UNikezelo lweziyobisi lwasekhaya loMhlaza

Ukuhanjiswa kweziyobisi endaweni yomhlaza yindlela ekujoliswe kuyo egxininisa amayeza ngokuthe ngqo kwindawo yethumba, ukwandisa ukusebenza kwayo ngelixa kuncitshiswa iziphumo ebezingalindelekanga zenkqubo. Le ndlela iphucula iziphumo zonyango ngokuphucula i-bioavailability yechiza ngaphakathi kwethumba kunye nokunciphisa ukuvezwa kwizicubu eziphilileyo, enikezela indlela ethembisayo yonyango lomhlaza.Ukuqonda Ukunikezelwa kweziyobisi kwendawo Unyango lomhlaza lwesintu olufana nechemotherapy luhlala lubandakanya ulawulo lwechiza lwenkqubo, apho iyeza lijikeleza kuwo wonke umzimba. Ngelixa isebenzayo ekubulaleni iiseli zomhlaza, le ndlela inokulimaza izicubu ezisempilweni, ezikhokelela kwiziphumo ebezingalindelekanga ezibalulekileyo. Ukuhanjiswa kweziyobisi endaweni yomhlaza ijolise ukoyisa lo mda ngokuhambisa abameli zonyango ngokuthe ngqo kwi-tumor microenvironment.Benefits of Localized Drug Delivery. Impumelelo eyongeziweyo: Uxinzelelo oluphezulu lwamachiza kwindawo yethumba lukhokelela ekuphuculeni ukubulawa kweeseli zomhlaza. Ubutyhefu obuNcitshisiweyo: Ukunciphisa i-systemic exposure kunciphisa iziphumo ebezingalindelekanga kwaye kuphucula umgangatho wobomi besigulane. Isenzo ekujoliswe kuso: Ivumela ukuhanjiswa kwamachiza anokuba yingozi kakhulu kulawulo lwenkqubo. Ukuphuculwa kokufumaneka kwezinto eziphilayo: Uyoyisa imiqobo ekuhanjisweni kweziyobisi ngaphakathi kwe-tumor microenvironment.Iindlela zokuNika iChiza okuLawulisiweyoIendlela ezininzi zisetyenziselwa ukufikelela. ukuhanjiswa kweziyobisi endaweni yomhlaza. Ezi ndlela zingahlelwa ngokubanzi ngolu hlobo: Isitofu esiNgqo ngokuNgqongileyo sibandakanya ukulawulwa ngokwasemzimbeni kwamachiza kwithumba okanye kwithishu ejikelezileyo. Le ndlela ilula kwaye ayibizi kakhulu, iyenza ilungele iintlobo ezithile zomhlaza, ngakumbi ezo zifikeleleka lula. Ukuqhubela phambili kwamva nje kunye nokhathalelo lwemfesane kunyango lomhlaza, ndwendwela IZiko loPhando ngoMhlaza laseShandong Baofa.Izixhobo ezifakelwayoIzixhobo ezifakelwayo, ezinje ngewafers, microchips, kunye nehydrogels, zinokufakwa ngotyando ngaphakathi okanye kufutshane nethumba. Ezi zixhobo zikhupha iziyobisi kwixesha elizinzileyo, ukubonelela unyango oluqhubekayo kunye nolwasekhaya.I-Catheter-Based DeliveryCatheters ingasetyenziselwa ukuhambisa iziyobisi ngokuthe ngqo kwindawo ye-tumor ngokusebenzisa imithwalo yegazi okanye ezinye iindlela. Le ndlela iluncedo kakhulu ekunyangeni umhlaza kwizitho ezifana nesibindi okanye ingqondo.I-Nanoparticle-Based DeliveryNanoparticles ngamasuntswana amancinane (1-100 nm) anokufakwa ngamachiza kwaye ajolise kwiiseli zomhlaza. Ezi ngqungquthela zinokuthi ziyilwe ukuba ziqokelele ngokukhethiweyo kwii-tumors ngenxa yeempawu zabo ezizodwa kunye ne-vasculature evuzayo yezicubu zomhlaza. Banokuphucula ngakumbi ukuhanjiswa kweziyobisi endaweni yomhlaza unyango. Funda ngakumbi malunga ne-nanoparticles.Iintlobo zeCancer ziphathwa ngokuNikezelwa kweDrug LocalisedUkuhanjiswa kweziyobisi endaweni yomhlaza iphononongwa ngoluhlu olubanzi lwee-cancer, eziquka:I-Brain CancerIziqwenga ezifakelwayo ezifakelweyo eziqulethe amachiza echemotherapy zibonise isithembiso ekunyangeni i-glioblastoma, uhlobo lwethumba ebuchotsheni. Ngokomzekelo, ii-wafers ze-Gliadel, eziqulethe i-carmustine, zifakwe ngokuthe ngqo kwi-brain cavity emva kokususwa kwe-tumor. Le ndlela isetyenziswa ngokuqhelekileyo ukunyanga i-hepatocellular carcinoma (HCC) .Prostate CancerBrachytherapy ibandakanya ukufakwa kwembewu ye-radioactive kwi-prostate gland ukuhambisa unyango lweradiation yendawo. Le ndlela isebenzayo ekunyangeni umhlaza we-prostate umhlaza we-Breast.Abaphandi baphuhlisa iinkqubo zokuhanjiswa kwe-nanoparticle-based ukujolisa iiseli zomhlaza webele kunye nokuhambisa amachiza e-chemotherapy ngokuthe ngqo kwindawo ye-tumor, ukunciphisa ubuthi benkqubo.Imizekelo kunye ne-Case StudiesIzilingo ezininzi