Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza: Isiqondisi esibanzi 

Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza Ihlose ukuthuthukisa ukusebenza ngempumelelo yokwelashwa futhi inciphise imiphumela emibi ngokukhetha ama-ejenti wezokwelapha kumaseli womdlavuza ngenkathi uvikela izicubu ezinempilo. Le ndlela ithola amasu ahlukahlukene ahlukahlukene kanye namasu wokuhlose ukuthuthukisa ukunqwabelana kwezidakamizwa ngaphakathi kwesimila esingu-Microenvelo, okuholela emiphumeleni yeziguli ethuthukisiwe.

-Zwayo Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza

Yini Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza?

Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza kuyindlela eyinkimbinkimbi yokuphatha umuthi ngqo kumaseli womdlavuza. Ngokungafani nendabuko ye-chemotherapy, ethinta wonke umzimba, izinhlelo ezihlosiwe zokulethwa zigxile ekuletheni izidakamizwa ngqo kwisiza se-tumor. Le ndlela inciphisa ukulimala kwezicubu ezinempilo futhi inciphise imiphumela emibi enzima evame ukuhlotshaniswa nokwelashwa komdlavuza okuvamile.

Kungani Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza Kubalulekile?

Umgomo oyinhloko we Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza ukuthuthukisa ukusebenza kahle kwezindlela zokwelapha umdlavuza ngenkathi kunciphisa imiphumela enobuthi kumaseli anempilo. Ngokuletha izidakamizwa ngqo ku-turos, ukugxila okuphezulu kwe-ejenti yokwelapha kungatholakala endaweni okuhlosiwe, kuthuthukise amathuba okuthola ukwelashwa okuphumelelayo. Lokhu futhi kunciphisa ukuvezwa kwesidakamizwa, okuholela emiphumeleni emibi embalwa futhi enzima kakhulu yesiguli.

Isondela ku- Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza

Ukuqondiswa kokuphawula

Ukuhlobisa okungenakuphikwa kuthembela ezimfanelweni zemvelo zama-tumors, njenge-vasculat yazo ye-vasculat ye-vasculat kanye nokuvumela izidakamizwa ukuba ziqongelele isimila microenvelo. Ama-nanoparticles anosayizi ofanele kanye nezindawo ezingaphezulu zingaxhaphaza lezi zici kuma-tumors aqondiswe ngokuqinile. Isibonelo esisodwa ama-liposomes ama-vesicles ayindilinga aqanjwa ngababili be-lipid.

Ukuqondiswa okusebenzayo

Ukuqondiswa okusebenzayo kubandakanya ukuguqula abathwali bezidakamizwa ngama-ligands athile ahlanganisa ama-receptors avelele kumaseli womdlavuza. Lokhu kusebenzisana kusiza ukwenziwa okukhethiwe kwesithwali sezidakamizwa ngamaseli womdlavuza. Ama-ligands ajwayelekile afaka ama-antibodies, ama-peptides nama-aphamers.

Ukuqondisisa okuvuselelayo

Ukuhlobisa okusabela okuvuselelayo kusebenzisa ukukhuthaza kwangaphakathi noma kwangaphandle, okufana ne-PH, lokushisa, noma ukukhanya, ukudala ukukhishwa kwezidakamizwa endaweni ye-tumor. Le ndlela ivumela ukulawulwa okuqondile kokulethwa kwezidakamizwa, kwandise ukusebenza kahle kwezokwelapha ngenkathi kunciphisa imiphumela ye-off-okuqondiwe. Ama-nanoparticles abucayi be-PH

Izithwali ezisetshenziswe ngaphakathi Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza

Ama-Nanoparticles

Ama-nanoparticles asetshenziswa kabanzi njengezithwali ngaphakathi Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza Ngenxa yobukhulu babo obuncane, indawo enkulu engaphezulu, kanye nokuguquguquka okuhlukahlukene. Zingenziwa kusuka ezintweni ezahlukahlukene, kufaka phakathi ama-lipid, ama-polymers kanye namakhompiyutha e-inorganic. Ama-nanoparticles angathuthukiswa ukuze avume izidakamizwa, zivikele ekudleni ngokweqile, futhi zihambise ukulethwa kwazo okuhlosiwe kumaseli womdlavuza. Le khasi I-Shandong Baafa Cancer Research Institute Isebenzisa izinhlobonhlobo zama-nanoparticles ocwaningweni lwazo oluqhubekayo emidlalweni yomdlavuza wenoveli.

