ukwelashwa Ukulethwa Kwezidakamizwa Kwasendaweni YeCancer

Ukwelashwa Kokulethwa Kwezidakamizwa Kwasendaweni Komdlavuza

Lesi sihloko sinikeza ukubuka okuphelele kwezinhlelo zendawo zokulethwa kwezidakamizwa zokwelashwa komdlavuza, ukuhlola amasu ahlukahlukene, izinzuzo, imikhawulo, nezikhombisi-ndlela zesikhathi esizayo. Sihlolisisa izindlela, izicelo zomtholampilo, kanye nemizamo yocwaningo eqhubekayo kulo mkhakha othuthukayo. Funda mayelana nokuthuthuka kwakamuva kwezindlela zokwelapha eziqondisiwe okuhloswe ngazo ukukhulisa ukusebenza kahle kuyilapho kuncishiswa imiphumela engemihle yesistimu.

Ukuqonda Ukulethwa Kwezidakamizwa Kwendawo

Kuyini Ukulethwa Kwezidakamizwa Kwendawo?

Ukulethwa kwezidakamizwa endaweni Umdlavuza ubhekisela ezindleleni eziletha imithi yokwelapha ngokuqondile endaweni yesimila, enciphisa ukuchayeka ezicutshini ezinempilo. Le ndlela ehlosiwe ihlose ukuthuthukisa ukusebenza kahle, ukunciphisa ubuthi, nokuthuthukisa imiphumela yesiguli uma kuqhathaniswa nemithi yokwelapha yesistimu yendabuko. Kusetshenziswa amasu amaningana, ngalinye linezinzuzo zalo kanye nokulinganiselwa kwalo.

Izindlela Zokulethwa Kwezidakamizwa Kwasendaweni

Izindlela eziningana zisiza ukulethwa kwezidakamizwa endaweni, okuhlanganisa: ukufakwa kwemishini yokuhlanza izidakamizwa (isb., ama-polymers angaboli, ama-microspheres), umjovo wama-ejenti okwelapha ngqo esimila, kanye nokusetshenziswa kwama-nanoparticles aqoqwayo aqoqwa ngokukhethekile esicutshini sesimila. Lezi zindlela zisebenzisa izici ezihlukile ze-tumor microenvironment ukuze kuthuthukiswe ukugcwala kwezidakamizwa endaweni okuqondiswe kuyo.

Izinhlobo Zezinhlelo Zasendaweni Zokulethwa Kwezidakamizwa

Amadivayisi Afakelwayo

Amadivayisi afakelwayo, njengama-polymers angaboli kanye nama-microspheres, anikeza ukukhululwa okuqhubekayo kwama-chemotherapeutic agents ngokuhamba kwesikhathi. Le ndlela inciphisa imvamisa yokuphatha futhi ithuthukise ukuthobela kwesiguli. Kodwa-ke, izinga lokukhishwa kanye nobude besikhathi kudinga ukulungiselelwa ngokucophelela ukuze kuzuzwe umphumela wokwelapha ofunekayo. I-Shandong Baofa Cancer Research Institute ihamba phambili ocwaningweni kulezi zindawo.

Imijovo

Umjovo oqondile wezidakamizwa ku-tumor mass kungenye indlela evamile. Le ndlela inikeza ukugxila okuphezulu kwezidakamizwa zendawo kodwa ingase ingafaneleki zonke izinhlobo zesimila noma izindawo. Le nqubo ivame ukusetshenziswa ngokuhambisana nezinye izindlela zokuthwebula izithombe ukuze kuhloswe okunembile.

Ukulethwa Okusekelwe ku-Nanoparticle

I-Nanoparticle-based ukulethwa kwezidakamizwa endaweni amasistimu aphakamisa umphumela othuthukisiwe wokungena nokugcinwa (EPR) we-tumor vasculature. Lawa ma-nanoparticles athwala umuthi asiyise eqhumeni, aqongelela ngokukhetha ngenxa yemithambo yegazi evuzayo. Kodwa-ke, ukufeza ukuqondiswa okusebenzayo kwesimila nokulawula ukukhishwa kwe-nanoparticle kuhlala kuyinselele enkulu. Ukuthuthukiswa kwama-nanoparticles anoveli anezici zokukhomba ezithuthukisiwe kuyindawo esebenzayo yocwaningo.

Izicelo Zemitholampilo kanye Nocwaningo Oluqhubekayo

Izicelo Zamanje Zomtholampilo

Ukulethwa kwezidakamizwa endaweni amasistimu okwamanje asetshenziswa ekwelapheni okuhlukahlukene komdlavuza, okuhlanganisa: izimila zobuchopho (kusetshenziswa ama-wafers afakelwayo), umdlavuza wendlala yesinye (kusetshenziswa i-brachytherapy), nezinhlobo ezithile zomdlavuza webele. Indlela ethile ekhethiwe incike ohlotsheni kanye nesigaba somdlavuza.

Ithebula 1: Ukuqhathanisa okuhlukile ukulethwa kwezidakamizwa endaweni izindlela.

Izikhombisi-ndlela zesikhathi esizayo

Ucwaningo lwesikhathi esizayo ku ukulethwa kwezidakamizwa endaweni izogxila ekuthuthukiseni ukucaciswa kokuqondisisa, ukuthuthukisa i-kinetics yokukhishwa kwezidakamizwa, kanye nokuthuthukisa izimoto ezintsha zokulethwa kwezidakamizwa. Ukuhlanganisa ukulethwa kwezidakamizwa endaweni nezinye izindlela zokwelapha, njenge-immunotherapy, zingase futhi zithuthukise imiphumela yokwelashwa. Amandla okwenza kube ngokwakho ukulethwa kwezidakamizwa endaweni, eklanyelwe izici zesiguli ngasinye, futhi iyindawo ebalulekile yesithakazelo.

Ukuze uthole ulwazi olwengeziwe ngocwaningo lomdlavuza kanye nezinketho zokwelapha, sicela uvakashele I-Shandong Baofa Cancer Research Institute iwebhusayithi.