Intego yo Gutanga Ibiyobyabwenge Kuri Kanseri: Igitabo Cyuzuye 

Gutanga imiti igenewe kanseri igamije kunoza imikorere yubuvuzi no kugabanya ingaruka mbi muguhitamo gutanga imiti ivura kanseri ya kanseri mugihe urinze ingirabuzimafatizo. Ubu buryo bukoresha uburyo butandukanye bwo gutwara no gufata ingamba zo kuzamura ibiyobyabwenge muri microen ibidukikije yibibyimba, biganisha ku barwayi neza.

Gusobanukirwa Gutanga ibiyobyabwenge bigenewe Kanseri

Niki Gutanga ibiyobyabwenge bigenewe Kanseri?

Gutanga imiti igenewe kanseri ni uburyo buhanitse bwo gutanga imiti mu ngirabuzimafatizo za kanseri. Bitandukanye na chimiotherapie gakondo, ifata umubiri wose, sisitemu yo gutanga yibanda ku gutanga imiti cyane cyane kubyimba. Ubu buryo bugabanya kwangirika kwinyama nzima kandi bikagabanya ingaruka zikomeye akenshi zijyanye no kuvura kanseri bisanzwe.

Kuki Gutanga ibiyobyabwenge bigenewe Kanseri Ni ngombwa?

Intego y'ibanze ya intego yo gutanga imiti ya kanseri ni ukongera imbaraga zo kuvura kanseri mugihe ugabanya ingaruka zuburozi kuri selile nzima. Mugutanga imiti yibibyimba, imbaraga nyinshi zubuvuzi zishobora kugerwaho ahabigenewe, bikongerera amahirwe yo kuvurwa neza. Ibi kandi bigabanya ingaruka ziterwa nibiyobyabwenge, biganisha ku ngaruka nke kandi nkeya ku murwayi.

Inzira Kuri Gutanga ibiyobyabwenge bigenewe Kanseri

Intego ya Passive

Kwibasirwa gusa bishingiye ku miterere karemano y'ibibyimba, nk'imitsi iva mu mitsi ndetse no kwangirika kw'amazi ya lymphatike, kugira ngo ibiyobyabwenge byegerane mu bidukikije. Nanoparticles ifite ubunini bukwiye hamwe nubuso burashobora gukoresha ibyo bintu kugirango yibasire ibibyimba. Akarorero kamwe ni liposomes ari spicical vesicles igizwe na lipid bilayers.

Intego ifatika

Intego yibikorwa ikubiyemo guhindura abatwara ibiyobyabwenge hamwe na ligande yihariye ihuza reseptors bikabije kanseri ya kanseri. Iyi mikoranire yorohereza gufata imiti itwara kanseri. Ligands isanzwe irimo antibodies, peptide, na aptamers.

Intego ya Stimuli

Intego ya Stimuli-yifashisha ibitera imbere cyangwa hanze, nka pH, ubushyuhe, cyangwa urumuri, kugirango ibiyobyabwenge bisohore ahabyimba. Ubu buryo butuma habaho kugenzura neza itangwa ryibiyobyabwenge, kugabanya uburyo bwo kuvura mugihe hagabanijwe ingaruka zitari nziza. pH-yunvikana nanoparticles, kurugero, kurekura imiti yabyo mumashanyarazi ya acide yibidukikije bya microen ibidukikije.

Abatwara Byakoreshejwe Gutanga ibiyobyabwenge bigenewe Kanseri

Nanoparticles

Nanoparticles ikoreshwa cyane nkabatwara muri intego yo gutanga imiti ya kanseri bitewe nubunini bwazo, ubuso bunini, hamwe na byinshi. Birashobora gukorwa mubikoresho bitandukanye, birimo lipide, polymers, hamwe ninganda zidasanzwe. Nanoparticles irashobora guhindurwa kugirango ikingire ibiyobyabwenge, ibarinde kwangirika, kandi byorohereze kwanduza kanseri ya kanseri. Uwiteka Shandong Baofa Ikigo Cyubushakashatsi cya Kanseri ikoresha nanoparticles zitandukanye mubushakashatsi bwabo bukomeje kuvura kanseri yubuvuzi.

