ʻO ka lawe ʻana i ka lāʻau lapaʻau i manaʻo ʻia no ka maʻi maʻi: He alakaʻi piha 

Hāʻawi ʻia ka lāʻau lapaʻau no ka maʻi kanesa ka manaʻo e hoʻomaikaʻi i ka maikaʻi o ka mālama ʻana a hōʻemi i nā hopena ʻaoʻao ma o ka hāʻawi ʻana i nā mea lapaʻau i nā maʻi maʻi maʻi ʻoiai e mālama ana i nā ʻiʻo olakino. Hoʻohana kēia ala i nā mea lawe like ʻole a me nā hoʻolālā hoʻolālā e hoʻonui i ka hōʻiliʻili lāʻau i loko o ka microenvironment tumor, e alakaʻi ana i ka hopena o ka maʻi.

ka hoomaopopo ana Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi

He aha ka Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi?

Hāʻawi ʻia ka lāʻau lapaʻau no ka maʻi kanesa he ala maʻalahi o ka lawelawe ʻana i ka lāʻau lapaʻau i nā pūnaeau maʻi maʻi. ʻAʻole e like me ka chemotherapy maʻamau, e pili ana i ke kino holoʻokoʻa, ʻo nā ʻōnaehana hoʻopuka i manaʻo ʻia e nānā pono i ka hāʻawi ʻana i nā lāʻau lapaʻau i ka pūnaewele tumora. Hoʻemi kēia ala i ka pōʻino i nā ʻiʻo olakino a hōʻemi i nā hopena ʻaoʻao koʻikoʻi i pili pinepine ʻia me nā lāʻau lapaʻau maʻamau.

No ke aha Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi Mea nui?

ʻO ka pahuhopu mua o ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa ʻo ia ka hoʻomaikaʻi ʻana i ka maikaʻi o ka mālama ʻana i ka maʻi maʻi ʻoiai e hōʻemi ana i nā hopena ʻona i nā cell olakino. Ma ka hāʻawi pololei ʻana i nā lāʻau lapaʻau i ka ʻōpū, hiki ke hoʻokō ʻia nā kiʻekiʻe kiʻekiʻe o ka lāʻau lapaʻau ma ka wahi i hoʻopaʻa ʻia, e hoʻomaikaʻi ana i nā manawa o ka mālama kūleʻa. Hoʻemi kēia i ka ʻike ʻana o ka ʻōnaehana i ka lāʻau lapaʻau, e alakaʻi ana i ka liʻiliʻi a me ka liʻiliʻi o nā hopena koʻikoʻi no ka mea maʻi.

Hoʻokokoke i Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi

Hoʻopaʻa ʻia ʻana

Ke hilinaʻi nei ka huli ʻana i nā hiʻohiʻona kūlohelohe o nā ʻōpū, e like me kā lākou leaky vasculature a me ka hoʻohaʻahaʻa lymphatic impaired, e ʻae i nā lāʻau e hōʻiliʻili i loko o ka microenvironment tumor. Hiki i nā nanoparticles me ka nui kūpono a me ka waiwai o ka ʻili ke hoʻohana i kēia mau hiʻohiʻona e hoʻopaʻa paʻa i nā ʻōpū. ʻO kekahi laʻana, ʻo ia nā liposomes he vesicles spherical i haku ʻia me nā lipid bilayers.

Hoʻopalau ʻeleu

ʻO ka hoʻoikaika ʻana e pili ana i ka hoʻololi ʻana i nā mea lawe lāʻau me nā ligand kikoʻī e hoʻopaʻa ʻia i nā mea hoʻokipa i hōʻike nui ʻia ma nā cell cancer. Hoʻomaʻamaʻa kēia pilina i ka lawe ʻana i ka mea lawe lāʻau e nā maʻi kanesa. ʻO nā ligand maʻamau e pili ana i nā antibodies, peptides, a me nā aptamers.

ʻO ka hoʻoulu ʻana-pane ʻana

Hoʻohana ka stimuli-responsive targeting i nā mea hoʻoulu i loko a i waho paha, e like me ka pH, ka mahana, a i ʻole ka māmā, e hoʻomaka ai i ka hoʻokuʻu ʻana i ka lāʻau lapaʻau ma ka pūnaewele tumor. Hāʻawi kēia ala i ka mana pololei ma luna o ka lawe ʻana i ka lāʻau lapaʻau, e hoʻonui i ka hopena therapeutic aʻo ka hōʻemi ʻana i nā hopena o waho. ʻO nā nanoparticles koʻikoʻi pH, no ka laʻana, e hoʻokuʻu i kā lākou uku lāʻau i loko o ke kaiapuni waikawa o ka microenvironment tumor.

