umhlaza webele we-metastatic

Umhlaza webele weMetastatic, ekwaziwa ngokuba yinqanaba le-IV lomhlaza wamabele, ngumhlaza wamabele oye wasasazeka ngaphaya kwebele kunye ne-lymph nodes ezikufutshane ukuya kwamanye amalungu omzimba. Nangona inganyangeki, iyanyangeka. Unyango lunokulawula umhlaza, lulawule iimpawu, kwaye luphucule umgangatho wobomi. Kugxilwe ekucutheni ukukhula nokusasazeka komhlaza, ukuthomalalisa iimpawu, kunye nokunceda izigulane ziphile ixesha elide kwaye ngokukhululeka kangangoko kunokwenzeka. Yintoni uMhlaza weMetastatic Breast?Umhlaza webele weMetastatic kwenzeka xa iiseli zomhlaza wamabele zigqabhuka zisuka kwithumba lokuqala ebeleni kwaye zihambe ngegazi okanye inkqubo ye-lymphatic ukuya kwamanye amalungu omzimba. Ezi seli zinokuthi ke zenze amathumba amatsha kwamanye amalungu, njengamathambo, imiphunga, isibindi, okanye ubuchopho.Ukhula Njani Umhlaza Webele?Inkqubo yemetastasis intsonkothile kwaye ibandakanya amanyathelo aliqela: Iqela: Iiseli zomhlaza ziyazisusa kwithumba eliphambili. Uhlaselo: Iiseli zomhlaza zihlasela izicubu ezijikelezileyo. Ukungena kuSaziso: Iiseli zomhlaza zingena kwigazi okanye inkqubo ye-lymphatic. Ukusinda kuMjikelezo: Iiseli zomhlaza ziphila kuhambo ngegazi okanye inkqubo ye-lymphatic. Ukubanjwa kunye nokongezwa: Iiseli zomhlaza zimisa kwimithambo yegazi emincinci okanye i-lymph nodes kwizitho ezikude kwaye ziphume kwinqanawa. Ukwenziwa kwamathanga: Iiseli zomhlaza ziqala ukukhula kwindawo entsha, zenza ithumba elitsha. Ayizizo zonke iiseli zomhlaza wamabele eziqhawulayo kwithumba eliphambili ziya kuphumelela ukwenza i-metastases. Amajoni omzimba adla ngokutshabalalisa ezi seli phambi kokuba zibe nethuba lokukhula.Iimpawu zeMetastatic Breast Cancer umhlaza webele we-metastatic ziyahluka ngokuxhomekeke apho umhlaza unwenwe khona. Ezinye iimpawu eziqhelekileyo ziquka: I-metastases yamathambo: Iintlungu zamathambo, iifractures, ukuqunjelwa, amanqanaba aphezulu e-calcium. Imetastases emiphungeni: Ukuphefumula okufutshane, ukukhohlela, intlungu yesifuba. I-metastases yesibindi: Ubuhlungu besisu, i-jaundice, ukuvuvukala kwisisu, ukukhathala, ukulahlekelwa ngumdla. Imetastases yobuchopho: Intloko ebuhlungu, ukuxhuzula, iingxaki zombono, ubuthathaka, ukutshintsha ubuntu okanye ukuziphatha. Kubalulekile ukuqaphela ukuba abanye abantu umhlaza webele we-metastatic ayinakufumana naziphi na iimpawu, ngakumbi kumanqanaba okuqala e-metastasis. Ukujongwa rhoqo kunye nemifanekiso kubalulekile ekubhaqeni i-metastases kwangethuba. Ukuxilongwa kweMetastatic Breast CancerUmhlaza webele weMetastatic Ngokuqhelekileyo kufunyaniswa ngendibaniselwano yovavanyo lokucinga kunye ne-biopsies.Uvavanyo lomfanekiso Uvavanyo lwemifanekiso oluqhelekileyo olusetyenziselwa ukufumanisa i-metastases lubandakanya: Ukuskena amathambo: Ufumanisa ukungahambi kakuhle kwamathambo. CT scan: Inika imifanekiso eneenkcukacha yamalungu angaphakathi. I-MRI: Inika imifanekiso eneenkcukacha yezicubu ezithambileyo. PET scan: Ifumanisa iindawo zokwanda komsebenzi we-metabolic, ezinokubonisa umhlaza. X-reyi: Ifumanisa izinto ezingaqhelekanga emathanjeni nasemiphungeni.I-BiopsyUkuxilongwa kwe-biopsy ibandakanya ukuthatha isampulu yethishu kwindawo ekurhaneleka ukuba yimetastatic kwaye iyivavanye phantsi kwemakroskopu. Le kuphela kwendlela yokuqinisekisa ngokuqinisekileyo ukuba umhlaza usasazekile kwaye ufumanise iimpawu zeeseli ze-metastatic, ezinokuchaphazela izigqibo zonyango. I-biopsy iqinisekisa ukuba umhlaza umhlaza webele we-metastatic. Ngokuqhelekileyo i-immunohistochemistry isetyenziselwa ukuchonga ukuba umhlaza uvakalisa i-hormone receptors (ER / PR) okanye i-HER2. IiKhetho zoNyango lweMetastatic Breast CancerWhile umhlaza webele we-metastatic ayinyangeki, iyanyangeka. Iinjongo zonyango kukulawula ukukhula komhlaza, ukulawula iimpawu, kunye nokuphucula umgangatho wobomi. Ukhetho lonyango lunokubandakanya: Unyango lweHormone: Isetyenziselwa umhlaza webele we-hormone receptor-positive. Imizekelo