I-Ultra-ubuncinci i-ofisi ye-GARMUMORAL ye-CHEmoimmunourapy: Isikhokelo esibanzi 

Ubuncinci be-Ultra-ubuncinci i-Intratumoral chemoimmunourapy Inkqubo yonyango oluyintshabalalo idibanisa utyando oluhlaselweyo oluncinci kunye ne-chemoimmunourapy ichetyiwe ngqo kwi-tumor. Le ndlela ijolise ekukhuliseni ukusebenza ngonyango ngelixa incipha iziphumo ebezingalindelekanga, enokubakho kukhokelela kwiziphumo eziphuculweyo. Eli nqaku livuka kwiinkcukacha zolu buchule, kubandakanya imigaqo, iinkqubo, izibonelelo, kunye nezikhokelo ezizayo.

Ukuqonda i-Intramoral chemoimmunourapy

Intramoral chemoimmunourapudUpy ibandakanya ngokuthe ngqo i-chemotherapeutic agents kunye / okanye iiarhente zokuziphatha kwi-tumar. Olu hambo lwasekhaya luvumela uxinzelelo oluphezulu lwechiza lokufikelela kwindawo ye-tumor, ukunciphisa ukubonakaliswa kwenkqubo kunye netyhefu xa kuthelekiswa ne-Intravenous yendabuko. Ihlala isetyenziswa ngokudibeneyo kunye nolunye unyango olunjengotyando okanye i-radiation phanya.

Indaleko yonyango lomhlaza

Unyango lomhlaza wemveli, njengokuhamba kwenkqubo ye-chemotherapy kunye nonyango lwe-radiation, ihlala ichaphazela umzimba wonke, okhokelela kwiziphumo ezibekiweyo. Unyango lwe-intramumoral lubonisa utshintsho ekufikeleleni kwiindlela ekujoliswe kuzo kunye nezomntu. Ngokujonga unyango ngqo kwi-tumoor, ijolise ekuphelisweni kwezicubu ezinempilo kunye nokuphucula umgangatho wobomi bomguli. IZiko loPhando lweShandong Baeo uzibophelele kwizinto ezintsha kule ndawo.

'Indlela ye-Ultra-ubuncinci

Ingcaciso 'ye-Ultra-encinci ibhekisele kubuchule bokuhlinzwa osetyenziselwa ukufikelela kwithumbu inaliti. Oku kubandakanya ukwenziwa kwezinto ezincinci, kudla ngokukhokelwa kukucinga itekhnoloji efana ne-ultrasound okanye i-CT Scans, ukuqinisekisa ukuhanjiswa ngokuchanekileyo kweearhente zonyango. Ukuhlaselwa okuncinci kwenkqubo kufane negalelo ekhawuleze amaxesha akhangeleke kwaye anciphise iintlungu zentsebenzo.

Izibonelelo zoqhaqho kancinci

• Izibonda ezincinci
• Intlungu encinci
• Ukuhlala isibhedlele
• Ukubuyiselwa ngokukhawuleza
• Ukucuthwa komngcipheko weengxaki

I-chemoimmunourapy: Ukulungelelanisa unyango kumntu ngamnye

Ukwenza ubuqu yinto ephambili yale ndlela. Ngaphambi konyango, ithumba lesigulana lihlaziywa ukuze lichonge iimpawu zalo, ezinje ngovelwano kunye nokumakishwa kwemfuza. Olu lwazi ke lusetyenziselwa ukukhetha ezona sumothepic kunye neearhente zokuziphatha kakuhle kwi-tumor ethile. Le ndlela iphambili yobuqu yandisa amathuba empumelelo yonyango kwaye inciphise umngcipheko wokuphendula okugwenxa.

Indima yohlalutyo lwe-biomarker

Uhlalutyo lwe-biomarker lubalulekile kunyango lwe-chemoimmunother. Ngokuchonga ii-bimamaskis ezithile kwi-tumore, abantu basekliniki banokuxela ukuba zeziphi iziyobisi ezinokwenzeka ukuba zisebenze kakuhle. Umzekelo, ibinzana le-PD-L1 linokubonisa ukuphendula okunokubakho kuphuculo oluthile.