Hoʻohana ʻia nā mea lawe ma Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi

Nanoparticles

Hoʻohana nui ʻia nā nanoparticles e like me nā mea lawe i loko ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa ma muli o ko lākou liʻiliʻi liʻiliʻi, ka ʻili nui, a me ka versatility. Hiki iā lākou ke hana ʻia mai nā mea like ʻole, me nā lipids, polymers, a me nā pūhui inorganic. Hiki ke hana ʻia nā nanoparticles e hoʻopili i nā lāʻau lapaʻau, pale iā lākou mai ka hoʻohaʻahaʻa ʻana, a hoʻomaʻamaʻa i kā lākou hāʻawi ʻia ʻana i nā maʻi kanesa. ʻO ka Shandong Baofa Cancer Research Institute hoʻohana i nā ʻano nanoparticles i kā lākou noiʻi ʻana i nā lāʻau lapaʻau maʻi maʻi hou.

Liposome

ʻO nā liposome he mau vesicles spherical i haku ʻia me nā lipid bilayers. He biocompatible, biodegradable, a hiki ke hoʻopili i nā lāʻau hydrophilic a me hydrophobic. Hiki ke hoʻololi ʻia nā liposome me nā ligands e hoʻonui i kā lākou koho no nā maʻi maʻi maʻi.

ʻO nā mea hoʻohui lāʻau antibody (ADC)

Hoʻokumu ʻia nā ADC me kahi antibody monoclonal i hoʻopili ʻia i kahi lāʻau cytotoxic. Hoʻopili paʻa ka antibody i nā pūnaeau maʻi kanesa, e hāʻawi pololei ana i ka lāʻau lapaʻau i ka pūnaewele tumor. Hoʻohui kēia ala i ka kikoʻī o nā antibodies me ka ikaika o nā lāʻau cytotoxic.

Nā laʻana o Hoʻouna ʻia i ka lāʻau lapaʻau no ka maʻi maʻi maʻi i ka hoʻohana lāʻau lapaʻau

Doxil? (Liposomal Doxorubicin)

Doxil? he hana liposomal o doxorubicin, he lāʻau chemotherapy anthracycline. ʻO ka liposomal encapsulation o doxorubicin e hoʻolōʻihi i kona manawa kaʻa a hoʻonui i kona hōʻiliʻili ʻana i nā ʻōpū me ka leaky vasculature. Doxil? ua ʻae ʻia no ka mālama ʻana i ka maʻi maʻi ovarian, myeloma lehulehu, a me ka sarcoma o Kaposi.

Kadcyla? (Trastuzumab Emtansine)

Kadcyla? he ADC i haku ʻia me trastuzumab, he antibody monoclonal e kuhikuhi ana i ka HER2, i hoʻopili ʻia me ka emtansine, kahi mea hoʻopaneʻe microtubule. Kadcyla? ua ʻae ʻia no ka mālama ʻana i ka maʻi maʻi umauma metastatic HER2 maikaʻi. ʻO ka ʻāpana trastuzumab o Kadcyla? hoʻopaʻa i ka HER2-maikaʻi o ka maʻi kanesa, hāʻawi pololei i ka emtansine i ka pūnaewele tumor.

Nā Luʻi a me nā kuhikuhi e hiki mai ana

Ka Lanakila ʻana i nā Paʻi Ola

ʻO kekahi o nā pilikia nui ma ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa ke lanakila nei i nā pale olaola, e like me ka pale koko-lolo a me ka microenvironment tumor. ʻO nā hoʻolālā no ka lanakila ʻana i kēia mau pale, ʻo ia ka hoʻohana ʻana i nā nanoparticles liʻiliʻi, ka hoʻololi ʻana i kā lākou mau waiwai o ka ʻili, a me ka hoʻohana ʻana i ka stimuli-responsive targeting.

Hoʻomaikaʻi ʻana i ka kikoʻī kikoʻī

ʻO ka hoʻomaikaʻi ʻana i ka kikoʻī o nā ʻōnaehana hoʻopuka lāʻau i manaʻo ʻia he mea koʻikoʻi ia e hōʻemi i nā hopena o waho a hoʻonui i ka hopena therapeutic. Hiki ke hoʻokō ʻia kēia ma o ka hoʻomohala ʻana i nā ligand koho, ka hoʻolālā ʻana i ka hoʻolālā o nā mea lawe lāʻau, a me ka hoʻohana ʻana i nā lāʻau lapaʻau hui.

Lapaau Pilikino

ʻO nā ala lapaʻau pilikino i hoʻohiki nui no ka hoʻomaikaʻi ʻana i ka pono o ka lawe ʻana i ka lāʻau lapaʻau no ka maʻi kanesa. Ma ka hoʻohālikelike ʻana i nā hoʻolālā lapaʻau i nā hiʻohiʻona o kēlā me kēia maʻi a me ko lākou maʻi maʻi, hiki paha ke hoʻonui i ka lawe ʻana i ka lāʻau a hoʻonui i nā hopena lapaʻau. Hoʻopili paha kēia i ka nānā ʻana i ka moʻo o ka ʻōpū e ʻike i nā pahuhopu kikoʻī no ka lawe ʻana i ka lāʻau.

Papa o ka FDA-Aponoia Manawa Laau Laau Hoolaha no ka ma'i ma'i

Hōʻole: No ka ʻike wale nō kēia ʻatikala a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. Kūkākūkā me kekahi ʻoihana mālama ola kūpono no ka ʻike a me ka mālama ʻana i ka maʻi kanesa.