Isibhedlela somdlavuza saseChina siqasha owathola umklomelo weNobel, uSolwazi CraigC.Melloas onguSosayensi Omkhulu 

NgoJuni 8-9, uSolwazi Craig Melo, owathola umklomelo kaNobel kuPhysiology noma Medicine, kanye noSolwazi Jiang Wei ovela eSibhedlela Somdlavuza we-Chinese Academy of Medical Sciences bavakashela e-Dongping, eShandong futhi babamba iqhaza “eNgqungqutheleni Yokuhwebelana NgeNobel Medical Prize Oncology Academic Exchange” eyayisingethwe yiSibhedlela Somdlavuza sase-Taimei Baofa ukuze bashintshisane ngezifundo. Lolu hambo luphawula ukuhlanganiswa okukhulu kobuchwepheshe bayo bokugxambukela be-RNA obuzuze umklomelo kaNobel kanye “nokwelashwa komtapo wolwazi okhishwa kancane” esibhedlela, okufaka umfutho onamandla emkhakheni wokwelapha umdlavuza womhlaba wonke, ikakhulukazi ukwelashwa komdlavuza we-pancreatic.

Ngo-2016, uSolwazi Merleau wancoma kakhulu uSolwazi Yu Baofa, umqondisi weSibhedlela Somdlavuza sase-Taimei Baofa, ngokusungula i-“UMIPIC” “eNgqungqutheleni Yezemithi Yesithathu YeNobel Laureate”. Ngemva kweminyaka eyisishiyagalolunye, le ngxoxo evela ezinkundleni zemfundo ephakeme yamazwe ngamazwe izoqhubeka nokubhala isahluko esisha e-Dongping, eShandong. Ukuvakasha kukaSolwazi Meiluo akuyona nje inkhulumomphendvulwano ejulile phakathi kwemiqondo yesayensi esezingeni lomhlaba kanye nokusungulwa kwasekhaya eChina, kodwa futhi kuyibhuloho elisha lokubambisana ocwaningweni lwesimila phakathi kweChina namazwe angaphandle.

Emhlanganweni wokushintshisana, uSolwazi Melo wabelane ngemininingwane yakhe yakamuva emkhakheni wokuphazamiseka kwe-RNA kanye nocwaningo lwesimila. USolwazi Jiang Wei ovela eSibhedlela Somdlavuza we-Chinese Academy of Medical Sciences wabelane 《Ubuciko Bokucwaninga Ngomdlavuza: Izicelo ze-RNAi, Amamodeli Ezilwane kanye Ne-Super Resolution Imaging》.Isazi sezemfundo u-Yu Baofa wabelane ngocwaningo lomtholampilo olumayelana ne-self nano induced tumor immunotherapy ukuze uthole izimila eziqinile emhlanganweni wokushintshisana, futhi wabelane ngeminyaka engu-27 yokuhlangenwe nakho komtholampilo ekusetshenzisweni kokwelapha umdlavuza ukuze kunqandwe ukwelashwa okuqhubekayo. Ngaphambi kokuthi kuqale umhlangano wokushintshisana, uSolwazi Merleau kanye noSolwazi Yu Baofa bafinyelele isivumelwano sokubambisana ngocwaningo lomdlavuza futhi bakwamukela ngenjabulo ukuqokwa kukaSosayensi Omkhulu we-Baofa Medical. USolwazi u-Yu Baofa unikeze uSolwazi Merleau isipho - umdwebo kawoyela wesithombe se-Merleau osayinwe nguSolwazi Yu Baofa. Inhlanganisela ephelele yobuchwepheshe bokugxambukela be-RNA ethole umklomelo kaNobel kanye nobuchwepheshe obunelungelo lobunikazi bukaProfessor Yu Baofa “umtapo wolwazi okhishwa ngokuqhubekayo” kuyisibusiso esikhulu ezigulini ezinomdlavuza. Lokhu kushintshana kuzoba inkundla yokuqoqa ubuhlakani bomhlaba wonke kanye nezinhlansi ezintsha ezishayisanayo, futhi umbono wakho wesayensi osezingeni eliphezulu kulindeleke ukuthi uveze izikhombisi-ndlela zentuthuko yomphakathi wasekhaya we-oncology.

