umhlaza wesibindi ubangela

Umhlaza wesibindi ubangela zintsonkothile kwaye zihlala zibandakanya indibaniselwano yezinto. Usulelo olungapheliyo kunye ne-hepatitis B okanye i-C, ukusetyenziswa kotywala obuninzi, kunye nesifo se-non-alcoholic fat fat (NAFLD) ziphakathi kweyona nto ibalulekileyo. Ukufunyaniswa kwangethuba kunye nokujongana nezi meko zisisiseko kubalulekile kuthintelo kunye neziphumo eziphuculweyo.Ukuqonda Umhlaza Wesibindi Umhlaza wesibindi, okwaziwa ngokuba ngumhlaza wesibindi, kwenzeka xa iiseli esibindini zingaqhelekanga kwaye zikhula ngaphandle kolawulo. Kukho iintlobo ezininzi zomhlaza wesibindi, kunye ne-hepatocellular carcinoma (HCC) eyona ixhaphakileyo. Ezinye iintlobo ziquka i-cholangiocarcinoma (umhlaza wombhobho webile) kunye ne-hepatoblastoma (umhlaza wabantwana onqabileyo). Iimbangela zoMhlaza Wesibindi kunye neRisk FactorsNangona oyena nobangela womhlaza wesibindi ungasoloko usaziwa, izinto ezininzi zomngcipheko zandisa kakhulu amathuba okuba sisifo. Ezi zibandakanya:Ukosuleleka kweHepatitis eZingapheliyo Usulelo olungapheliyo kunye nentsholongwane ye-hepatitis B (HBV) okanye intsholongwane ye-hepatitis C (HCV) iphambili. umhlaza wesibindi unobangela kwihlabathi jikelele. Ezi ntsholongwane zinokubangela ukudumba kwexesha elide kunye nomonakalo esibindini, ekugqibeleni kukhokelele kwi-cirrhosis kunye nomngcipheko wokwanda komhlaza. Ngokutsho koMbutho wezeMpilo weHlabathi (i-WHO), i-HBV kunye ne-HCV zifikelela kwi-80% yezehlo zomhlaza wesibindi kwihlabathi jikelele. [1]I-CirrhosisIsifo sesibindi, imeko ebonakala ngokukrala kwesibindi, ngomnye umngcipheko omkhulu. Inokubangelwa yimiba eyahlukeneyo, kubandakanywa i-hepatitis engapheliyo, ukusetyenziswa kotywala ngokugqithiseleyo, isifo sesibindi esingenalo utywala (NAFLD), kunye neemeko ezithile zofuzo. Ngokuhamba kwexesha, i-cirrhosis inokuphazamisa ukusebenza kwesibindi kwaye yandise kakhulu umngcipheko wokuphuhlisa umhlaza wesibindi.Ukusetyenziswa kotywala Ukusetyenziswa kakubi kotywala ngumngcipheko osekwe kakuhle wesifo sesibindi, kuquka i-cirrhosis kunye ne-cirrhosis. umhlaza wesibindi. Ukusela utywala ngokugqithisileyo kunokonakalisa iiseli zesibindi, nto leyo ekhokelela ekudumbeni nasekuqhawukeni. INational Institute on Alcohol Abuse and Alcoholism (NIAAA) ichaza ukusela kakhulu njengokusela iziselo ezingaphezu kwezine ngalo naluphi na usuku okanye ngaphezulu kweziselo ezili-14 ngeveki kumadoda, kunye neziselo ezingaphezu kwesithathu ngalo naluphi na usuku okanye ngaphezulu kweziselo ezisixhenxe ngeveki kubasetyhini. [2]I-Non-Alcoholic Fatty Liver Disease (NAFLD) kunye ne-NASHNon-alcoholic fatty disease (NAFLD) yimeko apho amanqatha aqokelela kwisibindi sabantu abaphuza utywala obuncinane okanye abangenayo. I-Nonalcoholic steatohepatitis (NASH) luhlobo olubi kakhulu lwe-NAFLD