
2026-04-09
Ukwelashwa komdlavuza wamaphaphu ngesigaba ngo-2026 kubhekiselwa kumigomo ejwayelekile, esekwe ebufakazini esetshenziswa eChina ukuphatha umdlavuza wamaphaphu oyinhloko ngokuya ngezinga lokusabalala kwawo. Okwakamuva 2026 Izinkombandlela Zokwelashwa KwaseShayina gcizelela ukushintshela ekwelashweni okunembayo, okuhlanganisa izindlela zokwelapha ezihlosiwe zamangqamuzana kanye nokwelashwa kwamasosha omzimba kanye nokwelashwa ngamakhemikhali okungokwesiko nemisebe. Ezifweni eziqala ukuvela, ukuhlinzwa kuhlala kwelapha, kuyilapho abaphathi beSigaba IV manje sebebeka phambili ukuphrofayilisa ngezakhi zofuzo ukuze bakhethe ukwelashwa okuhlelekile okufanelekile, okunweba kakhulu ukuphila kanye nokwenza ngcono izinga lempilo yezigidi zeziguli.
Isiteji esinembayo siyisisekelo sokusebenza ngempumelelo ukwelashwa komdlavuza wamaphaphu ngesiteji. Ngo-2026, izazi ze-oncologists zaseShayina zibambelela ngokuqinile kuHlelo lwesi-9 lohlelo lwesiteji lwe-TNM olusungulwe yi-International Association for the Study of Lung Cancer (IASLC). Lolu hlelo luhlukanisa izimila ngokusekelwe kusayizi (T), ukubandakanyeka kwe-lymph node (N), kanye ne-metastasis ekude (M). Ukuqonda lezi zigaba kubalulekile ngoba amasu okwelapha ahluka kakhulu phakathi kokukhula kwendawo kanye nezifo ezisabalele.
Isimo somdlavuza wamaphaphu eChina sisalokhu siyinselele. Idatha evela ku-National Cancer Center ikhombisa ukuthi umdlavuza wamaphaphu uyithumba eliyingozi elidlange kakhulu, cishe nezigidi eziyi-1.06 zezehlakalo ezintsha kanye nokufa kwabantu abangu-733,300 ngo-2022. Naphezu kokwanda kokuqwashisa umphakathi mayelana nokuhlolwa, ingxenye enkulu yeziguli itholakala eSigabeni IV. Ngenxa yalokho, i- 2026 imihlahlandlela gxila kakhulu ekuthuthukiseni imiphumela yezifo ezithuthukisiwe kuyilapho uqinisa izinqubo zokutholwa kusenesikhathi.
Incazelo yokunakekelwa okujwayelekile isishintshile. Ngenkathi i-chemotherapy ike yaba ukuphela komgogodla wokwelapha, isibuyekezo sango-2026 siyakubona lokho ukwelapha okuhlosiwe kwamangqamuzana futhi i-immunotherapy manje seziyizinsika ezimaphakathi. Izinqumo zokwelashwa azisasekelwe kuphela ku-histology (njenge-adenocarcinoma vs. squamous cell carcinoma) kodwa ziqhutshwa ukuguqulwa kofuzo okuthile. Lokhu kushintsha kwepharadigm kuqinisekisa ukuthi iziguli zithola izidakamizwa ezisebenza kahle kakhulu zebhayoloji yazo ethile yesimila.
Ezigulini ezitholwe zinomdlavuza weSigaba I kanye neSigaba II ongewona omncane wamaphaphu wamaphaphu (NSCLC), umgomo oyinhloko uwukwelapha. Imihlahlandlela yase-China yango-2026 iqinisekisa kabusha ukuthi ukuhlinzwa kabusha kuyindinganiso eyigolide kumakhandidethi asebenzayo. Kodwa-ke, indlela yokuhlinzwa kanye nokwelashwa kwe-adjuvant isiphenduke inkimbinkimbi ukuze kwandiswe ukuphila kwesikhathi eside.
