Chemoimmunotherapy Intratumoral ahaziri nke ọma kacha nta: ntuziaka zuru oke 

Ọgwụgwọ Intratumoral Chemoimmunotherapy nkeonwe nke kacha nta kacha nta bụ usoro ọgwụgwọ ọrịa cancer ọhụrụ na-ejikọta ịwa ahụ dị ntakịrị na chemoimmunotherapy ahaziri ahazi nke ewepụtara na etuto ahụ. Usoro a bu n'obi ime ka ọgwụgwọ ọgwụgwọ dịkwuo elu ma na-ebelata mmetụta ndị na-adịghị mma, nke nwere ike ibute nsonaazụ ndị ọrịa ka mma. Edemede a na-enyocha nkọwa nke usoro a, gụnyere ụkpụrụ ya, usoro ya, uru ya na ntụzịaka ya n'ọdịnihu.

Ịghọta Chemoimmunotherapy Intratumoral

Intratumoral chemoimmunotherapy gụnyere ịgbanye ọgwụ chemotherapeutic na/ma ọ bụ ọgwụ immunotherapeutic n'ime etuto ahụ. Nnyefe mpaghara a na-enye ohere maka ntinye ọgwụ dị elu ruo ebe akpụ ahụ, na-ebelata mkpughe usoro na nsị ma e jiri ya tụnyere chemotherapy omenala. A na-ejikarị ya na ọgwụgwọ ndị ọzọ dị ka ịwa ahụ ma ọ bụ ọgwụgwọ radieshon.

The Evolution of Cancer Ọgwụgwọ

Ọgwụgwọ ọrịa kansa ọdịnala, dị ka chemotherapy sistemu na ọgwụgwọ radieshọn, na-emetụtakarị ahụ dum, na-ebute nnukwu mmetụta. Usoro ọgwụgwọ intratumoral na-anọchite anya ngbanwe gaa n'ụzọ ezubere iche na nke ahaziri iche. Site n'ilekwasị anya na ọgwụgwọ ozugbo na etuto ahụ, ọ na-achọ ịchekwa anụ ahụ dị mma ma melite ogo ndụ onye ọrịa. Shandong Baofa Cancer Research Institute na-agba mbọ ime ihe ọhụrụ na ngalaba a.

Ụzọ 'Ultra-Opekempe mbepụ'

Akụkụ 'Ultra-Opekempe mbepụ' na-ezo aka na usoro ịwa ahụ a na-eji nweta etuto ahụ maka ịgba ogwu. Nke a na-agụnyekarị obere mbepụ, nke teknụzụ onyonyo dị ka ultrasound ma ọ bụ CT na-eduzi, iji hụ na a na-ebuga ndị na-ahụ maka ọgwụgwọ ahụ kpọmkwem. Ọdịdị dị ntakịrị na-emerụ ahụ nke usoro ahụ na-enye aka na oge mgbake ngwa ngwa ma belata mgbu mgbe ịwachara ahụ gasịrị.

Uru nke ịwa ahụ nke pere mpe

• Obere scars
• Obere mgbu
• Ọnụnọ ụlọ ọgwụ dị mkpụmkpụ
• Mgbake ngwa ngwa
• Mbelata ihe ize ndụ nke nsogbu

Chemoimmunotherapy ahaziri onwe ya: Ịkwado ọgwụgwọ nye onye ọ bụla

Nhazi onwe onye bụ isi ihe nke ụzọ a. Tupu ọgwụgwọ, a na-enyocha akpụ nke onye ọrịa iji chọpụta njirimara ya kpọmkwem, dị ka mkpụrụ ndụ ihe nketa na ihe nrịbama mgbochi. A na-eji ozi a wee họrọ ndị ọrụ chemotherapeutic na immunotherapeutic kachasị dị irè maka etuto ahụ. Ụzọ a ahaziri onwe ya na-ebuli ohere nke ịga nke ọma ọgwụgwọ ma na-ebelata ihe ize ndụ nke mmeghachi omume ọjọọ.

