isigaba 1b unyango lomhlaza wemiphunga

Inqanaba 1B isigaba 1b unyango lomhlaza wemiphunga ngokuqhelekileyo kubandakanya utyando ukususa ithumba. I-Adjuvant chemotherapy inokucetyiswa emva kotyando ukunciphisa umngcipheko wokuphindaphinda. Unyango lwemitha ngamanye amaxesha lusetyenziswa ukuba utyando alukho ukhetho okanye ukuba ithumba alinakususwa ngokupheleleyo. Ukuqonda olu khetho kubalulekile ukwenza izigqibo ezinolwazi kunye neqela lakho lezempilo. I-Shandong Baofa Cancer Research Institute izibophelele ekuboneleleni ngolwazi oluphangaleleyo kunye nenkxaso kwizigulana neentsapho zazo.Ukuqonda iNqanaba 1B Umhlaza WemiphungaYintoni inqanaba 1B loMhlaza weMiphunga?Inqanaba 1b umhlaza wemiphunga luhlobo lomhlaza wemiphunga weseli engeyiyo encinci (NSCLC). Kuthetha ukuba umhlaza unwenwele ngaphaya komgca wemiphunga kodwa usahlala kwindawo. Ngokukodwa, ithumba likhulu kune-3 cm kodwa alikho ngaphezu kwe-4 cm. Kweli nqanaba, umhlaza awusasazeki kwii-lymph nodes ezikufutshane okanye kwiindawo ezikude. Ukufunyaniswa kwangoko kunye nonyango olukhawulezileyo lubalulekile kwiziphumo ezingcono. Ukufumana iinkcukacha ezithe vetshe kunye nokuqonda kophando, ungandwendwela IZiko loPhando ngoMhlaza laseShandong Baofa.Ukuxilongwa kweNqanaba loku-1B loMhlaza weMiphunga isigaba 1b somhlaza wemiphunga Ibandakanya indibaniselwano yovavanyo lokucinga kunye ne-biopsies. Iinkqubo zoxilongo eziqhelekileyo ziquka:X-reyi yesifuba: Rhoqo luvavanyo lokuqala lokujonga ukufumanisa izinto ezingaqhelekanga kwimiphunga.CT Scan: Ibonelela ngemifanekiso eneenkcukacha ezininzi zemiphunga kunye nezakhiwo ezingqongileyo.I-PET Scan: Inokunceda ukuchonga iindawo zokwanda komsebenzi we-metabolic, ebonisa umhlaza.Ibronchoscopy: Inkqubo apho ityhubhu ebhityileyo, ebhetyebhetye enekhamera ifakwe kwimizila yomoya ukujonga imiphunga kwaye iqokelele iisampulu zethishu.I-Biopsy: Isampuli yezicubu zemiphunga iyathathwa kwaye ihlolwe phantsi kwe-microscope ukuqinisekisa ubukho beeseli zomhlaza. Oku kunokwenziwa ngebronchoscopy, inaliti biopsy, okanye utyando.Unyango oKhetho lweNqanaba loku-1B lomhlaza wemiphunga Utyando lolona nyango luphambili isigaba 1b somhlaza wemiphunga xa isigulane sisempilweni ngokwaneleyo ukuba singene kwinkqubo. Injongo kukususa i-tumor yonke kunye nomda wezicubu eziphilileyo. Iinkqubo zotyando eziqhelekileyo ziquka:Lobectomy: Ukususwa kwe-lobe yonke yomphunga apho i-tumor ikhona.Ukuhlanjululwa kwemikhono: Ukususwa kwecandelo lendlela yomoya (bronchus) kunye nethumba.Ukususwa kweWedge/Segmentectomy: Ukususwa kwenxalenye encinci yomphunga. Ezi azixhaphakanga kangako isigaba 1b somhlaza wemiphunga kodwa inokuqwalaselwa ukuba isigulane sinezinye iingxaki zempilo ezenza ukuba i-lobectomy ibe yingozi kakhulu.Inyumoniya: Ukususwa komphunga wonke. Oku kunqabile ukuba kuyimfuneko isigaba 1b somhlaza wemiphunga.I-Adjuvant