Ukuhlinzwa kuseyindlela ephumelela kakhulu yokususa izimila ezisaqala. Ezikhungweni zezokwelapha ezinkulu zaseShayina, Ukuhlinzwa Kwethoracoscopic Okusizwa Ngevidiyo (i-VATS) kanye Nokuhlinzwa Kwethoracic Okusizwa ngeRobot sekuyinto evamile. Lezi zindlela zokuhlasela kancane zinciphisa isikhathi sokutakula kanye nezinkinga uma kuqhathaniswa ne-thoracotomy yendabuko evulekile.
Ukwelashwa kwangemva kokuhlinzwa, okwaziwa ngokuthi i-adjuvant therapy, kubalulekile ekuqedeni izifo ezincane kakhulu nokuvimbela ukuphindeka. Imihlahlandlela yango-2026 inikeza izincomo ezibuyekeziwe ezisuselwe ezivivinyweni zakamuva zomtholampilo.
Ezigulini zeSigaba IB kuya ku-III ezinezinguquko ezithile zofuzo, njenge-EGFR positivity, i-adjuvant target therapy manje isinconywe kakhulu. Lokhu kubonisa intuthuko enkulu eminyakeni edlule lapho i-chemotherapy yayiwukuphela kwenketho. Ngokufanayo, ezigulini ezingenazo izinguquko zomshayeli kodwa ezinenkulumo ephezulu ye-PD-L1, i-adjuvant immunotherapy ingasetshenziswa ngemva kwe-chemotherapy-based chemotherapy.
Isigaba sesi-III somdlavuza wamaphaphu siveza isimo somtholampilo esiyinkimbinkimbi lapho lesi sifo sesisakazekele kuma-lymph node aseduze kodwa hhayi ezithweni ezikude. Lesi sigaba sivame ukubizwa ngokuthi "esithuthukisiwe endaweni." Indlela yokwelapha idinga ithimba lezinhlaka eziningi elibandakanya odokotela abahlinzayo, odokotela be-oncologist bezokwelapha, nama-oncologists emisebe.
Isisekelo sokwelashwa kweSigaba III yi ukwelashwa kwe-multimodal, ehlanganisa izindlela ezahlukene zokwelapha. Ukulandelana okuqondile kuncike ekutheni isimila sithathwa njengesikhiphekayo yini.
Impumelelo ekulawuleni isifo seSigaba III esingenakuvinjelwa ukusetshenziswa kwe-consolidation immunotherapy. Ngemva kokuqeda i-chemoradiotherapy kanyekanye, iziguli ezingakathuthuki zelashwa ngama-immune checkpoint inhibitors. Imihlahlandlela yango-2026 igqamisa lelisu njengokungenelela okubalulekile okuthuthukise kakhulu ukusinda okungenanqubekelaphambili kanye namazinga okusinda esewonke kubantu baseShayina.
Isigaba IV, noma umdlavuza wamaphaphu we-metastatic, senzeka lapho lesi sifo sisakazekela ezithweni ezikude njengobuchopho, amathambo, isibindi, noma elinye iphaphu. Ngokomlando, ukubikezelwa kweSigaba IV kwakungekuhle, izikhathi zokusinda zemvelo zisukela ezinyangeni ezi-1 kuye kwezingu-3 kuphela. Nokho, i 2026 Izinkombandlela Zokwelashwa KwaseShayina khombisa uguquko olumangalisayo emiphumeleni ngenxa yokuthuthuka kwezindlela zokwelapha ezihlelekile.
Ngaphambi kokuqala noma yikuphi ukwelashwa kweSigaba IV NSCLC, ukuhlolwa kwamangqamuzana okuphelele kuyadingeka. Imihlahlandlela igcizelela ukuthi i-tissue biopsy noma i-liquid biopsy (ukuhlolwa kwegazi) kufanele kwenziwe ukuze kutholwe ukuguqulwa komshayeli. Okuhlosiwe okujwayelekile kufaka i-EGFR, ALK, ROS1, BRAF, KRAS, MET, RET, kanye ne-NTRK.
