Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza: Isikhokelo esibanzi 

Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Ijolise ekuphuculeni ukusebenza kakuhle konyango kwaye inciphise iziphumo ebezingalindelekanga Ukuhambisa iiarhente zonyango kwiiseli zomhlaza ngelixa isusa izicubu ezisempilweni. Le ndlela ifumana abathwali ngeendlela ezahlukeneyo kunye nezicwangciso ezijolise ekuphuculeni ukuqokelelwa kweziyobisi ngaphakathi kwe-tumor micronvisvialvisintwini, ekhokelela kwiziphumo eziphuculweyo.

Ukuqonda Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza

Yintoni i Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza?

Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza yindlela enobunkunkqele yokulawula amayeza ngokuthe ngqo kwiiseli zohlaza. Ngokungafaniyo nonyango lwendabuko, oluchaphazela wonke umzimba, iinkqubo zokuhambisa ezijolisiweyo zigxile ekunikezeleni iziyobisi ngokuthe ngqo kwindawo ye-tumoor. Le ndlela inciphisa umonakalo kwizicubu ezisempilweni kwaye inciphise iziphumo ebezingalindelekanga ezihlala zinxulunyaniswa nonyango oluqhelekileyo lomhlaza.

Kutheni Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Ibalulekile?

Eyona njongo iphambili ye Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza kukuphucula ukusebenza ngonyango lomhlaza ngelixa kuncitshiswa iziphumo eziyityhefu kwiiseli ezisempilweni. Ngokuhambisa amachiza ngqo kwithumba, ukugxininiswa okuphezulu kwe-arhente yonyango kunokufezekiswa kwindawo ekujoliswe kuyo, ukuphucula amathuba onyango olwenziweyo. Oku kunciphisa ukuvezwa kwenkqubo yechiza, kukhokelela kwiziphumo ezimbalwa nezingaphantsi kakhulu kwisigulana.

Iindlela ze Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza

Ukujolisa kujoliso

Eyona nto ijolise kuyo ixhomekeke kwiimpawu zendalo zamathumba, ezinjengeVasculare yabo evuzayo kunye ne-lymphatic suinage, ukuvumela iziyobisi ukuba ziqokelele kwi-micronvialvien. I-Nanopalicals enesayizi efanelekileyo kunye neepropathi ezingaphezulu zinokuxhaphaza ezi mpawu zijolise ekujoliseni ngamathumba. Omnye umzekelo zii-zusosomes eziyimibala ye-vesicle eqokelelwe ii-lipid bilayers.

Ukujolisa ekujoliseni

Ukugxininiswa okusebenzayo kubandakanya ukutshintsha abathwali ngamachiza nge-ligands ethile ebophelelanayo kwi-receptors esokola kwiiseli zomhlaza. Oku kudibana kuye kwenza ukuthathwa okukhethiweyo kwesixhobo seziyobisi ngeeseli zomhlaza. I-ligands eqhelekileyo ibandakanya i-antibodies, i-peptides kunye nee-aptamers.

Ukujolisa kwi-Sumimuli

Ukugxininiswa okuphendulayo okusebenzayo kusetyenziswa isikhumba sangaphakathi okanye yangaphandle, njenge-pH, ubushushu, okanye ukukhanya, ukukhulula ukukhutshwa kweziyobisi kwindawo ye-tumor kwindawo ye-tumor. Le ndlela ivumela ulawulo oluchanekileyo malunga nokuhanjiswa kweziyobisi, ukwandisa ukusebenza ngempumelelo ngonyango ngelixa kuncitshiswa iziphumo. I-PH-ejongene ne-nanopalicles, umzekelo, ukukhupha amachiza abo kwimo ye-acidic ye-tumor micronvicevicrove.

Abathwali basebenzisa Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza

I-nanoparclecles

I-nanopalicles isetyenziswa ngokubanzi njengabathwali ngaphakathi Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Ngenxa yobungakanani babo obuncinci, indawo enkulu yomphezulu, kunye nokuqalisa. Banokwenziwa kwizinto ezahlukeneyo, kubandakanya i-lipids, iipolymers, kunye ne-inrganic. I-Nanopalicals inokubekwa ekuboneni iziyobisi, ukukhusela ekuthandeni, kwaye ukuqhubekise ukuhanjiswa kwabo ekujoliswe kubo kwiiseli zomhlaza. I IZiko loPhando lweShandong Baeo Sebenzisa iintlobo ezahlukeneyo ze-nanopalicals kuphando lwazo oluqhubekayo kubaphikisi bomhlaza we-novel.