olubonakaliswa ngokukrala kunye nomonakalo weseli yesibindi. I-NAFLD kunye ne-NASH ziye zaqatshelwa ngakumbi njengemingcipheko ebalulekileyo ye-cirrhosis kunye umhlaza wesibindi, ngakumbi kumazwe asele ephuhlileyo.Ii-AflatoxinsIi-flatoxins ziityhefu eziveliswa kukungunda okuthile okunokonakalisa izityalo zokutya ezifana namandongomane, umbona, kunye nerayisi. Ukuba sesichengeni kwii-aflatoxins kuye kwanxulunyaniswa nomngcipheko owongeziweyo umhlaza wesibindi, ngakumbi kwimimandla apho oku kutya kusisityalo esisisiseko kunye neemeko zogcino zimbi. I-Arhente yamazwe ngamazwe yoPhando ngoMhlaza (IARC) ihlela i-aflatoxins njengeqela le-carcinogens yeQela. [3]Ezinye izinto zoMngcipheko Isifo seswekile: Abantu abanesifo sikashukela banomngcipheko ophezulu wokuphuhlisa i-NAFLD kunye nomhlaza wesibindi. Ukutyeba: Ukutyeba kakhulu ngumngcipheko we-NAFLD kunye ne-NASH, enokunyusa umngcipheko womhlaza wesibindi. Iimeko ezithile zemfuzo: Ezinye iimeko ezizuzwe njengelifa, njenge-hemochromatosis (i-iron overload), inokunyusa umngcipheko wesifo sesibindi kunye nomhlaza. Ukutshaya: Ukutshaya kuye kwanxulunyaniswa nomngcipheko owongeziweyo weentlobo ezahlukeneyo zomhlaza, kuquka umhlaza wesibindi. Ukusetyenziswa kweAnabolic Steroid: Ukusetyenziswa ixesha elide kwe-anabolic steroids kunokonakalisa isibindi kwaye kwandise umngcipheko womhlaza wesibindi. IVinyl Chloride Exposure: Ukubonakaliswa kwexesha elide kwi-vinyl chloride, ikhemikhali esetyenziswa kwimveliso yeeplastiki, inokunyusa umngcipheko wohlobo olunqabileyo lomhlaza wesibindi obizwa ngokuba yi-angiosarcoma. Umhlaza WesibindiNgelixa ingezizo zonke iimeko zomhlaza wesibindi ezinokuthintelwa, kukho amanyathelo amaninzi onokuwathatha ukunciphisa umngcipheko wakho: Ugonyo oluchasene neHepatitis BVaccination ngokuchasene ne-hepatitis B lusebenza kakhulu ekuthinteleni usulelo lwe-HBV kwaye, ngenxa yoko, ukunciphisa umngcipheko womhlaza wesibindi. I-WHO icebisa ukuba ugonyo lwe-hepatitis B lwehlabathi lonke kuzo zonke iintsana. [1]UThintelo noNyango lweHepatitis CAkukho sitofu sokugonya ihepatitis C, kodwa unyango olusebenzayo lukhona ukunyanga usulelo. Ukuhlolwa kwe-HCV kunye nokubonelela ngonyango kubantu abosulelekileyo kunokunceda ukuthintela ukukhula kwe-cirrhosis kunye nomhlaza wesibindi. [4]Ukunciphisa Ukusetyenziswa kotywala Ukunciphisa okanye ukuphelisa ukusetyenziswa kotywala kunokunciphisa kakhulu ingozi yesifo sesibindi kunye nomhlaza. Ukuba ukhetha ukusela utywala, yenza oko ngokumodareyitha.Ukugcina ubunzima obunempilo kunye nokutyaUkugcina ubunzima obunempilo kunye nokutya ukutya okunokulinganisela kunokunceda ukukhusela i-NAFLD kunye ne-NASH. Oku kuquka ukunciphisa ukuselwa kwakho kweziselo ezineswekile, ukutya okugayiweyo, kunye namafutha ahluthayo.Kuphephe Ukuvezwa kweAflatoxin Ukugcinwa ngokufanelekileyo