Ọrụ nke nyocha biomarker

Nyocha biomarker dị mkpa maka chemoimmunotherapy nkeonwe. Site n'ịchọpụta kpọmkwem biomarkers na etuto ahụ, ndị dọkịta nwere ike ịkọ ọgwụ ndị nwere ike ịdị irè. Dịka ọmụmaatụ, okwu PD-L1 nwere ike igosi nnabata nke ụfọdụ immunotherapies.

Usoro: Nzọụkwụ-site-Nzọụkwụ

Nke Ọgwụgwọ Intratumoral Chemoimmunotherapy nkeonwe nke kacha nta kacha nta N'ezie, usoro a na-agụnye usoro ndị a:

1. Ntụle tupu ịwa ahụ: Onye ọrịa ahụ na-enyocha nyocha nke ọma, gụnyere ọmụmụ ihe onyonyo na nyocha biomarker.
2. Atụmatụ ọgwụgwọ: Dabere na nyocha ahụ, a na-emepụta atụmatụ ọgwụgwọ ahaziri onwe ya, na-akọwapụta chemotherapeutic na immunotherapeutic agents ga-eji.
3. Usoro: Onye ọrịa ahụ na-enweta usoro mmekpa ahụ dị ntakịrị, n'oge a na-agbanye ọgwụ ndị ahụ ozugbo na etuto ahụ n'okpuru nduzi onyonyo.
4. Nleba anya mgbe ọwachara ahụ gasịrị: A na-enyocha onye ọrịa ahụ nke ọma maka mmetụta ọ bụla ma ọ bụ nsogbu ọ bụla. A na-eme nchọpụta ihe nleba anya na-esote iji chọpụta nzaghachi na ọgwụgwọ.

Uru enwere ike nke Ọgwụgwọ Intratumoral Chemoimmunotherapy nkeonwe nke kacha nta kacha nta

Ụzọ ọhụrụ a na-enye ọtụtụ uru dị iche iche ma e jiri ya tụnyere ọgwụgwọ ọrịa cancer omenala:

• Nrụpụta emelitere: Ọnụ ọgụgụ dị elu nke ọgwụ na saịtị tumor.
• Mbelata nsi: Mkpughe sistemu dị ala na chemotherapy.
• Ọgwụgwọ ahaziri onwe ya: Edebere na njirimara akpụ nke onye ọrịa.
• Obere mwakpo: Mgbake ngwa ngwa na obere mgbu.
• Enwere ike maka mkpali mgbochi: Intratumoral nnyefe nke immunotherapeutic agents nwere ike ime ka usoro ahụ ji alụso ọrịa ọgụ ọgụ akpụ ahụ.

Ihe Nlereanya nke Ọrịa Cancer Eji Intratumoral Chemoimmunotherapy gwọọ

Ka nyocha na-aga n'ihu, Ọgwụgwọ Intratumoral Chemoimmunotherapy nkeonwe nke kacha nta kacha nta egosila nkwa n'ịgwọ ọrịa cancer dị iche iche, gụnyere:

• Melanoma
• Ọrịa imeju imeju (hepatocellular carcinoma)
• Ọrịa ara ara
• Ọrịa cancer akpa ume
• Ndị ọzọ siri ike etuto

Data nnwale ụlọ ọgwụ na nyocha

Ọtụtụ ule ụlọ ọgwụ na-aga n'ihu iji nyochaa nchekwa na ịdị irè nke Ọgwụgwọ Intratumoral Chemoimmunotherapy nkeonwe nke kacha nta kacha nta. Nsonaazụ mmalite bụ ihe na-ekwe nkwa, na ụfọdụ ọmụmụ na-egosi nnukwu nlọghachi azụ tumor yana mmụba dị ndụ na ndị ọrịa na-emeso usoro a. Dịka ọmụmaatụ, ọmụmụ e bipụtara na Akwụkwọ akụkọ nke Clinical Oncology gosipụtara mmụba dị ukwuu na nlanarị n'ozuzu maka ndị ọrịa nwere melanoma dị elu a na-agwọ ya na immunotherapy intratumoral ma e jiri ya tụnyere ndị a na-eji usoro chemotherapy. ^[1].