Kungani ukuhlola kubalulekile: Ukuhlonza ukuguqulwa okuthile kuvumela odokotela ukuba banikeze imithi yomlomo ehlosiwe esebenza kahle kakhulu futhi engenabuthi obuncane kunokwelapha ngamakhemikhali endabuko. Ezigulini ezingenazo izinguquko ezingenzeka, ukuhlolwa kwe-PD-L1 kuqondisa ukusetshenziswa kwe-immunotherapy.
Isibuyekezo sika-2026 sihlanganisa yonke imithi emisha egunyazwe i-National Medical Products Administration (NMPA) yase-China kuze kube sekupheleni kuka-2025. Lokhu kufaka phakathi isizukulwane sesithathu se-EGFR inhibitors kanye nesizukulwane esilandelayo se-ALK inhibitors esinamandla aphakeme okungena kumgoqo wegazi nobuchopho.
Ezigulini ezintula ukuguqulwa komshayeli, i-immunotherapy ehlanganiswe ne-chemotherapy isiphenduke indinganiso entsha. Imihlahlandlela incoma izinhlobo ezahlukene zemithi ezisuselwe kuhlobo oluncane lwe-histological (i-squamous vs. non-squamous) kanye namaleveli wokusho we-PD-L1. Ezimeni zokuvezwa okuphezulu kwe-PD-L1, i-immunotherapy monotherapy ingase ibhekwe ukuze isindise iziguli ebusheni be-chemotherapy.
Ama-metastases ebuchosheni ayinkinga evamile futhi enzima yomdlavuza wamaphaphu, ethinta ingxenye enkulu yeziguli zeSigaba IV. NgoJanuwari 2026, iChina yakhulula abazinikele "Iziqondiso Zokwelashwa KwaseShayina Zomdlavuza Wamaphaphu Metastases (Ushicilelo luka-2026)". Lo mbhalo ukhuluma ngezinselelo ezithile zokwelapha umdlavuza osusabalele ebuchosheni.
Imihlahlandlela ikubeka ngokusobala lokho I-Magnetic Resonance Imaging (MRI) yekhanda iyindlela ethandwayo yokucabanga yokuxilonga nokuqapha ama-metastases obuchopho. Ama-CT scan awanele ukuthola izilonda ezincane. Ukuhlolwa kwe-MRI okuvamile kunconywa ezigulini ezisengozini enkulu ngisho nalapho kungabikho izimpawu zemizwa.
Ukuphathwa kwe-metastase yobuchopho kudinga indlela ehambisanayo ehlanganisa izindlela zokwelapha zendawo nezesistimu:
Nakuba Umdlavuza Ongewona Owomncane Wengqamuzana Wamaphaphu (NSCLC) uthatha cishe u-85% wamacala, Umdlavuza Weseli Encane Wamaphaphu (SCLC) uluhlobo oluncane oluhlukile futhi olunolaka. Imihlahlandlela yango-2026 igcina indlela ehlukile ye-SCLC ngenxa yokukhula kwayo ngokushesha kanye ne-metastasis yokuqala.
I-SCLC ihlukaniswe kabanzi ku-Limited Stage (evalelwe ku-hemithorax eyodwa) kanye ne-Extensive Stage (sabalala ngaphesheya).
Ukuqonda isici sezezimali kubalulekile ezigulini ezifunayo ukwelashwa komdlavuza wamaphaphu ngesiteji eChina. Izindleko ziyahlukahluka ngokuya ngesiteji, indlela yokwelashwa, izinga lesibhedlela, kanye nokuhlinzekwa komshwalense. Uhlelo lukazwelonke lokunakekelwa kwezempilo lwaseChina selwenze inqubekelaphambili enkulu ekwehliseni umthwalo wesiguli ngoHlelo Lukazwelonke Lokubuyisela Izidakamizwa (NRDL).