I-liposomes

I-PLOSOMESs zizilwanyana ezibekwe zii-vesics ze-lipid Bilayers. Ziyi-biompact, biodegrades, kwaye zinokuthetha amachiza amabini e-hydrophobic. I-Liposomes inokuguqulwa ngokujonga i-ligands yokuphucula ukukhetha kwabo kwiiseli zohlaza.

I-Antictur-Iyobisi leziyobisi (ADCs)

I-ADCS iqulunqwe nge-antidforlonional antids edityaniswe kwichiza le-cytotoovity. I-antiddy ibophelelekile kwiiseli zomhlaza, ihambisa ichiza ngqo kwindawo ye-tumor. Le ndlela idibanisa ubunyani bee-antibodies kunye ne-potenacy yamachiza amacytotoovis.

Imizekelo ye Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza ekusebenziseni kweklinikhi

I-Doxil? (I-liposomal doxorcicin)

I-Doxil? Ngaba i-piposomal ye-doxormal ye-doxormicin, i-andhhranderline chemotherapy ichiza. I-Liposomal e-Inkcaza ye-Doxormacin yandisa ixesha lokujikeleza kwalo kwaye liphucula ukuqokelelwa kwe-sumurs kunye ne-leaky vasculature. I-Doxil? ivunyiweyo kunyango lwe-ovarian yomhlaza, ezininzi ze-myloma, kunye ne-sarcoma kaKapoi.

Kadcyla? (I-Trastuzumab Eltansine)

Kadcyla? Ngaba i-adc edityaniswe nge-trastuzumab, i-monoclonional antibous ejolise kuye2, enxibelelene ne-EMTANAPINE, i-microtubule. Kadcyla? ivunyiwe kunyango lomhlaza we-metastaticatic ye-metatitic. Icandelo le-trastuzumab ye-kadcyla? Ukubopha iiseli zomhlaza we-HE2, ukuhambisa i-EMTTANINE ngokuthe ngqo kwi-tumoor.

Imiceli mngeni kunye nezikhokelo ezizayo

Ukoyisa imiqobo yebhayoloji

Omnye wemiceli mngeni iphambili kwi Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza Ukoyisa izithintelo zendalo, ezinjengesithili segazi kunye ne-tumor micronvicevicrove. Izicwangciso eziliqili zokoyisa ezi zithintelo zibandakanya ukusebenzisa i-nanopalicals ezincinci, ukulungisa iipropathi zawo zomhlaba, kunye nokuqesha ukujolisa ekujoliseni.

Ukuphuculwa kokujolisa ngqo

Ukuphuculwa kobuso beenkqubo ekujoliswe kuzo iziyobisi kubalulekile ukunciphisa iziphumo zokujolisa ngaphandle kunye nokonyusa ukusebenza ngonyango. Oku kunokufezekiswa ngokuphuhlisa i-ligands okhethekayo ngakumbi, kokwenza uyilo lwabathwali iziyobisi, kunye nokusebenzisa unyango.

Iyeza elomeleleyo

Iyeza elenziwa ngokwakho lisondela kwisithembiso esikhulu sokuphucula ukusebenza kwe Ukuhanjiswa kweziyobisi ekujoliswe kuwo kuMhlaza. Ngokulinganisa izicwangciso zonyango kwiimpawu zomntu ngamnye zesigulana kunye nethumbu yazo, kunokwenzeka ukuba zisebenzele ukuhanjiswa kweziyobisi kunye nokomeleza iziphumo zonyango. Oku kunokubandakanya ukuhlalutya iprofayili yemvelo ye-tumoor ukuze ichonge iithagethi ezithile zokuhanjiswa kweziyobisi.

Itheyibhile ye-FDA-evunyiweyo yokuhambisa iziyobisi ngomhlaza

Iphepha elichazayo: Eli nqaku leli nqaku lenzelwe ulwazi kuphela kwaye akufuneki ithathwe njengengcebiso yonyango. Nxibelelana nengcali yezempilo efanelekileyo ukuze ufumane umhlaza.