Chemotherapy I-chemotherapy ye-Adjuvant idla ngokucetyiswa emva kotyando ukuze kubulawe naziphi na iiseli zomhlaza eziseleyo ezinokuthi zingabonakali kwizikena. Oku kunciphisa umngcipheko wokuphindaphinda. Irejimeni ethile yechemotherapy iya kuxhomekeka kwizinto ezininzi, kubandakanywa uhlobo lomhlaza wemiphunga, impilo yesigulana iyonke, kunye nengcebiso kagqirha wotyando. Iziyobisi eziqhelekileyo ze-chemotherapy ezisetyenziselwa i-NSCLC ziquka i-cisplatin, i-carboplatin, i-paclitaxel, i-docetaxel, kunye ne-gemcitabine.Unyango lwe-Radiation TherapyRadiation therapy isebenzisa imitha ephezulu yamandla ukubulala iiseli zomhlaza. Isenokusetyenziswa kwiimeko ezithile, ezinje:Ukuba isigulana asingomgqatswa olungileyo wotyando.Ukuba ithumba alinakususwa ngokupheleleyo ngexesha lotyando.Njengokhathalelo lokuthomalalisa ukuthomalalisa iimpawu.Iintlobo zonyango lwemitha ziquka:Unyango lweBeam Radiation yangaphandle (EBRT): Imitha ihanjiswa kumatshini ongaphandle komzimba.Unyango lweRadiation Body Stereotactic (SBRT): Indlela echane ngakumbi yonyango lwemitha olunikezela ngeedosi eziphezulu zokusasazeka kwemitha kwindawo encinci.Amachiza onyango ekuJoliswe kuwo ajolise kwizinto ezingaqhelekanga kwiiseli zomhlaza. La machiza akasebenzi kuzo zonke izigulane ezine isigaba 1b somhlaza wemiphunga, kodwa zinokuba lukhetho ukuba iiseli zomhlaza zineenguqu ezithile. Iithagethi eziqhelekileyo ziquka i-EGFR, i-ALK, kunye ne-ROS1. Uvavanyo luyafuneka ukufumanisa ukuba umhlaza unalo na olu tshintsho. Thetha neqela ku IZiko loPhando ngoMhlaza laseShandong Baofa ukuhlola iindlela zonyango. ImmunotherapyImmunotherapy amayeza anceda amajoni omzimba ukulwa umhlaza. La machiza anokuba lukhetho lwezinye izigulane ezine isigaba 1b somhlaza wemiphunga, ngakumbi ukuba umhlaza unamanqanaba aphezulu e-PD-L1. Amachiza aqhelekileyo e-immunotherapy aquka i-pembrolizumab, i-nivolumab, kunye ne-atezolizumab.I-Prognosis kunye namazinga okusinda kwiSigaba 1B soMhlaza weMiphuphu. isigaba 1b somhlaza wemiphunga ilungile ngokubanzi, ngakumbi ukuba ithumba lisuswe ngokupheleleyo ngotyando. Izinga lokusinda leminyaka emi-5 ye isigaba 1b somhlaza wemiphunga malunga ne-60-70%. Oku kuthetha ukuba 60-70% yabantu abane isigaba 1b somhlaza wemiphunga basaphila iminyaka emi-5 emva kokuxilongwa.Imiba emininzi inokuchaphazela uqikelelo, kubandakanywa:Impilo yesigulana iyonkeUbukhulu kunye nendawo yethumbaUkuba umhlaza unwenwele kwii-lymph nodes ezikufutshaneUhlobo lomhlaza wemiphungaUnyango olufunyenweIziphumo ezisecaleni zonyangoLonke unyango lomhlaza lunokubangela iziphumo ebezingalindelekanga. Iziphumo ezithile ebezingalindelekanga ziya kuxhomekeka kuhlobo lonyango, ithamo, kunye nempilo yonke yesigulane. Iziphumo ebezingalindelekanga eziqhelekileyo zotyando ziquka iintlungu, usulelo, nokopha. Iziphumo ebezingalindelekanga