I-Ultra-minc ecancision eyenziwe ngezifiso i-intratubonal Chemoimmunotherapy: umhlahlandlela ophelele 

I-Ultra-lisenction incision eyenziwe ngezifiso ze-intratubonal chemoimmunotherapy Indlela yokuthola umdlavuza yokwelashwa komdlavuza ehlanganisa ukuhlinzwa okuncane okuhlaselayo nge-chemoimmunotherapy eyenziwe ngezifiso elethwe ngqo kwisimila. Le ndlela ihlose ukukhulisa ukusebenza kahle kokwelashwa ngenkathi inciphisa imiphumela emibi, eholela emiphumeleni yeziguli ethuthukisiwe. Le ndatshana ingena ngemininingwane yale ndlela, kufaka phakathi izimiso zayo, izinqubo, izinzuzo, kanye nezinkomba zesikhathi esizayo.

Ukuqonda i-Intratubal Chemoimmunotherapy

I-Intratubal Chemoimmunotherapy ibandakanya ukujova ngokuqondile ama-ejenti we-chemotherapeapeutic kanye / noma ama-agements amgnonoSapeTic abe isimila. Lokhu kulethwa kwasendaweni kuvumela ukugxila okuphezulu kwesidakamizwa ukufinyelela isigcawu, kunciphisa ukuvezwa okuhlelekile kanye nobuthi buqhathaniswa ne-chemotherapy yendabuko yendabuko. Ngokuvamile kusetshenziswa ngokubambisana nezinye izindlela zokwelapha njengokuhlinzwa noma ukwelashwa kwemisebe.

Ukuvela komdlavuza ukwelashwa komdlavuza

Ukwelashwa komdlavuza wendabuko kwendabuko, njengokuhleleka kwe-chemotherapy kanye nokwelashwa kwemisebe, kuvame ukuthinta wonke umzimba, okuholela emiphumeleni emibi ebalulekile. Ukwelashwa kwe-intratubal kubonisa ukushintshwa kuya ezindleleni ezihlosiwe nezihlonziwe ngokwezifiso. Ngokugxila ekwelashweni ngqo esiswini, ihlose ukusindisa izicubu ezinempilo futhi sithuthukise ikhwalithi yempilo yesiguli. I-Shandong Baafa Cancer Research Institute uzibophezele ekusungulweni okusha kulo mkhakha.

Indlela 'ye-Ultra-mincy incision'

Isici 'se-Ultra-gennerc incision' sibhekisela kwinqubo yokuhlinzwa esetshenziselwa ukufinyelela isimila ngomjovo. Lokhu kuhlanganisa ukufakwa okuncane, okuvame ukuqondiswa ubuchwepheshe bokucabanga njenge-ultrasound noma i-CT Scans, ukuqinisekisa ukulethwa okunembile kwabezokwelapha. Uhlobo oluhlaselayo lwenqubo oluncane lunikela ezikhathini zokutakula ngokushesha futhi lwehlise izinhlungu zeposi ngemuva.

Izinzuzo zokuhlinzwa okuncane okuhlaselayo

• Izibazi ezincane
• Ubuhlungu obuncane
• Ukuhlala okufushane kwesibhedlela
• Ukuvuselelwa okusheshayo
• Ubungozi obuncishisiwe bezinkinga

I-chemoimmunotherapy eyenziwe ngezifiso: ukwelashwa okuhambisana nomuntu ngamunye

Ukwenza okuthandwa nguwe kuyinto ebalulekile yale ndlela. Ngaphambi kokwelashwa, isimilo sesiguli siyahlaziywa ukuze sikhombe izici zayo ezithile, njengokuguqulwa kwezakhi zofuzo kanye nezimpawu zomzimba. Lolu lwazi lusetshenziselwa ukukhetha ama-chemotherapeapeutic aphumelela kakhulu ama-chemotherapeutic kanye ne-ammunoSapeTic agents ngalesosimila esithile. Le ndlela eqondene nomuntu uqobo yandisa amathuba empumelelo yokwelashwa futhi inciphisa ubungozi bokuphendula okuhlukile.

