Umhlaza webele ongalunganga kathathu

Umhlaza wamabele kaThathu oNegative: IsiKhokelo esiBanziUkuqonda uMhlaza wamabele kaThathu-Negative: IsiKhokelo seSigulanaUmhlaza wamabele ka-Triple-negative (TNBC) luhlobo oluncinane lomhlaza wamabele olungavezi ii-receptors ze-estrogen, iprogesterone, okanye i-HER2. Oku kunqongophala kwama-receptors kwenza kube ndlongondlongo kwaye kube nzima ukunyanga xa kuthelekiswa nezinye ii-subtypes zomhlaza wamabele. Esi sikhokelo sinika amagqabantshintshi abanzi Umhlaza webele ongalunganga kathathu, egubungela iimpawu zayo, ukuxilongwa, ukhetho lonyango, kunye nezibonelelo zenkxaso. Sijonge ukukuxhobisa ngolwazi kunye nokuqonda ukuze uhambe kolu hambo lucela umngeni.

Ukuqonda iimpawu ze-TNBC

Yintoni eyenza i-TNBC yahluke?

Ngokungafaniyo nezinye iintlobo zomhlaza wamabele, Umhlaza webele ongalunganga kathathu ayinayo i-estrogen receptor (ER), i-progesterone receptor (PR), kunye ne-epidermal growth factor receptor 2 (HER2). Ezi zamkeli zidla ngokujoliswa kunyango lwezinye ii-cancer zamabele, kodwa ukungabikho kwazo kwi-TNBC kuthintela ukhetho lonyango. Oku kudla ngokukhokelela kwikhosi yesifo esindlongondlongo kunye nomngcipheko ophezulu wokuphindaphinda.

Ukuxhaphaka kunye nezinto zoMngcipheko

Umhlaza webele ongalunganga kathathu yenza malunga ne-10-20% yazo zonke ii-cancer zamabele. Imingcipheko enxulumene ne-TNBC ibandakanya iminyaka emncinci ekuxilongeni, ukuguqulwa kofuzo lwe-BRCA1, ubuhlanga base-Afrika baseMelika, kunye nembali yosapho yomhlaza wamabele. Nangona kunjalo, uninzi lwabasetyhini abafunyaniswa bene-TNBC abanayo imingcipheko ebonakalayo.

Uxilongo kunye nokubekwa kwe-TNBC

Iinkqubo zokuxilonga

Ukuxilonga Umhlaza webele ongalunganga kathathu Ngokuqhelekileyo kubandakanya i-biopsy ukujonga iiseli zethumba phantsi kwe-microscope. Uvavanyo lwe-Immunohistochemical staining (IHC) lumisela ubukho okanye ukungabikho kwe-ER, PR, kunye ne-HER2 receptors. Ezinye iimvavanyo, ezifana ne-imaging scans (i-mammography, i-ultrasound, i-MRI), ingasetyenziselwa ukuhlola ubungakanani bomhlaza.

Inqanaba kunye nePrognosis

Iqonga limisela ubungakanani kunye nobungakanani bomhlaza, okuchaphazela izigqibo zonyango kunye noxilongo. Inkqubo yesiteji ye-TNM isetyenziswa ngokuqhelekileyo, ukuvavanya ubukhulu be-tumor (T), ukubandakanyeka kwe-lymph node (N), kunye ne-metastasis ekude (M). I-prognosis ye-TNBC iyahluka ngokuxhomekeke kwinqanaba kunye nezinye izinto; ukufunyaniswa kwangoko kunye nonyango lwangethuba lubalulekile ekuphuculeni iziphumo.

Iinketho zonyango lwe-TNBC

Utyando

Utyando ludla ngokuba ngumgca wokuqala wonyango Umhlaza webele ongalunganga kathathu, ejolise ekususeni ithumba lomhlaza. Oku kunokubandakanya i-lumpectomy (ukususwa kwethumba) okanye ukususwa kwebele (ukususwa kwebele). I-Sentinel lymph node biopsy okanye i-axillary lymph node dissection inokwenziwa ukuvavanya ukubandakanyeka kwe-lymph node.

Unyango ngamachiza

I-Chemotherapy lilitye lembombo kunyango lwe-TNBC, esoloko isetyenziswa phambi kotyando (neoadjuvant chemotherapy) ukucutha ithumba okanye emva kotyando (i-adjuvant chemotherapy) ukunciphisa umngcipheko wokuphinda. Iirejimeni ezahlukeneyo zechemotherapy ziyafumaneka, zikhethwa ngokusekelwe kwizinto ezizimeleyo. Uphando iyaqhubeka nokuphonononga indibaniselwano entsha yechemotherapy ukuphucula ukusebenza kakuhle.

Unyango ngemitha

Unyango ngemitha lusebenzisa imitha yamandla aphezulu ukubulala iiseli zomhlaza. Ihlala isetyenziswa emva kotyando ukutshabalalisa naziphi na iiseli zomhlaza eziseleyo ebeleni okanye kwi-lymph nodes ezikufutshane. Isenokusetyenziselwa ukunyanga isifo semetastatic.

Unyango ekujoliswe kulo kunye ne-Immunotherapy

Ngelixa i-TNBC ingaphenduli kunyango lwe-hormone okanye kunyango olujoliswe yi-HER2, uphando luyaqhubeka kunyango olujoliswe kuyo kunye ne-immunotherapies. Ezinye iindlela zonyango ezijoliswe kuzo zijolise kwiindlela ezithile ezibandakanyekayo ekukhuleni kwe-TNBC, ngelixa i-immunotherapies ijolise ekukhuliseni amajoni omzimba ukulwa nomhlaza. Olu nyango lubonisa isithembiso kodwa lusaphandwa.

Ukuhlala kunye naNgaphaya kwe-TNBC

Ukulandelela Unonophelo

Ukuqeshwa okulandelwa rhoqo kubalulekile emva konyango ukubeka iliso lokuphindaphinda. Olu qeshwa lubandakanya uvavanyo lomzimba, ukuskena umfanekiso, kunye novavanyo lwegazi. Ukufunyaniswa kwangethuba kokuphindaphinda kubalulekile kulawulo olusebenzayo.

Inkxaso kunye nezibonelelo

Ukumelana nokuxilongwa kwe Umhlaza webele ongalunganga kathathu kunokuba lucelomngeni. Inkxaso yosapho, izihlobo, kunye namaqela enkxaso ixabiseke kakhulu. Imibutho emininzi inikezela ngezibonelelo kunye nenkxaso kubantu abachatshazelwe yi-TNBC. Cinga ngokuqhagamshelana ne IZiko loPhando ngoMhlaza laseShandong Baofa ngolwazi olongezelelweyo kunye nezibonelelo. Banikezela ngokhathalelo olubanzi lomhlaza, kubandakanya ubuchwephesha bokunyanga iintlobo ezahlukeneyo zomhlaza wamabele.

Uphando olongezelelweyo kunye novavanyo lwezonyango

Uphando kwi Umhlaza webele ongalunganga kathathu ihlala iguquka, kunye nezilingo zeklinikhi eziqhubekayo zihlola izicwangciso ezintsha zonyango kunye nokuphucula iziphumo. I-oncologist yakho inokuxoxa ngokuthatha inxaxheba okunokubakho kwizilingo zeklinikhi ezinokuthi zilungele imeko yakho ethile. Ukuhlala unolwazi malunga nenkqubela phambili yamva nje kuphando lwe-TNBC kubalulekile.