Selokhu sasungulwa eminyakeni engama-27 edlule, iSibhedlela Somdlavuza sase-Taimei Baofa sizuze imiphumela ebalulekile ekusetshenzisweni kwe-“UMIPIC” yokwelapha ngamakhemikhali kanye nokwelashwa kwamasosha omzimba ngaphakathi kwamathumba, ikakhulukazi umdlavuza wamaphaphu. Kufakwe "Kumihlahlandlela Yokusebenza Komtholampilo Wokwelashwa Okungenelela Kwe-Advanced Pancreatic Cancer" (Isivivinyo) (Uhlelo Lwesikhombisa). Kodwa-ke, kusenomehluko ngamunye ekusebenzeni ngempumelelo kokwelapha ekusebenzeni kwangempela komtholampilo, futhi ithimba le-Yu Baofa lithole umsuka wembangela yomehluko. USolwazi Merleau waklonyeliswa ngendondo kaNobel ngokuthola ngokubambisana ukugxambukela kwe-RNA no-Andrew Farr ngo-2006. Lokhu okutholakele kuveza indlela ewumnyombo lapho i-RNA enemigqa ephindwe kabili ingavimbela ngokuqondile ukubonakaliswa kofuzo, ivule indlela yoguquko yokufunda ukusebenza kwezakhi zofuzo kanye nokuhlola izimbangela zezifo. Ubuchwepheshe bokugxambukela kwe-RNA sebuphenduke ithuluzi eliyisisekelo ocwaningweni lwesimanje lwe-biomedical, buhlinzeka ngemibono emisha yokwelashwa kwezifo ezahlukahlukene kubandakanya nomdlavuza. Ubuchwepheshe bokuphazamiseka kwe-RNA kaProfessor Melo kulindeleke ukuthi buxazulule ngokunembile le nkinga futhi buthuthukise kakhulu ukuvumelana kokuphumelela kokwelapha. Ukuhlanganiswa kwezobuchwepheshe kwezinhlangothi zombili akuyona nje impumelelo enkulu ekwelapheni umdlavuza wamanyikwe emhlabeni, kodwa futhi kuzothuthukisa ngokuphelele umphumela wokwelapha “wokwelashwa komtapo wokukhipha kancane” kuwo wonke amathumba aqinile.

Kusukela ekunyakazeni kwezemfundo ngo-2016 kuya ekusetshenzisweni kwamanje kwezobuchwepheshe, lokhu kubambisana kuyimodeli yokuhlanganiswa okujulile phakathi kwezimpumelelo zocwaningo lwesayensi eziphezulu zamazwe ngamazwe kanye nokusebenza komtholampilo waseShayina. Njengoba kwahlolwa uGu Fangzhou, owayengumongameli wePeking Union Medical College, uProfesa Yu Baofa “usungule ucwaningo lwesayensi lwezibhedlela ezizimele”. Ukwethulwa kobuchwepheshe bukaProfessor Melo ngeke nje kuthuthukise izinga lokwelashwa kwesimila ezindaweni zendawo nasezindaweni ezizungezile, kodwa futhi kuzothungela inqalabutho entsha yokuphila kweziguli ezinomdlavuza emhlabeni wonke, futhi kukhuthaze imbangela yokulwa nomdlavuza kubantu ibe ukuphakama okusha. Ngaphambi kohambo, uSolwazi Merleau uphinde washo ngokuqondile ukuthi isayensi ayinamingcele, futhi ukulwa nomdlavuza kudinga ubuhlakani bomhlaba wonke. “Ngibheke ngabomvu ukubambisana okujulile nethimba likaSolwazi Yu Baofa ukuze sihlole izixazululo ezisebenza ngempumelelo zomdlavuza ngokubambisana.