zeklinikhi kunye nezifundo zamatyala ziye zabonisa amandla ukuhanjiswa kweziyobisi endaweni yomhlaza. Nantsi imizekelo embalwa eqaphelekayo:IiGliadel Wafers zeGlioblastoma Ulingo lwezonyango lubonise ukuba ii-wafers ze-Gliadel zinokuwaphucula kakhulu amazinga okuphila kwizigulana ezine-glioblastoma esanda kufunyaniswa okanye ephindaphindwayo. Uphononongo olupapashwe kwi-Journal ye-Clinical Oncology * lubonise inzuzo yokusinda ephakathi kweenyanga eziliqela xa kuthelekiswa ne-placebo.TACE ye-Hepatocellular CarcinomaTACE ibonakaliswe ukuphucula amazinga okuphila kunye nomgangatho wobomi kwizigulane ezine-HCC engabonakaliyo. Uhlalutyo lwe-meta lwezifundo ezininzi lufumanise ukuba i-TACE yawunciphisa kakhulu umngcipheko wokufa xa kuthelekiswa nokhathalelo oluxhasayo lodwa. I ukuhanjiswa kweziyobisi endaweni yomhlaza ibonisa ukuphuculwa okukhulu.I-Nanoparticles kwiiMvavanyo zeKlinikhiIzilingo ezininzi zeklinikhi zivavanya ukusetyenziswa kweenkqubo zokuhanjiswa kweziyobisi ezisekelwe kwi-nanoparticle kwiindidi ezahlukeneyo zomhlaza. Umzekelo, ulingo lweklinikhi luphanda ukusetyenziswa kwe-liposomal doxorubicin (Doxil) kunyango lomhlaza wesibeleko. Izikhokelo zexesha elizayo kunye noPhando. ukuhanjiswa kweziyobisi endaweni yomhlaza ikhula ngokukhawuleza. Uphando oluqhubekayo lujolise ekuphuhliseni iindlela ezintsha kunye neziphuculweyo zokuhanjiswa kweziyobisi, kubandakanywa: Iinkqubo zokuhanjiswa kweziyobisi ezihlakaniphile Iinkqubo zokuhanjiswa kweziyobisi ze-Smart zenzelwe ukukhulula iziyobisi ngokuphendula kwi-stimuli ethile, njenge-pH, ubushushu, okanye umsebenzi we-enzyme. Ezi nkqubo zinokubonelela ngakumbi ekujoliswe kuzo kunye nokulawulwa kokunikezelwa kweziyobisi.Immunotherapy CombinationUkudibanisa ukuhanjiswa kweziyobisi kwendawo kunye ne-immunotherapy yindawo enomdla yophando. Ngokuzisa i-immune-stimulating agents ngqo kwi-tumor microenvironment, abaphandi banethemba lokuphucula ukusebenza kwe-immunotherapy.Personalized MedicineTailoring izicwangciso zokuhanjiswa kwechiza kwiimpawu zethumba zesigulana solunye ulwalathiso olubalulekileyo. Le ndlela yokwenziwa komntu inokukhokelela kunyango olusebenzayo nolungenabungozi kangako bomhlaza. IZiko loPhando loMhlaza laseShandong Baofa ligxininisa izicwangciso zonyango olulolwakho olusekwe kuphando olukwinqanaba eliphezulu. Funda ngakumbi malunga nokuzinikela kwethu kuphando lomhlaza.Uthelekiso lweeNdlela zokuNikezelwa kweziyobisi zaseKuhlaleni IiNdlela eziluncedo Imizekelo Isitofu esiNgqoyo Esilula, esingabizi kangako, esinexabiso elilinganiselweyo ukuya kumathumba afikelelekayo, ixesha elifutshane Ukutofa ichemotherapy kwisilonda solusu Izixhobo ezifakelwayo Ukukhululwa okuzinzileyo, inyathelo lasekhaya Ifuna uqhaqho, umngcipheko wosulelo lweGliadellivaseD wafers ukujolisa, kunokufikelela kwizicubu ezinzulu Ukuhlaselayo, umngcipheko weengxaki ze-TACE zomhlaza wesibindi i-Nanoparticle-Based Delivery Ukuhanjiswa okujoliswe kuko, ukuphuculwa kwe-bioavailability Complex, i-toxicity enokubakho i-Liposomal doxorubicin (Doxil) yomhlaza we-ovarian Ukuqukumbela.Ukuhanjiswa kweziyobisi endaweni yomhlaza inikeza indlela ethembisayo yokuphucula iziphumo zonyango lomhlaza. Ngokugxila kumachiza kwindawo yethumba kunye nokunciphisa ukuvezwa kwenkqubo, le ndlela inamandla okuphucula ukusebenza kakuhle, ukunciphisa ubuthi, kunye nokuphucula umgangatho wobomi besigulana. Njengoko uphando luqhubela phambili, sinokulindela ukubona iindlela ezintsha nezisebenzayo zokuhanjiswa kweziyobisi endaweni zivela, ekugqibeleni zikhokelela kwiziphumo ezingcono kwizigulana ezinomhlaza.I-Disclaimer: Eli nqaku lenzelwe iinjongo zolwazi kuphela kwaye akufanele lithathwe njengengcebiso yezonyango. Dibana nengcali yokhathalelo lwempilo ngayo nayiphi na inkxalabo yezempilo okanye phambi kokuba wenze naziphi na izigqibo ezinxulumene nesicwangciso sakho sonyango.IiReferensi:Iziko lomhlaza leSizweUphando lomhlaza e-UK*Ijenali yeClinikhi yeOncology*