Inkqubo: Inyathelo lenyathelo

I Ubuncinci be-Ultra-ubuncinci i-Intratumoral chemoimmunourapy Inkqubo iqhele ukubandakanya la manyathelo alandelayo:

1. UVAVANYO LWE-PAELTIONATER: Isigulana siphantsi kovavanyo olucokisekileyo, kubandakanya nezifundo zokucinga kunye nohlalutyo lwe-biomarker.
2. Ucwangciso lonyango: Ngokusekwe kuvavanyo, kuphuhliswa isicwangciso sonyango, sicacisa i-chemotheutic kunye neearhente zokuziphatha eziza kusetyenziswa.
3. Inkqubo: Isigulana sijonga inkqubo encinci engahlaseli, apho amachiza athunyelwa ngqo kwithumba phantsi kwesikhokelo semifanekiso.
4. Ukubeka iliso kwi-post-Page: Isigulana sibekwe esweni ngokusondeleyo nayiphi na iziphumo ebezingalindelekanga okanye iingxaki. Izifundo zokucinga zenziwa ukuvavanya impendulo kunyango.

Izibonelelo ezinokubakho Ubuncinci be-Ultra-ubuncinci i-Intratumoral chemoimmunourapy

Le ndlela imveliso imveliso ibonelela ngezibonelelo ezininzi ezinokubakho xa kuthelekiswa nonyango lomhlaza:

• Ukuphuculwa kokusebenza kakuhle: Uxinzelelo oluphezulu lweziyobisi kwindawo yethumba.
• Incitshiswe ityhefu yobuso: Ukuvezwa kwenkqubo esezantsi kwi-chemotherapy.
• Unyango olwenziweyo: Ilungiselelwe kwiimpawu ze-tumas zomntu ngamnye.
• Ukuhlaselwa kancinci: Ukuvuselela ngokukhawuleza kunye nentlungu encinci.
• Ukubakho kokuvuselela amajoni omzimba: Ukuhanjiswa kwe-intramumoral yeearhente zokuziphatha okunyanzelayo zinokuvuselela amajoni omzimba ahlasele isithungu.

Imizekelo yoCawa inyangwa nge-intramoral chemoimmunourapy

Ngelixa uphando luyaqhubeka, Ubuncinci be-Ultra-ubuncinci i-Intratumoral chemoimmunourapy ubonakalise isithembiso xa ephatha iindidi zomhlaza, kubandakanya:

• I-melanoma
• I-HepatoceLlar ye-Carcnoma (Umhlaza osibindi)
• Umhlaza webele
• Umhlaza wemiphunga
• Amanye amathumba aqinileyo

Idatha yeKlinikhi yeKlinikhi kunye noPhando

Iimvavanyo ezininzi zeklinikhi ziyaqhubeka ukuvavanya ukhuseleko kunye nokusebenza kakuhle kwe Ubuncinci be-Ultra-ubuncinci i-Intratumoral chemoimmunourapy. Iziphumo zakwangoko zithembisa, kunye nezifundo ezibonisa uhlengahlengiso lwe-tumoor obalulekileyo kunye nokuphuculwa kwamaxabiso okusinda kwizigulana ezinyangwa ngale ndlela. Umzekelo, uphononongo olupapashwe kwi Ijenali yeKlinikhi yeKlinikhi yeKlinikhi ibonakalise ukuphuculwa okukhulu kokusinda ngokubanzi kwizigulana ezine-hulanomapperm ephathwe nge-Intratheral i-Intsumotheral ithelekiswa nezo ziphathwayo ^[1].

