy, kuxhomekeke kubukhulu bethumba kunye nendawo.
• Unyango ngamachiza: Isetyenziselwa ukucutha amathumba phambi kotyando (neoadjuvant) okanye emva kotyando (adjuvant) ukuphelisa iiseli zomhlaza eziseleyo.
• Unyango ngemitha: Ijolise kwiiseli zomhlaza emva kotyando ukunqanda ukuphinda.
• Unyango olujolisiweyo: Ngelixa iindlela zonyango ezijoliswe kuzo zingasebenzi ngokuchasene I-TNBC ngenxa yokunqongophala kokubonakaliswa kwe-receptor, uphando oluqhubekayo luhlola iindlela zonyango ezijoliswe kuzo. Immunotherapy ikwayindawo ekhulayo yophando kunye nonyango.

Uphando oluQhubekayo kunye nezikhokelo zexesha elizayo

Iimvavanyo zeklinikhi kunye nokuqhubela phambili

Inkqubela ephawulekayo yenziwa ekuqondeni nasekunyangweni I-TNBC. Ulingo oluninzi lwezonyango luyaqhubeka e-China nakwihlabathi jikelele, luphanda amachiza amatsha kunye nezicwangciso zonyango. Olu lingo lunika ithemba kwiziphumo eziphuculweyo kunye nezicwangciso zonyango ezenzelwe wena.

Indima yeGenomics kunye neYeza eyenzelwe wena

Uhlalutyo lwe-Genomic lunceda ukuchonga utshintsho oluthile lwemfuza oluqhuba I-TNBC, ivula indlela yonyango lobuqu. Oku kuvumela unyango olulungelelanisiweyo olusekelwe kwiimpawu zesigulane ngasinye kunye neeprofayili zofuzo. Ikamva le I-TNBC unyango lulele kwiindlela zonyango ezichanekileyo.

Inkxaso kunye nezibonelelo

Ukujongana nokuxilongwa kwe I-TNBC kunokuba lucelomngeni. Amaqela enkxaso, iinkonzo zokucebisa, kunye nemibutho exhasa izigulane zinika uncedo oluxabisekileyo. Ukufikelela kulwazi oluthembekileyo kunye nenkxaso yezonyango eqhubekayo kubalulekile ekuhambeni kolu hambo. Khumbula, ukufunyanwa kwangoko kunye nokufikelela kukhathalelo lwempilo olusemgangathweni kunempembelelo enkulu kwiziphumo.

Ukuqukumbela

China umhlaza webele kathathu-negative inika imingeni ebalulekileyo, kodwa uphando oluqhubekayo kunye nokuhambela phambili kunyango kunika ithemba elitsha. Ukufunyaniswa kwangethuba, iindlela zonyango olulolwakho, kunye nofikelelo kwizixhobo ezixhasayo zibalulekile ekuphuculeni ubomi babantu abachatshazelwe lolu hlobo lomhlaza webele. I-Shandong Baofa Cancer Research Institute izinikele ekuboneleleni ngokhathalelo olubanzi noluphezulu kwizigulane ezine I-TNBC.