ukwelashwa okusha kwempumelelo yokwelashwa komdlavuza wamaphaphu ngo-2020

Ukuphumelela Okusha Kokwelashwa Komdlavuza Wamaphaphu: 2020 nangaphezulu

Lesi sihloko sinikeza ukubuka konke kwentuthuko ebalulekile ukwelashwa okusha kwempumelelo yokwelashwa komdlavuza wamaphaphu ngo-2020 nangale kwalokho. Sihlola intuthuko ebalulekile ekwelapheni okuhlosiwe, ama-immunotherapies, nezinye izindlela ezintsha, sigxile ekusebenzeni kwazo kanye nomthelela ongaba khona emiphumeleni yesiguli. Funda mayelana nocwaningo lwakamuva kanye nezivivinyo zomtholampilo eziqhubekayo ezakha ikusasa lokunakekelwa komdlavuza wamaphaphu.

Ukwelapha Okuhlosiwe: Umuthi Onembile Uthatha Isiteji Sesikhungo

Intuthuko ku-EGFR kanye ne-ALK Inhibitors

Sekwenziwe inqubekelaphambili enkulu ekwelashweni okuhlosiwe, ikakhulukazi ezigulini ezinezinguquko ezithile zofuzo. Ukwelashwa kwempumelelo entsha yokwelashwa komdlavuza wamaphaphu ngo-2020 ibone ukugunyazwa kwama-EGFR amasha ambalwa kanye ne-ALK inhibitor, enikeza ukusebenza okuthuthukisiwe nokubekezeleleka uma kuqhathaniswa nezizukulwane zangaphambili. Le mithi iqoka ngokukhethekile amangqamuzana omdlavuza ngalezi zinguquko, inciphisa ukulimala kwezicubu ezinempilo. Isibonelo, ukuthuthukiswa kwama-EGFR inhibitors esizukulwane sesithathu kubonise isithembiso ekunqobeni ukumelana nokwelashwa kwangaphambili. Ucwaningo olwengeziwe luyaqhubeka nokuhlola amandla alezi zindlela zokwelapha ezihlosiwe ngokuhlangana nezinye izindlela zokwelapha.

I-Immunotherapies: Ukusebenzisa Amandla Ohlelo Lwamasosha omzimba

Ama-Checkpoint Inhibitors kanye Neqhaza Lawo Ekwelapheni Umdlavuza Wamaphaphu

Ama-Immunotherapies, asebenzisa amasosha omzimba ukuze alwe nomdlavuza, aseshintshile ukwelashwa okusha kwempumelelo yokwelashwa komdlavuza wamaphaphu ngo-2020. Ama-Checkpoint inhibitors, njenge-PD-1 ne-PD-L1 inhibitors, abonise impumelelo emangalisayo ekwandiseni ukuphila ezigulini ezinomdlavuza wamaphaphu othuthukile. Le mithi ivimba izimpawu ezisetshenziswa amangqamuzana omdlavuza ukubalekela amasosha omzimba, ivumela amaseli omzimba ukuthi ahlasele futhi abhubhise isimila. Kodwa-ke, akuzona zonke iziguli ezisabela ku-immunotherapy, futhi ucwaningo lusaqhubeka lokukhomba ama-biomarker ukubikezela ukuthi yiziphi iziguli ezizozuza kakhulu. Ngaphezu kwalokho, ucwaningo luhlola ukusetshenziswa kwe-immunotherapy ngokuhlanganiswa nezinye izindlela zokwelapha, njenge-chemotherapy noma ukwelashwa okuhlosiwe, ukuze kuthuthukiswe ukusebenza kahle.

Ezinye Izindlela Ezithembisayo

Ukwelashwa Okusafufusa kanye Nezilingo Zomtholampilo Eziqhubekayo

Ngaphandle kwezindlela zokwelapha ezihlosiwe kanye ne-immunotherapies, ezinye izindlela ezimbalwa ezithembisayo ziyaphenywa ukwelashwa okusha kwempumelelo yokwelashwa komdlavuza wamaphaphu ngo-2020. Lokhu kufaka phakathi imishanguzo yenoveli yokwelapha ngamakhemikhali, intuthuko yokwelashwa ngeradiation (njenge-stereotactic body radiotherapy noma i-SBRT), kanye nezinhlelo ezintsha zokulethwa kwezidakamizwa. Izivivinyo eziningi zemitholampilo ziyaqhubeka, kuhlolwa ukusebenza kwalokhu kwelashwa okusha kanye nokuhlola inhlanganisela engaba khona ukuze kuthuthukiswe imiphumela. Ukuhlala unolwazi mayelana nezinhlolo zokwelashwa eziqhubekayo kubalulekile ezigulini nasemindenini yazo ezifuna izinketho zokwelashwa ezithuthuke kakhulu. ClinicalTrials.gov iwumthombo obalulekile wokuthola ulwazi ngezivivinyo zamanje.

Ikusasa Lokwelashwa Komdlavuza Wamaphaphu

Isimo sokwelashwa komdlavuza wamaphaphu sihlala sishintsha, ucwaningo oluqhubekayo nentuthuko icindezela imingcele yalokho okungenzeka. Ukuhlanganiswa kwemithi enembile, i-immunotherapy, nezinye izindlela ezintsha kunesithembiso esikhulu sokuthuthukisa imiphumela yesiguli namazinga okusinda. Kubalulekile ukuthi abantu ababhekene nokuxilongwa komdlavuza wamaphaphu baxhumane nodokotela wabo we-oncologist ukuze baxoxe ngesu elifaneleka kakhulu lokwelapha elenzelwe isimo sabo esithile kanye nephrofayili yofuzo. Ukuze uthole ukunakekelwa okuphelele komdlavuza, cabanga ukuhlola ubuchwepheshe obutholakala ezikhungweni ezifana ne- I-Shandong Baofa Cancer Research Institute.

Ukuqhathaniswa Kwedatha: Intuthuko Ebalulekile Yokwelashwa ()

Qaphela: Lolu lwazi ololwazi olujwayelekile kanye nezinjongo zolwazi kuphela, futhi aluhlanganisi iseluleko sezokwelapha. Hlala uthintana nochwepheshe bezempilo abaqeqeshiwe nganoma yikuphi ukukhathazeka ngezempilo noma ngaphambi kokwenza noma yiziphi izinqumo ezihlobene nempilo noma ukwelashwa kwakho.