kwezityalo zokutya kunganceda ukuthintela ukosuleleka kwe-aflatoxin. Hlola ukutya kokungunda ngaphambi kokusetyenziswa, kwaye ugweme ukutya ukutya okubonakala kungundo.Ukuhlolwa rhoqo kwabantu abaMngcipheko oPhezuluAbantu abane-hepatitis engapheliyo, i-cirrhosis, okanye ezinye izinto ezinobungozi bomhlaza wesibindi kufuneka zihlolwe rhoqo nge-ultrasound kunye ne-alpha-fetoprotein (AFP) yovavanyo lwegazi. Ukufunyanwa kwangethuba kunokuphucula iziphumo zonyango.Abaphandi abazinikeleyo kwi IZiko loPhando ngoMhlaza laseShandong Baofa sizimisele ukuqhubela phambili ukuqonda kwethu umhlaza wesibindi kunye nokuphucula iindlela zonyango. Ukuba unenkxalabo malunga nomngcipheko wakho womhlaza wesibindi, thetha nogqirha wakho malunga neendlela ezifanelekileyo zokuhlola kunye nokuthintela. Iziko lethu ligxile kuphando lomhlaza kunye nonyango, lizama ukwenza impembelelo ebalulekileyo kukhathalelo lwezigulane. Ukuze ufunde ngakumbi malunga IZiko loPhando ngoMhlaza laseShandong Baofa kunye nomsebenzi wethu, nceda undwendwele iwebhusayithi yethu. Ukuthelekiswa kweNqanaba eliPhambili loMhlaza weSibindi Imiba yoMngcipheko Umngcipheko Inkcazo Amaqhinga oThintelo I-Hepatitis B & C Izifo ezingapheliyo zentsholongwane ezibangela ukuvutha kwesibindi kunye nomonakalo. Ugonyo (HBV), unyango lwe-antiviral (HCV & HBV), iindlela ezikhuselekileyo zokutofa. Cirrhosis Ukukrala kwesibindi ngenxa yezizathu ezahlukeneyo (utywala, i-hepatitis, NAFLD). Lawula izizathu ezisisiseko (ukupheliswa kotywala, unyango lwe-antiviral, ulawulo lobunzima). Ukusela utywala ngokugqithisileyo ukusela utywala ngokugqithisileyo okukhokelela ekonakaleni kwesibindi. Nciphisa okanye uyeke ukusela utywala. I-NAFLD / NASH Ukuqokelela kwamafutha kunye nokuvuvukala esibindini (ngokuqhelekileyo kudibaniswa nokukhuluphala kunye nesifo sikashukela). Ukulawula ubunzima, ukutya okunempilo, ukulawula isifo sikashukela kunye ne-cholesterol. Ii-Aflatoxins Iityhefu eziveliswa kukungunda ekutyeni okungcolisekileyo. Ukugcinwa ngokufanelekileyo kokutya, kuphephe ukutya okungundayo. IiReferensi zeWorld Health Organisation. (2023, Julayi 19). IHepatitis B. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b Iziko leSizwe lokuSetyenziswa kakubi koTywala kunye nokuSetyenziswa koTywala. (n.d.). Yintoni Isiselo Esisemgangathweni?. https://www.niaaa.nih.gov/alcohol-health/overview-alcohol-consumption/what-standard-drink I-Arhente yeHlabathi yoPhando ngoMhlaza. (2012). I-IARC Monographs Volume 100B: Uvavanyo lwee-Polycyclic Aromatic Hydrocarbons ezintlanu kunye neNitroarenes ezithile. https://www.iarc.fr/fr/news-events/iarc-monographs-volume-100b-evaluation-of-five-polycyclic-aromatic-hydrocarbons-and-some-nitroarenes/ Amaziko oLawulo noThintelo lweZifo. (2024, Januwari 29). IHepatitis C. https://www.cdc.gov/hepatitis/hcv/index.htm