metastatic non small cell lung cancer treatment

ʻO ka maʻi maʻi ʻaʻai māmā liʻiliʻi liʻiliʻi metastatic (mNSCLC) he maʻi paʻakikī e koi ana i nā hoʻolālā lapaʻau pilikino. Hāʻawi kēia alakaʻi i kahi hiʻohiʻona o nā koho lapaʻau hou loa, e pili ana i nā lāʻau lapaʻau i hoʻopaʻa ʻia, immunotherapy, chemotherapy, a me nā hoʻokolohua lapaʻau, e hoʻoikaika ana i nā poʻe maʻi a me ko lākou ʻohana me ka ʻike e hana i nā hoʻoholo ʻike.Metastatic non-small cell lung cancer, ʻike ʻia hoʻi ʻo ka pae IV NSCLC, ʻo ia hoʻi, ua laha ke kanesa mai ka māmā a i nā wahi ʻē aʻe o ke kino. ʻO nā wahi maʻamau o ka metastasis ka lolo, ka iwi, ka ate, a me nā ʻāʻī adrenal. ʻOiai ʻoi aku ka paʻakikī o ka mālama ʻana i ka maʻi metastatic, ua hoʻomaikaʻi maikaʻi ʻia ka holomua o nā koho lapaʻau i nā hopena a me ka maikaʻi o ke ola no nā maʻi he nui. He mea koʻikoʻi ka ʻike mua, a hiki iā ʻoe ke aʻo hou aku e pili ana i ka noiʻi maʻi maʻi ma ka Shandong Baofa Cancer Research Institute. Nā ʻano o ka maʻi maʻi maʻi ʻaʻole liʻiliʻi ʻo ka NSCLC ʻelua ʻo ka adenocarcinoma a me ka squamous cell carcinoma. ʻO Adenocarcinoma ka maʻi maʻamau a loaʻa pinepine i ka poʻe ʻaʻole puhi. Hoʻopili pinepine ʻia ka maʻi maʻi maʻi Squamous cell i ka puhi paka. ʻO nā ʻano ʻano liʻiliʻi ʻē aʻe e pili ana i ka carcinoma cell nui a me ka carcinoma adenosquamous. Pono ka hōʻoia pololei o ka subtype no ka hoʻoholo ʻana i ke ala lapaʻau kūpono loa.Diagnosis and StagingDiagnosing metastatic non small cell lung cancer treatment ʻO ka mea maʻamau ka hui pū ʻana o nā hoʻokolohua kiʻi (CT scans, PET scans, MRI), biopsies, a me ka hoʻāʻo molecular. ʻIke ʻia ka hoʻāʻo ʻana i ka molecular cell no nā hoʻololi genetic kikoʻī a i ʻole biomarkers i hiki ke kuhikuhi ʻia me nā lāʻau lapaʻau kūikawā. Hoʻoholo ka staging i ka nui o ka laha ʻana o ka maʻi kanesa, kōkua i nā kauka e hoʻoponopono i ka hoʻolālā lapaʻau. metastatic non small cell lung cancer treatment ʻo ka maʻamau ka ʻōnaehana, ʻo ia hoʻi, pili ia i ke kino holoʻokoʻa. ʻO nā ʻano lāʻau lapaʻau maʻamau, ʻo ia hoʻi: Targeted Therapy ʻO nā lāʻau lapaʻau i hoʻopaʻa ʻia e kuhikuhi pono i kekahi mau mole (e like me nā protein a i ʻole nā ​​genes) e kōkua i ka ulu a laha ʻana o nā maʻi kanesa. Hoʻohana pinepine ʻia kēia mau lāʻau lapaʻau i nā poʻe maʻi i loaʻa i nā maʻi koko nā hoʻololi genetic kikoʻī. ʻO nā mea hoʻopaneʻe EGFR maʻamau: Osimertinib (Tagrisso) Erlotinib (Tarceva) Gefitinib (Iressa) Afatinib (Gilotrif) Hoʻopaʻa kēia mau lāʻau i ka protein EGFR, e pale ana i ka ulu ʻana o nā maʻi kanesa. ʻO nā mea hoʻopaneʻe ALK maʻamau: Alectinib (Alecensa) Brigatinib (Alunbrig) Ceritinib (Zykadia) Crizotinib (Xalkori) ʻO kēia mau lāʻau lapaʻau e kāohi i ka protein ALK, hoʻolohi a hoʻōki paha i ka ulu ʻana o ka maʻi maʻi. E hoʻoholo ana kāu kauka oncologist inā loaʻa kēia mau hoʻololi ʻana i kāu maʻi maʻi. Hoʻohana pinepine ʻia kēia mau lāʻau