I-Liposomes

Ama-liposomes ama-vesicles ayindilinga aqukethe ama-lipid balayers. Ahambisane, ayihambelani, futhi angavuma zombili izidakamizwa ze-hydrophilic kanye ne-hydrophobic. Ama-liposomes angashintshwa ngama-ligands ahlose ukuthuthukisa ukukhetha kwawo kokukhetha kwawo amaseli womdlavuza.

Izimbotshana zezidakamizwa ze-antibody-Drug (ADCs)

I-ADCS yakhiwa i-monoclonal antibody exhumene nomuthi we-cytotoxic. I-antibody ibopha amaseli womdlavuza, iletha umuthi ngqo kwisiza se-tumor. Le ndlela ihlanganisa ukucaciswa kwama-antibodies nge-potency yezidakamizwa ze-cytotoxic.

Izibonelo ze Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza Ekusetshenzisweni kwemitholampilo

Doxil? (I-Liposomal Doxorubicin)

Doxil? Ingabe ukwakhiwa kwe-MIPOROMAL ye-Doxorubicin, isidakamizwa se-anthracycline chemotherapy. I-Liposomisol EncopSunsicin ye-Doxorubicin isondele isikhathi sayo sokujikeleza kwayo futhi ithuthukisa ukunqwabelana kwayo kuma-tumors ane-vasculature evuzayo. Doxil? Kuvunyelwe ukwelashwa komdlavuza we-ovarian, i-myoloma eningi, ne-kapo's sarcoma.

Kadcyla? (I-trastuzumab emtansine)

Kadcyla? Ingabe i-ADC eyakhiwe ngeTrastuzumab, i-antibody ye-monoclonal ehlose i-Her2, exhunywe kwi-Emtansine, i-Microtuubeule Invibitor. Kadcyla? kuvunyelwe ukwelashwa komdlavuza webele we-metastatic. Ingxenye yeTrastuzumab yeKadcyla? Ibopha amaseli omdlavuza wakhe angama-100, alethe i-Emtansine ngqo kwisiza se-tumor.

Izinselelo nezinkomba zesikhathi esizayo

Ukunqoba izithiyo zemvelo

Enye yezinselelo ezinkulu ku- Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza inqoba izithiyo zemvelo, ezinjengesithiyo segazi-ubuchopho kanye nesimila se-microenvelo. Amasu okunqoba lezi zingqinamba zifaka ukusebenzisa ama-nanoparticles amancane, elungisa izakhiwo zawo ongaphezulu, futhi asebenzise ukuqondiswa okusabela okuvuselelayo.

Ukwenza ngcono ukucaciswa kokuqondisa

Ukwenza ngcono ukucaciswa kwezinhlelo ezihlosiwe kwezidakamizwa kubalulekile ukunciphisa imiphumela ye-off-okuqondiwe futhi kuthuthukise ukusebenza kwezokwelapha. Lokhu kungatholakala ngokuthuthukisa ama-ligands akhethiwe amaningi, okwenza ukwakheka kwabathwali bezidakamizwa, kanye nokusebenzisa izindlela zokwelapha ezihlanganisiwe.

Umuthi owenziwe umuntu

Izindlela zomuntu uqobo zibamba isithembiso esihle sokwenza ngcono ukusebenza kwe Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza. Ngokuvumelanisa amasu okulashwa ezimfanelweni ngazinye zesiguli ngasinye kanye nesimila sawo, kungenzeka ukuthi kwenzeke ukulethwa kwezidakamizwa futhi kuthuthukise imiphumela yokwelashwa. Lokhu kungafaka ukuhlaziya iphrofayili yofuzo yesimila ukukhomba imigomo ethile yokulethwa kwezidakamizwa.

Ithebula lezinhlelo ezihlosiwe ze-FDA ezihlosiwe ezihlosiwe zomdlavuza

Ukuzikhulula: Le ndatshana yenzelwe izinjongo zolwazi kuphela futhi akufanele ibhekwe njengezeluleko zezokwelapha. Thintana nochwepheshe wezempilo ofanelekayo wokuxilongwa kanye nokwelashwa komdlavuza.