Izindleko ngokuvamile ziphansi e-China uma kuqhathaniswa namazwe aseNtshonalanga, ikakhulukazi emithini emisha efakwe ohlelweni lomshwalense kazwelonke.
Uhlelo Lomshwalense Wezempilo Oyisisekelo eShayina luhlanganisa inqwaba yemithi elwa nomdlavuza. Imihlahlandlela yango-2026 ibhekisisa ukutholakala kwezidakamizwa kanye nesimo sembuyiselo lapho kwenziwa izincomo. Iziguli zelulekwa ukuthi zithintane nosonhlalakahle basesibhedlela noma ochwepheshe bomshuwalense ukuze kwandiswe izinzuzo zazo. Ukwengeza, umshwalense owengeziwe wezohwebo kanye nezinhlelo zokusiza abampofu ziqhubekisela phambili ukudambisa ubuthi bezezimali emindenini.
Ukuthola ukunakekelwa kwekhwalithi ephezulu kubalulekile ukuze kube nemiphumela emihle. I-China inezikhungo eziningi zomdlavuza ezisezingeni lomhlaba ezihola ocwaningweni nasekusetshenzisweni komtholampilo kwemihlahlandlela ka-2026. Uma usesha izibhedlela eziseduze kwami, iziguli kufanele zibheke izikhungo ezineminyango ekhethekile ye-thoracic oncology.
Izibhedlela ezithile e-China ziyaziwa kuzwelonke ngobuchwepheshe bazo ekulawulweni komdlavuza wamaphaphu:
Lapho ukhetha isibhedlela, cabangela izici ezilandelayo:
Ukuze uqonde kangcono izinketho ezitholakala ngaphansi kwemihlahlandlela yango-2026, ithebula elilandelayo liqhathanisa izindlela zokwelapha eziyinhloko ezisetshenziswa e-China namuhla.
| Ukuziphatha | Izimpawu Ezisemqoka | I-Ideal Application Scenario |
|---|---|---|
| Ukuhlinzwa | Inhloso yokwelapha, ehlaselayo, idinga isikhathi sokululama | Isigaba I, II, kanye neSigaba III esikhethiwe se-NSCLC |
| I-Chemotherapy | I-Systemic, i-cytotoxic, isisekelo kodwa inobuthi | Zonke izigaba (i-adjuvant/neoadjuvant), i-SCLC, ikhophi yasenqolobaneni kwabanye |
| Ukwelapha Okuhlosiwe | Amaphilisi omlomo, okunembile, ubuthi obuphansi, ukumelana kungenzeka | I-Stage IV NSCLC enokuguqulwa okuthile komshayeli (EGFR, ALK, njll.) |
| I-Immunotherapy | Ukumnika, kusebenze amasosha omzimba, izimpendulo ezihlala njalo | Isigaba III/IV NSCLC ngaphandle kwabashayeli, i-SCLC isiteji esibanzi |
| Imisebe (SRS/WBRT) | Ukulawula kwendawo, okungahlanyisi, okuqondene ngqo nobuchopho/umzimba | Ama-metastases ebuchosheni, isifo esithuthukisiwe endaweni esingenakunqandeka |
Ukuzulazula ohlelweni lokunakekelwa kwezempilo kungase kube nzima. Ngezansi kuyindlela eqondile yesiguli okusolwa ukuthi sinomdlavuza wamaphaphu e-China, ehambisana neziqondiso zakamuva.
Ukuqaliswa kwemihlahlandlela yango-2026 kuletha izinzuzo ezibalulekile kodwa futhi kuveza izinselele ezithile iziguli nabahlinzeki okufanele bazizuzise.