lapaʻau ma ke ʻano he koho lapaʻau mua no metastatic non small cell lung cancer treatment.PD-1 a me PD-L1 Inhibitors ʻO kēia mau lāʻau lapaʻau e hoʻopaʻa i ka PD-1 (programmed cell death protein 1) a i ʻole PD-L1 (programmed cell death ligand 1) proteins, e kōkua ana i nā maʻi kanesa e pale aku i ka ʻōnaehana pale. ʻO nā mea hoʻopaneʻe PD-1 a me PD-L1 maʻamau ka: Pembrolizumab (Keytruda) Nivolumab (Opdivo) Atezolizumab (Tecentriq) Durvalumab (Imfinzi) - Hoʻohana pinepine ʻia ma hope o ka chemoradiation i ka pae III NSCLC. Hiki ke hoʻohana ʻia kēia mau lāʻau hoʻokahi a i hui pū ʻia me nā lāʻau lapaʻau. ʻO T-lymphocyte-associated protein 4) protein, ka mea e kōkua pū i nā maʻi kanesa e pale aku i ka ʻōnaehana pale. ʻO Ipilimumab (Yervoy) he mea hoʻopaneʻe CTLA-4 maʻamau, hoʻohana ʻia i kekahi manawa me ka hui pū ʻana me PD-1. ʻOiai ua ʻoi aku ka nui o nā lāʻau lapaʻau a me nā immunotherapies i hoʻopaʻa ʻia, noho mau ka chemotherapy i kahi koho lapaʻau maʻamau, ʻoi aku ka hui pū ʻana me nā lāʻau lapaʻau ʻē aʻe. Hoʻohana ʻia nā lāʻau lapaʻau maʻamau no ka chemotherapy metastatic non small cell lung cancer treatment ʻO nā lāʻau lapaʻau Platinum-based (Cisplatin, Carboplatin) Taxanes (Paclitaxel, Docetaxel) Pemetrexed (Alimta) Gemcitabine (Gemzar)Radiation Therapy Hoʻohana ka lāʻau lapaʻau i nā kukuna ikaika kiʻekiʻe e pepehi i nā maʻi kanesa. Hoʻohana pinepine ʻia e hoʻomaha i nā hōʻailona e like me ka ʻeha a i ʻole ka pōkole o ka hanu i ka wā i laha ai ka maʻi kanesa i nā wahi kikoʻī e like me ka iwi a i ʻole ka lolo. Hiki ke hoʻohana ʻia no ka mālama ʻana i ka maʻi maʻi mua metastatic non small cell lung cancer treatment, akā hiki ke hoʻohana ʻia i kekahi mau kūlana no ka wehe ʻana i kahi metastasis hoʻokahi, ʻoi aku hoʻi i loko o ka lolo a i ʻole nā ʻōpū adrenal. He ʻāpana pinepine kēia o ka papa hana lapaʻau. Hāʻawi lākou i nā poʻe maʻi i ke komo ʻana i nā lāʻau lapaʻau ʻokiʻoki ʻaʻole i loaʻa ākea. E noʻonoʻo e kūkākūkā i nā koho hoʻokolohua lapaʻau me kāu kauka. Ke komo ikaika nei ka Shandong Baofa Cancer Research Institute a paipai i ka noiʻi lapaʻau. Hiki i kāu kauka ke kōkua iā ʻoe e mālama i kēia mau hopena ʻaoʻao me nā lāʻau lapaʻau a me nā mālama kākoʻo ʻē aʻe. ʻO nā hopena ʻaoʻao maʻamau e pili ana i ka luhi, nausea, ʻeha, a me ka lauoho lauoho. He mea koʻikoʻi ke kamaʻilio ʻana i nā hopena ʻaoʻao āu e ʻike ai i kāu hui mālama ola. metastatic non small cell lung cancer treatment ʻokoʻa ma muli o kekahi mau kumu, e like me ka pae o ka maʻi kanesa, ke olakino holoʻokoʻa o ka mea maʻi, a me ka lāʻau lapaʻau kūikawā i loaʻa. ʻOiai ke piʻi pinepine nei ka maʻi, ua hoʻomaikaʻi nui ʻia ka nui o ke ola me ka hoʻomohala ʻana i nā lāʻau lapaʻau hou. Kūkākūkā i kāu prognosis me kāu oncologist.Palliative Care ʻO ka mālama palliative e kālele ana i ka hoʻomaha ʻana i nā hōʻailona a me ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola