unyango olutsha olungelulo oluncinci unyango lomhlaza wemiphunga weseli

Unyango loMhlaza oMtsha weMiphunga weSeli engeNcinci

Esi sikhokelo sibanzi siphonononga inkqubela phambili yamva nje kwi unyango olutsha olungelulo oluncinci unyango lomhlaza wemiphunga weseli. Siza kugubungela iindlela ezahlukeneyo zonyango, kubandakanywa unyango ekujoliswe kulo, i-immunotherapy, kunye ne-chemotherapy, ukubonelela ngolwazi malunga nokusebenza kwabo, iziphumo ebezingalindelekanga kunye nokufaneleka kweeprofayili zesigulana ezahlukeneyo. Funda malunga nokuvela komhlaba wonyango lwe-NSCLC kunye nendlela abaphandi abaqhubeka ngayo besebenzela ukhetho olusebenzayo nolungenatyhefu.

Ukuqonda uMhlaza weMiphunga yeSeli engeNcinci (NSCLC)

Yintoni i-NSCLC?

Umhlaza wemiphunga weseli engeyiyo encinci (NSCLC) ubalelwa malunga ne-85% yawo wonke umhlaza wemiphunga. Liqela lemihlaza ekhula emiphungeni kwaye ibonakaliswa ngokubonakala kweeseli ezahlukeneyo phantsi kwemakroskopu. Ukuxilongwa kwangoko kubalulekile kwiziphumo zonyango eziphuculweyo. Inqanaba lomhlaza ekuxilongeni lichaphazela kakhulu izigqibo zonyango kunye ne-prognosis. Iziko loPhando ngoMhlaza laseShandong Baofa (https://www.baofahospital.com/) yinkokeli kwintsimi, enikezela ngononophelo olubanzi kunye nophando kwi-NSCLC.

Ukubekwa kunye nokuxilongwa kwe-NSCLC

Iqonga elichanekileyo libalulekile ekumiseleni eyona ndlela ilungileyo unyango olutsha olungelulo oluncinci unyango lomhlaza wemiphunga weseli. Oku kuquka iimvavanyo ezahlukahlukeneyo, kuquka iimaging scans (CT, PET), ibiopsy, novavanyo lwegazi. Inkqubo yesiteji ye-TNM isetyenziswa ngokuqhelekileyo ukuhlula i-NSCLC ngokusekelwe kubukhulu be-tumor (T), ukubandakanyeka kwe-lymph node (N), kunye ne-metastasis (M). Ukufunyaniswa kwangoko, rhoqo ngokuhlolwa rhoqo kwabantu abasemngciphekweni ophezulu, kuphucula amathuba onyango oluyimpumelelo.

Iinketho zonyango lwe-NSCLC

Unyango ekujoliswe kulo

Unyango olujoliswe kuyo lujolise kwiimolekyuli ezithile ezibandakanyekayo ekukhuleni komhlaza. La machiza anokusebenza ngakumbi kwaye abe neziphumo ebezingalindelekanga ezimbalwa kunechemotherapy yemveli kwezinye izigulana. Imizekelo ibandakanya i-EGFR inhibitors (njenge-gefitinib kunye ne-erlotinib) kunye ne-ALK inhibitors (njenge-crizotinib). Ukukhethwa kwonyango olujoliswe kuyo kuxhomekeke kwiinguqu ezithile zofuzo ezikhoyo kwiiseli zomhlaza.

Immunotherapy

I-Immunotherapy isebenzisa amandla amajoni omzimba okulwa nomhlaza. I-Checkpoint inhibitors, efana ne-pembrolizumab kunye ne-nivolumab, iiprotheni ezithintela amajoni omzimba ekuhlaseleni iiseli zomhlaza. La machiza abonise impumelelo ephawulekayo ekunyangeni i-NSCLC, ngakumbi kwizigulane ezinee-biomarkers ezithile. Unyango lwe-Immunotherapy lunokuba nemiphumo emibi eyahlukileyo kune-chemotherapy, efuna ukujongwa ngononophelo ngabasebenzi bezonyango.