Indima yokuhlaziywa kwe-biomarker

Ukuhlaziywa kwe-biomarker kubalulekile ukuze wenze i-chemoimmunotherapy eyenziwe ngezifiso. Ngokuhlonza ama-biomarkers athile ku-turos, odokotela bangabikezela ukuthi yiziphi izidakamizwa okungenzeka ukuthi zisebenze kahle. Isibonelo, inkulumo ye-PD-L1 ingakhombisa ukuphendula okungaba khona kuma-ackwoctockalies athile.

Inqubo: Isinyathelo-ngesinyathelo

Le khasi I-Ultra-lisenction incision eyenziwe ngezifiso ze-intratubonal chemoimmunotherapy Inqubo ngokuvamile ifaka izinyathelo ezilandelayo:

1. Ukuhlolwa kwangaphambi kokusebenza: Isiguli sithola ukuhlolwa okuphelele, kufaka phakathi izifundo zokucabanga nokuhlaziywa kwe-biomarker.
2. Ukuhlelwa Kwezokwelapha: Ngokusekelwe ekuhlolweni, uhlelo lokwelashwa oluqondene nomuntu uqobo luthuthukiswa, lucacisa ama-chemotherapeapeutic kanye nama-agements ammnguluninoSapetic azosetshenziswa.
3. Inqubo: Isiguli sibhekene nenqubo engahlaseli kancane, lapho izidakamizwa zingena ngqo esimisweni ngaphansi kwesiqondiso sezithombe.
4. Ukuqapha ngemuva kokusebenza: Isiguli sibhekwe eduze noma yimiphi imiphumela emibi noma izinkinga. Kwenziwa izifundo zokulinganisa ukucabanga ukuze zihlole impendulo yokwelashwa.

Izinzuzo ezingaba khona ze I-Ultra-lisenction incision eyenziwe ngezifiso ze-intratubonal chemoimmunotherapy

Le ndlela entsha inikeza izinzuzo eziningana ezingaba khona uma kuqhathaniswa nokwelashwa komdlavuza wendabuko:

• Impumelelo ethuthukisiwe: Ukuqoqwa okuphezulu kwezidakamizwa endaweni ye-tumor.
• Ubuthi obuncishisiwe: Ukuvezwa okuhleliwe kwe-chemotherapy.
• Ukwelashwa okwenziwe umuntu: Iqondiswe kwizimo ze-tumor zesiguli ngazinye.
• Ukuhlasela okuncane: Ukululama ngokushesha nobuhlungu obuncane.
• Amandla okuvuselela amandla okuvikelwa komzimba: Ukulethwa kwe -nttatubal kwama-ejenti ama-immunoSatic kungavusa amasosha omzimba ukuhlasela isimila.

Izibonelo Zomdlavuzo ziphathwa nge-intratubal Chemoimmunotherapy

Ngenkathi ucwaningo luyaqhubeka, I-Ultra-lisenction incision eyenziwe ngezifiso ze-intratubonal chemoimmunotherapy Ukhombisile ukuthembisa ekwelapheni umdlavuza ohlukahlukene, kufaka phakathi:

• Imenyama
• I-hepatocellular carcinoma (umdlavuza wesibindi)
• Umdlavuza webele
• Umdlavuza wamaphaphu
• Amanye ama-humors aqinile

Idatha Yesivivinyo Yomtholampilo Nocwaningo

Izilingo eziningi zemitholampilo ziyaqhubeka zihlola ukuphepha nokusebenza kahle kwe I-Ultra-lisenction incision eyenziwe ngezifiso ze-intratubonal chemoimmunotherapy. Imiphumela yakuqala iyathembisa, ngezifundo ezithile ezibonisa ukubuyiselwa kwabantu okubalulekile kwezimoto kanye namazinga okusinda athuthukile ezigulini aphathwa ngale ndlela. Ngokwesibonelo, ucwaningo olushicilelwe ku I-Journal of Clinical Oncology kukhombise ukuthuthuka okukhulu ekusindeni okuphelele kweziguli ezine-melanoma ethuthukisiwe ephathwa nge-intratunomal immunotherapy uma kuqhathaniswa nalabo abaphathwa nge-systemic chemotherapy ^[1].