ibandakanya i-tamoxifen, i-aromatase inhibitors (efana ne-anastrozole, i-letrozole, kunye ne-exemestane), kunye nokunyanzeliswa kwe-ovarian. Unyango olujolisiweyo: Kujoliswe kwiiprotheyini ezithile okanye iindlela ezibandakanyekayo ekukhuleni komhlaza. Imizekelo ibandakanya unyango olujoliswe ku-HER2 (olufana ne-trastuzumab, i-pertuzumab, kunye ne-T-DM1) kunye ne-CDK4/6 inhibitors (ezifana ne-palbociclib, i-ribociclib, kunye ne-abemaciclib). Unyango ngamachiza: Usebenzisa iziyobisi ukubulala iiseli zomhlaza. I-Immunotherapy: Inceda amajoni omzimba ukulwa umhlaza. Unyango ngemitha: Isebenzisa imitha ephezulu yamandla ukubulala iiseli zomhlaza okanye ukukhulula iimpawu ezinjengeentlungu. Utyando: Isenokusetyenziselwa ukususa imetastases nganye okanye ukuthomalalisa iimpawu.Ukhetho lonyango luxhomekeke kwizinto eziliqela, kuquka uhlobo lomhlaza wamabele, indawo kunye nobungakanani bemetastases, impilo yesigulana iyonke, kunye nezinto abazikhethayo. Izicwangciso zonyango zihlala zihlengahlengiswa ngokuhamba kwexesha njengoko umhlaza uphendula okanye uqhubela phambili. IZiko loPhando ngoMhlaza laseShandong Baofa izinikele ekuqhubeleni phambili ukhetho lonyango lomhlaza kunye nokuphucula iziphumo zesigulana ngophando olutsha kunye nokhathalelo olunovelwano.Ukuphila ngeMetastatic Breast CancerUkuhlala nomhlaza webele weMetastatic. umhlaza webele we-metastatic kunokuba lucelomngeni, ngokwasemzimbeni nangokweemvakalelo. Kubalulekile ukuba nenkqubo yenkxaso eyomeleleyo endaweni, kubandakanywa usapho, izihlobo, kunye nabasebenzi bezempilo. Nantsi imiba ebalulekileyo ekufuneka iqwalaselwe: Ukulawula iimpawuUlawulo lweempawu olusebenzayo lubalulekile ekugcineni umgangatho wobomi. Oku kunokubandakanya amayeza eentlungu, amayeza achasene nesicaphucaphu, kunye nolunye unyango oluxhasayo. umhlaza webele we-metastatic kunokuba nzima. Amaqela enkxaso, ukucebisa, kunye nonyango lunokunceda izigulane zijamelane neemvakalelo zokuxhalaba, ukudakumba, kunye noloyiko.Ukugcina indlela yokuphila enempiloUkugcina indlela yokuphila enempilo, kuquka ukutya ukutya okunokulinganisela, ukuzivocavoca rhoqo, kunye nokulala ngokwaneleyo, kunokunceda ukuphucula amanqanaba omandla kunye nokuphila kakuhle. Inokubonelelwa ngalo naliphi na inqanaba lesi sifo kwaye isoloko idityaniswa nolunye unyango.Iprognosis yeMetastatic Breast CancerI-prognosis for umhlaza webele we-metastatic iyahluka ngokuxhomekeke kwizinto eziliqela, kuquka uhlobo lomhlaza wamabele, indawo nobungakanani bemetastases, nendlela umguli asabela ngayo kunyango. Ngelixa umhlaza webele we-metastatic ayinyangeki, abantu abaninzi baphila iminyaka emininzi nesi sifo. Inkqubela phambili kunyango iphucule kakhulu izinga lokusinda kunye nomgangatho wobomi kwizigulane ezine umhlaza webele we-metastatic. Ngokutsho kwe-American Cancer Society, izinga leminyaka emi-5 lokusinda kwabasetyhini abanomhlaza webele we-metastatic yi-29%. Oku kuthetha ukuba i-29 kwi-100 yabasetyhini abanomhlaza webele we-metastatic basaphila kwiminyaka emi-5 emva kokuba befunyaniswe. ImiNyaka emi-5 yokuPhila okuNxulumeneyo kumanqanaba oMhlaza wamabele iNqanaba leMinyaka emi-5 yokuPhila okuNxulumeneyo lweMinyaka eKuhlala i-99% yoMmandla 86% Ukude (Metastatic) 29% Umthombo: Umbutho womhlaza waseMelikaUphando kunye nokuqhubela phambili kwiMetastatic Breast CancerUphando oluqhubekayo lugxile ekuphuhliseni unyango olutsha nolusebenzayo ngakumbi. umhlaza webele we-metastatic. Iinkalo zophando ziquka: Unyango olutsha ekujoliswe kulo: Ukujolisa iimolekyuli ezithile ezibandakanyekayo ekukhuleni komhlaza kunye nokusasazeka. I-Immunotherapy: Ukuqinisa amandla amajoni omzimba ukulwa umhlaza. Iyeza elenzelwe wena: Ukulungelelanisa unyango kwiimpawu zomntu ngamnye zomhlaza wesigulane ngasinye. Ukufunyanwa kwangoko: Ukuphuhlisa iindlela ezintsha zokubona i-metastases kwangethuba, xa zinyangeka ngakumbi. Ezi nkqubela zinika ithemba lokuphucula iziphumo kunye nomgangatho wobomi babantu abahlala nabo. umhlaza webele we-metastatic.