no nā poʻe maʻi me nā maʻi koʻikoʻi, me ka maʻi kanesa maʻi metastatic. Hiki ke hāʻawi ʻia i kēlā me kēia pae o ka maʻi, a hoʻohana pinepine ʻia me nā lāʻau lapaʻau ʻē aʻe. Hiki i ka mālama palliative ke kōkua i ka mālama ʻana i ka ʻeha, ka pōkole o ka hanu, ka luhi, a me nā hōʻailona ʻē aʻe. Nā Manaʻo Koʻikoʻi no nā Hoʻoholo Lapaʻau Ke koho ʻana i ka lapaʻau kūpono no metastatic non small cell lung cancer treatment he hoʻoholo paʻakikī e hana ʻia me ke kūkākūkā me kāu kauka oncologist. Eia kekahi mau manaʻo nui: Nā hualoaʻa hoʻāʻo molekula: He mea koʻikoʻi ka hoʻomaopopo ʻana i nā mutation genetic kikoʻī a i ʻole biomarkers i kāu mau maʻi maʻi maʻi no ka hoʻoholo ʻana inā he koho nā lāʻau lapaʻau. Ola holookoa: E hoʻololi kou pae olakino a me kou kino holoʻokoʻa i nā lapaʻau kūpono. Nā Pahuhopu Lapaʻau: E kūkākūkā i kāu mau pahuhopu no ka mālama ʻana me kāu kauka, inā paha e hoʻonui i ke ola, hoʻomaikaʻi i ka maikaʻi o ke ola, a i ʻole nā mea ʻelua. Nā hopena ʻaoʻao: E hoʻomaopopo i nā hopena ʻaoʻao o kēlā me kēia koho lapaʻau a pehea e mālama ʻia ai. Nā hoʻokolohua lapaʻau: E noʻonoʻo inā kūpono ʻoe i ke komo ʻana i kahi hoʻokolohua lapaʻau. Hoʻomohala mau ʻia nā lāʻau lapaʻau hou a me nā ala. ʻO kekahi o nā holomua hou loa: Nā mea hoʻohui lāʻau antibody (ADCs): Hoʻohui kēia mau lāʻau lapaʻau i ka kikoʻī o ka lāʻau lapaʻau i manaʻo ʻia me ka mana pepehi cell o ka chemotherapy. ʻO nā antibodies Bispecific: Hoʻopili kēia mau antibodies i nā cell immune e huli a pepehi i nā maʻi maʻi maʻi. Hoʻomaikaʻi ʻia nā ʻenehana radiation: ʻO nā ʻenehana e like me ka stereotactic body radiation therapy (SBRT) e hāʻawi i nā kiʻekiʻe kiʻekiʻe o ka radiation i nā maʻi maʻi ʻoiai e hōʻemi ana i ka pōʻino i nā ʻiʻo a puni. Noho me Metastatic Non-Small Cell Lung CancerLiving me metastatic non small cell lung cancer treatment hiki ke paʻakikī, akā he nui nā kumuwaiwai e kōkua ai i nā maʻi a me ko lākou ʻohana. Hiki i nā hui kākoʻo, nā ʻōlelo aʻo, a me nā kaiāulu pūnaewele ke hāʻawi i ke kākoʻo noʻonoʻo a me nā ʻōlelo aʻo kūpono. ʻO ka mālama ʻana i ke ola olakino, me ka ʻai kaulike a me ka hoʻoikaika mau, hiki ke hoʻomaikaʻi i ka maikaʻi o ke ola. Hōʻole: Kuhi ʻia kēia ʻike no ka ʻike ākea a me ka ʻike ʻike wale nō, ʻaʻole ia he ʻōlelo aʻoaʻo olakino. He mea nui e kūkākūkā me kekahi kauka lapaʻau koʻikoʻi no nā pilikia olakino a i ʻole ma mua o ka hoʻoholo ʻana e pili ana i kou olakino a lapaʻau paha.Nā Punawai Kūwaho:American Cancer Society - Ka mālama 'ana i ka ma'i ma'i 'a'ai ma'i 'ole li'ili'i ma ka paeCancer.Net - Ka ma'i 'a'ai ma'i 'a'ai - 'a'ole li'ili'i - nā koho lapa'auNational Comprehensive Cancer Network (NCCN) - Non-Small Cell Lung Cancer Guidelines for Patients (PDF)Kuhikuhi: Hoʻokumu ʻia ka ʻikepili a me ka ʻike i hōʻike ʻia ma ka ʻike olakino o kēia manawa a loaʻa mai nā hui olakino kaulana e like me ʻOkakopa 26, 2023.