Ikusasa le-intratubobal chemoimmunotherapy

Inkambu ye-intratubobal Chemoimmunotherapy ivela ngokushesha. Izikhombisi zesikhathi esizayo zifaka:

• Ukuthuthukiswa kwama-chemotherapeapeutic amasha asebenza ngempumelelo kanye nama-ammunoSapeTapeutic agents.
• Izindlela ezithuthukisiwe zokwelashwa okwenziwe ngezifiso ezisuselwa kwizici ze-tumor.
• Inhlanganisela yokwelashwa kwe-intratubobal nezinye izindlela zokwelapha umdlavuza, njengokulashwa kwemisebe kanye nokwelashwa okuhlosiwe.
• Ukusetshenziswa kwe-nanotechnology ukuletha izidakamizwa ngokunembile kusayithi le-tumor.

Ukukhethwa kwesiguli kanye nokucatshangelwa

Akuzona zonke iziguli ezifanelekile I-Ultra-lisenction incision eyenziwe ngezifiso ze-intratubonal chemoimmunotherapy. Izici okufanele zicatshangelwe zifaka:

• Ubukhulu be-tumor nendawo
• Impilo yesiguli iphelele
• Ukwelashwa kwangaphambilini komdlavuza
• Ukuba khona kwama-biomarkers athile

Ukuhlolwa okuphelele kweqembu lama-Oncologists, odokotela abahlinzayo, kanye nabanye ongoti kubalulekile ukuthola ukuthi ngabe le ndlela yokwelashwa ilungele yini isiguli esithile. Iziguli ezifuna imininingwane eminingi zamukelekile ukuxhumana nathi ngokubonisana kokuqala.

Izingozi ezingaba khona nemiphumela emibi

Njenganoma iyiphi inqubo yezokwelapha, I-Ultra-lisenction incision eyenziwe ngezifiso ze-intratubonal chemoimmunotherapy uphethe ezinye izingozi nemiphumela emibi engaba khona. Lokhu kungafaka:

• Ubuhlungu nokuvuvukala endaweni yokujova
• Okuthelelayo isifo
• -Ophayo
• I-allergic reactions emithini yezidakamizwa
• Imiphumela emibi ye-systemic ye-chemotherapy

Kubalulekile ukuxoxa ngalezi zingozi nodokotela wakho ngaphambi kokulashwa.

Izindleko nokutholakala

Izindleko ze I-Ultra-lisenction incision eyenziwe ngezifiso ze-intratubonal chemoimmunotherapy ingahluka ngokuya ngemithi ethile esetshenzisiwe, ubunzima benqubo, nendawo yendawo yokwelashwa. Kubalulekile ukuxoxa ngezindleko nomhlinzeki wakho wezokunakekelwa kwempilo kanye nenkampani yomshuwalense. Ukutholakala kungaba yimbangela, njengoba lokhu kwelashwa kungatholakali kabanzi kuzo zonke izikhungo zomdlavuza.

Ukugcina

I-Ultra-lisenction incision eyenziwe ngezifiso ze-intratubonal chemoimmunotherapy imele indlela ethembisayo yokuthola umdlavuza. Ngokuhlanganisa ukuhlinzwa okuncane okuhlaselayo nge-chemoimmunotherapy yomuntu uqobo, inikeza amandla okuthuthukisa ukusebenza ngempumelelo, ukunciphisa ubuthi, futhi uthuthukise ikhwalithi yempilo yesiguli. Ngenkathi kudingeka ucwaningo olunye, le ndlela entsha ibamba isithembiso esihle ngekusasa lokunakekelwa komdlavuza. E- I-Shandong Baafa Cancer Research Institute, sihlala sinikezelwe entuthukweni yokuphayona ekwelashweni komdlavuza nasekuhlinzekeni iziguli ngokunakekelwa okungcono kakhulu. Xhumana nathi ukuze ufunde kabanzi ngezinketho zethu eziphelele zomdlavuza wezinketho.

Ukunqubekela phambili

[1] URibas, A., et al. (2018). I-Intratubal immunotherapapy. I-Journal of Clinical Oncology, 36 (9), 919-927.