eziqhelekileyo zechemotherapy ziquka isicaphucaphu, ukuhlanza, ukudinwa, nokulahleka kweenwele. Iziphumo ebezingalindelekanga eziqhelekileyo zonyango lwemitha ziquka ukucaphuka kwesikhumba, ukudinwa, kunye nobunzima bokugwinya.Izilingo zeKlinikhi zeSigaba 1B somhlaza wemiphungaUlingo lweClinical luphononongo lophando oluvavanya unyango olutsha okanye iindlela ezintsha zokusebenzisa unyango olukhoyo. Izigulane ezine isigaba 1b somhlaza wemiphunga unokufuna ukucinga ngokuthatha inxaxheba kulingo lwezonyango. Ulingo lwezonyango lunokunikezela ngofikelelo kunyango olukwinqanaba eliphezulu olungekafumaneki ngokubanzi. Ukufumana ulwazi oluthe kratya malunga nolingo lwezonyango, thetha nogqirha wakho okanye undwendwele iwebhusayithi yeZiko loMhlaza leSizwe. isigaba 1b somhlaza wemiphunga kunokuba lucelomngeni, ngokwasemzimbeni nangokweemvakalelo. Kubalulekile ukuba kubekho inkqubo yenkxaso eyomeleleyo. Oku kunokubandakanya amalungu osapho, abahlobo, amaqela enkxaso, kunye nabasebenzi bezempilo. Nanga amanye amacebiso okuphila nawo isigaba 1b somhlaza wemiphunga:Yitya ukutya okunempilo.Zilolonge rhoqo.Lala ngokwaneleyo.Lawula uxinzelelo.Dibanisa neqela lenkxaso.Thetha nogqirha wakho ngazo naziphi na izinto ezikuxhalabisayo.Landelela iNkathaleloEmva konyango isigaba 1b somhlaza wemiphunga, kubalulekile ukuba ube nexesha lokulandelelana rhoqo kunye nogqirha wakho. Oku kuqeshwa kunokubandakanya iimvavanyo zomzimba, iimvavanyo zemifanekiso, kunye novavanyo lwegazi. Injongo yokunyamekela okulandelwayo kukubeka iliso kuzo naziphi na iimpawu zokuphindaphinda kunye nokulawula nayiphi na imiphumo yexesha elide yonyango.Iingqwalasela eziphambili kunye nemibuzo yokubuza uGqirha wakhoXa uxoxa. isigaba 1b unyango lomhlaza wemiphunga ukhetho kunye nogqirha wakho, cinga ngokubuza le mibuzo ibalulekileyo:Ziziphi iingenelo kunye nobungozi bokhetho ngalunye lonyango?Ziziphi iziphumo ebezingalindelekanga zonyango ngalunye?Siyintoni isiphumo esilindelekileyo kunyango ngalunye?Unyango luya kuwuchaphazela njani umgangatho wobomi bam?Sithini isicwangciso sokhathalelo olulandelelweyo emva konyango?Ngaba kukho naziphi na iimvavanyo zeklinikhi ekufuneka ndiziqwalasele? Ukwenza izigqibo ezinolwazi malunga nonyango lwakho? isigaba 1b unyango lomhlaza wemiphunga kufuna ukuqwalaselwa ngononophelo kunye nonxibelelwano oluvulekileyo neqela lakho lezempilo. Ulwazi olunikelwe apha lujongwe njengesikhokelo jikelele kwaye akufuneki luthathe indawo yengcebiso yezonyango. I-Shandong Baofa Cancer Research Institute ibonelela ngezixhobo ezinokukunceda.Inqanaba lokusinda kwiTheyibhile ye-5-year Survival Rate Stage 1A Umhlaza wemiphunga malunga ne-70-90% Inqanaba 1B Umhlaza wemiphunga Malunga ne-60-70% inqanaba lesi-2 loMhlaza weMiphunga Malunga ne-40-60% Qaphela: Amazinga okusinda ayaqikelelwa kwaye anokwahluka ngokusekelwe kwizinto ngamnye.