Imihlahlandlela yango-2026 igcizelela kakhulu ukuvikela nokutholwa kusenesikhathi. IKhomishana Yezempilo Kazwelonke ikhiphe izikimu eziqondile zokuhlola umdlavuza wamaphaphu, okubhekiswe kubantu abasengozini enkulu. Ukutholwa kusenesikhathi kuseyindlela eyodwa ephumelela kakhulu yokuthuthukisa izinga lokusinda leminyaka emi-5.
Ukuhlolwa kunconyiwe kubantu abaneminyaka engama-50 kuye kwengama-74 abahlangabezana okungenani nenqubo eyodwa kwezilandelayo:
I-Low-Dose Spiral CT (LDCT) ukuphela kwendlela yokuhlola enconyiwe. Ama-X-ray esifuba adikibala ngokusobala njengoba egeja amaqhuqhuva asekuqaleni. Imihlahlandlela icacisa ukuthi i-LDCT kufanele yenziwe kusetshenziswa izikena ezinemigqa okungenani engu-16 yomtshina, ehunyushwa ochwepheshe be-radiologist abanolwazi.
Njengoba sithuthuka ngo-2026, inkambu yokwelashwa komdlavuza wamaphaphu iyaqhubeka nokuvela ngokushesha. Ucwaningo lugxile ekunqobeni ukumelana nemithi, ukuhlanganisa izindlela zokwelapha zemiphumela ye-synergistic, kanye nokwakha imithi yokugoma.
Ama-antibody-drug conjugates (ADCs) avela njengesigaba esisha esinamandla sezidakamizwa, abonisa isithembiso ezigulini ezihlulekile emithini yokwelapha eqondisiwe yangaphambilini. Ngaphezu kwalokho, ubuhlakani bokwenziwa buya ngokuya buhlanganiswa ku-radiology ukuze kutholwe izigaxana ngaphambi kwesikhathi nokubikezela izimpendulo zokwelashwa ngokunembe kakhudlwana.
Ukuzinikela kwezinhlangano zezokwelapha zaseShayina ekubuyekezeni njalo imihlahlandlela kuqinisekisa ukuthi iziguli ziyahlomula ekuthuthukisweni kwakamuva kwesayensi ngaphandle kokulibala. Ukusebenzisana phakathi kwezinkampani ezikhiqiza imithi yasekhaya kanye nezinhlangano zocwaningo emhlabeni wonke kusheshisa ukutholakala kwemithi emisha ngaphakathi kwe-China.
Indawo ye ukwelashwa komdlavuza wamaphaphu ngesiteji ngo-2026 kuchazwa ngokunemba, ukwenza kube ngokwakho, kanye nethemba. Ukukhululwa kwe- 2026 Izinkombandlela Zokwelashwa KwaseShayina kuphawula ingqopha-mlando ebalulekile, ehlanganisa iminyaka yocwaningo emikhondo yomtholampilo engasebenza. Kusukela emandleni okwelapha okuhlinzwa ezigabeni zokuqala kuya emandleni okwandisa impilo yokwelashwa okuqondiwe kanye nokwelashwa kwamasosha omzimba eSigabeni IV, iziguli namuhla zinezinketho eziningi kunangaphambili.
Nakuba izinselele ezifana namazinga okutholwa kusenesikhathi kanye nokumelana nezidakamizwa ziqhubeka, indlela ehlelekile ekhuthazwa odokotela be-oncologist baseShayina abaphambili inikeza uhlaka oluqinile lokunakekelwa. Ngokusebenzisa ukuxilonga okuthuthukile, ukunamathela ezivumelwaneni ezijwayelekile, nokusebenzisa ukwesekwa okuphelele kohlelo lwezempilo lukazwelonke, ukubikezelwa kweziguli ezinomdlavuza wamaphaphu eChina kuyaqhubeka nokuba ngcono. Kunoma ubani othintwe yilesi sifo, ukuqonda lezi zigaba kanye nokwelashwa okutholakalayo kuyisinyathelo sokuqala sokuzulazula ohambweni ngokuzethemba nokufinyelela ekunakekelweni okungcono kakhulu.