Unyango ngamachiza

I-Chemotherapy isebenzisa amayeza ukubulala iiseli zomhlaza. Ingasetyenziswa yodwa okanye idityaniswe nolunye unyango. Iirejimeni ezahlukeneyo zechemotherapy zikhona, ezilungiselelwe iimfuno ezithile zesigulana kunye nenqanaba lomhlaza wabo. Iziyobisi ezisetyenziswa ngokuqhelekileyo ziquka i-cisplatin, i-carboplatin, kunye ne-paclitaxel. Unyango ngamachiza lunokuba neziphumo ebezingalindelekanga ezibalulekileyo, kwaye ukulawula ezi ziphumo bezingalindelekanga yinxalenye ebalulekileyo yonyango.

Unyango ngemitha

Unyango ngemitha lusebenzisa imitha yemitha ephezulu ukutshabalalisa iiseli zomhlaza. Ingasetyenziselwa ukunciphisa amathumba, ukukhulula iimpawu, okanye ukuthintela ukuphindaphinda komhlaza. Iindidi ezahlukeneyo zonyango lwemitha zikhona, kubandakanywa ukusasazeka kwemitha yangaphandle kunye nebrachytherapy. Unyango ngemitha lunokuba neziphumo ebezingalindelekanga, ngokuxhomekeke kwindawo enyangwayo kunye nethamo.

Unyango olusakhulayo kunye noPhando

Iimvavanyo zeklinikhi

Ukuthatha inxaxheba kulingo lwezonyango kunokunika ufikelelo kwizinto ezintsha unyango olutsha olungelulo oluncinci unyango lomhlaza wemiphunga weseli ngaphambi kokuba zifumaneke ngokubanzi. Ezi zilingo zibekwe esweni ngononophelo kwaye zinika izigulane ithuba lokufaka isandla kwinkqubela phambili yezonyango ngelixa zifumana ukhathalelo lwangoku. Abaphandi kwiZiko loPhando loMhlaza laseShandong Baofa bathatha inxaxheba ngokukhutheleyo kumalingo amaninzi ezonyango abaphonononga inoveli yonyango ye-NSCLC.

IiBiopsies zolwelo

I-biopsies yolwelo yindlela encinci yokufumanisa kunye nokubeka iliso kumhlaza. Zibandakanya ukuhlalutya iisampulu zegazi lokujikeleza i-tumor DNA (ctDNA), enokubonelela ngengqiqo exabisekileyo kwimizila yemfuza yomhlaza kunye nezigqibo zonyango ezikhokelayo. Obu buchwephesha bokusungula buvumela iindlela zamayeza omntu ngamnye, ukwenza izicwangciso zonyango ezisekelwe kwiimfuno zesigulana ngasinye.

Ukukhetha Unyango Olululo

Eyona ilungileyo unyango olutsha olungelulo oluncinci unyango lomhlaza wemiphunga weseli indlela iyahluka ngokuxhomekeke kwizinto ezininzi, kubandakanywa inqanaba lomhlaza, impilo yesigulana iyonke, kunye nobukho beenguqu ezithile zofuzo. Iqela lezinto ezininzi ze-oncologists, oogqirha botyando, kunye nezinye iingcali zempilo zihlala zibandakanyeka ekuphuhliseni isicwangciso sonyango lomntu. Unxibelelwano oluvulekileyo kunye nomboneleli wakho wezempilo kubalulekile ukuqinisekisa ukuba uyaziqonda iinketho zakho kwaye wenze izigqibo ezinolwazi.

I-Disclaimer: Le ngcaciso yenzelwe iinjongo zemfundo kuphela kwaye akufanele ithathwe njengengcebiso yezonyango. Soloko udibana nengcali yokhathalelo lwempilo olufanelekileyo ukuze uxilongwe kunye nonyango lwaso nasiphi na isimo sonyango.