Liposomes

Liposomes ni vicicles spherical igizwe na lipide bilayers. Nibinyabuzima bihuza, biodegradable, kandi birashobora gukwirakwiza imiti ya hydrophilique na hydrophobique. Liposomes irashobora guhindurwa hamwe na ligande igamije kongera ubushobozi bwa selile ya kanseri.

Antibody-Ibiyobyabwenge (ADCs)

ADCs igizwe na antibody ya monoclonal ihuza imiti ya cytotoxic. Antibody ihitamo guhuza ingirangingo za kanseri, igatanga imiti aho ikibyimba. Ubu buryo bukomatanya umwihariko wa antibodies hamwe nimbaraga zibiyobyabwenge bya cytotoxic.

Ingero za Gutanga ibiyobyabwenge bigenewe Kanseri mu Gukoresha Ivuriro

Doxil? (Liposomal Doxorubicin)

Doxil? ni liposomal formulaire ya doxorubicin, imiti ya anthracycline ya chimiotherapie. Liposomal enapsulation ya doxorubicin yongerera igihe cyo kuzenguruka kandi ikongerera ubwinshi bwikibyimba hamwe na vasculature itemba. Doxil? yemerewe kuvura kanseri yintanga, myeloma myinshi, na sarcoma ya Kaposi.

Kadcyla? (Trastuzumab Emtansine)

Kadcyla? ni ADC igizwe na trastuzumab, antibody ya monoclonal yibasira HER2, ifitanye isano na emtansine, inhibitor ya microtubule. Kadcyla? yemerewe kuvura kanseri y'ibere HER2-nziza. Igice cya trastuzumab cya Kadcyla? Ihuza na kanseri ya HER2-nziza ya kanseri, igatanga emtansine mu kibanza cyibibyimba.

Ibibazo hamwe nicyerekezo kizaza

Kunesha inzitizi zibinyabuzima

Imwe mu mbogamizi zikomeye muri intego yo gutanga imiti ya kanseri ni ugutsinda inzitizi zishingiye ku binyabuzima, nka barrière yamaraso-ubwonko hamwe na microen ibidukikije yibibyimba. Ingamba zo gutsinda izo nzitizi zirimo gukoresha nanoparticles ntoya, guhindura imiterere yabyo, no gukoresha intego-itera imbaraga.

Gutezimbere Intego yihariye

Kunoza umwihariko wa sisitemu yo gutanga imiti igamije ni ngombwa kugirango hagabanuke ingaruka zitari nziza kandi zongere imbaraga zo kuvura. Ibi birashobora kugerwaho mugutezimbere ligande nyinshi, guhitamo igishushanyo mbonera cyabatwara ibiyobyabwenge, no gukoresha imiti ivura.

Ubuvuzi bwihariye

Uburyo bwubuvuzi bwihariye bufite amasezerano akomeye yo kunoza imikorere ya intego yo gutanga imiti ya kanseri. Muguhuza ingamba zo kuvura kubiranga buri murwayi nibibyimba byabo, birashoboka ko uburyo bwogutanga imiti no kuzamura ibisubizo byubuvuzi. Ibi bishobora kuba bikubiyemo gusesengura imiterere yimiterere yikibyimba kugirango umenye intego zihariye zo gutanga ibiyobyabwenge.

Imbonerahamwe ya FDA Yemewe Kugamije Gutanga Ibiyobyabwenge kuri Kanseri

Inshingano: Iyi ngingo igamije amakuru gusa kandi ntigomba gufatwa nkinama zubuvuzi. Menyesha inzobere mu buvuzi zujuje ibyangombwa byo gusuzuma no kuvura kanseri.