Ikamva le-Intramoral chemoimmunourapy

Intsimi ye-Intramoral Chemoimmunonotherpy ivela ngokukhawuleza. Izikhombisi zexesha elizayo zibandakanya:

• Ukuphuhliswa kwe-chemotheutic ye-chemotheutic kunye neearhente zokuziphatha kakuhle.
• Iindlela zokuphucula iindlela zokunyanga ngokwakho ngokwakho kwiimpawu ze-tumoor.
• Ukudityaniswa kwe-intrumoral unyango kunye nolunye unyango lomhlaza, njengokunyanga kwe-radiation kunye nonyango olujolise kuyo.
• Ukusetyenziswa kwe-nanotechnology ukuhambisa iziyobisi ngokuchanekileyo kwi-tumoor.

Ukukhetha isigulana kunye nokuqwalaselwa

Ayizizo zonke izigulana ezifanelekileyo Ubuncinci be-Ultra-ubuncinci i-Intratumoral chemoimmunourapy. Izinto ekufuneka ziqwalaselwe zibandakanya:

• Ubungakanani be-tumar kunye nendawo
• Impilo epheleleyo yesigulana
• Unyango lomhlaza odlulileyo
• Ubukho bee-biomarkers ezithile

Uvavanyo olucokisekileyo ngeqela le-oncologists, oogqirha, kunye nezinye iingcali kubalulekile ukufumanisa ukuba indlela yonyango ilungele isigulana esithile. Abaguli abafuna ulwazi ngakumbi bayamkelekile ukuba banxibelelane nathi ngokubonisana.

Umngcipheko onokubakho kunye neziphumo ebezingalindelekanga

Njengayo nayiphi na inkqubo yezonyango, Ubuncinci be-Ultra-ubuncinci i-Intratumoral chemoimmunourapy ithwala umngcipheko othile kunye neziphumo ebezingalindelekanga. Oku kunokubandakanya:

• Intlungu kunye nokudumba kwindawo yenaliti
• Usulelo
• Ukopha
• I-allergic Reaction kwiziyobisi
• Iziphumo ezicwangcisiweyo ze-chemotherapy

Kubalulekile ukuba uxoxe ngezi ntsizi kunye nogqirha wakho ngaphambi kokuba afumane unyango.

Iindleko kunye nokufikeleleka

Ixabiso le Ubuncinci be-Ultra-ubuncinci i-Intratumoral chemoimmunourapy inokwahluka ngokuxhomekeke kumachiza athile asetyenzisiweyo, ubunzima benkqubo, kunye nendawo ekusetyenzwa ngayo iziko lonyango. Kubalulekile ukuxoxa ngeendleko kunye nomnikezeli wakho wezempilo kunye nenkampani yeinshurensi. Ukufikeleleka kusenokuba yinto, njengoko olu nyango alukho ngokubanzi kuwo onke amaziko amahlaza.

Ukuqukumbela

Ubuncinci be-Ultra-ubuncinci i-Intratumoral chemoimmunourapy imele indlela ethembekileyo yonyango lomhlaza. Ngokudibanisa utyando oluhlaselayo ngokuncitshisiweyo kunye ne-chemoimmunonotherapyun, inika amandla okuphucula ukusebenza kakuhle, ukunciphisa ubuthi, kwaye uphucule umgangatho wobomi bomguli. Ngelixa kufuneka uphando olongezelelekileyo, le ndlela imbonakalo intshabalalo ibamba isithembiso esikhulu kwikamva loKhathalelo loMhlaza. Kwi IZiko loPhando lweShandong Baeo, sihlala sinikezelwe kwiinkqubela phambili kubuvulindlela kunyango lomhlaza kunye nokubonelela abaguli ngononophelo olunokwenzeka. Nxibelelana nathi ukuze ufunde ngakumbi malunga neendlela zethu zonyango olubanzi lomhlaza.

Izalathiso

[1] I-ribas, A., et al. (2018). I-IntMUTOTRARALONIRALY. Ijenali yeKlinikhi yeKlinikhi yeKlinikhi, 36 (9), 919-927.