Ọdịnihu nke Chemoimmunotherapy Intratumoral

Ugbo nke intratumoral chemoimmunotherapy na-etolite ngwa ngwa. Ntuziaka n'ọdịnihu gụnyere:

• Mmepe nke chemotherapeutic na immunotherapeutic ọhụrụ dị irè karị.
• Ụzọ emelitere maka ịhazi ọgwụgwọ onwe onye dabere na njirimara etuto ahụ.
• Ngwakọta ọgwụgwọ intratumoral na ọgwụgwọ ọrịa kansa ndị ọzọ, dị ka ọgwụgwọ radieshon na ọgwụgwọ ezubere iche.
• Iji nanotechnology na-ebuga ọgwụ kpọmkwem na saịtị etuto ahụ.

Nhọrọ ndị ọrịa na echiche

Ọ bụghị ndị ọrịa niile dabara adaba maka Ọgwụgwọ Intratumoral Chemoimmunotherapy nkeonwe nke kacha nta kacha nta. Ihe ndị a ga-atụle gụnyere:

• Nha etuto na ọnọdụ
• Ahụ ike zuru oke nke onye ọrịa
• Ọgwụgwọ ọrịa kansa gara aga
• Ọnụnọ nke kpọmkwem biomarkers

Nyocha nke ọma site n'aka otu ndị ọkachamara na-ahụ maka oncologists, ndị dọkịta na-awa ahụ, na ndị ọkachamara ndị ọzọ dị mkpa iji chọpụta ma usoro ọgwụgwọ a dabara adaba maka otu onye ọrịa. A na-anabata ndị ọrịa na-achọ ozi ndị ọzọ ịkpọtụrụ anyị maka nyocha mbụ.

Ihe ize ndụ nwere ike na mmetụta

Dị ka usoro ahụike ọ bụla, Ọgwụgwọ Intratumoral Chemoimmunotherapy nkeonwe nke kacha nta kacha nta na-ebu ụfọdụ ihe egwu yana mmetụta ndị nwere ike ime. Ndị a nwere ike ịgụnye:

• Mgbu na ọzịza na ebe ịgba ọgwụ
• Ọrịa
• Ọbara
• Mmeghachi omume nfụkasị na ọgwụ
• Mmetụta usoro ọgwụgwọ chemotherapy

Ọ dị mkpa ka gị na dọkịta gị kparịta ihe ize ndụ ndị a tupu ịmalite ọgwụgwọ.

Ọnụ na nnweta

Ọnụ nke Ọgwụgwọ Intratumoral Chemoimmunotherapy nkeonwe nke kacha nta kacha nta nwere ike ịdịgasị iche dabere na ọgwụ ndị a kapịrị ọnụ ejiri, mgbagwoju anya nke usoro ahụ, na ebe ebe a na-agwọ ọrịa. Ọ dị mkpa ka gị na onye na-ahụ maka ahụike gị na ụlọ ọrụ inshọransị kparịta ụgwọ. Ịnweta nwekwara ike ịbụ ihe kpatara ya, ebe ọ bụ na ọgwụgwọ a adịbeghị ebe niile na ụlọ ọrụ ọrịa cancer niile.

Mmechi

Ọgwụgwọ Intratumoral Chemoimmunotherapy nkeonwe nke kacha nta kacha nta na-anọchi anya ụzọ ọhụrụ na-ekwe nkwa ọgwụgwọ ọrịa kansa. Site n'ijikọta ịwa ahụ pere mpe na chemoimmunotherapy ahaziri ahazi, ọ na-enye ikike ịkwalite nrụpụta ọrụ, belata nsị, yana welie ogo ndụ onye ọrịa. Ọ bụ ezie na achọrọ nyocha ọzọ, ụzọ ọhụrụ a na-ekwe nkwa maka ọdịnihu nke nlekọta ọrịa cancer. Na Shandong Baofa Cancer Research Institute, anyị na-anọgide na-arara onwe anyị nye ọganihu ịsụ ụzọ na ọgwụgwọ ọrịa cancer na inye ndị ọrịa nlekọta kachasị mma. Kpọtụrụ anyị ka ịmatakwu gbasara nhọrọ ọgwụgwọ ọrịa kansa zuru oke.

Ntụaka

[1] Ribas, A., et al. (2018). Intratumoral Immunotherapy. Akwụkwọ akụkọ nke Clinical Oncology, 36 (9), 919-927.