IZibhedlele zoNyango eziNika iziyobisi

UNyango oluZinzileyo loNikezelo lweziyobisi kwizibhedlele

Eli nqaku libonelela ngesishwankathelo esibanzi sonyango lokuhanjiswa kweziyobisi oluzinzileyo (SRDD) kunye nezicelo zalo ngaphakathi kwezicwangciso zesibhedlele. Siza kuphonononga iintlobo ngeentlobo zeenkqubo ze-SRDD, izinto eziluncedo nezingeloncedo, kunye nendima ebalulekileyo eziyidlalayo ekuphuculeni iziphumo zesigulana. Siza kuphinda sijonge izinto eziqwalaselwayo kwizibhedlele ezisebenzisa unyango lwe-SRDD.

Yintoni iSustained Release Delivery Therapy?

Ukukhululwa konyango lokunikezelwa kweziyobisi, okwakwaziwa njengokukhululwa okulawulwayo okanye unyango olukhutshwayo olwandisiweyo, lubandakanya ukunika iyeza ngendlela ethi ngokuthe ngcembe ikhuphe iyeza kwithuba elide. Oku kuchasene nemixube ekhutshwe kwangoko, apho iyeza likhutshwa ngokukhawuleza. I-SRDD ijolise ekugcineni ukugxininiswa kweyeza zonyango ixesha elide, ukunciphisa ukuphindaphinda kolawulo kunye nokuphucula ukuthotyelwa kwesigulane. Le ndlela iluncedo kakhulu kumachiza anobomi obufutshane obufutshane okanye lawo afuna idosi rhoqo. Iinzuzo zinwenwela ekuphuculweni kwentuthuzelo yesigulana kunye neziphumo ebezingalindelekanga ezinokuncitshiswa ezinxulunyaniswa nokuguquguquka kwamanqanaba echiza.

Iindidi zokuKhupha okuZinzileyo kweNkqubo yokuhanjiswa kweziyobisi

Iinkqubo ezininzi ze-SRDD zikhona, nganye ineempawu ezizodwa:

Iimpompo ezifakelwayo

Iimpompo ezifakelwayo zibonelela ngokukhululwa okuqhubekayo kunye nokulawulwa kwamayeza. Ezi zihlala zisetyenziselwa ukulawula amayeza afuna idosi echanekileyo ixesha elide, elifana nolawulo lweentlungu okanye ichemotherapy.

Iimatriki

Iinkqubo zeMatrix zibandakanya ichiza ngaphakathi kwepolymer matrix ekhupha ichiza ngokucothayo ekuhambeni kwexesha. Izinga lokukhululwa lixhomekeke kwizinto ezifana neempawu zepolymer kunye nokunyibilika kwechiza.

Iinkqubo zamadama

Iisistim zamadama zigquma iyeza ngaphakathi kwesikhongozeli, kunye nenwebu engene ngaphakathi elawula izinga lokukhululwa. Ezi nkqubo zinokubonelela ngeprofayile yokukhululwa engaguqukiyo kuneenkqubo zematrix.

I-Liposomes kunye neNanoparticles

I-Liposomes kunye ne-nanoparticles zi-microscopic vesicles okanye amaqhekeza afaka iziyobisi. Banikezela ngonikezelo olujoliswe kuyo, ukwandisa ukuxinana kweziyobisi kwindawo yesenzo kunye nokunciphisa iziphumo ebezingalindelekanga.

Izinto eziluncedo kwi-SRDD kwizibhedlele

Ukuphunyezwa kwe Ukukhutshwa okuzinzileyo konyango lokuhanjiswa kweziyobisi kwizibhedlele zibonelela ngeenzuzo ezininzi eziphambili:

• Ukuphuculwa kokuthotyelwa kwesigulana ngokunciphisa i-dosing frequency
• Ukuphucula ukusebenza konyango ngokugcina amanqanaba angaguqukiyo amachiza
• Iziphumo ebezingalindelekanga ezincitshisiweyo ezinxulumene nokuguquguquka koxinzelelo lweziyobisi
• Umgangatho wobomi obuphuculweyo kwizigulane, ngakumbi ezo zineemeko ezingapheliyo
• Ukubanakho ukongiwa kweendleko ngenxa yokuhla kokuhlala esibhedlele kunye nolawulo lwamayeza

Imingeni kunye neeNgqwalasela zeZibhedlele

Ngaphandle kweenzuzo, ukuphumeza i-SRDD ezibhedlele kuzisa imingeni:

• Iindleko zokuqala eziphezulu zeenkqubo ze-SRDD xa kuthelekiswa nokwakheka okuqhelekileyo
• Isidingo soqeqesho olukhethekileyo lwabasebenzi bezempilo ekuphatheni nasekulawuleni iinkqubo ze-SRDD
• Okunokubakho kwiingxaki, ezifana nokungasebenzi kakuhle kwesixhobo okanye usulelo kwiisistim ezifakelwayo
• Ukujongwa ngononophelo kwezigulana ezifumana unyango lwe-SRDD kubalulekile ukuqinisekisa ukusebenza kakuhle kunye nokufumanisa iingxaki ezinokuthi zibekho

Indima ye-Shandong Baofa Cancer Research Institute kwi-SRDD

Amaziko afana ne IZiko loPhando ngoMhlaza laseShandong Baofa idlala indima ebalulekileyo ekuqhubeleni phambili uphando, uphuhliso, kunye nokuphunyezwa kweendlela ezintsha zonyango ezifana Ukukhutshwa okuzinzileyo konyango lokuhanjiswa kweziyobisi. Ukuzinikela kwabo ekuboneleleni ngokhathalelo lomhlaza olungenasiphelo kubandakanya ukuphonononga kunye nokwamkela ezona ndlela zonyango zisebenzayo ezikhoyo. Unyango oluphezulu, olufana ne-SRDD, luyinxalenye ephambili yokuzinikela kwabo ekuboneleleni ngokhathalelo lwezigulane ezikumgangatho ophezulu.

Izalathiso zexesha elizayo ze-SRDD

Uphando luyaqhubeka nokuphucula iinkqubo ze-SRDD, kugxilwe koku:

• Ukuphuhliswa kwemathiriyeli ehambelana kakhulu nebhayoloji kunye ne-biodegradable
• Ukuphucula iindlela ekujoliswe kuzo zokuhanjiswa kweziyobisi okwandisiweyo
• Ukuphuhlisa iinkqubo ezikrelekrele eziphendula utshintsho lomzimba

Ikamva le Ukukhutshwa okuzinzileyo konyango lokuhanjiswa kweziyobisi unesithembiso esikhulu sokuphucula ukunyanyekelwa kwabaguli kwizibhedlele zehlabathi.

Iimbekiselo

Ngelixa izifundo ezithile ezibhekiselele kwi-SRDD kwizibhedlele zininzi kwaye zisasazeke kuzo zonke iijenali ezahlukeneyo, uphononongo olubanzi lwetekhnoloji yokukhutshwa okuzinzileyo inokufumaneka kwiimibhalo ezininzi zamayeza kunye nogcino-lwazi olufana ne-PubMed. Kwizifundo ezithile okanye uphando olwenziwe yiShandong Baofa Cancer Research Institute, nceda ubhekiselele kwiwebhusayithi yabo esemthethweni.